Usefulness of self-guided digital services among mental health patients: The role of health confidence and sociodemographic characteristics.

Background: Remote services provided via telephone or the internet have become an essential part of mental health provision. Alongside services involving healthcare personnel (HCP), self-guided digital services hold great promise for improved self-management and health outcomes without increasing the burden on HCP. Therefore, better understanding of patients' use and experienced benefits of these services are needed.

Strontium-Substituted Nanohydroxyapatite Containing Biodegradable 3D Printed Composite Scaffolds for Bone Regeneration.

Treatment of large-size bone defects is difficult, and acquiring autografts may be challenging due to limited availability. A synthetic patient-specific bone substitute can be developed by using 3D printing technologies in such cases. In the present study, we have developed photocurable composite resins with poly(trimethylene carbonate) (PTMC) containing a high percentage of biodegradable bioactive strontium-substituted nanohydroxyapatite (SrHA, size 30-70 nm).

Fluctuations of Attention During Self-paced Naturalistic Goal-Directed Behavior in Attention-Deficit/Hyperactivity Disorder.

Objective: Temporal fluctuations of attention detected with strictly controlled neuropsychological tests is an important objective behavioral marker for attention-deficit/hyperactivity disorder (ADHD). This study examined whether intraindividual variability in response latencies is also detectable in more realistic open-ended virtual contexts where the participants can freely interact with the surroundings when performing instructed everyday tasks from memory.

Method: Three ex-Gaussian parameters, μ, σ, and τ, were derived from response latencies in 2 tasks obtained from 2 datasets comprising 9- to 13-year-old children (72 with ADHD and 71 typically developing controls).

A Systematic Review of the Diagnostic Accuracy of Deep Learning Models for the Automatic Detection, Localization, and Characterization of Clinically Significant Prostate Cancer on Magnetic Resonance Imaging.

Background And Objective: Magnetic resonance imaging (MRI) plays a critical role in prostate cancer diagnosis, but is limited by variability in interpretation and diagnostic accuracy. This systematic review evaluates the current state of deep learning (DL) models in enhancing the automatic detection, localization, and characterization of clinically significant prostate cancer (csPCa) on MRI.

Methods: A systematic search was conducted across Medline/PubMed, Embase, Web of Science, and ScienceDirect for studies published between January 2020 and September 2023.

Visual Modeling Languages in Patient Pathways: Scoping Review.

Background: Patient pathways (PPs) are presented as a panacea solution to enhance health system functions. It is a complex concept that needs to be described and communicated well. Modeling plays a crucial role in promoting communication, fostering a shared understanding, and streamlining processes.

Optomechanics Driven by Noisy and Narrowband Fields.

We report a study of a cavity optomechanical system driven by narrowband electromagnetic fields, which are applied either in the form of uncorrelated noise, or as a more structured spectrum. The bandwidth of the driving spectra is smaller than the mechanical resonant frequency, and thus we can describe the resulting physics using concepts familiar from regular cavity optomechanics in the resolved-sideband limit. With a blue-detuned noise driving, the noise-induced interaction leads to anti-damping of the mechanical oscillator, and a self-oscillation threshold at an average noise power that is comparable to that of a coherent driving tone.

Detailed-level modelling of influence spreading on complex networks.

The progress in high-performance computing makes it increasingly possible to build detailed models to investigate spreading processes on complex networks. However, current studies have been lacking detailed computational methods to describe spreading processes in large complex networks. To fill this gap we present a new modelling approach for analysing influence spreading via individual nodes and links on various network structures.

Local and interareal alpha and low-beta band oscillation dynamics underlie the bilateral field advantage in visual working memory.

Visual working memory has a limited maximum capacity, which can be larger if stimuli are presented bilaterally vs. unilaterally. However, the neuronal mechanisms underlying this bilateral field advantage are not known.

Working memory related functional connectivity in adult ADHD and its amenability to training: A randomized controlled trial.

Background: Working memory (WM) deficits are among the most prominent cognitive impairments in attention deficit hyperactivity disorder (ADHD). While functional connectivity is a prevailing approach in brain imaging of ADHD, alterations in WM-related functional brain networks and their malleability by cognitive training are not well known. We examined whole-brain functional connectivity differences between adults with and without ADHD during n-back WM tasks and rest at pretest, as well as the effects of WM training on functional and structural brain connectivity in the ADHD group.

Complexity data science: A spin-off from digital twins.

Digital twins offer a new and exciting framework that has recently attracted significant interest in fields such as oncology, immunology, and cardiology. The basic idea of a digital twin is to combine simulation and learning to create a virtual model of a physical object. In this paper, we explore how the concept of digital twins can be generalized into a broader, overarching field.

Elevated Levels of Serum Thymidine Kinase 1 Predict Poor Survival for Patients with Metastatic Prostate Cancer.

Background And Objective: Prostate-specific antigen (PSA) is of limited value as a surrogate marker for overall survival (OS) in prostate cancer (PC). Serum thymidine kinase 1 (sTK1) is an enzyme expressed by actively dividing cells. Our aim was to evaluate the value of sTK1 as prognostic biomarker in metastatic hormone-sensitive PC (mHSPC) and metastatic castration-resistant PC (mCRPC).

Linking the microarchitecture of neurotransmitter systems to large-scale MEG resting state networks.

Neuronal oscillations are ubiquitous in brain activity at all scales and their synchronization dynamics are essential for information processing in neuronal systems. The underlying synaptic mechanisms, while mainly based on GABA- and glutamatergic neurotransmission, are influenced by neuromodulatory systems that have highly variable densities of neurotransmitter receptors and transporters across the cortical mantle. How they constrain the network structures of interacting oscillations has remained a central unaddressed question.

