136 results match your criteria: "Academic Teaching Hospital of the Technical University[Affiliation]"

Cause and management of lipedema-associated pain.

Dermatol Ther

January 2021

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University, Dresden, Germany.

Lipedema is a painful, underdiagnosed adipose tissue disorder, characterized by symmetrical swelling of the extremities due to subcutaneous fat deposition in the buttocks, thighs, legs, and arms, sparing the most distal part of the extremities. Although etiology and pathogenesis of lipedema is unclear, possible role of hormonal and genetic factors have been proposed previously. Patients with lipedema suffer from pain, easy bruising, tenderness, and disfigurement.

View Article and Find Full Text PDF

Basic teledermatology solving two cases of crusted scabies.

Dermatol Ther

November 2020

Sexually Transmitted Diseases Unit, Ambulatório de Dermatologia Sanitária, State Health Secretariat, Rio Grande, Brazil.

View Article and Find Full Text PDF

Atypical vascular proliferations of the neck.

Wien Med Wochenschr

March 2021

Department of Dermatology, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey.

Atypical vascular proliferations (AVP) are a late complication after radiotherapy. Most cases have been reported in female breast cancer patients on the chest wall. These lesions are mostly of the lymphatic type.

View Article and Find Full Text PDF

Angiotensin II receptors: Impact for COVID-19 severity.

Dermatol Ther

November 2020

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University, Dresden, Germany.

COVID-19 is an outbreak of viral pneumonia which became a global health crisis, and the risk of morbidity and mortality of people with obesity are higher. SARS-CoV-2, the pathogen of COVID-19, enters into cells through binding to the Angiotensin Converting Enzyme (ACE) homolog-2 (ACE2). ACE2 is a regulator of two contrary pathways in renin angiotensin system (RAS): ACE-Ang-II-AT1R axis and ACE2-Ang 1-7-Mas axis.

View Article and Find Full Text PDF

Background: Pancreatic cancer is a devastating disease with a 5-year survival rate of 20-25%. As approximately only 20% of patients diagnosed with pancreatic cancer are initially staged as resectable, it is necessary to evaluate new therapeutic approaches. Hence, neoadjuvant (radio)chemotherapy is a promising therapeutic option, especially in patients with a borderline resectable tumor.

View Article and Find Full Text PDF

Hidradenitis suppurativa/acne inversa (HS/AI) is one of the most debilitating dermatoses with a strong negative impact on every dimension of quality of life. Treatment is dependent on the severity of clinical manifestations and comorbidities. While anti-inflammatory and antimicrobial approaches are recommended for mild and moderate stages, immunomodulatory drugs have gained increasing interest in all stages of HS/AI.

View Article and Find Full Text PDF

Successful correction of ichthyosis-related ectropion by autografts.

Dermatol Ther

November 2020

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University, Dresden, Germany.

Ectropion is a rather frequent complication of ichthyosis with negative functional and esthetic impact. Lid surgery can provide significant improvement. We report on a series of four ichthyosis patients with ongoing bilateral eye problems despite intense medical treatment (mean age 27.

View Article and Find Full Text PDF

Olfactory loss impacts around 20% of the population and is associated with the reduction of pleasure from eating and drinking, sex and depression (1). Encouragingly, research findings have consistently demonstrated that olfactory training (OT) can improve olfactory function in people with olfactory loss due to various aetiologies (2). The most commonly used method for OT involves smelling four different odours (lemon, eucalyptus, rose and cloves), twice daily, for 12 weeks.

View Article and Find Full Text PDF
Article Synopsis
  • Psoriasis is a chronic skin condition driven by T-cell activity, with complex causes that researchers are actively exploring to improve treatment options.
  • Recent advancements have led to biologic drugs targeting specific immune pathways, including new IL-23p19 inhibitors that offer a safer approach to managing psoriasis.
  • This review will focus on how IL-23 and Th17 cell signaling contribute to psoriasis and will summarize the clinical outcomes of using the IL-23p19 inhibitor mirikizumab in treating chronic plaque psoriasis.
View Article and Find Full Text PDF

Melanoma constitutes one of the most sinister and troublesome malignancies encountered by humanity. Generally, the diagnosis of advanced melanoma connotes a grave prognosis, prompting a sense of looming threat of death, however, the early-stage detected disease responds well to robust treatment resulting in reasonable survivorship. Scalp melanomas are even more troublesome, because they typically exhibit more aggressive biologic behavior and are often diagnosed at a late stage.

