Navigating Children's Risky Play: A Comparative Analysis of Saudi Mothers and Fathers.

Despite documented benefits for development, children are engaging in considerably fewer risky play activities. Research on parent gender and children's risky play is inconsistent. Gender and cultural context shape how individuals perceive and tolerate children's risky play.

Pulmonary Arterial Hypertension in a Patient With a Lung Mass: Any Link?

A 52-year-old female patient with a history of atrial septal defect repair presented with progressive dyspnea and echocardiographic findings suggestive of pulmonary hypertension (PH). Incidentally, a lung mass was discovered on computed tomography (CT). Initial evaluation revealed World Health Organization functional class III symptoms and significant weight loss.

Association Between Preoperative Radiological Findings and Outcomes After Total Knee Arthroplasty.

Introduction Total knee arthroplasty (TKA) is a widely accepted surgical intervention for patients with advanced knee osteoarthritis, aimed at reducing pain and improving functional mobility. Preoperative radiological evaluations, including assessments of joint space narrowing, osteophytes, varus/valgus deformities, and subchondral sclerosis, are essential for planning the surgery and predicting postoperative outcomes. Although extensive research has been conducted internationally, data focusing on populations in Saudi Arabia remain limited.

Comparison of 4-factor fixed dose versus 4-factor weight-based dose prothrombin complex concentrate for emergent warfarin reversal: a systematic review and meta-analysis.

Objectives: The objective of this systematic review and meta-analysis is to evaluate the efficacy, safety, time to INR reversal, total volume of 4-factor prothrombin complex concentrate (PCC) administered of fixed-dose versus weight-based dosing strategies in patients requiring urgent warfarin reversal, with specific focus on clinical outcomes such as hemostatic efficacy, thromboembolic events, and mortality rates.

Methods: A comprehensive systematic review was conducted using the PubMed, Embase, and Cochrane databases from inception through October 2023. We searched for randomized clinical trials or observational studies that compared efficacy or safety outcomes of fixed-dose vs.

Hand Rejuvenation Using Autologous Fat Grafting: A Systematic Review of Recommended Doses, Complications, and Patient Satisfaction.

Introduction: Hand rejuvenation addresses aging-related changes such as subcutaneous fat loss, skin degradation, and photodamage. Autologous fat transfer (AFT) has emerged as a promising treatment, offering durable volume augmentation and regenerative effects. This study aims to systematically review the evidence on the techniques, outcomes, and complications of AFT for hand rejuvenation.

Off-pump Laks-type central shunt for tricuspid atresia with small branch pulmonary arteries.

Prostaglandin E1 is a potent vasodilator that prevents the ductus arteriosus from closing. Its use in neonates with cyanotic heart defects has revolutionized the management of children with cyanotic heart defects. Although the use of prostaglandin E1 is a temporary solution, the establishment of dependable pulmonary blood flow is of paramount importance.

Oncogenic Osteomalacia as the Initial Presentation of Pleural Epithelioid Hemangioendothelioma: A Case Report.

Epithelioid hemangioendothelioma (EHE) is a rare form of vascular neoplasm that can manifest with various symptoms or be discovered incidentally in asymptomatic patients. In this report, we describe a case of a 56-year-old male who presented with progressive lower limb weakness over four years. The evaluation revealed severe hypophosphatemia, an inappropriately normal fibroblast growth factor 23 C-terminal (cFGF-23) level, and a 30 x 20 mm hypermetabolic right pleural mass, which was subsequently proven to be EHE.

Examining the Impact of Digital Detox Interventions on Anxiety and Depression Levels Among Young Adults.

Background: With increasing reliance on digital devices, concerns about their impact on mental health have grown, particularly among young adults.

Aim: This study aims to evaluate the impact of a digital detox intervention on reducing anxiety and depression among young adults across diverse demographic backgrounds.

Methods: A pre-test, followed by a digital detox intervention, and a post-test using an online survey was carried out.

