3,144 results match your criteria: "Abruptio Placentae"

Placental abruption and perinatal mortality in twins: novel insight into management at preterm versus term gestations.

Eur J Epidemiol

November 2024

Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Twins suffer a disproportionately higher burden of adverse perinatal outcomes than singletons. However, the degree to which preterm delivery shapes the relationship between abruption and perinatal mortality in twins is unknown. Through causal mediation decomposition, we examine how preterm delivery mediates the effect of abruption on perinatal mortality among twins using the US-matched multiple birth data (1995-2000).

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Article Synopsis
  • The study investigates relationships between placental histopathological abnormalities and adverse obstetric outcomes, focusing on conditions like poor blood flow and inflammation.
  • Conducted from January 2017 to January 2020, the study analyzed 191 women who experienced adverse outcomes such as preterm labor (25.1%) and fetal growth restriction (19.4%).
  • Findings revealed that 74% of women had abnormal placental results, with specific lesions correlating to conditions like preterm labor and preeclampsia, highlighting the necessity of histopathological exams for better management in future pregnancies.
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The effect of hereditary thrombophilia on recurrent pregnancy loss: a retrospective cohort study.

BMC Pregnancy Childbirth

November 2024

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University Medical Faculty, Ankara, Turkey.

Objective: Thrombophilia screening has been performed in patients with conditions such as previous fetal death, (fetal growth restriction) FGR, preeclampsia, (hemolysis. elevated liver enzyme, low platelet count) HELLP Syndrome, previous abruptio placentae, previous thrombosis in pregnancy, and abnormal placental histology. The actual role of hereditary thrombophilia in recurrent pregnancy loss (RPL) is still debated.

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Evaluation of outcomes and risk factors for recurrent preeclampsia in a subsequent pregnancy.

Arch Gynecol Obstet

November 2024

Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China.

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Article Synopsis
  • The study analyzed how the pregnancy modified DIC score relates to underlying diseases in obstetric conditions and its impact on patient outcomes.
  • 224 out of 154,233 deliveries had a DIC score ≥ 26, with the lowest rates of blood transfusions and hysterectomies observed in patients with preeclampsia/HELLP syndrome compared to other conditions.
  • Understanding the underlying disease is crucial for predicting prognosis when diagnosing DIC in pregnant women using the modified score.
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Introduction: Placental abruption (PA) is a major obstetric complication associated with worse maternal and neonatal outcomes. Though ultrasound findings may support the diagnosis of PA, the association of such findings to the severity of PA and maternal and neonatal outcomes is not yet clear. We aimed to assess the maternal and neonatal outcomes of PA cases with vs.

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Fetal major anomalies and related maternal, obstetrical, and neonatal outcomes.

Arch Gynecol Obstet

October 2024

Department of Obstetrics and Gynecology, Galilee Medical Center, 2210001, Nahariya, Israel.

Article Synopsis
  • The study investigated the maternal, obstetrical, and neonatal outcomes of pregnancies with major fetal anomalies over a 10-year period at a university hospital, comparing these outcomes to a control group with normal pregnancies.
  • Findings revealed that pregnancies with fetal anomalies had significantly lower median gestational ages, higher preterm delivery rates, increased rates of placental abruption, and elevated occurrences of cesarean sections and postpartum hemorrhages.
  • The results suggest that pregnancies complicated by major fetal anomalies pose a higher risk for both mothers and newborns, highlighting the need for careful management and monitoring of these high-risk pregnancies.
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Background: Antepartum hemorrhage is defined as any bleeding from or into the genital tract during pregnancy, after the period of viability until delivery of the fetus. APH complicates 2-5% of pregnancies and is a primary cause of perinatal and maternal mortality globally. Aim of this study is to evaluate maternal and perinatal outcome in patients with APH at a tertiary care hospital.

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Peripartum cardiomyopathy and hypertensive disorders of pregnancy are not very uncommon in routine practice, but when associated with abruptio placentae and significant hypotension, survival of both child and mother becomes challenging. We report a case of a 20-year-old primigravida who presented in the gynecology emergency unit of our hospital with an ejection fraction of < 20%, severe preeclampsia with abruptio placentae leading to fetal demise, and renal failure in the immediate postoperative period. Challenges faced during decision making regarding the mode of delivery and grave concerns during intraoperative and postoperative periods are discussed.

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The aims of this study were as follows: the (a) creation of a pregnant occupant finite element model based on pregnant uterine data from sonography, (b) development of the evaluation method for placental abruption using this model and (c) analysis of the effects of three factors (collision speed, seatbelt position and placental position) on the severity of placental abruption in simulations of vehicle collisions. The 30-week pregnant occupant model was developed with the uterine model including the placenta, uterine-placental interface, fetus, amniotic fluid and surrounding ligaments. A method for evaluating the severity of placental abruption on this pregnant model was established, and the effects of these factors on the severity of the injury were analyzed.

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Objective: This study aimed to clarify the maternal and neonatal outcomes based on the presence or absence of a Couvelaire uterus with placental abruption.

