2 results match your criteria: "AZ Sint Lucas General Hospital[Affiliation]"

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial.

Lancet Respir Med

December 2021

Laboratory of Mucosal Immunology, VIB-UGhent Center for Inflammation Research, Ghent University, Ghent, Belgium; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; Department of Pulmonary Medicine, University Hospital Ghent, Ghent, Belgium. Electronic address:

Article Synopsis
  • This study investigated whether blocking the IL-6 or IL-1 pathways could help improve clinical outcomes in hospitalized COVID-19 patients suffering from hypoxic respiratory failure and cytokine release syndrome.
  • A randomized, multicenter trial was conducted with 16 hospitals in Belgium, focusing on patients with specific criteria related to COVID-19 symptoms, oxygen levels, and markers of systemic inflammation.
  • The trial employed a factorial design to assess the effectiveness of IL-1 blockade with anakinra compared to a control group, exploring its impact on the recovery timeline for severely ill patients.
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