Prophylactic administration of PEPITEM in experimental autoimmune encephalomyelitis delays disease onset, inhibits leukocyte infiltration, and alleviates severity.

Background: Multiple sclerosis (MS) is a chronic, immune-mediated neurological disorder in which the immune system mistakenly attacks the myelin sheath, affecting the communication between the brain and the rest of the body.

Objective: This study investigated the prophylactic use of peptide inhibitor of trans-endothelial migration (PEPITEM), a novel peptide, in alleviating experimental autoimmune encephalomyelitis (EAE), a mouse model for Multiple Sclerosis (MS).

Methods: Female C57BL/6 female mice were assigned to the control, untreated EAE, or PEPITEM group.

Preoperative smoking cessation interventions: a systematic review and meta-analysis.

Background: Smoking is the leading single cause of preventable death in England and also increases the risk of postoperative complications. The preoperative period is a potential opportunity to introduce smoking cessation interventions to smokers to reduce the risk of postoperative complications. A systematic search was conducted to find all studies that investigated the effectiveness of preoperative smoking cessation interventions.

Saudi dental postgraduate education (2013-2023): demographic shifts and potential employment challenges.

Background: Dentistry is essential for oral health, focusing on the diagnosis, prevention, and treatment of oral diseases. In recent decades, Saudi Arabia has expanded its dental education system, adding new dental schools and postgraduate programs to meet the growing demand for professionals. This study provided a detailed analysis of the trends and demographic characteristics of dental postgraduate programs in Saudi Arabia between 2013 and 2023.

Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature.

Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to a large group of -mutated patients, we aimed at characterizing the immunopathology associated with each phenotype. Although defective T and B cell development is common to all phenotypes, patients with hypomorphic variants can generate T and B cells with signatures of immune dysregulation and produce autoantibodies to a broad range of self-antigens, including type I interferons.

Popularity and Perceptions of Protein Supplementation: A Cross-Sectional Study Among Undergraduate University Students Aged 18 to 25 Years in Riyadh, Saudi Arabia.

Background And Aim:  Young adults, particularly those aged 18-25, exhibit varying perceptions and choices regarding the use of protein supplements (PS). Understanding these perceptions can significantly enhance professional guidance and nutrition education for undergraduate students. This study, conducted in Riyadh, Saudi Arabia, aims to explore the perceptions of PS use and identify the most popular PS among university students.

Paramedics and emergency medical technicians' perceptions of geriatric trauma care in Saudi Arabia.

Background: Saudi ambulance clinicians face unique challenges in providing prehospital care to older trauma patients. Limited geriatric-specific training and complex needs of this population hinder effective management, leading to adverse outcomes. This study explores the perceptions of Saudi ambulance clinicians regarding geriatric trauma care and identify facilitators and barriers to improved care.

Comparison of Incision Closure in Hand Plastic Surgery Using Non-absorbable Versus Absorbable Sutures: A Systematic Review of Randomized Controlled Trials.

Introduction: Surgeons prioritize scar appearance after surgery, making suture choice crucial. Traditionally, non-absorbable sutures were standard but require removal, causing patient discomfort and extra visits. Absorbable sutures, while offering convenience, might raise concerns about scar quality.

Mechanical and optical properties of additively manufactured denture base resin in different colors modified with antimicrobial substances: An in vitro study.

Statement Of Problem: Acrylic denture base resins are subject to colonization by oral and nonoral bacteria, contributing to the onset of denture stomatitis. However, how the addition of antimicrobial substances affects the mechanical and optical properties of additively manufactured denture base resin remains unclear.

Purpose: The purpose of this in vitro study was to investigate the surface roughness, color stainability, and flexural strength of antimicrobial-modified, additively manufactured polymethyl methacrylate (PMMA) denture base resin in tooth and gingiva colors.

Possible effects of radiofrequency electromagnetic radiation on contextual fear conditioning, hippocampal perivascular space, apoptosis and adrenal gland microarchitecture in rats.