Methods: This single-center retrospective study was conducted at a tertiary perinatal center in Japan, including patients diagnosed with acute placental abruption who delivered live births via cesarean section between 2016 and 2023. Patients were divided into two groups based on the presence or absence of a Couvelaire uterus during surgery: the Couvelaire and normal uterus groups.

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The profile of patients with postpartum hemorrhage admitted to the obstetric intensive care: a cross-sectional study.

Rev Bras Ginecol Obstet

July 2024

Instituto de Medicina Integral Prof. Fernando Figueira RecifePE Brazil Instituto de Medicina Integral Prof. Fernando Figueira, Recife, PE, Brazil.

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Importance: Patients using assisted reproductive technology (ART) may need additional counseling about the increased risks of placental abruption and preterm delivery. Further investigation into the potential additive risk of ART and placental abruption is needed.

Objective: To ascertain the risk of placental abruption in patients who conceived with ART and to evaluate if placental abruption and ART conception are associated with an increased risk of preterm delivery (<37 weeks' gestation) over and above the risks conferred by each factor alone.

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Abruptio placenta can be a catastrophic event with a high association with adverse maternal and fetal outcomes. We present a case of massive abruptio placenta occurring in a young asymptomatic mother at 30 weeks' gestation. Although electronic fetal monitoring and ultrasound allowed a prompt diagnosis of an 8 × 5 cm retroplacental hematoma, the fetus died at the time of emergency cesarean section.

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A retrospective study of the management and outcomes of pregnancies with inherited antithrombin deficiency.

J Obstet Gynaecol Res

September 2024

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.

Article Synopsis
  • * In a study at Peking Union Medical College Hospital between 2013 and 2024, 6 women with AT deficiency had 17 pregnancies, where 7 of those were treated with low-molecular-weight heparin (LMWH) and closely monitored.
  • * The findings indicated that proper management using LMWH improved pregnancy outcomes, with live births mainly occurring in women receiving this anticoagulant, highlighting the need for thorough risk assessments and tailored anticoagulation therapy during pregnancy for those with AT
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To analyze maternal and neonatal effects of placental abruption (PA) through a novel classification in the presence of hypertension. Initial hemoglobin parameters were also compared to predict pregnancy outcomes in addition to hypertension. This retrospective cohort designed study was conducted on 115 pregnant women with PA.

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Cesarean delivery is associated with lower neonatal mortality among breech pregnancies: a systematic review and meta-analysis of preterm deliveries ≤32 weeks of gestation.

Am J Obstet Gynecol

December 2024

Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary; Division of Neonatology, Pediatric Center, Semmelweis University, Budapest, Hungary. Electronic address:

Objective: To investigate the association between actual and planned modes of delivery, neonatal mortality, and short-term outcomes among preterm pregnancies ≤32 weeks of gestation.

Data Sources: A systematic literature search was conducted in 3 main databases (PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from inception to November 16, 2022. The protocol was registered in advance in the International Prospective Register of Systematic Reviews (CRD42022377870).

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Pregnancy, delivery, and neonatal outcomes among women with PCOS and endometriosis: a population database cohort.

Arch Gynecol Obstet

August 2024

Department of Obstetrics and Gynecology, McGill University Health Center, Royal Victoria Hospital (Glen Site), 1001 Boul. Decarie, Quebec D05.2553, Montreal, H4A 3J1, Canada.

Article Synopsis
  • The study investigates the pregnancy, delivery, and neonatal outcomes of women with both polycystic ovary syndrome (PCOS) and endometriosis compared to those with PCOS alone.
  • Researchers analyzed data from a large U.S. database between 2004 and 2014, finding significant differences in demographics and pregnancy complications.
  • Women with both conditions were more likely to be white, of lower socioeconomic status, and experienced higher rates of complications like placental abruption and cesarean sections, indicating a need for better clinical management and patient counseling.
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Succenturiate Placental Lobe Abruption.

Int J Womens Health

June 2024

Obstetrics and Gynecology I, Mother and Child Department, University of Medicine and Pharmacy "iuliu Hatieganu", Cluj-Napoca, 400006, Romania.

Placental development is a complex process which sets the stage for normal fetal development. Any variation/disruption occurring during the initial stages of placental formation leads to placental malfunction causing increased maternal-fetal morbidity and mortality. The succenturiate lobe is a structural variation of the placenta that usually appears as a distinct lobe from the main placental mass.

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A case report of pegcetacoplan use for a pregnant woman with paroxysmal nocturnal hemoglobinuria.

Res Pract Thromb Haemost

May 2024

Department of Hematology and Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Paroxysmal nocturnal hemoglobinuria (PNH), a rare hematologic disease, is associated with high maternal and fetal mortality rates. Only 1 medication approved for PNH, the complement component 5 inhibitor eculizumab, has published evidence of use during pregnancy.

Key Clinical Question: What were the circumstances and outcomes of the first use of pegcetacoplan, a complement component 3 inhibitor, by a pregnant woman with PNH?

Clinical Approach: The patient, with a history of 2 miscarriages and a suboptimal response to eculizumab, had hematologic improvement after switching to pegcetacoplan.

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