27,446 results match your criteria: "Acinetobacter"
Int J Antimicrob Agents
December 2024
Department of Pharmacy, Singapore General Hospital, Singapore; Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore; Singhealth Duke-NUS Medicine Academic Clinical Programme, Singapore. Electronic address:
Treatment of multidrug resistant infections is challenging due to limited therapeutic options. To maximise treatment success of such infections, our infectious disease-trained pharmacists employ a two-pronged approach, using both in vitro antibiotic combination testing and therapeutic drug monitoring, to individualise antibiotic combination regimens for our patients, akin to precision medicine. This approach ensures that the most optimal antibiotic combination and dosing regimens are prescribed for our patients with multidrug resistant infection, to ensure adequate antibiotic exposure and maximal clinical efficacy.
View Article and Find Full Text PDFInt J Antimicrob Agents
December 2024
Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, Section 3, Zhongyang Rd., Hualien, Taiwan; Department of Surgery, School of Medicine, Tzu Chi University, No. 701, Section 3, Zhongyang Rd., Hualien, Taiwan. Electronic address:
Phage-based decontamination has rarely been explored in real-world settings, particularly in the environments of patients undergoing extracorporeal membrane oxygenation (ECMO). This four-year prospective study aimed to evaluate the effectiveness of aerosolized phage cocktails tailored to combat target antibiotic-resistant species of Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. The decontamination procedure with phage aerosols was proactively implemented before the admission of ECMO patients based on a thorough analysis of phage typing results from bacterial species isolated from prospective patient areas during the preceding two months.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
Technology Innovation Center for Food Safety Surveillance and Detection (Hainan), Sanya Institute of China Agricultural University, Sanya 572025, China; National Key Laboratory of Veterinary Public Health Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address:
Swine farm wastewater is a major reservoir of antimicrobial resistance genes (ARGs). Anaerobic digestion (AD), widely implemented in farms, has been extensively studied for ARG removal. However, a comparative study on ARG removal efficiency across the four principal AD systems - up-flow anaerobic sludge blanket (UASB), continuous stirred tank reactor (CSTR), buried biogas digester (BBD), and septic tank (SPT) - is lacking.
View Article and Find Full Text PDFEur J Clin Microbiol Infect Dis
December 2024
Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Proteus mirabilis is a Gram-negative bacterium found in the environment and also forms part of the commensal flora in the gastrointestinal tract of both humans and animals. P. mirabilis can cause a wide variety of infections, however it does not harbor any intrinsic β-lactamase genes and as such usually exhibits full susceptibility to β-lactams with the exception of imipenem, to which it is naturally resistant.
View Article and Find Full Text PDFEnviron Monit Assess
December 2024
College of Chemistry and Environmental Engineering, Shanghai Institute of Technology, Shanghai, 201418, China.
High salt concentrations pose a significant challenge to the efficiency of activated sludge (AS) in phenolic wastewater treatment. As a cellular osmoprotectant, proline (Pro) has the capacity to increase the salt tolerance of microbes in AS, hence improving the efficiency of phenolic wastewater degradation. Nevertheless, the precise mechanism behind this enhancement remains ambiguous.
View Article and Find Full Text PDFBiometals
December 2024
Microbiology Lab, School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat, 382030, India.
Increasing antibiotic resistance among the common nosocomial pathogen i.e. Acinetobacter baumannii poses life threat to the health care workers as well as to the society.
View Article and Find Full Text PDFAntimicrob Resist Infect Control
December 2024
Wolfson Medical Center, Holon, Israel.
Background: Active screening programs and early detection of asymptomatic carriers are effective in preventing carbapenem-resistant Acinetobacter baumannii (CRAB) dissemination in healthcare facilities. This study aims to identify risk factors associated with CRAB carriage among patients upon admission to an acute care hospital.
Methods: A case-case-control study was conducted at an acute care hospital.
Antimicrob Resist Infect Control
December 2024
Department of Microbiology, Immunology and Transplantation, KU Leuven, Louvain, Belgium.
Background: As part of the containment of the COVID-19 pandemic, mobile handwashing stations (mHWS) were deployed in healthcare facilities in low-resource settings. We assessed mHWS in hospitals in the Democratic Republic of the Congo for contamination with Gram-negative bacteria.
