Congenital Aortic Arch Malformation Presenting as Bilateral Pulsatile Neck Mass: A Unique Case Report.

Vascular malformations of the aortic arch and its main branches such as cervical aortic arch and high-riding brachiocephalic artery can present as pulsatile neck swelling. Although this entity is rare, an initial Doppler ultrasound is suggested before intervention to avoid complications from unidentified aberrant vessels.

Guillain-Barré Syndrome in Africa: Understanding, Addressing, and Empowering.

Introduction: Guillain-Barré Syndrome (GBS) is a spectrum of peripheral neuropathies characterized by rapid symmetrical limb weakness and sensory symptoms. GBS can be life-threatening and requires intensive care, particularly for patients with imminent respiratory failure. In Africa, limited research and high therapy costs pose challenges.

Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety.

The lack of adequate anti-leishmanial therapies has led to the continued suffering of millions of people from developing nations. Moreover, optimism for a therapeutic intervention by fexinidazole was dashed due to the inability to maintain cures and control unwanted side effects. To solve these shortcomings, the structural elements of fexinidazole responsible for anti-leishmanial activity and toxicities were explored.

Habitat suitability and distribution patterns of Rouget's rail ( Guérin-méneville, 1843) in Ethiopia.

Geographical distribution and diversity patterns of bird species are influenced by climate change. The Rouget's rail () is a ground-dwelling endemic bird species distributed in Ethiopia and Eritrea. It is a near-threatened species menaced by habitat loss, one of the main causes of population declines for bird species.

Surgical and oncologic approach to leiomyosarcoma of the inferior vena cava: A case report.

Key Clinical Message: LMS of IVC needs a multidisciplinary approach. Surgical excision with free margin is the cornerstone of management. Upon case-by-case selection, adjuvant chemotherapy may play a role in better oncologic outcome.

Unveiling the nephrotoxic profile of BCR-ABL tyrosine kinase inhibitors: A real-world experience in Africa.

Introduction: The efficacy of BCR-ABL tyrosine kinase inhibitors (TKIs) in treating chronic myelogenous leukemia and other malignancies is well-documented. However, concerns about potential nephrotoxicity have raised questions. This study, conducted at Tikur Anbesa Specialized Hospital (TASH) in Addis Ababa, Ethiopia, aimed to investigate the association between TKIs and renal toxicities.

Abdominal cocoon syndrome, a rare and interesting cause of intestinal obstruction: A case report.

Key Clinical Message: Abdominal cocoon syndrome is a rare cause of bowel obstruction, with variable presentation. It needs a high index of suspicion for diagnosis. Surgical management with the release of adhesions is the preferred option for a healthy bowel.

isolates from vegetable farms in Addis Ababa, Ethiopia: Antimicrobial susceptibility profile and associated resistance genetic markers.

The use of animal manure to fertilize soil is an emerging concern contributing to the transfer of antimicrobial-resistant pathogens to vegetables. Hence, assessing antimicrobial susceptibility profile of in vegetable farms is essential to design appropriate interventions against antimicrobial resistance (AMR) in the food chain. This study assessed antimicrobial resistance profile and associated genetic markers among isolated from vegetable farms fertilized with animal manure in Addis Ababa, Ethiopia.

Native and prosthetic valve infective endocarditis complicated by rapidly progressive glomerulonephritis and its diagnostic challenges and therapeutic implications.

Key Clinical Message: Concomitant native and prosthetic valve infective endocarditis (IE) is very rare, and both can rarely be complicated by rapidly progressive glomerulonephritis (RPGN). This diagnosis has therapeutic implications, as not all RPGN need immunosuppression therapy.

Abstract: Native and prosthetic valve infective endocarditis (IE) may be rarely complicated by rapidly progressive glomerulonephritis (RPGN).

Free intraperitoneal air in infected pancreatic necrosis with intraperitoneal rupture: A rare presentation of a complex diseases.

Key Clinical Message: Among the multitude of causes for acute abdomen patients presenting with free intraperitoneal air, one almost never finds infected pancreatic necrosis as one of the culprits. In patients with risk factors for acute pancreatitis presenting with generalized peritonitis with free intraperitoneal air, consideration should be given to this often deadly entity.

Abstract: Acute pancreatitis is a morbid acute abdominal pathology that has been increasing in incidence in recent years.

Comparative analysis of the physicochemical, proximate, and antioxidant characteristics of stingless bee () honey from modern and wild beehives in Ethiopia.

