1,415 results match your criteria: "Acute Retinal Necrosis"
The Host-Pathogen Interplay: A Tale of Two Stories within the Cornea and Posterior Segment.
Microorganisms
August 2023
Department of Ophthalmology and Visual Sciences, Truhlsen Eye Center, University of Nebraska Medical Center, Omaha, NE 68105, USA.
Ocular infectious diseases are an important cause of potentially preventable vision loss and blindness. In the following manuscript, we will review ocular immunology and the pathogenesis of herpesviruses and Pseudomonas aeruginosa infections of the cornea and posterior segment. We will highlight areas of future research and what is currently known to promote bench-to-bedside discoveries to improve clinical outcomes of these debilitating ocular diseases.
View Article and Find Full Text PDFAcute Retinal Necrosis: Experience in a Reference Center in Santander - Colombia.
Ocul Immunol Inflamm
September 2024
Fundación Oftalmológica de Santander Carlos Ardila Lule (FOSCAL), Floridablanca, Santander, Colombia.
Article Synopsis
- Acute retinal necrosis (ARN) is a serious eye condition that needs prompt antiviral and steroid treatment to avoid blindness.
- A case series involving eight patients diagnosed with ARN was studied, where various treatments and their outcomes were evaluated.
- The results showed that both oral and intravenous antiviral treatments had similar visual outcomes, but initial poor vision and involvement of the macula predicted worse final visual acuity.
Dexamethasone intravitreal implant for macular edema and some other rare indications in uveitis.
Med Int (Lond)
July 2023
Department of Ophthalmology, Dokuz Eylul University, 35330 Izmir, Turkey.
In the present study, 110 eyes of 81 patients with uveitis who underwent intravitreal dexamethasone implant (IDI) injection and had a follow-up of at least 6 months between January, 2012 and September, 2022, were retrospectively analyzed. A total of 298 IDI injections were administered (mean, 2.71±2.
View Article and Find Full Text PDFPigmentary retinopathy and nodular granuloma associated with acute retinal necrosis from varicella zoster virus and human herpes virus type 6: Case report.
Medicine (Baltimore)
June 2023
Department of Ophthalmology, Phramongkutklao Hospital, Phramongkutklao College of Medicine, Bangkok, Thailand.
Rationale: Acute retinal necrosis (ARN) caused by human herpes virus type 6 (HHV-6) is uncommon. We described a case of consecutive bilateral ARN, which was found to be a coinfection of varicella zoster virus (VZV) and HHV-6 in a 50-year-old woman, not well responded with systemic acyclovir. We showed the atypical findings with corresponding fundus and optical coherence tomography imaging.
View Article and Find Full Text PDFTreatment outcomes of PCR-positive acute retinal necrosis.
Ir J Med Sci
February 2024
Ophthalmology & Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
Background: Acute retinal necrosis (ARN) is a progressive necrotizing retinitis caused by viral infection. Optimal management strategies have not been established for this detrimental disease. Previous literature published suggests that Varicella-zoster virus (VZV) and Herpes simplex virus-1 (HSV1) are the most common promoters of acute retinal necrosis (ARN).
View Article and Find Full Text PDFAcute Retinal Necrosis Possibly Triggered by Contra-Lateral Penetrating Trauma.
Ocul Immunol Inflamm
September 2024
Department of Ophthalmology, The Second Hospital of Lanzhou University, Lanzhou, Gansu, P. R. China.
Article Synopsis
- Acute retinal necrosis (ARN) is a serious eye condition caused by herpes viruses, and this case discusses a rare instance following trauma to the opposite eye.
- A 61-year-old man was initially misdiagnosed with sympathetic ophthalmia, but after proper testing, ARN was confirmed following aggressive treatment that worsened his condition.
- The study emphasizes the need for ophthalmologists to consider ARN in similar cases and perform comprehensive eye exams to prevent misdiagnosis and ensure timely treatment.
Posterior Herpetic Uveitis: A Comprehensive Review.
Ocul Immunol Inflamm
September 2023
Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Purpose: To report and illustrate the main clinical presentations of posterior herpetic uveitis.
Methods: Narrative review.
Results: The ocular manifestations of posterior herpetic uveitis include different clinical presentations.
Sulfadiazine crystalluria in a patient with lupus nephritis.
Adv Lab Med
June 2022
Service of Clinical Biochemistry, Hospital Universitario Príncipe de Asturias, Madrid, Spain.
Article Synopsis
- * Urine analysis after treatment showed disturbing findings, including the presence of sulfadiazine crystals, which prompted immediate discontinuation of the drug to prevent kidney damage.
- * The report concludes that sulfadiazine can lead to kidney problems, particularly acute interstitial nephritis, due to crystal formation in the renal tubules, which can vary in shape depending on how the drug metabolizes.
