9,469 results match your criteria: "Adrenal Adenoma"

Molecular characterization of archival adrenal tumor tissue from patients with ACTHindependent Cushing syndrome.

J Steroid Biochem Mol Biol

December 2024

Department of Pathology, University of Michigan, Ann Arbor, MI, United States; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, United States; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, United States.

Cushing syndrome represents a multitude of signs and symptoms associated with long-term and excessive exposure to glucocorticoids. Solitary cortisol-producing adenomas (CPAs) account for most cases of ACTH-independent Cushing syndrome (CS). Technological advances in next-generation sequencing have significantly increased our understanding about the genetic landscape of CPAs.

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Background/objectives: Adrenocortical tumors (ACTs), including adrenocortical adenoma (ACA) and carcinoma (ACC), represent 0.3-0.4% of pediatric tumors.

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Background: Cushing syndrome increases morbidity and mortality, which is mainly caused by cardiovascular disorders. This study reports the cardiovascular risk outcomes at 3, 6, and 12 months after unilateral laparoscopic adrenalectomy in cortisol-secreting adrenal tumor and to identify the preoperative parameters predicting the resolution of cardiovascular risk factors after surgery.

Methods: All clinical data of patients with unilateral cortisol-secreting adrenal tumors who underwent laparoscopic adrenalectomy in King Chulalongkorn Memorial Hospital between 2001-2022 were retrospectively reviewed.

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Background: Since 2017, switching from laparoscopic transabdominal adrenalectomy (LTA), posterior retroperitoneoscopic adrenalectomy (RPA) is used as standard procedure in this institution. Aim of this retrospective study was to compare both techniques regarding operative time, length of stay and safety of the procedures.

Methods: All patients operated in our institution for adrenal tumors were prospectively documented in the EUROCRINE-database and retrospectively analyzed.

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Glucocorticoid replacement therapy after retroperitoneal laparoscopic unilateral adrenal adenoma resection in patients with non-cortisol secreting tumors: a retrospective cohort study.

Gland Surg

November 2024

Department of Urology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China.

Background: Adrenal Cushing's syndrome is caused by an adrenal tumor that produces hypercortisolism and requires glucocorticoid supplementation following resection of the tumour to prevent adrenal insufficiency. Few studies have examined whether glucocorticoid replacement (GR) therapy is required after retroperitoneal laparoscopic unilateral adrenal adenoma resection in patients with non-cortisol secreting tumors, or whether there is any correlation between preoperative biochemical indicators and postoperative cortisol function. This study sought to investigate which patients with non-cortisol secreting tumors required GR therapy after undergoing retroperitoneal laparoscopic resection of unilateral adrenal cortical adenoma.

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Context: Studies describing the coagulation profile in adrenal adenomas still need to be added.

Objective: We explored how sex and mild autonomous cortisol secretion (MACS) affect coagulation parameters in patients with adrenal adenomas.

Design: Cross-sectional study.

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[F]AlF-NOTA-pentixather PET/CT of CXCR4 in patients with suspected primary hyperaldosteronism.

Theranostics

December 2024

Department of Nuclear Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.

Distinguishing unilateral aldosterone-producing adenomas (APA) from idiopathic hyperaldosteronism (IHA), nonfunctional adrenal adenoma (NFA), and pheochromocytoma (PHEO) within primary aldosteronism (PA) presents a significant challenge. Studies have demonstrated high levels of chemokine receptor (CXCR) 4 expression in APA, thereby validating the use of Ga-labeled CXCR4 PET/CT for detecting APA. This study evaluates the efficacy of [F]AlF-NOTA-pentixather PET/CT in distinguishing APA from other PA types.

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In adrenal steroidogenesis, 17-hydroxyprogesterone (17-OHP) is a substrate for 21-hydroxylase, one of the crucial enzymes of the cortisol and aldosterone biosynthesis pathway. Thus, measurement serum 17-OHP concentration is used when the diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is suspected. In the classic 21-hydroxylase deficiency, randomly timed measurements of 17-OHP are generally significantly elevated using different immunoassays.

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Background: Ectopic cortisol-producing adrenocortical adenoma (ECPA) is extremely rare, with only a few cases reported. Retroperitoneal schwannoma is also uncommon, accounting for only 0.7-5% of all schwannomas.

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BACKGROUND Non-functioning adrenal adenomas (NFA) are prevalent tumors often associated with metabolic disturbances compared to the general population. This study aimed to evaluate cardiovascular disease (CVD) risk in 106 patients with NFA using SCORE2 and SCORE2-OP algorithms. MATERIAL AND METHODS The study sample comprised of 106 patients with NFA.

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Objective: In this retrospective study, we aimed to investigate the clinical, hormonal, and radiological characteristics of patients with adrenal incidentalomas (AIs), to assess the prevalence of metabolic syndrome components in patients with AIs, and to determine whether changes in tumor size or hormonal activity occur during long-term follow-up in patients with AIs.

