Nitric oxide as an independent regulatory factor in regenerating rat liver.

Nitric oxide production and lipid peroxidation modulate the proliferating activity of liver cells, but the relationship between enhanced nitric oxide production, lipid peroxidation, and liver regeneration remains unclear. We examined the role of nitric oxide and lipid peroxidation on experimental liver regeneration. Thirty-five male Wistar albino rats underwent a sham operation (I), partial hepatectomy alone (II, IV), partial hepatectomy and daily N-nitro-L-arginine methyl ester (L-NAME) treatment for 24-hrs (III) or 48-hrs (V).

Is synchronous bowel anastomosis safe?

In this study, we investigated the effects of synchronous anastomosis on intestinal healing in experimental colonic resection. Sprague-Dawley rats were randomized into 3 groups; control (group I), single anastomosis (group II) and synchronous (double) anastomosis (group III). Single and proximal anastomoses were located 3 cm distal to caecum, and distal anastomoses were done 3 cm distal to them.