Development and validation of UV spectrophotometric method for estimation of naringenin in phytosomal formulation: interlaboratory comparison, capability, and statistical analysis.

The goal of the current work was to establish a simple, reproducible, and reliable UV spectrophotometric method for determining naringenin in phytosomal formulations. The solvent methanol was optimized and spectrophotometric analysis was carried out at 289 nm. The proposed method was also validated for linearity, specificity, accuracy, precision, ruggedness, and robustness in accordance with the International Council for Harmonisation (ICH).

Synthesis and characterization of citric acid crosslinked carboxymethyl tamarind gum-polyvinyl alcohol hydrogel films.

The aim of present work was to synthesize and characterize carboxymethyl tamarind gum-polyvinyl alcohol (CMTG-PVA) hydrogel films using citric acid (CA) as a crosslinker. Hydrogel films were prepared by solvent casting technique. The films were evaluated for total carboxyl content (TCC), tensile strength, protein adsorption, permeability properties, hemocompatibility, swellability, moxifloxacin (MFX) loading and release, in-vivo wound healing activity and characterized using instrumental techniques.

Evaluation of Nootropic Activity of Against Scopolamine-induced Amnesia in Rats.

Objectives: The present study aimed to evaluate the nootropic activity of in rats.

Materials And Methods: Methanolic extract of was used to evaluate nootropic activity, piracetam (200 mg/kg, i.p.

Mung bean (Vigna radiata) porous starch for solubility and dissolution enhancement of poorly soluble drug by solid dispersion.

In this study, a novel Vigna radiata based porous starch (PS) is prepared by solvent exchange technique and explored as a solubilizer for model drug albendazole (ABZ). PS carrier was investigated for different chemical, functional, and micromeritic properties. Solubilizing potential of PS is evaluated by formulating ABZ-PS solid dispersion (1:0.

Sericin Inhibits Devitrification of Amorphous Drugs.

The purpose of the present investigation was to analyze devitrification of amorphous drugs such as lornoxicam, meloxicam, and felodipine in the presence of sericin. The binary solid dispersions comprising varying mass ratios of drug and sericin were subject to amorphization by spray drying, solvent evaporation, ball milling, and physical mixing. Further, obtained solid dispersions (SDs) were characterized by HPLC, ATR-FTIR, HNMR, molecular docking, accelerated stability study at 40°C and 75 ± 2% RH (XRD and DSC), and in vitro dissolution studies.

Synthesis of Asymmetric 1-Thiocarbamoyl Pyrazoles as Potent Anti- Colon Cancer, Antioxidant and Anti-Inflammatory Agent.

Background: Cancer is one of the leading diseases responsible for deaths in the society. According to the American cancer society, there will be 95,270 new cases of colon cancer in the U.S.

Phytochemicals Formulated As Nanoparticles: Inventions, Recent Patents and Future Prospects.

Background: The quest to improve the therapeutic effectiveness of herbal drugs has driven the pharmaceutical research towards the development of herbal nanoparticles.

Objective: Till date, various approaches have been adopted for the design of herbal nanoparticles.

Methods: We carried out an organized search of bibliographic databases consisting of an ample number of published abstracts and research articles using a focused review questionaries and insertion/ omission criteria.

Linked pyridinyl-thiadiazoles: Design and synthesis as potential candidate for treatment of XDR and MDR tuberculosis.

Multi-drug resistant (MDR) and extremely drug resistant (XDR) Mycobacterium tuberculosis strains have turned tuberculosis (TB) as "on the verge of eradication" to "most life threatening" disease. Furthermore, synergy with HIV and other immunosuppressive disease have strengthened its prevalence. This research reports small molecule anti-infectives which are specifically potent against several strains and isolates of TB.