Methods:  We retrospectively analyzed data from 384 patients diagnosed with AI between 2010 and 2020. Data regarding radiological, hormonal, and metabolic investigations in diagnosis and also during follow-ups were collected.

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Contrast Enhanced CISS/FIESTA Imaging for Increased Conspicuity of Pituitary Microadenomas in Cushing Disease.

AJNR Am J Neuroradiol

November 2024

From the Department of Radiology (I.T.M, E.G.S, J.T.L, D.R.J, S.A.M), Department of Endocrinology (I.B., L.M.G.), Department of Neurosurgery (M.P.C., J.V.G.), Mayo Clinic, Rochester, MN, USA.

Background And Purpose: Pituitary microadenomas can be challenging to see on MRI, particularly when they are small. The detection of microadenomas commonly relies on contrast-enhanced sequences, highlighting the adenoma that demonstrates hypoenhancement relative to the native pituitary on T1-weighted sequences. Detecting adenomas in patients with Cushing disease is crucial, as surgery is the standard of care treatment.

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Primary aldosteronism (PA) is the most common form of secondary hypertension. Recently, the genetic analysis of aldosterone-producing adenoma, a major cause of PA, has revealed several causative genes. Herein, we present a case of a 27-year-old Japanese female with PA.

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Shoulder osteoarthritis facilitating the diagnosis of acromegaly.

BMJ Case Rep

November 2024

Paris Cité University, Department of physical medicine and rehabilitation, Hôpital Cochin - Assistance Publique- Hôpitaux de Paris, Paris, Île-de-France, France.

Article Synopsis
  • - A 50-something man experienced chronic shoulder pain and reduced motion without any prior trauma, leading to imaging that showed osteophytosis but no severe joint issues.
  • - A second consultation revealed swelling in his hands and feet, raising suspicion of acromegaly, which was confirmed by further tests and an MRI showing a sellar tumor.
  • - The shoulder pain was linked to undiagnosed acromegalic arthropathy, prompting treatment through surgery and medication, emphasizing the importance of early acromegaly diagnosis to prevent complications.
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Cushing's syndrome (CS) is a rare disorder characterized by an excess of glucocorticoids, leading to distinctive clinical manifestations. However, its presentation can be atypical, complicating diagnosis. We describe a 53-year-old woman's case of endogenous, adrenocorticotropic hormone (ACTH)-independent CS, presenting with bilateral leg edema and shin ulceration, without the classic signs of moon face or truncal obesity initially.

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Cushing disease (CD), a rare endocrine disorder characterized by a pituitary adenoma that secretes excess adrenocorticotropic hormone (ACTH), leads to overproduction of cortisol by the adrenal glands and, depending on severity and duration, manifests with a broad spectrum of clinical signs and symptoms, ranging from classical features to more common conditions seen in the general population. Discovery of molecular and pathogenic mechanisms related to the development of CD tumors has increased in recent years, almost two-thirds of the somatic variants cases have been linked to the USP8 gene, while very rare germline variants in MEN1 and AIP genes have been associated with pituitary adenomas. Variants affecting the RET proto-oncogene, which encodes a receptor tyrosine kinase involved in cell growth and differentiation, are implicated in the development of medullary thyroid carcinoma (MTC) and its hereditary form, multiple endocrine neoplasia type 2 (MEN2).

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Protective Strategies for Pituitary Function During Endoscopic Transnasal Pituitary Adenoma Surgery: A Single-center Experience.

J Craniofac Surg

November 2024

Department of Neurosurgery, Pituitary Tumor Diagnosis and Treatment Research Center, The First Affiliated Hospital Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.

Article Synopsis
  • - This study examined the effects of endoscopic transnasal pituitary adenoma surgery on pituitary function and aimed to identify factors that influence postoperative outcomes.
  • - An analysis of 306 patients' data revealed varying rates of postoperative hypopituitarism among different hormone axes, with the pituitary-thyroid and adrenal axes showing higher incidence rates post-surgery.
  • - Results indicated that larger tumors (giant adenomas) had a significantly greater impact on adrenal function, while no substantial difference in new hypopituitarism rates was observed after surgery between different tumor sizes.
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Article Synopsis
  • Pituitary apoplexy is a serious condition often linked to underlying masses like adenomas, causing acute neurological symptoms that may require urgent surgical intervention.
  • The study compares the effects of different surgical timing (before or after 48 hours, 72 hours, and 7 days) on visual outcomes for patients with this condition, along with the effectiveness of surgical decompression versus conservative management.
  • A review of 29 studies found that most patients had visual deficits and were treated with surgery, particularly through the endoscopic endonasal approach, with a detailed analysis focusing on outcomes over a 7-day period.
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Evolutionary Characteristics in Primary Aldosteronism Patients.

Hypertension

January 2025

National Health Commission Key Laboratory of Endocrinology, Department of Endocrinology (Y.G., Y.W., Y. Zhou, M.N., A.T.), Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Article Synopsis
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