465 results match your criteria: "Acrodermatitis Chronica Atrophicans"
Evaluation of the Epitogen Lyme Detect IgG ELISA: a novel peptide multiplexing approach.
Microbiol Spectr
October 2024
EpitogenX Ltd, Foresterhill Health Campus, Aberdeen, United Kingdom.
Article Synopsis
- Lyme Borreliosis (LB), or Lyme disease, is increasingly concerning due to its severe health risks from untreated cases, often diagnosed too late with current tests having low sensitivity.
- A new diagnostic test, the Epitogen Lyme Detect IgG ELISA, was validated in this study using 220 serum samples to assess sensitivity and specificity against the standard LIAISON Borrelia IgG test.
- The Epitogen test showed comparable performance for late stages of LB and significantly higher sensitivity for early suspected cases, indicating it could improve early and accurate diagnosis of Lyme disease.
Bridging the gap: Insights in the immunopathology of Lyme borreliosis.
Eur J Immunol
December 2024
Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl) genospecies transmitted by Ixodes spp. ticks, is a significant public health concern in the Northern Hemisphere. This review highlights the complex interplay between Bbsl infection and host-immune responses, impacting clinical manifestations and long-term immunity.
View Article and Find Full Text PDFSkin Changes in Suspected Lyme Disease.
Acta Dermatovenerol Croat
December 2023
Pero Vržogić, MD, Naftalan Special Hospital for Medical Rehabilitation, Ivanić Grad, Croatia;
Article Synopsis
- Ticks are a significant health concern in Croatia and worldwide due to their role in transmitting various diseases, including Lyme borreliosis, which is caused by the Borrelia burgdorferi bacterium.
- In Croatia, the incidence rate of Lyme borreliosis is approximately 6.51 cases per 100,000 people, highlighting the risk of infection from ticks.
- The article describes a case of a 58-year-old woman with Lyme disease who had skin manifestations that fully regressed after successful treatment, demonstrating the importance of early diagnosis and intervention.
Clinical Manifestations of European Borreliosis on the Skin in Acute, Subacute and Chronic Disease.
Mater Sociomed
January 2024
Department of Biosciences, COMSATS University Islamabad (CUI), Park Road, Chakh Shahzad, Islamabad, Pakistan.
Article Synopsis
- Lyme borreliosis, caused by the Borrelia burgdorferi spirochete, is a complex infection primarily indicated by erythema migrans on the skin.
- A study examining 509 patients over nine years aimed to explore skin manifestations and their impact on diagnosis and treatment, revealing various clinical presentations beyond just erythema migrans.
- Findings showed that while erythema migrans is a key marker, other skin conditions like "pink borreliosis stretch marks" and "borreliosis palms or soles" are important for diagnosing chronic borreliosis.
[Cutaneous Lyme disease: not always a rash with a central clearing].
Ned Tijdschr Geneeskd
April 2024
Amsterdam UMC, Amsterdam. Afd. Inwendige Geneeskunde en Infectieziekten.
Article Synopsis
- Lyme disease diagnoses in the Netherlands have surged to 27,000 annually over the last 40 years, with an incidence rate of 111 to 131 cases per 100,000 people.
- Most cases (77-89%) involve skin-related symptoms, particularly erythema migrans, while other manifestations include borrelia lymphocytoma (2-3%) and acrodermatitis chronica atrophicans (1-3%).
- Early detection and treatment are crucial to avoid more serious systemic health issues that can arise from delayed diagnosis.
Case presentation and management of Lyme disease patients: a 9-year retrospective analysis in France.
Front Med (Lausanne)
January 2024
Unité Environnement et Risques Infectieux, Institut Pasteur, Université Paris Cité, Paris, France.
Article Synopsis
- - Lyme borreliosis (LB) is the most prevalent vector-borne disease in temperate regions of the northern hemisphere and is caused by the Borrelia bacteria complex.
- - The study involved sending questionnaires to around 700 physicians in France annually from 2003 to 2011, gathering data on 3,509 LB cases, which led to various findings on symptomatology and demographics.
- - Results showed that 60% of cases were confirmed, with notable differences in clinical presentations between children and adults as well as a gender effect, highlighting the need for ongoing research and better patient tracking post-treatment.
Lyme Disease: An Overview.
Indian Dermatol Online J
February 2023
Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur, Himachal Pradesh, India.
Article Synopsis
- Lyme disease is caused by a spirochete and is primarily transmitted through infected tick bites, with symptoms like an erythema migrans rash indicating early infection.
- The disease incidence is rising due to factors like reforestation and increased human interaction with tick habitats, and late stages can involve severe issues requiring complicated treatment approaches.
- Diagnosis typically involves a two-step serological testing process, and while oral doxycycline is the preferred treatment, prevention remains crucial as there is no vaccine and past infections do not provide lasting immunity.
