1 results match your criteria: "Aarhus Research Center for Innate Immunology Aarhus University Aarhus Denmark.[Affiliation]"
Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPS.
FASEB Bioadv
September 2024
Department of Biomedicine, Aarhus Research Center for Innate Immunology Aarhus University Aarhus Denmark.
Article Synopsis
- Stimulation of mammalian cells with inflammatory inducers, like lipopolysaccharide (LPS), alters cellular metabolic pathways, particularly affecting enzymes in the tricarboxylic acid (TCA) cycle, which is crucial for releasing pro-inflammatory cytokines.
- The study found that patients with certain genetic variants affecting fatty acid oxidation exhibited inadequate inflammatory responses to LPS due to issues with TLR4 expression and signaling.
- The findings suggest that genes involved in fatty acid metabolism are essential not just for energy production but also for proper immune responses, shedding light on disease mechanisms in conditions like long-chain fatty acid oxidation disorders (lcFAODs).