Whilst the world sees the tremendous growth of mobile phone technology, radiofrequency electromagnetic radiation (RF-EMR) induced possible health effects have emerged as a topic of recent day debate. The current study is designed to test the hypothesis that chronic 900MHz radiation exposure would potentially dysregulate the stress response system (HPA axis) in vivo, via, its non-thermal mechanisms, leading to alterations in the microarchitecture of the adrenal gland, vulnerable brain regions such as the hippocampus which may results in altered behaviours in rats. Male albino Wistar rats aged four weeks, weighing 50-60g were subjected to 900MHz radiation from a cellphone for four weeks at a rate of one hour per day.

ENT specialists' knowledge and their skills in detecting maxillary sinusitis of odontogenic origin, a cross-sectional study.

Background: Odontogenic maxillary sinusitis (OMS) is recognized in literature, but diagnosing it is challenging due to its different and overlapping clinical presentations of it. Misdiagnosis can lead to persistent symptoms and clinical burden. Interestingly, recent guidelines from the American Academy of Otolaryngology-Head and Neck Surgery lack recommendations for dental evaluation in adult sinusitis cases.

Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study.

Deep vein thrombosis (DVT) is a leading cause of death disability. DVT can be classified based on the location and extent of the clot into isolated distal DVT (iDDVT), isolated proximal DVT (iPDVT), or mixed DVT. The aim of this study is to explore the baseline characteristics and clinical outcomes of patients with different types of DVT.

Safety and Efficacy of Combination Therapy with Anti-Vascular Endothelial Growth Factor and Laser for Retinopathy of Prematurity: A Systematic Review and Meta-Analysis.

Aim: This systematic review and meta-analysis aimed to evaluate the safety and efficacy of combined laser and anti-VEGF therapy for (retinopathy of prematurity ROP), focusing on both structural and functional outcomes.

Methods: A comprehensive search was conducted in multiple databases to identify randomized controlled trials (RCTs) that investigated combination therapy for ROP. The PRISMA guidelines were followed.

Assessing outcomes of acute myocarditis in Saudi Arabia: A retrospective tertiary center experience.

Objectives: To assess the clinical course and long-term outcomes of complicated and uncomplicated AM in Saudi Arabia. Acute myocarditis (AM) can have different presentations and outcomes based on different factors, one of which is left ventricular ejection fraction (LVEF).

Methods: Data from 382 patients with suspected AM, admitted between January 2016 and October 2023, were reviewed.

An approach to COVID‑19 and oncology: From impact, staging and management to vaccine outcomes in cancer patients: A systematic review and meta‑analysis.

The COVID-19 pandemic has had a global impact, with >771 million confirmed cases and 6 million deaths reported by October 2023. Cancer patients, due to their immunosuppressed status, face an increased infection risk and higher COVID-19 complications. The present study aimed to assess clinical outcomes in COVID-19-infected cancer patients, focusing on mortality rates and other aspects, providing valuable insight for better protection and outcomes.

A Bibliometric Analysis of the 100 Top-Cited Articles on Vertical Root Fractures.

The aim of this study was to perform a meticulous analysis and bibliometric evaluation of the top 100 most cited articles in vertical root fractures (VRFs). The bibliometric research method included 100 top-cited articles on VRFs retrieved from the Web of Science database. The key terms "vertical root fracture" OR "vertical root fractures" were used to retrieve the required dataset.

A Review of Current Techniques in Lip Reposition Surgery for Treating Excessive Gingival Display.

Excessive gingival display (EGD), commonly known as a gummy smile (GS), is a cosmetic concern that involves exposing a significant area of gum tissue during a smile, rendering it unaesthetic. Gingival exposure greater than 3 mm is deemed aesthetically displeasing and often necessitates treatment to mask the gummy smile. The causes of EGD are multifactorial, including altered passive eruption (APE), hypermobile upper lip (HUL), short lip length, increased vertical maxillary component, gingival hyperplasia, dentoalveolar extrusion, and more.