Factors Associated With Feeling Ashamed of Disclosure of HIV-Positive Status Among Women Who Self-Reported to Health Facilities for HIV Testing in Kenya: Analysis of 2022 Kenya Demographic and Health Survey.

Background: This study aimed to determine the factors associated with feeling ashamed of disclosing HIV-positive status among females who self-reported to health facilities for HIV testing in Kenya.

Method: This study used the Kenya Demographic Health Survey data set for 2022. A total of 18,506 women aged 15-49 years were selected from the sample clusters; 13,815 had ever tested for HIV and 332 had positive results for HIV.

CORRELATION BETWEEN SERUM ALBUMIN LEVEL AND PACKED CELL VOLUME IN NEWLY DIAGNOSED PATIENTS WITH PULMONARY TUBERCULOSIS IN A TERTIARY HOSPITAL IN BAUCHI, NORTH-EASTERN, NIGERIA.

Introduction: Though some studies showed biochemical and haematologic derangements in patients with pulmonary tuberculosis (PTB), but information with regards to the correlation between serum albumin and packed cell volume (PCV) is scarce. The aim of this study was to determine the correlation between serum albumin level and PCV in newly diagnosed patients with PTB at Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH), Bauchi, Northeastern Nigeria.

Methodology: This was a cross-sectional study of consecutive newly diagnosed patients with PTB who were Sputum smear-positive as determined by Gene Expert/Rif MTB machine and HIV-negative by 'Determine' test, that were recruited from the medical outpatient department (MOPD) and directly observed treatment short course (DOTS) clinic of ATBUTH, Bauchi.

Antibiotic resistance and the COVID-19 pandemic: A dual crisis with complex challenges in LMICs.

Background And Aims: Antimicrobial resistance (AMR), a global health crisis of mounting urgency, has been further complicated by the ongoing COVID-19 pandemic. The intricate relationship between these two phenomena is especially pronounced in low- and middle-income countries (LMICs) due to the distinct obstacles encountered by their healthcare systems and policy structures. This study aims to explore the complex challenges arising from the coexistence of these two crises in LMICs and proffer specific recommendations for holistic management.

Risk Factors and Pattern of Lower Limb Deep Venous Thrombosis in Gombe, North-Eastern Nigeria.

Background: Deep venous thrombosis (DVT) is one of most common causes of morbidity and mortality among hospitalized patients. Many risk factors ranging from inherited to acquired are associated with increased risk of DVT.

Aims: The aim of the study was to review the pattern and risk factors of DVTs in Gombe.

induced cognitive impairment in rats via dysregulation of dopamine receptors and indoleamine 2,3 dioxygenase.

() is a parasite capable of residing in the brain of their host which influences behaviour changes due to alterations in the neurotransmitters. Consequently, dopamine receptors (DRD) and indoleamine 2, 3 dioxygenase (IDO) dysregulation facilitate the progression of behaviour changes in a host as a response to infection. This study tested the effect of neurotransmitter changes as a result of infection on rats cognitive impairment.

Fibreoptic Laryngoscopic Assessment of Patients with Hoarseness: A Cross-sectional Analysis.

Background: Hoarseness is a common clinical manifestation of laryngeal diseases. The cause of hoarseness may not always be a simple inflammatory disease, but it can be from other serious life-threatening conditions such as laryngeal cancer, for which a delay in diagnosis of such condition may compromise treatment, resulting in poor prognosis and a decreased survival rate. Against this background, we evaluated the causes of hoarseness using fibreoptic laryngoscopy in our environment.

Impact of IoT on Achieving Smart Primary Healthcare Building Facilities in Gauteng, South Africa.

Processes and services undertaken in smart primary healthcare building facilities capture operational data through advanced monitoring and enable experts to use these building facilities for efficient healthcare service delivery. This study assessed the impact of Internet of Things (IoT) services on achieving efficient primary healthcare in the rural areas of South Africa. The study identified three (3) basic constructs of IoT services.

Statistical Simulation of the Switching Mechanism in ZnO-Based RRAM Devices.

Resistive random access memory (RRAM) has two distinct processes, the SET and RESET processes, that control the formation and dissolution of conductive filament, respectively. The laws of thermodynamics state that these processes correspond to the lowest possible level of free energy. In an RRAM device, a high operating voltage causes device degradation, such as bends, cracks, or bubble-like patterns.