Association Between Torque Teno Virus and Systemic Immunodeficiency in Patients With Uveitis With a Suspected Infectious Etiology.
Am J Ophthalmol
October 2023
From the Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan (A.F.S., Y.K., H.U., K.K., K.F., D.O., M.K., K.Y., A.S., H.K., K.M.N.).
Article Synopsis
- The study aimed to investigate the link between the presence of torque teno virus (TTV) in the aqueous humor of uveitis patients and their medical history, particularly regarding immunodeficiency.
- Conducted as a multicenter, retrospective study, it included 58 uveitis patients and 24 control subjects, utilizing genetic testing methods to detect TTV and other pathogens.
- Results showed that ocular TTV was present in a significant percentage of uveitis patients, especially those with cytomegalovirus retinitis, and found a correlation between ocular TTV positivity and a clinical history of systemic immunodeficiency.
Changes in Density of Peripapillary and Intrapapillary Capillaries on OCT Angiography in Acute Retinal Necrosis Treated by Pharmacotherapy Alone without Surgery.
Ocul Immunol Inflamm
September 2024
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Article Synopsis
- The study aimed to investigate the radial peripapillary capillaris (RPC) and intra-papillary capillaris (IPC) in patients with acute retinal necrosis (ARN) using optical coherence tomography angiography (OCTA).
- Thirteen patients were analyzed, and while 12 showed no visual abnormalities through standard eye exams, OCTA revealed significant issues: 69% had RPC morphological abnormalities, and 62% showed a decrease in capillary networks.
- The findings indicate that even in cases of ARN that appear mild and have good visual outcomes, there are underlying impairments in the capillaries, suggesting possible optic nerve damage.
Choroidal Involvement and Chronic Macular Edema in Acute Retinal Necrosis: A Novel Finding and a Novel Treatment.
Ocul Immunol Inflamm
September 2024
Department of Refractive Surgery, Narayana Nethralaya, Bangalore, India.
Article Synopsis
- Acute retinal necrosis (ARN) is a serious condition characterized by necrotic inflammation of the retina, unlike toxoplasma retinochoroiditis, which shows choroidal thickening on scans.
- Following ARN, complications like chronic anterior uveitis and cystoid macular edema can arise, making treatment complex due to the risk of viral reactivation from steroids.
- A case study illustrated ARN caused by varicella zoster virus; after initial symptoms mimicking toxoplasma retinochoroiditis, the patient successfully treated chronic anterior uveitis and macular edema with topical interferon (IFN) alfa 2b after ARN resolution.
Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination.
Indian J Ophthalmol
May 2023
Department of Cataract and Refractive Surgery, Narayana Nethralaya, Bengaluru, Karnataka, India.
The aim of this study is to report the clinical features, imaging findings including confocal imaging, corneal nerve fiber analysis, and management outcomes in a series of three cases of varicella zoster virus (VZV) reactivation following one dose of coronavirus disease 2019 (COVID-19) vaccination. This was a retrospective and observational study. All the patients who developed uveitis post-vaccination were pooled together.
View Article and Find Full Text PDFHerpes zoster ophthalmicus: frequency and risk factors for developing uncommon ocular manifestations.
Can J Ophthalmol
June 2024
Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA. Electronic address:
Objective: To determine the frequency of herpes zoster ophthalmicus (HZO) and assess risk factors for developing uncommon ocular manifestations of laboratory-verified HZO.
Design: Retrospective cohort study.
Methods: The frequency of HZO out of all herpes zoster cases was calculated using International Classification of Diseases codes for patients seen at the University of Pittsburgh Medical Center from January 1, 2004 to October 31, 2021.
Long-term follow-up of acute retinal necrosis with retinal detachment secondary to herpes simplex virus type 2 with a successful visual outcome.
BMJ Case Rep
April 2023
Vitreo-retina, Narayana Nethralaya, Bengaluru, Karnataka, India.
Article Synopsis
"The Dead Zone": Images of acute retinal necrosis.
J Fr Ophtalmol
September 2023
Jinan-Mingshui Eye Hospital, PGH3+HFW, Gongyeer Road, Zhangqiu District, 250200 Jinan, Shandong, China. Electronic address:
[Value of wide-field fundus photography for monitoring of acute retinal necrosis].
J Fr Ophtalmol
May 2023
CHU de Lille, clinique d'ophtalmologie, hôpital Claude-Huriez, rue Michel-Polonowski, 59037 Lille, France.
Acute Necrotizing Retinopathy After Xen Gel Stent Implantation.
J Glaucoma
May 2023
Department of Ophthalmology, Taipei Veterans General Hospital.
Article Synopsis
- * Symptoms began 4 days post-surgery and included blurring vision, hypotony (low eye pressure), and uveitis (inflammation of the uvea).
- * Medical tests ruled out infections and autoimmune diseases; however, toxic retinopathy due to mitomycin-C might have contributed to her severe eye complications, leading to total blindness within 2 months.
