12 results match your criteria: "Addenbrooks' Hospital[Affiliation]"
An Unusual Presentation of Pseudoaneurysm of the Internal Carotid Artery Secondary to Lateral Skull Base Osteomyelitis.
Otol Neurotol
June 2023
East and North Hertfordshire NHS Trust, Otolaryngology, Lister Hospital, Stevenage, Hertfordshire, UK.
Gene Therapy with Etranacogene Dezaparvovec for Hemophilia B.
N Engl J Med
February 2023
From the Departments of Pediatrics and Pathology, University of Michigan, Ann Arbor (S.W.P.); the Department of Hematology, Erasmus University Medical Center, University Medical Center Rotterdam, Rotterdam (F.W.G.L.), Van Creveldkliniek, University Medical Center Utrecht, University Utrecht, Utrecht (P.V.V.), Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam (M.C.), Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis (M.C.), and uniQure Biopharma (Y.P.L.), Amsterdam, and University Medical Center Groningen, Groningen (K.M.) - all in the Netherlands; Yale University School of Medicine, New Haven, CT (M.R., S.L.); American Thrombosis and Hemostasis Network, Rochester, NY (M.R.); the Department of Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill (N.S.K.); the Center for Bleeding Disorders and Coagulation, Department of Oncology, Careggi University Hospital, Florence, Italy (G.C.); the Department of Hemostaseology and Hemophilia Center, Medical Clinic 2, Institute of Transfusion Medicine and Immunohematology, University Hospital Frankfurt, Frankfurt (W.M.), the Comprehensive Care Hemophilia Treatment Center, Vivantes Klinikum im Friedrichshain, Berlin, and the Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Medical Faculty, University of Bonn, Bonn (R. Klamroth) - all in Germany; the Department of Vascular Medicine and Hemostasis, Hemophilia Center, University Hospitals Leuven, Leuven (K.P.), the Division of Hematology, Cliniques Universitaires Saint-Luc, Brussels (C.R.J.R.H.), and Université Catholique de Louvain, Louvain-la-Neuve (C.R.J.R.H.) - all in Belgium; the Department of Hematology, Rigshopitalet Copenhagen, Copenhagen (P.K.); National Coagulation Centre, St. James's Hospital, Dublin (N.O.); Barts and the London School of Medicine and Dentistry, Queen Mary University of London (K.J.P., D.P.H.), and the Royal London Hospital Haemophilia Centre, Barts Health NHS Trust (D.P.H.), London, University Hospital Southampton and National Institute for Health and Care Research Clinical Research Facility, Southampton (R. Kazmi), and Cambridge University NHS Foundation Trust, Addenbrooks Hospital, Cambridge (E.S.) - all in the United Kingdom; the Department of Translational Medicine, Lund University, and the Department of Hematology Oncology and Radiation Physics, Skåne University Hospital - both in Malmö, Sweden (J.A.); the Department of Pediatrics, University of Utah, and Primary Children's Hospital, Salt Lake City (R.L.); University of South Florida, Tampa (N.V.); the Department of Medicine, Hemophilia and Thrombosis Treatment Center, San Diego (A.D.), the Cancer and Blood Disorders Institute, Children's Hospital Los Angeles (G.Y.), the Orthopaedic Hemophilia Treatment Center, the Luskin Orthopaedic Institute for Children (D.V.Q.), and the University of Southern California Keck School of Medicine (G.Y.), Los Angeles, and the Center for Inherited Blood Disorders, Orange (E.G.) - all in California; Arkansas Children's Hospital, Pulaski, and University of Arkansas for Medical Sciences, Little Rock (S.E.C.); University of Texas Health Science Center, McGovern Medical School, and Gulf States Hemophilia and Thrombophilia Center - both in Houston (M.E.); Washington Center for Bleeding Disorders and University of Washington, Seattle (R.K.-J.); Hemophilia and Thrombosis Center, University of Colorado Anschutz Medical Campus, Aurora (M.W.); the Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville (A.P.W.); uniQure, Lexington, MA (R.G., R.E.D., D.L.C.); and CSL Behring, King of Prussia, PA (Y.L., B.G., P.E.M.).
Article Synopsis
- The study investigates the effects of gene therapy (etranacogene dezaparvovec) for treating moderate-to-severe hemophilia B, comparing it with traditional factor IX replacement therapy.
- A phase 3 open-label trial involved 54 men who received a single infusion of AAV5 vector after a lead-in period of factor IX prophylaxis, with the goal of reducing annualized bleeding rates.
- Results showed a significant decrease in bleeding rates from 4.19 to 1.51 and an increase in factor IX activity, demonstrating that gene therapy is not only noninferior but also superior to standard treatment.
Identification of high risk clinical and imaging features for intracranial artery dissection using high-resolution cardiovascular magnetic resonance.
J Cardiovasc Magn Reson
June 2021
Department of Radiology, Changhai Hospital, Naval Medical University, 10 Building, 168 Changhai Road, Yangpu, Shanghai, 200433, China.
