388 results match your criteria: "Acne Conglobata"
Association of childhood obesity or weight change with early-onset follicular occlusion triad among children.
Br J Dermatol
October 2024
Laboratory of Intestinal Mucosa and Skin Immunology, Seoul, Republic of Korea.
Background: The effects of childhood obesity or weight gain on the development of early-onset follicular occlusion triad (FOT) among children, which includes hidradenitis suppurativa (HS), acne conglobata (AC), and dissecting cellulitis of the scalp (DCS), remain unknown.
Objectives: To investigate the association between body mass index (BMI) or its changes and early-onset FOT development.
Methods: This nationwide population-based longitudinal cohort study included a cohort of 2,012,928 Korean children who underwent two consecutive health examinations at 30-36 months and 42-48 months of age between 2009 and 2020.
Determinant Factors of Disease Severity for Patients With Hidradenitis Suppurativa Evaluated in a Spanish Hospital Over a 5-Year Period.
Actas Dermosifiliogr
October 2024
Department of Dermatology, Hospital Universitario Doctor Peset, University of Valencia, España.
Article Synopsis
- * Conducted in a Spanish hospital, the retrospective study analyzed data from 322 patients diagnosed with HS over five years.
- * Key findings indicated that delays in diagnosis, certain comorbidities like acne conglobata and cardiovascular issues, as well as perianal or truncal involvement, were linked to more severe cases of HS, while psychiatric conditions showed no significant relationship.
Determinant Factors of Disease Severity for Patients With Hidradenitis Suppurativa Evaluated in a Spanish Hospital Over a 5-Year Period.
Actas Dermosifiliogr
July 2024
Department of Dermatology, Hospital Universitario Doctor Peset, University of Valencia, Spain.
Article Synopsis
- - A study was conducted on 322 patients with hidradenitis suppurativa (HS) at a Spanish hospital to find out which factors indicate more severe cases of HS and may require aggressive treatment.
- - Results showed that longer diagnostic delays, conditions like acne conglobata, certain cardiovascular risk factors, and perianal or truncal involvement were linked to more severe HS.
- - Interestingly, psychiatric comorbidities did not influence HS severity, while being female and having a family history of HS were associated with an earlier onset of the disease.
Article Synopsis
- The study aimed to analyze ultrasound features of facial hidradenitis suppurativa (HS) and identify concurrent cases of acne vulgaris (AV).
- Researchers examined ultrasound images from 33 patients diagnosed with facial HS and used specific scoring and staging systems to categorize their conditions.
- Results indicated that HS lesions often contained hair tract fragments, while only a small percentage of patients presented with both HS and AV, highlighting differences in lesion characteristics that can aid in diagnosis and treatment.
Article Synopsis
- Acne fulminans (AF) is a severe type of acne characterized by painful, bleeding pustules and ulcerations, which may involve systemic symptoms and lab abnormalities.* -
- A review of 98 relevant articles revealed that different variants of AF present unique clinical features, with androgen-induced AF showing more nodules and cysts, while "miscellaneous AF" tends to have more ulcerations and erosions.* -
- Understanding the different presentations of AF is important for developing personalized treatment plans, leading to a proposed classification based on associated factors.*
A case of and acne conglobata effectively treated with a tumor necrosis factor α inhibitor.
Dermatol Reports
September 2023
Department of Dermatology, School of Medicine, Iwate Medical University, Shiwa-gun, Iwate, Japan.
Treating refractory acne conglobata with secukinumab: A case report.
J Dermatol
February 2024
Department of Dermatology, Xijing Hospital, Forth Military Medical University, Xi'an, China.
Hidradenitis suppurativa and follicular occlusion syndrome: Where is the pathogenetic link?
Clin Dermatol
December 2023
Department of Dermatology, Venereology, and Allergology, Wroclaw Medical University, Wroclaw, Poland.
Article Synopsis
- - The follicular occlusion tetrad complex includes four skin conditions: hidradenitis suppurativa, acne conglobata, dissecting cellulitis of the scalp, and pilonidal cyst, which share common traits and causes.
- - A key factor in the development of these conditions is follicular occlusion, leading to skin issues like nodules, abscesses, comedones, and draining sinuses, often resulting in scarring.
- - Although they have similarities, each condition has distinct differences that necessitate unique treatment strategies.
