1,492 results match your criteria: "Adenoma Bronchial"
Indian J Pathol Microbiol
August 2024
Department of Urology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Bronchial cyst (BC), also known as anterior intestinal cyst, is often located in the posterior mediastinum and rarely in the retroperitoneum, especially in the adrenal area. The patient was a 65-year-old male with a left adrenal lesion (adrenal adenoma was considered) indicated by imaging examination at initial diagnosis. After completing the preoperative preparation, the patient underwent laparoscopic partial adrenalectomy under general anesthesia.
View Article and Find Full Text PDFExp Mol Pathol
June 2024
Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany. Electronic address:
Objective: Little information is available concerning protein expression of the free fatty acid receptor 2 (FFAR2), especially in tumours. Therefore, the aim of the present study was to comprehensively characterise the expression profile of FFAR2 in a large series of human normal and neoplastic tissues using immunohistochemistry thus providing a basis for further in-depth investigations into its potential diagnostic or therapeutic importance.
Methods: We developed a novel rabbit polyclonal anti-FFAR2 antibody, 0524, directed against the C-terminal region of human FFAR2.
Medicine (Baltimore)
December 2023
Department of Radiology, Weifang No. 2 People's Hospital, Shandong Province, China.
Sci Rep
November 2023
Institute of Pharmacology and Toxicology, Jena University Hospital, Jena, Germany.
Little is known about the expression of the orphan G protein-coupled receptor GPR19 at the protein level. Therefore, we developed a rabbit antibody, targeting human GPR19. After verification of the antibody specificity using GPR19-expressing cell lines and a GPR19-specific siRNA, the antibody was used for immunohistochemical staining of a variety of formalin-fixed, paraffin-embedded normal and neoplastic human tissue samples.
View Article and Find Full Text PDFZhonghua Bing Li Xue Za Zhi
November 2023
Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Histopathology
January 2024
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
While lung cancer is one of the most common malignancies routinely encountered by pathologists, benign pulmonary neoplasms are quite rare. However, it is important for pathologists to be familiar with the typical diagnostic features of benign lung tumors to avoid confusing them with malignant morphological mimics. There have also been intriguing discoveries in the genetics of benign pulmonary neoplasms in the past decade.
View Article and Find Full Text PDFInt J Surg Pathol
May 2024
Department of Pathology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, OH, USA.
Papilloma of the lung is a rare benign entity and can be solitary or multiple. Solitary papilloma is subclassified into three categories: squamous papilloma, glandular papilloma, and mixed squamous and glandular papilloma. Glandular papilloma is the rarest subtype among them and occurs mostly in the sixth decade without any relation to smoking, syndrome, or infection.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
July 2023
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
Cushing's syndrome (CS) resulting from endogenous hypercortisolism can be sporadic or can occur in the context of familial disease because of pituitary or extra-pituitary neuroendocrine tumors. Multiple endocrine neoplasia type 1 (MEN1) is unique among familial endocrine tumor syndromes because hypercortisolism in this context can result from pituitary, adrenal, or thymic neuroendocrine tumors and can therefore reflect either ACTH-dependent or ACTH-independent pathophysiologies. The prominent expressions of MEN1 include primary hyperparathyroidism, tumors of the anterior pituitary, gastroenteropancreatic neuroendocrine tumors, and bronchial carcinoid tumors along with several common non-endocrine manifestations such as cutaneous angiofibromas and leiomyomas.
View Article and Find Full Text PDFJ Am Soc Cytopathol
November 2023
Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, Ohio. Electronic address:
Port J Card Thorac Vasc Surg
April 2023
Department of Thoracic Surgery, Gazi University, Ankara, Turkey.
Although Cushing's Syndrome (CS) is usually caused by pituitary/adrenal adenomas, in the remaining few cases, Adrenocorticotrophic hormone (ACTH) is secreted by extrapituitary neuroendocrine tumors (NET). In typical pulmonary / bronchial carcinoid tumors leading to ectopic ACTH syndrome (EAS). The main principle of treatment is the localization of the ACTH-secreting tumor and its surgical removal.
View Article and Find Full Text PDFMod Pathol
June 2023
Department of Respiratory Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Mucous gland adenoma (MGA) is a rare benign tumor that usually arises in the proximal airway and consists of mucus-secreting cells resembling bronchial glands. Here, we report 2 cases of MGAs and describe their morphologic, immunohistochemical, and molecular profiles in comparison with 19 pulmonary tumors of 5 other histologic types with mucinous cells (invasive mucinous adenocarcinoma, mucoepidermoid carcinoma, mixed squamous cell and glandular papilloma, bronchiolar adenoma/ciliated muconodular papillary tumor, and sialadenoma papilliferum). Two MGAs were found in 1 male patient and 1 female patient, located in the bronchus and trachea, respectively.
View Article and Find Full Text PDFHorm Res Paediatr
April 2024
Department of Pediatric Endocrinology and Diabetes, Koç University Hospital, Istanbul, Turkey.
Introduction: Endogenous Cushing's syndrome (CS) is a rare, severe disease that can cause multiple systemic involvements and behavioral problems due to excessive cortisol production. Structural changes can be noted in the brain magnetic resonance imaging (MRI) scans of these cases.
Cases: A 9-year-old girl and a 13-year-old boy were admitted with hypercortisolism.
Endocrinol Diabetes Nutr (Engl Ed)
November 2022
Service of Endocrinology and Nutrition, Hospital Clínico Universitario de Valencia, Valencia, Spain; Department of Medicine, University of Valencia, Spain; CIBER de Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Barcelona, Spain.
