2 results match your criteria: "Acad. I.P. Pavlov Saint Petersburg State Medical University[Affiliation]"

[On the histo- and morphogenesis of sclerosing pneumocytoma and its diagnostic criteria].

Arkh Patol

April 2019

Research Institute of Pulmonology, Acad. I.P. Pavlov Saint Petersburg State Medical University, Ministry of Health of the Russian Federation, St. Petersburg, Russia, Saint Petersburg Research Institute of Phthisiopulmonology, Ministry of Health of the Russian Federation, St. Petersburg, Russia, P.A. Bayandin Murmansk Regional Clinical Hospital, Murmansk, Russia.

The paper presents the data available in the literature on the pathogenesis, clinical and morphological, histological and immunohistochemical features of pulmonary sclerosing pneumocytoma (SP). The paper gives the detailed histological and immunohistochemical characteristics of 6 SP cases. The need for the differential diagnosis of SP is determined by the features and complexity of their histo- and morphogenesis within a single tumor and a complex diagnostic study.

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Article Synopsis
  • The study examines the underlying mechanisms and clinical implications of diffuse toxic goiter, specifically looking at proteins related to cell growth and survival in the thyroid.
  • Researchers evaluated 24 women who had surgery, measuring the expression of various proteins linked to proliferation and apoptosis using detailed immunohistochemical tests.
  • Findings suggest that high levels of the anti-apoptotic protein Bcl-2 and the proliferation marker Ki-67 significantly correlate with the risk of developing postoperative thyrotoxicosis, with high predictive accuracy.
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