There is a dearth of information on the comparative studies of the physicochemical, proximate, and antioxidant properties as well as quality standards of stingless bee honey (SBH) in Ethiopia. Hence, this study was designed to assess and compare the physicochemical, proximate, and antioxidant properties of SBH, specifically sourced from , and produced under both wild and modern apiary conditions at two distinct geographical locations. A total of forty-six honey samples were meticulously collected from domesticated stingless bee colonies and naturally occurring wild nests at Wolmera and Cheliya districts.

Time to develop adverse drug reactions and associated factors among children HIV positive patients on antiretroviral treatment in North West Amhara Specialized Hospitals: Retrospective cohort study, 2022.

Introduction: Adverse drug reactions (ADRs) are harmful and unintended reactions to medicines given at standard doses through a proper route of administration for the purpose of prophylaxis, diagnosis, or treatment.

Objective: The objective of this research paper was to assess median time to development of ADRs and associated factors among children HIV positive patients on antiretroviral treatment (ART) in North West Amhara Specialized Hospitals.

Methods: The adverse drug effect survival time was estimated using the Kaplan-Meier survival method and log-rank test curves was applied for analyze "time-to-event" data.

Diagnostic accuracy of barium enema versus full-thickness rectal biopsy in children with clinically suspected Hirschsprung's disease: A comparative cross-sectional study.

Background And Aims: Hirschsprung's disease (HSD) remains a common cause of pediatric intestinal obstruction. Barium contrast enema (BE) is the primary imaging modality for the evaluation of clinically suspected cases. Here, we aimed to assess the diagnostic accuracy of BE in children with clinically suspected HSD when compared to a gold standard full-thickness rectal biopsy (FTRB).

Examining energy and nutrient production across the different agroecological zones in rural Ethiopia using statistical methods.

Poor-quality diets are of huge concern in areas where consumption is dominated by locally sourced foods that provide inadequate nutrients. In agroecologically diverse countries like Ethiopia, food production is also likely to vary spatially. Yet, little is known about how nutrient production varies by agroecology.

Posttraumatic hydrocephalus: Recent advances and new therapeutic strategies.

Background: Hydrocephalus or ventriculomegaly is a condition brought on by an overabundance of cerebrospinal fluid (CSF) in the ventricular system. The major contributor to posttraumatic hydrocephalus (PTH) is traumatic brain injuries (TBIs), especially in individuals with occupations set in industrial settings. A variety of criteria have been employed for the diagnosis of PTH, including the combination of neurological symptoms like nerve deficits and headache, as well as an initial improvement followed by a worsened relapse of altered consciousness and neurological deterioration, which is detected by computed tomography-brain imaging that reveals gradual ventriculomegaly.

Heparin-induced hyperkalemia, can LMWH cause hyperkalemia? A systematic review.

Hyperkalemia, an elevated blood potassium concentration exceeding 5.0 mEq/L, is associated with adverse outcomes and is frequently observed in hospitalized patients. Drug-induced hyperkalemia accounts for a significant proportion of cases, with heparin, commonly used for venous thrombosis prevention, suspected to contribute, though less recognized than other heparin-related side effects.

Effect of enset () varieties and fermentation time on nutritional compositions, antinutritional factors, functional properties, and sensory acceptance of .

The effect of enset varieties and fermentation time on the nutritional composition, antinutritional content, functional properties, and sensory acceptance of bulla was assessed. Bulla samples were prepared from newly improved enset varieties , , , and and were fermented for 0, 15, and 30 days. The result revealed that bulla prepared from had relatively better values of fat (0.

Pulmonary thromboembolism as a rare complication of malaria: A case report.

Key Clinical Message: Low threshold is required to suspect complications of malaria. Pulmonary thromboembolism, though rare, should be considered as its complication in the presence of unexplained and sudden onset shortness of breath.

Abstract: The hypercoagulable complications of malaria typically manifest in the microvasculature.

Effectiveness of in enhancing the folate content of made with different cereals.

Fermentation can contribute to the supply of essential vitamins like folate, but studies exploring this potential are scarce. Injera is an Ethiopian fermented pancake-like flatbread made from different cereals. The study aimed to investigate the effect of injera-making process using different cereals (tef, sorghum, wheat, and barley) on folate content and to evaluate the effectiveness of in enhancing folate of injera made with different cereals.