Objective: Our aim was to characterise a cohort of patients with Cushing's disease (CD) who did not present pituitary adenoma in magnetic resonance imaging (MRI), needing a catheterisation of the inferior petrosal sinus (CIPS), and to study the pathological findings of the pituitary gland in these subjects after transsphenoidal surgery in order to establish the aetiology of CD. Furthermore, we evaluated possible differences in the features of the diagnosis between hyperplasia and adenoma.
Subjects And Methods: We included 16 subjects.
Rev Med Interne
January 2023
Service Endocrinologie et Oncologie endocrinienne, CHU de Bordeaux, hôpital Haut Lévêque, 33600 Pessac, France. Electronic address:
Front Oncol
September 2022
Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Afliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Parathyroid adenoma (PA), one of the most common causes of hyperparathyroidism, generally involves a single parathyroid gland and is manifested as hyperparathyroidism. Bronchogenic cysts are rare congenital cystic lesions caused by a development malformation in bronchi during the embryonic period, which mostly occur in the lung and mediastinum, with an extremely low morbidity rate in the neck. A 27-year-old young female was found to suffer from hyperparathyroidism on routine physical examination, and further examination suggested a cystic lesion in the right inferior parathyroid area combined with a tracheal diverticulum.
View Article and Find Full Text PDFFront Oncol
July 2022
School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
The transmembrane receptor Frizzled 9 (FZD9) is important for fetal neurologic and bone development through both canonical and non-canonical WNT/FZD signaling. In the adult lung, however, Fzd9 helps to maintain a normal epithelium by signaling through peroxisome proliferator activated receptor γ (PPARγ). The effect of FZD9 loss on normal lung epithelial cells and regulators of its expression in the lung are unknown.
View Article and Find Full Text PDFCrit Rev Toxicol
February 2022
Consultant in Toxicology, 40 Chemin de la Petite-Boissière, Geneva, Switzerland.
The potential toxic effects of short chrysotile and amphibole asbestos fibers with lengths <5 to ∼10 µm have been debated over the years. This stems from the large database of epidemiology, toxicology, and studies, each of which often provides different information in understanding and differentiating the effects of short fibers. The epidemiology studies in which the cancer potency estimates were based upon relatively high exposure concentrations provide a conservative assessment that shorter fibers would have little if any effect, especially under controlled exposure or environmental conditions that may occur today.
View Article and Find Full Text PDFWorld J Clin Cases
May 2022
Department of Pathology, The Affiliated Hospital of Shandong First Medical University (Liaocheng People's Hospital), Liaocheng 252000, Shandong Province, China.
Background: The clinicopathological features, immunohistochemical characteristics, and genetic mutation profile of two unusual cases of distal bronchiolar adenoma are retrospectively analyzed and the relevant literature is reviewed.
Case Summary: Case 1 was a 63-year-old female patient who had a mixed ground-glass nodule, with mild cells in morphology, visible cilia, and bilayer structures in focal areas. Immunohistochemical staining for P63 and cytokeratin (CK)5/6 revealed the lack of a continuous bilayer structure in most areas, and no mutations were found in epidermal growth factor receptor, anaplastic lymphoma kinase, ROS1, Kirsten rat sarcoma, PIK3CA, BRAF, human epidermal growth factor receptor-2 (HER2), RET, and neuroblastoma RAS genes.
Clin Lung Cancer
July 2022
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Pathologica
April 2022
Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Metastasis to the thyroid gland is a rare event. To date, only 11 cases of metastasis from neuroendocrine tumors (NETs) originating in the lung have been reported. We present a case of a patient in his 40s harboring two nodules in the thyroid gland that were diagnosed as well-differentiated NET (G1).
View Article and Find Full Text PDFThorac Cancer
May 2022
Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Shandong, China.
Bronchial carcinoid tumors are low-grade malignant and lung-sparing surgery is preferred for the removal of these tumors. We describe a surgical technique of robot-assisted sleeve segmentectomy via single utility port approach with three robotic arms. This operation was performed in an aged patient with decreased pulmonary function, whose carcinoid tumor was located at the origin of the right superior segmental bronchus.
View Article and Find Full Text PDFCell Death Dis
February 2022
Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Melchor Fernández Almagro 3, Madrid, E-28029, Spain.
The BRAF gene is frequently mutated in cancer. The most common genetic mutation is a single nucleotide transition which gives rise to a constitutively active BRAF kinase (BRAF) which in turn sustains continuous cell proliferation. The study of BRAF murine models has been mainly focused on the role of BRAF in tumor development but little is known on the early molecular impact of BRAF expression in vivo.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
March 2022
Drug Research and Development, Corcept Therapeutics, Menlo Park, CA, United States.
Somatostatin exhibits an inhibitory effect on pituitary hormone secretion, including inhibition of growth hormone and adrenocorticotropic hormone (ACTH), and it can have antisecretory and antitumor effects on neuroendocrine tumors (NETs) that express somatostatin receptors. Although the precise mechanism remains unclear, the finding that glucocorticoids downregulate somatostatin receptor subtype 2 (SSTR2) expression has been used to explain the lack of efficacy of traditional SSTR2-targeting analogs in patients with ACTH-secreting NETs. Glucocorticoid receptor (GR) antagonism with mifepristone has been shown to reverse the glucocorticoid-induced downregulation of SSTR2; however, the effects of GR modulation on SSTR2 expression in ACTH-secreting NETs, particularly corticotroph pituitary tumors, are not well known.
View Article and Find Full Text PDFJ Cardiothorac Surg
October 2021
Department of Cardiothoracic Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, People's Republic of China.