10,314 results match your criteria: "Abnormal Labor"

Rationale: Spontaneous uterine rupture, although rare, is a life-threatening obstetric emergency with a high maternal and fetal mortality rate. It can occur without warning, leading to severe complications, including hemorrhage, shock, and fetal demise. The risk factors contributing to uterine rupture are diverse and include a history of uterine surgery (such as cesarean section), trauma to the uterus, abnormal uterine contractions during labor, and underlying conditions like adenomyosis.

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Rhabdomyolysis is a potentially life-threatening condition in pediatric patients, often triggered by various factors, such as infections, trauma, hereditary metabolic disorders, and certain medications. Elevated creatine kinase levels are commonly observed in newborns and are often attributed to factors such as hypoxia, labor dystocia, and birth trauma. However, rhabdomyolysis in this population is rare and typically associated with hereditary metabolic disorders, medications, or infections.

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Clinical Utility of Bone Turnover Markers in Chronic Kidney Disease.

J Bone Metab

November 2024

Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.

Chronic kidney disease (CKD) often leads to mineral and bone disorders (CKD-MBDs), which are nearly universal in patients undergoing dialysis. CKD-MBD includes abnormal calcium-phosphate metabolism, vascular and soft tissue calcification, and bone abnormalities (renal osteodystrophy [ROD]). Bone fragility in CKD occurs due to low bone mass and poor bone quality, and patients with CKD have higher fracture and mortality rates.

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On causal inferences from retrospective and observational studies and their implications for neuraxial labor analgesia: the CHRISTMAS* study.

Int J Obstet Anesth

December 2024

Department of Opthalmology, Hadassah University Medical Center, and Faculty of Medicine, Hebrew University of Jerusalem, Israel; Department of Optometry and Vision Sciences, Hadassah Academic College, Jerusalem, Israel.

Background: Observational studies should not be used to infer causation as they are prone to confounding factors, selection bias, and reverse causality. Many observational studies of labor analgesia treated epidurals as an independent exposure and concluded that "epidurals" cause dystocia, despite multiple randomized controlled trials showing no effect. We highlight this problem using reductio ad absurdum.

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Introduction: The US maternity care system achieves worse outcomes for birthing people identifying as Black versus White. Assessment of fetal well-being in labor is an area of perinatal care subject to significant interobserver variability and therefore may be at particular risk of medical racism influencing care.

Methods: Statewide collaborative quality initiative data, focused on decreasing the nulliparous, term, singleton, vertex (NTSV) cesarean birth rate, were used to conduct a retrospective cohort study to assess differences in cesarean birth for nonreassuring fetal status between birthing people identifying as Black compared with White.

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Background: In dogs, data on reference intervals (RIs) for cobalamin, markers of metabolism (markersBmet), age and sex effects are limited.

Hypothesis/objectives: Establish RI for serum cobalamin, homocysteine, and methylmalonic acid (sMMA) concentrations, urinary methylmalonic acid-to-creatinine ratio (uMMA:crea), and determine effects of sex and age.

Methods: Prospective study using healthy dogs (1-10 years).

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Background: Labor intervention is intended to prevent perinatal morbidity and mortality. Labor durations traditionally defined as 'dystocia' drive primary cesarean birth rates, yet there is mixed evidence about the association between labor duration and poor neonatal outcomes. Using latent class analysis to study unknown patterns of neonatal health can refine understanding of these relationships and effect of labor duration on newborn outcomes.

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Sire mating advice framework for cattle to recommend which beef bull to mate to individual dairy females.

J Dairy Sci

December 2024

Irish Cattle Breeding Federation, Carrigrohane, Ballincollig, Co. Cork, P31 D452, Ireland.

A decision support tool or system is a computerized information system used to support decision-making in a business; one central component to profitable dairy cattle production systems is the appropriate mating of bulls and females. While tools have been described to aid mating decisions between dairy bulls and dairy females, or between beef bulls and beef females, there is a void of such tools that recommend which beef bull to mate to individual dairy females. The objective of the present study was to develop and validate a framework, founded on linear programming, to aid herd-level mating decisions where the bull-female mating is tailored based on complementarity and compatibility of both mates; consideration in the process was given to the genetic merit of both mates for a series of traits as well as the life history of the female herself.