Treatment of Acne with Isotretinoin Should Be Avoided in Patients with Hidradenitis Suppurativa "Conglobata Phenotype".
Dermatology
July 2023
Department of Dermatology, Hôpital Erasme, Université libre de Bruxelles (ULB), Brussels, Belgium.
Article Synopsis
- * Results showed that 87.8% of 82 participants did not experience worsened acne while on isotretinoin, although those with the HS "conglobata phenotype" were more likely to see their condition worsen.
- * The findings suggest that isotretinoin may not be beneficial for all HS patients, particularly those with higher BMI or who fit the "conglobata phenotype," and highlight the need for cautious use in this group.
Deeper Seated Than Skin Deep: Report of a Rare Case of Follicular Occlusion Tetrad and a Literature Review.
Cureus
May 2023
Plastic Surgery, Doctors Hospital at Renaissance, Edinburg, USA.
Article Synopsis
- Follicular occlusion tetrad (FOT) is a syndrome that includes hidradenitis suppurativa, acne conglobata, dissecting cellulitis of the scalp, and pilonidal cyst, which can occur together, but usually happen independently.
- These conditions share a common issue with apocrine glands and follicular hyperkeratinization, making understanding their similarities important for effective treatment.
- A case study of a 22-year-old man with FOT showed that despite initial conservative treatment, surgical intervention was necessary, highlighting the need for a multidisciplinary approach and the potential benefits of new biologic therapies.
An Updated Mutation Spectrum of the γ-Secretase Complex: Novel NCSTN Gene Mutation in an Indian Family with Hidradenitis Suppurativa and Acne Conglobata.
Indian J Dermatol
January 2023
Department of Obstetrics and Gynecology, Oakland University-William Beaumont School of Medicine, Royal Oak, MI, USA.
Article Synopsis
- - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder linked to genetic mutations, particularly in the γ-secretase gene, but its exact causes are still not fully understood due to high genetic variability and environmental influences.
- - This study aimed to explore the genetic causes of HS by screening 95 sporadic cases and one large family to identify mutations in the γ-secretase complex genes.
- - A novel mutation was found in a large family, specifically a stop codon mutation in the NCSTN gene, while no significant mutations were detected in the sporadic cases, highlighting genetic diversity in HS.
Acne conglobata caused by .
Postepy Dermatol Alergol
December 2022
Department of Dermatology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata.
Pediatr Rheumatol Online J
October 2022
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Article Synopsis
- - **SAPHO syndrome is a rare chronic inflammatory disease characterized by joint and skin issues, including severe acne called acne conglobata, particularly in adolescents.**
- - **Tumor necrosis factor inhibitors (TNFi) are typically used as a second-line treatment for SAPHO syndrome and have shown success in managing acne conglobata.**
- - **The report presents three cases of adolescents with SAPHO syndrome and acne conglobata who were effectively treated with TNFi therapy.**
S2k guideline: Laser therapy of the skin.
J Dtsch Dermatol Ges
September 2022
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine (dEBM), Berlin.
Article Synopsis
- This guideline focuses on enhancing the safety and effectiveness of laser treatments for various skin lesions, particularly emphasizing caution in treating lesions with higher melanocyte levels.
- It advises against the use of laser therapy for pigmented melanocytic nevi and provides specific recommendations for conditions like lentigines, café-au-lait spots, non-pigmented dermal nevi, and melasma among others.
- Additionally, the guideline addresses treatments for a wide range of skin issues, including inflammatory dermatoses, wrinkles, scars, benign growths, and different types of vascular and viral lesions.
Dissecting cellulitis of the scalp with typical clinical features: A retrospective cross-sectional study in a Department of Dermatology, Beijing, China.
J Dermatol
November 2022
Department of Dermatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- Dissecting cellulitis of the scalp (DCS) is a rare skin condition, and a study aimed to gather demographic and clinical data from patients diagnosed with it in Beijing's dermatology clinic.
- The study included 169 male patients, primarily in their 30s, with common comorbidities like seborrheic dermatitis and notable increases in white blood cell and neutrophil counts.
- The findings suggest that DCS predominantly affects younger men, and there is a need for further research to understand the clinical importance of the laboratory results observed.
