Speaking fluently with baclofen?

Baclofen is a new and promising pharmacological compound for the treatment of alcohol dependence (AD). Although several randomised trials found a reduction of craving and higher abstinence rates with low and high doses of baclofen, others failed to show positive effects. In this case study, the successful treatment of a patient with AD with daily 120 mg of baclofen is described.

Efficacy and safety of high-dose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial.

Previous randomised placebo-controlled trials with low-to-medium doses of baclofen (30-60mg) showed inconsistent results, but case studies suggested a dose-response effect and positive outcomes in patients on high doses of baclofen (up to 270mg). Its prescription was temporary permitted for the treatment of alcohol dependence (AD) in France, and baclofen is now widely prescribed. Recently, a small RCT found a strong effect of a mean dose of 180mg baclofen.

Traditional Chinese lipid-lowering agent red yeast rice results in significant LDL reduction but safety is uncertain - a systematic review and meta-analysis.

Objective: To verify the safety and effectiveness of traditional Chinese red yeast rice-extract (RYR) for reduction of LDL cholesterol.

Methods: Systematic literature review and meta-analysis. Medline and EMBASE were searched until November 2014.

The sulcus connection. On a mode of participation of outer hair cells in cochlear mechanics.

Motile outer hair cells (OHCs) can only participate well in cochlear mechanics when one end of the hair cells is more restrained in its movements than the other. On this thought a model of the organ of Corti (OoC) is developed in which (in every cross section) the tectorial membrane (TM) is considered to consist of two stiff segments connected by a hinge. Movements of the TM then induce movements of the fluid contained in the inner spiral sulcus (ISS) and the fluid dynamics of the sulcus will play an important part in restraining the top ends of the hair cells.