Unusual pattern of herpetic optic neuropathy: a case report and literature review of the pathophysiology of herpetic uveitis.
J Ophthalmic Inflamm Infect
March 2023
Ophthalmology Department, Hamad Medical Corporation, Doha, Qatar.
Herpetic uveitis is a relatively common type of intraocular inflammation with a broad spectrum of manifestations ranging from mild anterior uveitis to rapidly progressing vision threatening necrotizing retinitis. Posterior herpetic uveitis presents with different clinical patterns within a spectrum depending presumably on the immune status of the patient. Systemic steroid use for viral uveitis without prior antiviral coverage is inappropriate and can lead to dramatic sequelae.
View Article and Find Full Text PDFFirst-line management of necrotizing herpetic retinitis by prioritizing the investigation of immune status and prognostic factors for poor visual outcomes.
Int Ophthalmol
July 2023
Ophthalmology Department, Pierre-Paul Riquet Hospital, Toulouse University Hospital, CHU Toulouse, Place Baylac, 31059, Toulouse, France.
Article Synopsis
- The study reviews the management and outcomes of necrotizing herpetic retinitis (NHR) to propose a first-line treatment algorithm, based on a retrospective analysis of 41 patients treated between 2012 and 2021.
- The majority of patients diagnosed with NHR were categorized into acute retinal necrosis (ARN), progressive outer retinal necrosis (PORN), and CMV retinitis, with a significant portion being immunocompromised.
- Findings indicate that complications were high, with 83% of eyes affected, and poor visual outcomes were linked to certain factors, emphasizing the need for prompt evaluation of immune status and timely antiviral treatment.
En-face widefield optical coherence tomography angiography for understanding vascular networks changes in two cases of acute retinal necrosis.
J Ophthalmic Inflamm Infect
March 2023
Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, 545-8586, Japan.
Purpose: The present study assesses the utility of en-face widefield optical coherence tomography angiography (OCTA) imaging for evaluating the retinal vascular network during the course of treatment in acute retinal necrosis(ARN).
Observations: OCTA images of two cases of acute retinal necrosis were analyzed. Case 1 was a 15-year-old male with visual crowding in his right eye who had best-corrected visual acuity of 16/20 and intraocular pressure of 25 mmHg in his right eye on initial evaluation.
Acute retinal necrosis: pathophysiological aspects, diagnosis, and treatment.
Folia Med (Plovdiv)
December 2022
University Eye Clinic, St George University Hospital, Plovdiv, Bulgaria.
Article Synopsis
- Acute retinal necrosis (ARN) is a severe viral eye infection mainly caused by varicella zoster virus and herpes simplex viruses, often occurring in healthy individuals aged 50-70.
- The condition typically affects one eye, presenting symptoms like vitreitis and peripheral necrotizing retinitis, which appear as yellowish-white spots in the retina.
- Treatment involves systemic antivirals to halt viral replication and protect the other eye from infection, emphasizing the need for early diagnosis and prompt therapy to improve visual outcomes.
Acute Retinal Necrosis Associated with Pseudorabies Virus Infection: A Case Report and Literature Review.
Ocul Immunol Inflamm
July 2024
Senior Department of Ophthalmology, The Third Medical Center of PLA General Hospital, Beijing, China.
Article Synopsis
- * A 52-year-old woman with encephalitis exhibited symptoms such as vision loss, uveitis, and retinal detachment, with PRV confirmed in her cerebrospinal and vitreous fluids.
- * PRV can cause severe brain and eye infections in humans, often leading to high mortality rates, with ARN being a rapid and serious complication that is difficult to treat effectively.
Objectives: To evaluate the demographic characteristics, clinical findings, and treatment approach of patients with sympathetic ophthalmia (SO).
Materials And Methods: The records of 14 patients with SO between 2000 and 2020 were retrospectively reviewed. The patients' Snellen best corrected visual acuity (BCVA), detailed ophthalmological examination, optical coherence tomography (OCT), enhanced depth imaging-OCT (EDI-OCT), fundus fluorescein angiography findings, and treatment approaches were recorded.
Anterior Chamber Cytology Confirms the Diagnosis of T-cell Prolymphocytic Leukemia Masquerading as Viral Retinal Necrosis.
Ocul Immunol Inflamm
July 2024
Department of Ophthalmology, Pitié Salpetrière University Hospital, Sorbonne Université, Paris, France.
Purpose: To describe a case of T-cell prolymphocytic leukemia (T-PLL) masquerading as viral retinal necrosis (VRN).
Case Presentation: A 75-year-old-man with a history of T-PLL in complete remission complained of an acute vision loss in his right and only eye. Ophthalmic examination demonstrated the presence of anterior chamber cells, mild vitritis, and peripheral retinal whitening with intraretinal hemorrhages evocative of VRN.