Investigation of Andrographolide Effect on Non-Infected Red Blood Cells Using the H-NMR-Based Metabolomics Approach.

Andrographolide (AG) has been shown to have several medicinal and pharmaceutical effects, such as antimicrobial, anti-inflammatory, antioxidant, anti-diabetic, and anti-malarial activities. Moreover, studies to assess the pharmacological effect of AG on the metabolic changes of uninfected red blood cells (uRBCs) have not yet been investigated. This study aims to evaluate the pharmacological effects of AG compared to chloroquine (CQ) on the metabolic variations of uRBCs in vitro using a proton nuclear magnetic resonance (H-NMR)-based metabolomics approach coupled with multivariate data analysis (MVDA).

SARS-CoV-2 spike protein and RNA dependent RNA polymerase as targets for drug and vaccine development: A review.

The present pandemic has posed a crisis to the economy of the world and the health sector. Therefore, the race to expand research to understand some good molecular targets for vaccine and therapeutic development for SARS-CoV-2 is inevitable. The newly discovered coronavirus 2019 (COVID-19) is a positive sense, single-stranded RNA, and enveloped virus, assigned to the beta CoV genus.

Assessment of groundwater recharge potential in a typical geological transition zone in Bauchi, NE-Nigeria using remote sensing/GIS and MCDA approaches.

The increasing demand for water occasioned by harsh climatic conditions, population explosion, and increasing urbanization has necessitated more attention and reliance on groundwater resources, particularly in water-limited regions. Thus, judicious management of available groundwater resources becomes crucial to meet the freshwater requirements in such zones. In this study, remote sensing and geographic information system were deployed to delineate groundwater recharge zones in semi-arid geological transition zones of Bauchi, northeastern Nigeria.

Improved spinal cord gray matter morphology induced by following spinal cord injury in rat models.

Despite intense preclinical research focusing on developing potential strategies of mitigating spinal cord injury (SCI), SCI still results in permanent, debilitating symptoms for which there are currently no effective pharmacological interventions to improve the recovery of the fine ultrastructure of the spinal cord. is thought to have potential neuroprotective effects. We have previously demonstrated its protective potential on the lesioned corticospinal tracts and behavioral recovery.

Lack of methylation on transgene leads to high level and persistent transgene expression in induced pluripotent stem cells.

Short-lived therapeutic gene expression in mammalian cells by DNA methylation is one of the major challenges in gene therapy. In this study, we assessed the implication of DNA methylation on the duration of GFP expression in mouse embryonic stem (ES) and mouse induced pluripotent stem (iPS) cells. The cells were transduced with lentivirus (LV) carrying green fluorescent protein (GFP) driven by either human elongation factor (EF1α) or cytomegalovirus (CMV) promoter.

A Review on the Prevalence of in Humans and Animals Reported in Malaysia from 2008-2018.

Toxoplasmosis is a disease caused by the protozoan parasite (). Human toxoplasmosis seroprevalence in Malaysia has increased since it was first reported in 1973 as shown in previous reviews of 1991 and 2007. However, over a decade since the last review, comprehensive data on toxoplasmosis in Malaysia is lacking.

Neuroprotective potential of on lesioned spinal cord corticospinal tract under experimental conditions in rat models.

Spinal cord injury (SCI) results from penetrating or compressive traumatic injury to the spine in humans or by the surgical compression of the spinal cord in experimental animals. In this study, the neuroprotective potential of Spirulina platensis was investigated on ultrastructural and functional recovery of the spinal cord following surgical-induced injury. Twenty-four Sprague-Dawley rats were divided into three groups; sham group, control (trauma) group, and experimental () group (180 mg/kg) of eight rats each.

Silencing of transgene expression in mammalian cells by DNA methylation and histone modifications in gene therapy perspective.

DNA methylation and histone modifications are vital in maintaining genomic stability and modulating cellular functions in mammalian cells. These two epigenetic modifications are the most common gene regulatory systems known to spatially control gene expression. Transgene silencing by these two mechanisms is a major challenge to achieving effective gene therapy for many genetic conditions.