High-risk groups for alpha-gal sensitization.
Allergol Select
August 2023
Department of Dermatology and Allergy Biederstein, Faculty of Medicine, Technical University of Munich, Munich, Germany.
Article Synopsis
- The study examines sensitization to the oligosaccharide alpha-gal, which can cause allergic reactions from tick bites, comparing three groups with varying tick exposure.
- It analyzed specific IgE levels in 485 patients with Lyme disease and a control group of 200 individuals with less tick exposure, alongside 232 hunters and forest workers frequently exposed to ticks.
- Results indicate a higher prevalence of alpha-gal sensitization in tick-exposed individuals, especially among hunters and forest workers, suggesting increased tick contact may lead to sensitization over time.
[Erythema of the lower limb].
Rev Med Interne
January 2024
Service de dermatologie, groupe hospitalier du Havre, 76600 Le Havre, France.
Spotted fever group rickettsiae and in seropositive individuals with or without Lyme disease: A retrospective analysis.
New Microbes New Infect
June 2023
University of Zürich, Institute for Epidemiology, Biostatistics and Prevention, WHO Collaborating Centre for Travellers' Health, Department of Global and Public Health, MilMedBiol Competence Centre, Zürich, Switzerland.
Article Synopsis
- - **Tick-Borne Infections:** The study focuses on the prevalence of Spotted fever group Rickettsiae (SFG) infections in humans in Switzerland, noting that these infections are often underrecognized after tick bites. - **Testing Results:** Among 121 patients, 53.7% tested positive for IgG antibodies, with higher levels seen in late-stage Lyme disease compared to early stages; fatigue, headache, and muscle pain were linked to higher IgG prevalence. - **Need for Further Research:** The findings highlight a gap in understanding SFG rickettsiae's role in post-tick bite symptoms, suggesting the need for more research to confirm its impact and the necessity for treatment options.
[A man with unilateral erythema of the leg].
Ned Tijdschr Geneeskd
March 2023
Dijklander Ziekenhuis, afd. Dermatologie, Hoorn.
Article Synopsis
- - A healthy 47-year-old man visited a dermatology clinic due to a painless redness on one leg, without any swelling.
- - After examination, doctors diagnosed him with acrodermatitis chronica atrophicans, a skin condition.
- - The diagnosis was confirmed by the presence of IgG antibodies indicating infection with Borrelia burgdorferi, the bacteria responsible for Lyme disease.
Rare case of Lyme borreliosis in a patient presenting with dactylitis and skin rash.
BMJ Case Rep
February 2023
Departments of Medicine and Rheumatology, Gødstrup Regional Hospital, Herning, Denmark
Article Synopsis
- An immunocompetent male in his 70s was diagnosed with psoriatic arthritis based on symptoms like dactylitis and psoriasis, but initial treatments (corticosteroids and methotrexate) did not help.
- When TNF-alpha inhibitors were introduced, his condition worsened, leading to a skin biopsy that revealed Lyme borreliosis and confirmed acrodermatitis chronica atrophicans (ACA) and Lyme dactylitis.
- Treatment with phenoxymethylpenicillin showed significant improvement within two weeks, highlighting the importance of re-evaluating a patient's condition when treatments fail.
Post-Inflammatory Hypopigmentation: Review of the Etiology, Clinical Manifestations, and Treatment Options.
J Clin Med
February 2023
Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA.
Article Synopsis
- Post-inflammatory hypopigmentation is a skin condition that often affects people with darker skin tones, causing cosmetic and emotional challenges.
- While many cases heal on their own, a systematic diagnosis is essential to find the root cause and determine the best treatment options.
- There is a need for more established guidelines for diagnosing and treating this condition, despite existing classification tools for other types of hypopigmentation disorders.
Cutaneous Manifestations of Lyme Borreliosis in Children-A Case Series and Review.
Life (Basel)
December 2022
Department of Infectious Diseases and Child Neurology, Karol Marcinkowski University of Medical Sciences, 61-701 Poznań, Poland.
Article Synopsis
- * The skin symptoms of Lyme borreliosis can vary greatly, with typical lesions aiding diagnosis and atypical ones complicating it, especially if the patient doesn't recall a tick bite.
- * This study highlights various skin manifestations of Lyme disease in children, shares practical recognition strategies, and discusses diagnostic tips for different forms of the condition.
[CME: Neuroborreliosis].
Praxis (Bern 1994)
October 2022
Innere Medizin, Kantonsspital Graubünden, Schweiz.
Article Synopsis
- Lyme disease is the most common tick-borne infection in Europe, caused by bacteria from the Borrelia complex, and initially appears as a skin infection known as Erythema migrans.