Background: Intracranial artery dissection (IAD) often causes headache and cerebral vascular ischemic events. The imaging characteristics of IAD remain unclear. This study aims to characterize the appearance of culprit and non-culprit IAD using high-resolution cardiovascular magnetic resonance imaging (hrCMR) and quantify the incremental value of hrCMR in identifying higher risk lesions.
View Article and Find Full Text PDFWhen should we measure surgical site infection in patients undergoing a craniotomy? A consideration of the current practice.
Br J Neurosurg
December 2020
Department of Neurosurgery, Salford Royal Foundation Trust, Salford, UK.
Surgical site infection (SSI) is a common postoperative complication that causes significant morbidity, particularly in patients undergoing cranial neurosurgery. The treatment of SSI can attract a significant cost by way of increasing length of stay, readmission and reoperation in some cases. Cranial neurosurgical cases without implant surgery are recommended by the centre for disease control to be surveyed for SSI for a 30-day period.
View Article and Find Full Text PDFImplementing a theory-based intradialytic exercise programme in practice: a quality improvement project.
Clin Kidney J
December 2018
Leicester Kidney Exercise Team, Department of Infection, Immunity and Inflammation and John Walls Renal Unit, Leicester General Hospital, Leicester, UK.
Background: Research evidence outlines the benefits of intradialytic exercise (IDE), yet implementation into practice has been slow, ostensibly due to a lack of patient and staff engagement. The aim of this quality improvement project was to improve patient outcomes via the introduction of an IDE programme, evaluate patient uptake and sustainability and enhance the engagement of routine haemodialysis (HD) staff with the delivery of the IDE programme.
Methods: We developed and refined an IDE programme, including interventions designed to increase patient and staff engagement that were based on the Theoretical Domains Framework (TDF), using a series of 'Plan, Do, Study, Act' (PDSA) cycles.
British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 10 /L - RESPONSE to Yan et al.
Br J Haematol
July 2018
Kings College Hospital NHS Foundation Trust, London, UK.
Deficits in Limb Praxis in Patients With Obsessive-Compulsive Disorder.
J Neuropsychiatry Clin Neurosci
April 2017
From the Division of Clinical Neurology, Nuffield Dept. of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK (ER); the Dept. of Psychiatry, University of Cambridge, Addenbrooks Hospital, Cambridge, UK (PB, VV); and Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK (VV).
There is recent evidence of deficits in praxis in patients with primary dystonia. Obsessive-compulsive disorder (OCD) has been linked to disorders of higher-order motor function, such as dystonia. However, no clear mechanism underlying such a relationship has been found.
View Article and Find Full Text PDFDistal femoral fractures: The need to review the standard of care.
Injury
May 2016
Department of Orthopaedics, Southmead Hospital, Southmead Road, Bristol BS10 5NB, United Kingdom.
Background: Hip fracture care has evolved, largely due to standardisation of practice, measurement of outcomes and the introduction of the Best Practice Tariff, leading to the sustained improvements documented by the National Hip Fracture Database (NHFD). The treatment of distal femoral fractures in this population has not had the same emphasis. This study defines the epidemiology, current practice and outcomes of distal femoral fractures in four English centres.
View Article and Find Full Text PDFReview article: the surgical approach to the management of increased intracranial pressure after traumatic brain injury.
Anesth Analg
September 2010
Academic Neurosurgery Unit, University of Cambridge/Addenbrooks Hospital, Cambridge, CB2 0QH, UK.
Increased intracranial pressure occurring after severe traumatic brain injury is a common and potentially devastating phenomenon. It has been clearly demonstrated that increased intracranial pressure that is refractory to initial medical measures is a poor prognostic sign. Current optimal management is based on a sequential, target-driven approach combining both medical and surgical treatment strategies.
View Article and Find Full Text PDFMapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue.
Clin Cancer Res
November 2006
Department of Hematology and Oncology, Comprehensive Cancer Center, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA, and Department of Pathology, Addenbrooks' Hospital, Cambridge, UK.
Purpose: Genetic alterations were previously identified in normal epithelia adjacent to invasive cancers. The aim of this study was to determine DNA methylation in histologically normal tissues from multiple geographic zones adjacent to primary breast tumors.
Experimental Design: First, methylation status of a 4-kb region of RASSF1A promoter was interrogated using oligonucleotide-based microarray in 144 samples (primary tumors, 47; adjacent normals, 69; reduction mammoplasty tissues, 28).
A genome-wide screen for linkage disequilibrium in Sardinian multiple sclerosis.
J Neuroimmunol
October 2003
Neurology Unit, Addenbrooks Hospital, University of Cambridge, Hills Road, Cambridge CB2 2QQ, UK.
Using indirect whole genome association screening, we have searched for multiple sclerosis susceptibility genes in the genetically isolated high risk Sardinian population. Two screens were performed; the first was based on 229 cases and 264 unrelated controls, and the second on 235 trio families. Each screen employed a dense set of microsatellite markers and DNA pooling.
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