Methods: Water and soap samples of in-use mHWS in hospitals in Kinshasa and Lubumbashi were quantitatively cultured for Gram-negative bacteria which were tested for antibiotic susceptibility.
Ann Clin Microbiol Antimicrob
December 2024
Department of Pediatric Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, 3333 Binsheng Road, Binjiang District, Hangzhou, Zhejiang, China.
Background: Antimicrobial resistance (AMR) poses a significant threat to pediatric health; therefore, precise identification of pathogens as well as AMR is imperative. This study aimed at comprehending antibiotic resistance patterns among critically ill children with infectious diseases admitted to pediatric intensive care unit (PICU) and to clarify the impact of drug-resistant bacteria on the prognosis of children.
Methods: This study retrospectively collected clinical data, identified pathogens and AMR from 113 children's who performed metagenomic next-generation sequencing for pathogen and antibiotic resistance genes identification, and compared the clinical characteristic difference and prognostic effects between children with and without AMR detected.
Can J Microbiol
December 2024
The First Affiliated Hospital of Wenzhou Medical University, Department of Clinical Laboratory, Wenzhou, Zhejiang, China;
The objective of this study was to compare chlorhexidine digluconate and other antibiotics susceptibility of 4 species in Acinetobacter baumannii complex, and further investigate the CHG tolerance mechanisms and molecular epidemic characteristics. Of 889 A. baumannii complex isolates, A.
View Article and Find Full Text PDFPediatr Infect Dis J
December 2024
Department of Pediatrics, Hospital Universitario de Cabueñes Gijón, Spain.
Medicine (Baltimore)
December 2024
Heart Surgery Department, Kosuyolu High Specialization Training and Research Hospital, Istanbul, Turkey.
In this study, the blood culture results of patients aged >65 years who were admitted to the cardiology intensive care unit in a training and research hospital and who had positive blood cultures within the first 48 hours were evaluated. This was a retrospective, observational and nonrandomized study. Patient data at the time of the blood culture were included in the study.
View Article and Find Full Text PDFSci Adv
December 2024
Key Laboratory of Multiple Organ Failure (Ministry of Education), and Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.
The covalently attached cofactor biotin plays pivotal roles in central metabolism. The top-priority ESKAPE-type pathogens, and , constitute a public health challenge of global concern. Despite the fact that the late step of biotin synthesis is a validated anti-ESKAPE drug target, the primary stage remains fragmentarily understood.
View Article and Find Full Text PDFmBio
December 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
Type VI secretion system (T6SS) is utilized by many Gram-negative bacteria to eliminate competing bacterial species and manipulate host cells. ATCC 17978 utilizes T6SS at the expense of losing pAB3 plasmid to induce contact-dependent killing of competitor microbes, resulting in the loss of antibiotic resistance carried by pAB3. However, the regulatory network associated with T6SS in remains poorly understood.
View Article and Find Full Text PDFMicrobiol Spectr
December 2024
Institute for Medical Molecular Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sg. Buloh Campus, Jalan Hospital, Sg. Buloh, Selangor, Malaysia.
Genetic characterization of multidrug-resistant (MDR) remains scarce in Malaysia. This study aimed to characterize antibiotic resistance, genomic location, and genetic relatedness among the isolates obtained from a tertiary hospital in Malaysia. A total of 128 MDR isolates were collected from patients admitted to various wards (intensive care unit [ICU], neonatal intensive care unit, coronary care unit, high dependency ward [HDW], and general wards).
View Article and Find Full Text PDFBMC Res Notes
December 2024
Department of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Background: The nasopharynx is characterised by a rich microbial diversity, making it an important endogenous reservoir for respiratory infections. People living with diabetes (PLWD) have a high risk for acquisition of respiratory tract infections, but their nasopharyngeal bacterial flora have rarely been investigated.
Aim: To investigate the nasopharyngeal bacterial flora among PLWD and non-diabetics at the Korle Bu Teaching Hospital in Accra.
Syst Rev
December 2024
Department of Neurosurgical Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: For resistant Gram-positive bacteria, evidence suggests that combination therapy is more effective. However, for resistant Gram-negative bacteria, no consensus has been reached. This study aims to comprehensively summarize the evidence and evaluate the impact of combination versus monotherapy on infections caused by carbapenem-resistant Gram-negative bacteria (CRGNB).