Article Synopsis
- - Dissecting cellulitis of the scalp (DCS) is a chronic skin condition characterized by swollen, pus-filled bumps and nodules that can lead to scarring hair loss.
- - Initially thought to be an infectious disease when first described in 1903, DCS is now recognized mainly as an inflammatory issue that may later get infected.
- - DCS is part of a group of similar conditions known as the follicular occlusion tetrad, which includes hidradenitis suppurativa, acne conglobata, and pilonidal sinus.
A case of 5-aminolevulinic acid photodynamic therapy(ALA-PDT)combined with surgery for the treatment of acne conglobata.
Photodiagnosis Photodyn Ther
September 2022
Department of Dermatologic Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China.
Article Synopsis
- A 20-year-old man with severe acne conglobata (AC) underwent a unique treatment combining 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and fractional carbon dioxide laser for aesthetic improvements.
- AC is an aggressive form of acne that not only causes physical scarring but also impacts mental health and quality of life significantly.
- The case highlights a potentially effective treatment approach for patients with AC, especially those resistant to standard therapies.
Severe acne and its variants: Exploring its natural history and heritability.
Pediatr Dermatol
July 2022
Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital San Diego, San Diego, California, USA.
Article Synopsis
- Acne vulgaris has different levels of severity, from mild to severe cases that can lead to scarring, with a family history increasing the risk of developing the condition.
- The study examined 101 patients with severe acne undergoing isotretinoin therapy, focusing on their family history and using scoring systems to assess the severity of their condition.
- Results showed that severe acne tends to be hereditary, with many subjects having relatives with similar or worse acne conditions, suggesting the importance of family history in predicting acne severity.
ALA-iPDT for follicular occlusion tetrad concomitant with pachyonychia congenital type Ⅱ and ankylosing spondylitis.
Photodiagnosis Photodyn Ther
September 2022
Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, PR China. Electronic address:
Article Synopsis
- * A young male patient presented with the tetrad along with congenital pachyonychia type II and ankylosing spondylitis, linked to a mutation in the KRT17 gene.
- * Treatment involving a combination of photodynamic therapy and surgery showed promising results, highlighting a potential management approach for this complex condition.
Comorbid diseases of hidradenitis suppurativa: a 15-year population-based study in Olmsted County, Minnesota, USA.
Int J Dermatol
November 2022
Department of Dermatology, Sutter Medical Foundation, Sacramento, CA, USA.
Background: Like other chronic, inflammatory skin disorders, hidradenitis suppurativa (HS) is increasingly recognized to be associated with various medical disorders.
Objective: Using the Rochester Epidemiology Project (REP), we sought to conduct the first American population-based study examining the association between HS and various comorbid conditions.
Methods: From the REP database, we identified patients diagnosed with HS from 2003 through 2018 who were residents of Olmsted County, Minnesota, USA, along with age- and gender-matched controls.
Dissecting cellulitis of the scalp associated with peripheral and axial spondyloarthritis: report of a case and review of the literature.
Clin Rheumatol
August 2022
Division of Rheumatology, Department of Medicine, and Division of Dermatology, Keck School of Medicine, University of Southern California and Los Angeles County, Los Angeles, CA, USA.
Article Synopsis
- Dissecting cellulitis of the scalp (DCS) is a rare inflammatory hair loss condition that can lead to scarring and is associated with other diseases like hidradenitis suppurativa (HS) and acne conglobata (AC), but its link to spondyloarthritis is less recognized.
- A recent study reviewed 12 cases of DCS patients who also had spondyloarthritis and highlighted important clinical features and treatment options, indicating that inflammatory arthritis can flare during DCS episodes.
- Treatment challenges exist, and while anti-TNF-α medications have shown promise in managing both the skin and joint symptoms, further research into biologic therapies is needed to explore
Comprehensive Treatment of Severe Follicular Occlusion Triad: A Case Report.
Clin Cosmet Investig Dermatol
March 2022
Department of Plastic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
Follicular occlusion triad (FOT) is a chronic inflammatory skin disease that comprises hidradenitis suppurativa, acne conglobata, and perifolliculitis capitis abscedens et suffodiens and can seriously affect a patient's quality of life. Currently, there is no consensus on the treatment plan for FOT. There are also only a few reports on the treatment of severe FOT.
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