1 results match your criteria: "Academic Hospital Vrije Universiteit Brussel Research group[Affiliation]"
Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3.
Haematologica
April 2007
Stem Cell Laboratory, Academic Hospital Vrije Universiteit Brussel Research group, Brussels, Belgium.
Article Synopsis
- MSC (mesenchymal stem cells) can potentially restore the bone marrow microenvironment and aid recovery after hematopoietic stem cell transplantation by successfully migrating through bone marrow endothelium.
- The study involved in vitro assays to examine MSC's ability to invade and migrate through the endothelium, highlighting the role of MMP-2 in this process.
- Results showed that higher cell density in cultures increased the production of TIMP-3, which inhibits MSC migration, suggesting that growth conditions directly affect their extravasation capacity.