4,933 results match your criteria: "Actinic Keratosis"
Unveiling the potential of pioglitazone: efficacy in actinic keratosis treatment.
Int J Dermatol
September 2024
Department of Pathology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Reflectance Confocal Microscopy and Dermoscopy for the Diagnosis of Solitary Hypopigmented Pink Lesions: A Narrative Review.
Cancers (Basel)
August 2024
IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy.
Article Synopsis
- Diagnosing solitary pink skin lesions is challenging due to the overlap of clinical features among both benign (like cherry angiomas) and malignant lesions (such as basal cell carcinoma).
- Reflectance confocal microscopy (RCM) improves diagnostic accuracy beyond traditional dermoscopy, offering better sensitivity and specificity for identifying these lesions.
- Despite advancements, a definitive diagnosis still requires surgical excision and histopathological analysis to ensure correct treatment.
Article Synopsis
- Tirbanibulin, a treatment for actinic keratosis (AK), is typically approved for smaller fields (up to 25 cm), but this study aimed to assess its safety and tolerability on a larger area of approximately 100 cm.
- In a Phase 3 study, 105 adult patients with multiple AKs on the face or balding scalp applied tirbanibulin daily for 5 days, with results showing common mild-to-moderate side effects like erythema and flaking, while effectiveness led to a significant reduction in AK lesions.
- The findings suggest that tirbanibulin is safe and tolerable for larger treatment areas, although the study lacked a control group and long-term follow-up data
Awareness of skin cancer screening coverage in U.S. healthcare plans: Is there a need to better educate the public?
Prev Med Rep
October 2024
Health Outcomes & Research, The Sun Bus, LLC, Aurora, CO, United States.
Article Synopsis
- The study aimed to find out if people didn't get skin checks because they couldn't afford it or couldn't easily see a dermatologist.
- Almost half of the people who got free skin checks had suspicious spots, and many had a history of skin cancer, but few said cost or long waits were why they came in.
- The results showed that many people, especially younger ones, didn't know their health plans covered skin screenings, so there's a need to inform the public about these services.
The utility and reliability of a deep learning algorithm as a diagnosis support tool in head & neck non-melanoma skin malignancies.
Eur Arch Otorhinolaryngol
September 2024
Department of Otorhinolaryngology-Head & Neck Surgery, Osakidetza, Donostia University Hospital, San Sebastian, 20014, Spain.
Article Synopsis
- Non-melanoma skin cancers like basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are increasingly common, necessitating better diagnostic tools.
- A prospective study evaluated a CE-certified deep learning-based medical device for diagnosing skin lesions in a head & neck outpatient clinic, involving 135 patients with a focus on BCC, cSCC, and benign lesions.
- The device showed over 90% accuracy in identifying malignant lesions as one of the top-5 diagnoses, indicating its potential for early detection and treatment of skin cancers, and further research is recommended to explore its applications in various medical settings.
Interobserver agreement on line-field confocal optical coherence tomography image markers in keratinocyte carcinomas and precursor lesions.
Arch Dermatol Res
September 2024
Department of Dermatology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Article Synopsis
- Line-field confocal optical coherence tomography (LC-OCT) is a new technique for diagnosing skin cancers like basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), but little is known about how consistently different observers identify specific image markers of these conditions.
- The study involved six evaluators with varying dermatological imaging experience assessing 75 LC-OCT images to determine the interobserver agreement (IOA) on 10 key image markers related to skin cancers and their precursors.
- It was found that IOA was highest for markers typically seen in BCC, such as lobules and clefting, while other markers showed lower agreement, particularly those related to the dermal-epidermal junction, indicating
Photodynamic therapy in dermatology: established and new indications.
J Dtsch Dermatol Ges
December 2024
Center for Dermatology, Allergology and Dermatosurgery, Helios University Hospital Wuppertal, University of Witten/Herdecke, Wuppertal, Germany.
Photodynamic therapy (PDT) is internationally established as an approved treatment option for in situ forms of keratinocytic skin cancer (actinic keratoses, Bowen's disease, basal cell carcinoma). For these indications, there are standardized treatment protocols using narrow-spectrum light sources or (artificial) daylight, the use of which is associated with successful healing, a low rate of lesion recurrence, and a very good cosmetic result. Daylight PDT is superior to conventional PDT in terms of significantly less pain and associated higher patient acceptance.
View Article and Find Full Text PDFComparison of Ophthalmologists versus Dermatologists for the Diagnosis and Management of Periorbital Atypical Pigmented Skin Lesions.
J Clin Med
August 2024
Department of Ophthalmology, University of Catania, 95123 Catania, Italy.
Article Synopsis
- Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are key melanoma subtypes with an incidence of 1.37 per 100,000 in the U.S., often misdiagnosed, especially among the elderly, leading to treatment delays.
- A study evaluated the diagnostic abilities of ophthalmologists in identifying pigmented skin lesions in the periorbital region by reviewing 79 cases, comparing their results with dermatologists.
- Results showed that ophthalmologists had a diagnostic accuracy of 63.5% and lower sensitivity compared to dermatologists (33.3% vs. 46.9%), with a significantly higher percentage of ophthalmologists rating cases as "difficult" and suggesting fewer biopsies
Enhancing Dermatological Diagnostics with EfficientNet: A Deep Learning Approach.
