Comparing nnU-Net and deepflash2 for Histopathological Tumor Segmentation.

Machine Learning (ML) has evolved beyond being a specialized technique exclusively used by computer scientists. Besides the general ease of use, automated pipelines allow for training sophisticated ML models with minimal knowledge of computer science. In recent years, Automated ML (AutoML) frameworks have become serious competitors for specialized ML models and have even been able to outperform the latter for specific tasks.

Evaluation of two study demands-resources-based interventions: a randomized controlled trial.

Introduction: Higher education students experience significant levels of exhaustion in their studies, yet there are limited evidence-based support programs available. Therefore, this study evaluated a novel intervention approach by testing the effectiveness of two online interventions based on the study demands-resources framework. These interventions aimed to balance demands and resources.

A Small Change in Structure, a Big Change in Flexibility.

Studies of the rotational barrier energy of the amide bond using quantum computing and nuclear magnetic resonance (NMR) are focused mainly on its use as a model of the peptide bond. The results of these studies are valuable not only in terms of the fundamental conformational properties of amide bonds, but also in the design of molecular machines, which have recently attracted interest. We investigate the fluxionality of the amide and enamide bonds of compound 3-[()-(dimethylamino)methylidene]-1,1-dimethylurea using advanced dynamic NMR experiments and a theoretical evaluation of the density functional theory (DFT) calculation.

Effects of strain on boundary management: findings from a daily diary study and an experimental vignette study.

Introduction: Transformations in the work-nonwork interface highlight the importance of effectively managing the boundaries between life domains. However, do the ways individuals manage the boundaries between work and nonwork life change from one day to the next? If so, which antecedents may explain these intra-individual fluctuations in boundary management? Drawing on boundary management, spillover, and resource theories, we investigate daily changes in segmentation preferences and integration enactments as a function of experiencing strain in work and nonwork life. Assuming that changes in segmentation preferences reflect an individual's strategy to regulate negative cross-role spillover, we suppose that strain increases individuals' segmentation preferences; at the same time, however, it could force individuals to enact more integration.

Joining of Aluminum and CFRP via Laser Powder Bed Fusion: Influence of Experimental Set-Up and Laser Processing on Microstructure and Mechanical Properties.

Additive-manufacturing-based joining methods enable tailored or even functionalized joints and allow for hybridization at small scales. The current study explored an innovative joining method for aluminum cast alloys (AlSi12) with thermoset carbon-fiber-reinforced polymers (CFRPs) via laser powder bed fusion (LPBF). The direct build-up of AlSi12 on a CFRP substrate proved to be challenging due to the dissimilar thermal properties of the considered materials, which led to substrate damage and low joint adhesion.

Additive Manufacturing of WC-Co Specimens with Internal Channels.

Most material removal in modern manufacturing is currently performed using tools with indexable inserts. Additive manufacturing allows for the creation of new, experimental insert shapes and, more importantly, internal structures, such as channels for coolant. This study deals with developing a process for efficiently manufacturing WC-Co specimens with internal coolant channels with a focus on obtaining a suitable microstructure and surface finish, especially inside the channels.

Chromatic dispersion of soft contact lens materials.

Purpose: To investigate and evaluate the chromatic dispersion of various hydrogel and silicon hydrogel contact lens materials.

Methods: Eighteen different soft contact lens materials with high and low water content in lens power of -1.00 DS were measured by one operator at temperature of 20 °C ± 0.

Treatment With Erythropoietin for Patients With Optic Neuritis: Long-term Follow-up.

Background And Objective: Erythropoietin (EPO) is a candidate neuroprotective drug. We assessed its long-term safety and efficacy as an adjunct to methylprednisolone in patients with optic neuritis and focused on conversions to multiple sclerosis (MS).

Methods: The TONE trial randomized 108 patients with acute optic neuritis but without previously known MS to either 33,000 IU EPO or placebo in conjunction with 1,000 mg methylprednisolone daily for 3 days.

Psychological stress and strain in laboratory animal professionals - a systematic review.

Laboratory animal professionals (LAP) are faced with various situations and tasks influencing their mental well-being. A systematic review has been conducted to investigate whether there are specific stressors for LAP and which moderators are relevant for the development of psychological strain. A comprehensive search following PRISMA Guidelines was carried out in June 2021.

The transformation of global value chains in the age of Covid-19 and Digitization.

Almost everyone on the globe had to adjust to new conditions as a result of Covid-19 in conjunction with digitization. Contact and entry limitations damaged global business, trade and social connections. In addition, there is an increasing impact of digitization in supply chain.

Dissociation between red and white stimulus perception: A perimetric quantification of protanopic color vision deficiencies.

Significance: Horizontal visual field extension was assessed for red and white stimuli in subjects with protanopia using semi-automated kinetic perimetry. In contrast to a conventional anomaloscope, the "red/white dissociation ratio" (RWR) allows to describe protanopia numerically. For the majority of subjects with protanopia a restriction for faint red stimuli was found.

Safety and efficacy of erythropoietin for the treatment of patients with optic neuritis (TONE): a randomised, double-blind, multicentre, placebo-controlled study.

Background: The human cytokine erythropoietin conveys neuroprotection in animal models but has shown ambiguous results in phase 2 clinical trials in patients with optic neuritis. We assessed the safety and efficacy of erythropoietin in patients with optic neuritis as a clinically isolated syndrome in a multicentre, prospective, randomised clinical trial.