A modelling study to explore the effects of regional socio-economics on the spreading of epidemics.

Epidemics, apart from affecting the health of populations, can have large impacts on their social and economic behavior and subsequently feed back to and influence the spreading of the disease. This calls for systematic investigation which factors affect significantly and either beneficially or adversely the disease spreading and regional socio-economics. Based on our recently developed hybrid agent-based socio-economy and epidemic spreading model we perform extensive exploration of its six-dimensional parameter space of the socio-economic part of the model, namely, the attitudes towards the spread of the pandemic, health and the economic situation for both, the population and government agents who impose regulations.

New Vistas for the Relationship between Empathy and Political Ideology.

The study of ideological asymmetries in empathy has consistently yielded inconclusive findings. Yet, until recently these inconsistencies relied exclusively on self-reports, which are known to be prone to biases and inaccuracies when evaluating empathy levels. Very recently, we reported ideological asymmetries in cognitive-affective empathy while relying on neuroimaging for the first time to address this question.

Transport effects of twist-angle disorder in mesoscopic twisted bilayer graphene.

Magic-angle twisted bilayer graphene (TBG) is a tunable material with remarkably flat energy bands near the Fermi level, leading to fascinating transport properties and correlated states at low temperatures. However, grown pristine samples of this material tend to break up into landscapes of twist-angle domains, strongly influencing the physical properties of each individual sample. This poses a significant problem to the interpretation and comparison between measurements obtained from different samples.

The impact of COVID-19 on private healthcare service utilisation: time series analysis in the capital region of Finland during 2020-2022.

Background: Most current studies on COVID-19 have focused on the first weeks or months of the pandemic or have addressed specific diseases. The long-term effects of the COVID-19 pandemic on healthcare services are insufficiently understood. We analysed the long-term effects of the COVID-19 pandemic on outpatient healthcare utilisation in the full spectrum of diseases in Uusimaa, the capital region of Finland.

Understanding of a Ni-Rich O3-Layered Cathode for Sodium-Ion Batteries: Synthesis Mechanism and Al-Gradient Doping.

O3-type NaNiMnCoO (NaNMC811) cathode active materials for sodium-ion batteries (SIBs), with a theoretical high specific capacity (∼ 187 mAh g), are in the preliminary exploration stage. This study comprehensively investigates NaNMC811 from multiple perspectives. For the first time, the phase evolution ( - - ) during the solid-state synthesis is systemically investigated, which elucidates in-depth the mechanisms of the thermal sodiation process.

The effect of water on the crystallization of phytosterols and phytostanols in organic solutions.

Phytosterols (CHO), also known as plant sterols and stanols, are valuable biomolecules with a variety of applications in the pharma, food, and cosmetics industries. Phytosterols are typically manufactured from vegetable oil and tall oil feedstocks through a cooling crystallization process. Depending on the feedstock used, the composition regarding individual phytosterols and phytostanols (saturated analogs of phytosterols), also varies to a large extent.

Empathy enhances decoding accuracy of human neurophysiological responses to emotional facial expressions of humans and dogs.

Despite the growing interest in the nonhuman animal emotionality, we currently know little about the human brain processing of nonconspecific emotional expressions. Here, we characterized the millisecond-scale temporal dynamics of human brain responses to conspecific human and nonconspecific canine emotional facial expressions. Our results revealed generally similar cortical responses to human and dog facial expressions in the occipital cortex during the first 500 ms, temporal cortex at 100-500 ms and parietal cortex at 150-350 ms from the stimulus onset.

Temporal trends of catheter ablation procedures in patients with atrial fibrillation and atrial flutter: A nationwide cohort study.

Background: Catheter ablation is a well-established treatment to prevent atrial fibrillation (AF) and atrial flutter (AFL) recurrences and to relieve symptoms, whereas pacemaker implantation and atrioventricular node (AVN) ablation is used for rate control when medical therapy fails.

Aims: We investigated temporal trends and patient characteristics in catheter ablation procedures for AF, AFL and AVN in Finland between 2012-2018.

Methods: Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) is a registry-based study including all patients with AF or AFL in Finland between 2012-2018.

Simulated conformality of atomic layer deposition in lateral channels: the impact of the Knudsen number on the saturation profile characteristics.

Atomic layer deposition (ALD) is exceptionally suitable for coating complex three-dimensional structures with conformal thin films. Studies of ALD conformality in high-aspect-ratio (HAR) features typically assume free molecular flow conditions with Knudsen diffusion. However, the free molecular flow assumption might not be valid for real ALD processes.

Neurophysiological evidence of motor contribution to vicarious affective touch.

Understanding observed interpersonal touch, particularly the so-called affective touch targeting the CT fibers, is essential for social interactions. Research has documented that observing other people being touched activates the same cortical areas involved in direct tactile experiences. However, observing interpersonal touch also activates an inner simulation of the movements in the observer's motor system.

Highly Charged Cellulose Nanocrystals via Electrochemical Oxidation.

Due to their exceptional properties, cellulose nanocrystals (CNCs) have been proposed for various applications in sustainable materials science. However, state-of-the-art production methods suffer from low yields and rely on hazardous and environmentally harmful chemicals, representing a bottleneck for more widespread utilization of CNCs. In this study, we present a novel two-step approach that combines previously established HCl gas hydrolysis with electrochemical TEMPO oxidation.

Phase separation drives the folding of recombinant collagen.

Recombinantly produced collagens present a sustainable, ethical, and safe substitute for collagens derived from natural sources. However, controlling the folding of the recombinant collagens, crucial for replicating the mechanical properties of natural materials, remains a formidable task. Collagen-like proteins from willow sawfly are relatively small and contain no hydroxyprolines, presenting an attractive alternative to the large and post-translationally modified mammalian collagens.