Bioengineering (Basel)
August 2024
2nd Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Article Synopsis
- Medical technology, especially in the field of precision medicine, is advancing rapidly due to machine learning innovations, particularly in dermatology.
- A deep learning model based on EfficientNetB3 was developed for skin lesion classification, providing better results in terms of cost and speed compared to other models.
- The model achieved a validation accuracy of 95.4% across four skin conditions and maintained good performance on new images, though accuracy dropped to 88.8% when tested with two additional categories.
The Mutational and Microenvironmental Landscape of Cutaneous Squamous Cell Carcinoma: A Review.
Cancers (Basel)
August 2024
Gleiberman Head and Neck Cancer Center, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Cutaneous squamous cell carcinoma (cSCC) manifests through the complex interactions of UV-induced DNA damage, genetic mutations, and alterations in the tumor microenvironment. A high mutational burden is present in cSCC, as well as both cSCC precursors and normal skin, making driver genes difficult to differentiate. Despite this, several key driver genes have been identified, including TP53, the NOTCH family, CDKN2A, PIK3CA, and EGFR.
View Article and Find Full Text PDFThe Loss of PPARγ Expression and Signaling Is a Key Feature of Cutaneous Actinic Disease and Squamous Cell Carcinoma: Association with Tumor Stromal Inflammation.
Cells
August 2024
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Article Synopsis
- The study investigates the role of PPAR-gamma in skin inflammation and cancer using PPARγ-deficient mice, revealing significant changes in gene expression related to cancer and inflammation.
- Single-cell sequencing highlighted increased inflammatory cell infiltration and alterations in fibroblast activity, linking PPARγ loss to heightened epithelial malignancy risks.
- Overall, PPARγ and potentially PPARα appear to function as important tumor suppressors by inhibiting inflammation associated with actinic keratoses and cutaneous squamous cell carcinomas.
If patients had a choice - Treatment satisfaction and patients' preference in therapy of actinic keratoses.
J Dtsch Dermatol Ges
October 2024
Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
Article Synopsis
- Actinic keratoses (AK) are increasingly common (pre-)cancerous lesions in fair-skinned individuals, highlighting the need for effective treatment and patient adherence evaluations.
- A study of 100 AK patients focused on their satisfaction with various treatments using the Treatment Satisfaction Questionnaire and a Likert scale, revealing varying satisfaction levels across eight treatment options.
- Results indicated that patients prioritized low recurrence rates and safe removal as essential treatment goals, emphasizing the significance of understanding patient preferences for successful AK therapy.
Actinic keratosis metrics.
Arch Dermatol Res
August 2024
University of California San Francisco, San Francisco, CA, USA.
Article Synopsis
- * Current diagnostic methods for AK show considerable variability among clinicians, making consistent diagnosis challenging, as there is no universally accepted standard for evaluation.
- * The review highlights the need for improved diagnostic tools and proposes using 1,3-dihydroxyacetone (DHA) staining to enhance the detection of AK lesions, aiming for better clinical practices and patient outcomes.
Precision therapy for cancer prevention by targeting carcinogenesis.
Mol Carcinog
November 2024
China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan, China.
Article Synopsis
- Cancer cases are expected to rise significantly, from 14 million in 2012 to 24 million by 2035, highlighting the need for effective prevention strategies.
- Primary prevention methods, like banning tobacco and HPV vaccination, have shown success in reducing specific cancer incidences, but many cancer types have unclear causes that make prevention challenging.
- The review focuses on precision therapy targeting the entire cancer development process for high-risk groups, emphasizing the importance of addressing chronic inflammation, treating precancerous lesions, and removing tissue with inherited mutations for effective cancer prevention.
Dynamic optical coherence tomography unveils subclinical, vascular differences across actinic keratosis grades I-III.
Exp Dermatol
August 2024
Department of Dermatology, Copenhagen University Hospital, Copenhagen, Denmark.
Article Synopsis
- * The study involved 47 patients, revealing that D-OCT identified distinct vascular differences between AK grades and photodamaged skin, especially at a depth of 300μm, and showed significant differences in vessel arrangement and patterns across the various grades of AK.
- * The combined use of D-OCT and dermatoscopy proved effective in differentiating between AK grades, with results indicating increased vascularization and vessel disorganization in higher-grade AK lesions.
Clinical and Dermoscopic Diagnosis of Actinic Keratosis.
Dermatol Pract Concept
July 2024
Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Epidemiology and Risk Factors of Actinic Keratosis. What is New for The Management for Sun-Damaged Skin.
Dermatol Pract Concept
September 2024
Department of Dermatology and Allergology, University Hospital Augsburg, Germany.
Actinic keratosis (AK) is considered a chronic skin disease mostly caused by long-term exposure to UV radiation and other risk factors such as immunosuppression, leading to an individual susceptibility for skin cancer manifestation. The treatment of AK is laborious and costly, and the incidence of skin cancer is forecasted to double until the year 2030 in an aging society.Risk factors in AK for malignant transformation in cutaneous squamous cell carcinoma (cSCC) are not fully understood, but studies suggest that histological features, such as atypia in the basal epidermal third and basal proliferation (PRO score) in AK play a pivotal role for development of malignancy.