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Background: The optimal duration of second stage of labor has been largely discussed in literature, but there are no uniformly accepted contemporary criteria for defining normal or abnormal length. Available evidence suggests that longer duration of second stage of labor is associated with a lower rate of spontaneous vaginal delivery and increased maternal morbidity. On the neonatal side, it seems that longer second stage doesn't affect new-born morbidity, in a context of very rare neonatal complications.

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Background and objectives Hypoxic-ischemic encephalopathy (HIE) remains a critical concern in newborns, with therapeutic hypothermia (TH) serving as a key treatment strategy. However, assessing long-term outcomes requires a comprehensive approach, as children may develop neuropsychological and learning challenges even in the absence of noticeable motor impairments. This study aims to explore the correlation between electroencephalography (EEG) and neuroimaging findings with the clinical severity of HIE.

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Article Synopsis
  • * Results showed that GDM diagnoses were more common (17%) with the one-step test compared to the two-step method (6%), and that adverse outcomes were generally low regardless of the testing approach.
  • * The findings suggested that stricter testing (one-step) could lead to more GDM diagnoses but also indicated a potential increased risk for larger babies and preterm births linked to abnormal glucose levels just below diagnostic thresholds.
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Feline dystocia and kitten mortality up to 12 weeks in pedigree cats.

J Feline Med Surg

December 2024

The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Edinburgh, UK.

Objectives: The aim of the present study was to establish the incidence of dystocia in pedigree cat breeds and investigate mortality rates in kittens up to the age of 12 weeks.

Methods: A retrospective study was conducted that utilised convenience sampling. Registered cat breeders from 29 countries whose cats had given birth within a single year (2019) were asked to complete an online questionnaire.

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The first objective of this study was to quantify the impact and disability weight (DW) of frequent diseases or syndromes of pre-weaned dairy calves using the perceptions of producers and veterinarians. The second objective was to compare the opinions of producers and veterinarians regarding the impact and DW of dairy calves' frequent diseases and syndromes. A survey was conducted to obtain demographic information and opinions of 39 dairy producers and 52 veterinarians on the impact of frequent disease and syndromes on calf health.

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Associations between serum indium levels and preserved ratio impaired spirometry among non-smoking industrial workers: A nationwide cross-sectional study in Taiwan.

Respir Med

December 2024

Department of Occupational Medicine, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taiwan; Master of Science Degree Program in Innovation for Smart Medicine, Chang Gung University, Taiwan. Electronic address:

Background: Indium, a rare heavy metal, extensively used in flat panel display manufacturing, poses potential respiratory health risks to workers. Preserved ratio impaired spirometry (PRISm), a term describing nonobstructive lung function abnormalities, is associated with adverse health outcomes. Despite known risks, the relationship between serum indium levels and PRISm remains underexplored.

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Objective: In this study, we aim to determine if machine learning can reduce manual smear review (MSR) rates while meeting or exceeding the performance of traditional MSR criteria.

Method: 9938 automated CBCs with paired MSRs were performed on samples from rhesus and cynomolgus macaques. The definition of a positive (abnormal) smear was determined.

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Analysis of the outcomes and factors influencing vaginal trial labor in primiparas at term.

Arch Gynecol Obstet

December 2024

Department of Obstetrics and Gynecology, Peking University First Hospital, No. 1 Xi'anmen Street, Beijing, 100034, China.

Purpose: To explore the outcomes and factors influencing vaginal trial labor in primiparas with term singleton fetuses.

Methods: A retrospective analysis of 9174 first-time mothers who opted for a vaginal trial of labor at Peking University First Hospital from October 2019 to September 2022 was performed. The primary outcomes included the outcome of the trial of labor and influencing factors.

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Outcomes for women with diabetes admitted for labour care to midwifery units in the UK: a national prospective cohort study and survey of practice using the UK Midwifery Study System (UKMidSS).

