3 results match your criteria: "Academie Universitaire Louvain[Affiliation]"
A gene-specific requirement of RNA polymerase II CTD phosphorylation for sexual differentiation in S. pombe.
Curr Biol
June 2010
Academie Universitaire Louvain, Laboratoire de Genetique Moleculaire (GEMO), Rue de Bruxelles 61, 5000 Namur, Belgium.
Background: The switch from cellular proliferation to differentiation occurs to a large extent through specific programs of gene expression. In fission yeast, the master regulator of sexual differentiation, ste11, is induced by environmental conditions leading to mating and meiosis.
Results: We show that phosphorylation of serine 2 (S2P) in the C-terminal domain of the largest subunit of the RNA polymerase II (PolII) enzyme by the Lsk1 cyclin-dependent kinase has only a minor impact on global gene expression during vegetative growth but is critical for the induction of ste11 transcription during sexual differentiation.
CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells.
Toxicol Lett
December 2009
Biochimie cellulaire, nutritionnelle & toxicologique, Institut des Sciences de la Vie, Académie universitaire Louvain, UCL-Louvain-la-Neuve, Croix du Sud 5, B-1348 Louvain-la-Neuve, Belgium.
Article Synopsis
- Flavonoids may have health benefits but can also exhibit toxic properties, raising concerns about their interactions with drug metabolism.
- A study examined nine flavonoids and their effects on cytochrome P450 enzymes (CYP1A1 and CYP3A4) in human intestinal cells, revealing that genistein, quercetin, and chrysin cause a dose-dependent increase in CYP1A1 activity without altering gene expression.
- Chrysin showed strong inhibition of CYP1A1 activity induced by TCDD, while quercetin inhibited the activity of CYP3A4 and interfered with its induction by vitamin D, suggesting these flavonoids could affect drug metabolism and the activation of potential carcinogens in the intestine.
Dietary polyphenols can modulate the intestinal inflammatory response.
Nutr Rev
July 2009
Biochimie cellulaire, nutritionnelle & toxicologique, Institut des Sciences de la Vie & UCL, Académie universitaire Louvain, Louvain-la-Neuve, Belgium.
Inflammatory bowel diseases (IBD) arise from multiple causes, including environmental factors, gut microflora, immunity, and genetic predispositions. In the course of IBD, immune homeostasis and intestinal mucosa barrier integrity are impaired. Among natural preventive treatments that have been identified to date, polyphenols appear as promising candidates.
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