View Article and Find Full Text PDFTopical Pharmacological Treatment of Actinic Keratoses: Focus on Tirbanibulin 1% Ointment.
Dermatol Pract Concept
July 2024
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Actinic keratosis (AK) is a frequent precancerous skin lesion that mostly affects chronically sun-exposed areas. Chronic sun damage leads to various mutations in onco-suppressor and oncogenic genes which cause an uncontrolled proliferation of atypical keratinocytes. Untreated AKs may evolve in cutaneous squamous cell carcinoma (cSCC), with the consequent need for dermato-surgical excision or even for systemic immunotherapy in case of invasive/metastatic cSCCs.
View Article and Find Full Text PDFEfficacy of BF-200 ALA PDT with half- versus full-light dose in treating actinic keratosis with large field cancerization.
Int J Dermatol
November 2024
Universidad de Alcalá, Madrid, Spain.
Diseases with oral malignant potential: Need for change to inform research, policy, and practice.
J Oral Pathol Med
September 2024
Melbourne Dental School, Faculty of Medicine, Dentistry & Health Sciences, University of Melbourne, Parkville, Victoria, Australia.
Article Synopsis
- The manuscript critiques the existing classification of oral potentially malignant disorders, arguing that labeling many cases as precancerous is misleading since most do not progress to oral cancer.
- It calls for a reclassification system that better reflects the actual risk of malignancy and proposes new categories for different levels of risk, including Oral Precancerous Diseases and Systemic Conditions with Oral Malignant Potential.
- The authors aim to improve diagnostic and management strategies, reducing overdiagnosis and the associated burden on patients, while providing practical examples for research and clinical application.
[Translated article] Dermoscopy of Squamous Cell Carcinoma: From Actinic Keratosis to Invasive Forms.
Actas Dermosifiliogr
October 2024
Servicio de Dermatología, Hospital de Sant Pau i Santa Tecla, Tarragona, Spain.
Article Synopsis
- The dermoscopy of squamous cell carcinoma (SCC) helps differentiate between types based on keratin, vascular, and pigment features.
- Non-pigmented actinic keratoses have a "strawberry pattern," while pigmented actinic keratosis shows similarities to lentigo maligna but can be distinguished by specific signs like pigmented scales and erythema.
- Dermoscopy is crucial for early detection of invasive SCC, with its presentation varying by tumor differentiation—keratin features in well-differentiated tumors and atypical vascular patterns in poorly differentiated ones.
A European Consensus on the Consistent Use of the Term "Keratinocyte Cancer".
Acta Derm Venereol
August 2024
Klinikum Vest GmbH, Knappschaftskrankenhaus Recklinghausen, Germany.
Article Synopsis
Efficacy of Photodynamic Therapy in the Treatment of Actinic Keratosis: A Network Meta-Analysis.
J Cutan Med Surg
November 2024
Department of Dermatology, The Third Xiangya Hospital/Central South University, Changsha, Hunan, China.
Article Synopsis
- Photodynamic therapy (PDT) is effective for treating actinic keratosis (AK) and can be used alone or with other therapies.
- This study conducted a network meta-analysis of 26 randomized controlled trials to compare the effectiveness of different PDT treatments for AK lesions.
- The findings suggest that AFL-MAL-LED-PDT is the most effective treatment, and that using LED light and ALA photosensitizer may enhance PDT efficacy; further research is needed for confirmation.
A pragmatic primary care approach to the patient with significant solar damage.
Aust J Gen Pract
August 2024
MBBS (Hons), BMedSci, FRACGP, FSCCA, College Censor, Skin Cancer College Australasia, Brisbane, Qld; Clinical Senior Lecturer, University of Queensland, Faculty of Health Sciences Primary Care Unit, Brisbane, Qld; Honorary Senior Lecturer, Macquarie University MQ Health, Sydney, NSW; General Practitioner, SkinSense Clinic, Sydney, NSW; General Practitioner, Icon Cancer Centre, Sydney, NSW.
Background: Australian general practice patients commonly have significant solar damage. This can lead to the manifestation of actinic keratoses (AKs) as discreet lesions or as field disease, with these lesions potentially giving rise to keratinocyte cancers (KCs). Therefore, a pragmatic approach is needed to assess and manage these higher-risk patients.
View Article and Find Full Text PDFEnhanced skin regeneration and therapeutic delivery using novel diamond-augmented zinc oxide.
J Cosmet Dermatol
December 2024
Gold Skin Care Center, Nashville, Tennessee, USA.
Background: Recent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond-Augmented Zinc Oxide (ND-ZnO) technology combines zinc oxide with diamond particles in a unique core-shell structure, offering a multifaceted approach to overall skin health.
Aims: This study evaluates the efficacy of ND-ZnO in promoting human dermal fibroblast migration and growth, enhancing total collagen synthesis, and improving transdermal delivery of active ingredients as a daily comprehensive skin regeneration topical therapy.