Methods: This randomised, placebo-controlled, double-blind phase 3 trial, conducted at 12 tertiary referral centres in Germany, included participants aged 18-50 years, within 10 days of onset of unilateral optic neuritis, with visual acuity of 0·5 or less, and without a previous diagnosis of multiple sclerosis.

Response time and response time variability as indicators of response quality during static automated perimetry.

Purpose: Perimetry is a both demanding and strenuous examination method that is often accompanied by signs of fatigue, leading to false responses and thus incorrect results. Therefore, it is essential to monitor the response quality. The purpose of this study was to evaluate the response time (RT) and its variability (RTV) as quality indicators during static automated perimetry.

Anatomical Location of the Raphe and Extended Raphe in the Human Retina: Implications for Assessment of the Optic Nerve with OCT.

Purpose: To determine the location of (1) the superior-inferior watershed between the fovea and optic disc (extended raphe) at the peripapillary optical coherence tomography (OCT) measurement circle and (2) the raphe, temporal to the fovea.

Methods: We used existing data consisting of 2285 traced retinal nerve fiber bundle trajectories from 83 fundus images. For localization of the extended raphe at the 3.

Gender-specific hearing loss in German adults aged 18 to 84 years compared to US-American and current European studies.

Introduction: From an epidemiological point of view, the increase of pure-tone hearing thresholds as one aspect of biological ageing is moderated by societal factors. Since health policies refer to empirical findings, it is reasonable to replicate population-based hearing surveys and to compare estimates for different birth cohorts from the same regions or, conversely, for the same birth cohorts from different regions.

Methods: We pooled data from two independent cross-sectional German studies conducted between 2008 and 2012 and including 3105 adults.

Heat Treatments and Critical Quenching Rates in Additively Manufactured Al-Si-Mg Alloys.

Laser powder-bed fusion (LPBF) has significantly gained in importance and has become one of the major fabrication techniques within metal additive manufacturing. The fast cooling rates achieved in LPBF due to a relatively small melt pool on a much larger component or substrate, acting as heat sink, result in fine-grained microstructures and high oversaturation of alloying elements in the α-aluminum. Al-Si-Mg alloys thus can be effectively precipitation hardened.

Clinical benefit of wideband-tympanometry: a pediatric audiology clinical study.

Purpose: Wideband-tympanometry (WBT) could give more informative data about the tympanic condition than the conventional tympanometry. In the actual literature, the clinical profit of wideband-tympanometry in pediatric audiological settings is not well evaluated. The aim of this study was to analyze the additional clinical benefit.

Retinal nerve fiber bundle trajectories in Chinese myopic eyes: Comparison with a Caucasian based mathematical model.

Previously we developed a mathematical model for describing the retinal nerve fiber bundle (RNFB) trajectories in the human retina. The model was based on Caucasian eyes that were not selected regarding refraction. The aim of this study was to determine the characteristics of the RNFB trajectories in Chinese myopic eyes.

On the Anisotropic Mechanical Properties of Selective Laser-Melted Stainless Steel.

The thorough description of the peculiarities of additively manufactured (AM) structures represents a current challenge for aspiring freeform fabrication methods, such as selective laser melting (SLM). These methods have an immense advantage in the fast fabrication (no special tooling or moulds required) of components, geometrical flexibility in their design, and efficiency when only small quantities are required. However, designs demand precise knowledge of the material properties, which in the case of additively manufactured structures are anisotropic and, under certain circumstances, inhomogeneous in nature.

Refractive errors.

Background: All over the world, refractive errors are among the most frequently occuring treatable distur - bances of visual function. Ametropias have a prevalence of nearly 70% among adults in Germany and are thus of great epidemiologic and socio-economic relevance.

Methods: In the light of their own clinical experience, the authors review pertinent articles retrieved by a selective literature search employing the terms "ametropia, "anisometropia," "refraction," "visual acuity," and epidemiology.

Long-term follow-up of astigmatic keratotomy for corneal astigmatism after penetrating keratoplasty.

Purpose: To report the long-term stability of paired arcuate corneal keratotomies (AKs) in patients with high regular postpenetrating keratoplasty astigmatism.

Methods: Retrospective chart review of best-corrected visual acuity, refraction and keratometric values of 41 eyes with AK between 2003 and 2012.

Results: Magnitude of median target induced astigmatism vector was 9.

Morphometric Optic Nerve Head Analysis in Glaucoma Patients: A Comparison between the Simultaneous Nonmydriatic Stereoscopic Fundus Camera (Kowa Nonmyd WX3D) and the Heidelberg Scanning Laser Ophthalmoscope (HRT III).

Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods.

The bumpy road to socialise nature: sex education in Japan.

This study was prompted by an empirical puzzle: why is sex education in schools so underdeveloped in Japan compared to many other industrialised societies? On the one hand, formal pedagogy under state policy is conservative, emphasising reproductive and prophylactic purposes rather than a comprehensive understanding of sexuality. On the other hand, however, Japan has a highly visible sexual environment where a variety of commercial sex activities are tolerated and even encouraged. The aim of the paper is to provide an integrated picture of these apparently contradictory trends by examining the nexus of political, economic and sociocultural factors that affect sex education in contemporary Japan.