BMJ Open

December 2024

NIHR Policy Research Unit in Maternal and Neonatal Health and Care, National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK

Article Synopsis
  • The study aimed to analyze outcomes for women with gestational or pre-existing diabetes during labor in midwifery units, comparing them to women without diabetes.
  • Conducted through a national cohort study and practice survey, data was collected from midwifery units in the UK between October 2021 and February 2023.
  • Results indicated that women with diabetes did not have significantly different maternal or neonatal outcomes compared to those without diabetes, suggesting that selected diabetic women can be safely managed in these units.
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  • The study aimed to investigate the frequency of non-cephalic presentations seen in routine 36-week ultrasound scans, the effectiveness of external cephalic version (ECV), and cases of spontaneous rotation from non-cephalic to cephalic positions.
  • A retrospective analysis was conducted on data from over 107,000 women with singleton pregnancies to explore the influence of various maternal and pregnancy factors on non-cephalic presentations and ECV success.
  • Results showed that 5.8% of pregnancies had a non-cephalic presentation at the scan, with a small continuous rate of spontaneous rotation, and ECV was attempted in about 25.5% of these non-cephalic cases.
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Severe postpartum haemorrhage (PPH) is a dangerous condition, characterized by rapid progression and poor prognosis. It remains the leading preventable cause of maternal death worldwide. This study aimed to investigate the risk factors for severe PPH and establish a prediction model to identify severe PPH early, allowing for early intervention reduce maternal death.

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Article Synopsis
  • This study investigated the incidence and risk factors for complete uterine rupture among women attempting vaginal birth after cesarean delivery (VBAC) over a 16-year period in France.
  • Out of 48,124 patients with a prior cesarean section, 65.8% attempted a VBAC, with a uterine rupture rate of 0.63%.
  • Key findings indicated that prior vaginal delivery decreased the risk of uterine rupture, while labor induction increased it; additionally, specific factors during spontaneous labor, like a low Bishop score and an arrest of cervical dilation, also heightened the risk.
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  • The study focused on improving the detection of schistocytes, which are critical for diagnosing thrombotic microangiopathy, by using the automated digital microscopy system CellaVision® (DM1200), offering a more standardized approach compared to manual counting.* -
  • The automated system demonstrated high sensitivity (98.4%) and specificity (96.8%), and it had a lower variability between observers (25%) compared to traditional methods (50%), making it a strong candidate for training and standardization.* -
  • However, the technology has limitations, including occasional misclassification of platelets as schistocytes and a substantial percentage of red blood cells not being analyzed, which could potentially skew results.*
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  • The study aimed to explore how maternal race/ethnicity influences the risk factors associated with brachial plexus birth injury (BPBI) among live births in California from 1996-2012.
  • It analyzed data from over 6.2 million maternal-infant pairs and found that Black and Hispanic individuals faced higher risks of obesity, diabetes, and limited prenatal care but lower risks concerning other BPBI-related factors.
  • The findings suggest that these demographic groups are not only at lower risk for factors typically associated with BPBI, but the known risk factors explain only a small portion of the increased BPBI risk, indicating a need to investigate other contributing factors.
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Article Synopsis
  • Induction of labor (IOL) is increasingly common, particularly in high-income countries with more pregnant women facing health issues, raising concerns about higher cesarean section (CS) rates and the need for better delivery mode counseling.
  • The study aims to create a predictive model for vaginal delivery after IOL, as well as models for CS related to abnormal fetal heart rate and labor dystocia, using maternal clinical data and advanced computational techniques.
  • Results from a sample of 2,434 singleton pregnancies indicated the vaginal delivery model was quite effective (AUROC = 0.794), while the CS model was less discriminatory (AUROC = 0.590), highlighting the predictive power of certain labor-related factors.
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  • - A 4th lactation dairy cow had complications after an unsuccessful treatment for a left displaced abomasum (LDA) using the "blind-stitch" method, leading to abnormal health signs and inflammation at the incision site.
  • - After administering antibiotics and fluids, the cow underwent a laparotomy and omentopexy surgery to resolve adhesion issues, and was monitored before being discharged two weeks later.
  • - The cow produced 18,000 kg of milk post-treatment, with total costs for both interventions at 1,207 €, alongside an estimated revenue loss of 4,168 € due to complications, highlighting the need for careful method selection for LDA corrections.
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  • The eastern indigo snake, once widespread in the southeastern US, is now primarily found in southeastern Georgia and Florida and is considered federally threatened.
  • Concerns exist about how diet and nutrition affect the reproductive health of these snakes, particularly regarding issues like dystocia in females that have never bred.
  • A year-long study compared the health and nutrient levels of snakes on different diets, finding that while some nutrients were adequate, others—particularly vitamin D—were lower than those found in wild counterparts, suggesting further research on juvenile diets is needed to better understand nutrition's impact on reproduction.
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