- If untreated, it can lead to serious complications like neurological Lyme disease, Lyme carditis, and Lyme arthritis, with neuroborreliosis affecting 3-15% of patients, potentially causing polyradiculitis or meningitis.
- Treatment for neuroborreliosis typically involves antibiotics such as doxycycline, ceftriaxone, or penicillin G, while prevention focuses on reducing tick exposure, and a vaccine is being developed in Europe.
Acrodermatitis chronica atrophicans with clonal light chains and heavy chain rearrangement.
J Eur Acad Dermatol Venereol
March 2023
Kempf und Pfaltz Histologische Diagnostik, Zürich, Switzerland.
The Performance of Nine Commercial Serological Screening Assays for the Diagnosis of Lyme Borreliosis: a Multicenter Modified Two-Gate Design Study.
Microbiol Spectr
April 2022
Centre for Infectious Disease Control, National Institute for Public Health and the Environmentgrid.31147.30 (RIVM), Bilthoven, the Netherlands.
Article Synopsis
- A retrospective study assessed the effectiveness of nine serological assays for diagnosing Lyme borreliosis (LB) using sera from 74 LB cases and 122 controls.
- Sensitivity of these tests varied significantly, with higher detection rates in cases like Lyme neuroborreliosis compared to early Lyme cases, and overall performance was adequate across both early and late forms of LB.
- The study concluded that while serological assays are essential for diagnosing LB, IgM testing did not enhance diagnostic accuracy beyond IgG testing, and a two-tier testing approach is recommended to minimize false positives.
A persistent plaque on the back of the hand.
Clin Exp Dermatol
April 2022
Dermatology, Imperial College Healthcare NHS Trust, London, UK.
Article Synopsis
- A 75-year-old woman developed a skin condition called acrodermatitis chronica atrophicans on her right hand after being bitten by an insect in Greece.
- The diagnosis was verified through blood tests, PCR testing, and examination of tissue samples.
- Treatment with oral doxycycline for three weeks resulted in the resolution of her skin condition.
Diagnosis of Lyme Borreliosis With a Novel, Seminested Real-Time Polymerase Chain Reaction Targeting the 5S-23S Intergenic Spacer Region: Clinical Features, Histopathology, and Immunophenotype in 44 Patients.
Am J Dermatopathol
May 2022
Dermatologikum Hamburg, Hamburg, Germany ; and.
Article Synopsis
- Lyme borreliosis (LB) is the most prevalent tick-borne illness in Europe and North America, and a new seminested real-time PCR assay was developed to improve diagnostic accuracy compared to traditional methods.
- In a study of 596 skin biopsy samples, the seminested real-time PCR detected 46 cases of LB, outperforming three conventional PCR assays which identified fewer cases.
- Analysis of the PCR-positive cases revealed varying forms of LB and highlighted that certain immune cell markers, like CD123-positive plasmacytoid dendritic cells, are common, while CD34 loss complicates differential diagnosis with morphea.
[Acrodermatitis chronica atrophicans].
Ugeskr Laeger
November 2021
Diagnostisk Center, Regionshospitalet Silkeborg
Acrodermatitis chronica atrophicans in prolonged borrelia infection.
Tidsskr Nor Laegeforen
November 2021
Article Synopsis
- Acrodermatitis chronica atrophicans (ACA) is a rare skin condition that arises from Borrelia infection and can be easily missed, particularly in older adults.
- A case study of a woman in her fifties who experienced various neurological symptoms led to a misdiagnosis related to her psychiatric treatment, but further symptoms revealed significant skin changes indicative of ACA.
- The condition primarily affects women and typically presents with skin changes on the extremities, with a diagnosis confirmed through specific antibody tests and a skin PCR test for Borrelia.
Prevalence of persistent symptoms after treatment for lyme borreliosis: A prospective observational cohort study.
Lancet Reg Health Eur
July 2021
National Institute for Public Health and the Environment (RIVM), Center for Infectious Disease Control, P.O. Box 1, 3720 BA, Bilthoven, Netherlands.
Article Synopsis
- A large prospective study investigated long-lasting symptoms in adults treated for Lyme borreliosis (LB), comparing these patients to general population and tick-bite controls.
- The study found that 27.2% of LB patients experienced persistent symptoms, notably higher than the 21.2% and 23.3% found in the general population and tick-bite groups, respectively.
- These persistent symptoms included more severe fatigue, cognitive impairment, and pain among erythema migrans patients compared to those without LB, suggesting an association between LB and lingering health issues in some patients.
Exacerbation of acrodermatitis chronica atrophicans under antiretroviral treatment in an HIV-infected patient.
J Eur Acad Dermatol Venereol
February 2022
Infectious and Tropical Diseases Department, Angers University Hospital, Angers, France.