View Article and Find Full Text PDFJ Glob Antimicrob Resist
December 2024
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products & Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, 310021, China; Xianghu Laboratory, Hangzhou, 311231, China. Electronic address:
Objectives: Acinetobacter indicus is an important pathogen of nosocomial infection. The purpose of this study was to analyze the resistance and transmission of A. indicus strain AIBD14 isolated from slaughterhouse environment.
View Article and Find Full Text PDFPathog Glob Health
December 2024
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia.
is a multidrug-resistant bacterium that has emerged as a significant nosocomial pathogen globally and renowned for its ability to acquire antimicrobial resistance (AMR) genes. However, understanding of its resistance mechanisms to certain drug classes remains limited. This study focused on four bacterial strains (AB863, AB889, AB930, and AB960) exhibiting carbapenem resistance.
View Article and Find Full Text PDFEur J Clin Microbiol Infect Dis
December 2024
Department of Biotechnology, School of Life Sciences, Pondicherry University, R. Venkataraman Nagar, Kalapet, Pondicherry, 605014, India.
Purpose: Clinical isolates of multi-drug resistant Acinetobacter baumannii are a major cause of nosocomial infections, often attributed to the highly adaptable genome that helps it to thrive under environmental selection pressure. Here, we aim to provide genotypic-based surveys and comparative whole genome sequencing (WGS) analysis to explore the genomics of the rare pyomelanin-forming clinical isolates of A. baumannii from India.
View Article and Find Full Text PDFMicrobiol Spectr
December 2024
Department of Microbiology, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Unlabelled: There is a critical need for treatment strategies to combat carbapenem-resistant Gram-negative pathogens. This study investigates the efficacy of combining low concentrations of colistin with tigecycline against colistin- and carbapenem-resistant and strains. We used two strains of KPC-2-producing and OXA-23-producing , both of which are highly colistin-resistant.
View Article and Find Full Text PDFMicrob Cell Fact
December 2024
Department of Applied Biology, School of Applied Natural Science, Adama Science and Technology University, P. O. Box 1888, Adama, Ethiopia.
Background: The ongoing emergence and spread of drug-resistant pathogens necessitate urgent solutions. Natural products from bacterial sources are recognized as a promising source of antibiotics. This study aimed to isolate and characterize soil microorganisms from extremely hot environments and to screen their secondary metabolites for antibacterial activity.
View Article and Find Full Text PDFBMC Neurol
December 2024
Department of Medical Microbiology, University of Ghana Medical School, Accra, Ghana.
Background: Infection is a common complication in the acute phase after stroke; a systematic review in 2011 reported a post-stroke infection prevalence of 30%. Despite the plethora of primary data on post-stroke infections in recent times, a systematic review that synthesizes the data to provide comprehensive information to guide preventive, control, and management efforts is yet to be undertaken. This systematic review, therefore, aimed at bridging this gap by describing the epidemiology of post-stroke infections including the global prevalence and the associated mortality rates.
View Article and Find Full Text PDFBMC Microbiol
December 2024
Department of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Background: The Study for Monitoring Antimicrobial Resistance Trends (SMART) is an international surveillance program longitudinally monitoring aerobic and facultative Gram-negative bacteria (GNB) involvement in infections and their antimicrobial resistance profiles. Here the incidence and resistance patterns of Chinese GNB isolates from bloodstream infections (BSI), intraabdominal infections (IAI), respiratory tract infections (RTI) and urinary tract infections (UTI) to commonly used antibacterial agents has been updated. 4,975 GNB isolates collected from 22 hospitals across 7 regions of China from 2019 to 2020 were analyzed.
View Article and Find Full Text PDFCrit Care
December 2024
Infectious Diseases and Infection Control Service, Hospital Moinhos de Vento, 910 Ramiro Barcelos St, Porto Alegre, RS, 90035-000, Brazil.
Background: Shorter courses of antimicrobial therapy have been shown to be non-inferior to longer durations for the management of several infections. However, data on critically ill patients with severe infections by multidrug-resistant Gram-negative bacteria (MDR-GNB) are scarce. In the duratiOn of theraPy in severe infecTIons by MultIdrug-reSistant gram-nEgative bacteria (OPTIMISE) trial, we assessed the non-inferiority of 7-day versus 14-day antimicrobial therapy for patients with intensive care unit (ICU)-acquired severe infections by MDR-GNB.
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