View Article and Find Full Text PDF

Background: Acanthosis nigricans (AN) is a cutaneous disorder characterized by symmetric velvety hyperpigmented plaques on intertriginous areas like axilla, neck, inframammary, and groin.

Aims: To summarize the pathophysiology and classification of AN, provide an update of diagnostic testing strategies, and describe the current therapeutic options described so far in the literature for this disease.

Methods: A comprehensive english language literature search across multiple databases (PubMed, EMBASE, MEDLINE, and Cochrane) for keywords (alone and in combination) was performed.

View Article and Find Full Text PDF
Article Synopsis
  • Acute herpes zoster usually resolves on its own, but can lead to severe complications like postherpetic neuralgia, especially in older or immunocompromised individuals.
  • A case study of a healthy 30-year-old man revealed treatment-resistant postherpetic neuralgia following herpes zoster, along with recurring cystic lesions that required surgery.
  • After surgery, the man's skin lesions improved and the pain was resolved in 5 months, highlighting the importance of effective pain management for postherpetic neuralgia due to its significant impact on healthcare costs and quality of life.
View Article and Find Full Text PDF

Human scabies is a contagious skin infestation caused by the parasitic mite Sarcoptes scabiei var. hominis. It is a common skin disease worldwide that occurs not only in the underprivileged sections of society but also in developed countries.

View Article and Find Full Text PDF

Frontal fibrosing alopecia (FFA) mainly affects the anterior hairline and eyebrows and its etiology and associated factors remain obscure. The aim of this study was to evaluate the allergic contact dermatitis with patch test in patients with FFA. In this prospective study, 20 patients with FFA and 24 age and sex-matched healthy individuals were evaluated with patch testing.

View Article and Find Full Text PDF

Coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the epithelium of the airways. With the increasing involvement of dermatologist in management of this crisis, cutaneous symptoms gained more and more attention. In this review, we will describe cutaneous symptoms of patients of all ages in association with COVID-19.

View Article and Find Full Text PDF

The resistant and recalcitrant nature of severe allergic contact dermatitis (ACD) makes its management challenging. With advances in the understanding of the cellular and molecular pathogenesis of ACD, newer therapeutic targets are becoming apparent. In particular, the use of biologics has gained momentum, given the specificity of their action.

View Article and Find Full Text PDF

Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5-alpha reductase (5-AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes.

View Article and Find Full Text PDF

Acne scars are the ultimate outcome of acne vulgaris, a prevalent skin disorder affecting the pilo-sebaceous unit. Laser resurfacing has been demonstrated to be an efficient therapy option for acne scars. Hence, we adopted this concept and conducted a study to evaluate the safety and efficacy of low-energy double-pass 1450-nm diode laser on acne scars.

View Article and Find Full Text PDF
Article Synopsis
  • Androgenetic alopecia (AGA), commonly known as common baldness, is a condition where androgen hormones cause the conversion of strong hair (terminal hair) to weaker hair (vellus hair), affecting both males and females, though it's primarily seen in men.* -
  • AGA can have significant psychological impacts on patients due to its long-term treatment requirements and aesthetic concerns, making tailored treatment options essential based on individual needs and circumstances.* -
  • This review examines various treatment methods for AGA, highlighting low-level laser therapy (LLLT), while analyzing relevant studies from databases like MEDLINE and PubMed to provide insights on the subject.*
View Article and Find Full Text PDF

Background: Acne vulgaris is a chronic disfiguring inflammatory disease of adolescents and adults affecting up to 90% of the population around the world. The sequence of etiopathogenesis in acne is not completely understood but involves abnormalities in sebum production, follicular plugging, proliferation of propionibacterium acnes, and chronic inflammation.

Aims: This review aims to summarize the features of the topical selective RAR agonists in treating acne vulgaris with a special emphasis on the 4th generation topical retinoid trifarotene.

View Article and Find Full Text PDF

: Vitiligo is an acquired depigmenting skin disorder adversely affecting the patient's quality of life. Despite the presence of several treatment modalities, ranging from medical to physical to surgical options, none is curative. Each modality has its own drawbacks and side effects.

View Article and Find Full Text PDF