Factors affecting relationship issues among clients attending youth mental health promotion services in India.

Background: India today is home for the largest youth population in the world. Youth is a formative phase transitioning from childhood to adulthood. Relationship is fundamental for a healthy and satisfactory life.

A tetra-nuclear nickel(II) complex, [Ni()](ClO)·CHN·2HO, with an asymmetric NiO open-cubane-like core.

A tetra-nuclear complex with an open-cubane-like core structure was synthesized from 2-meth-oxy-6-(pyridin-2-yl-hydrazonometh-yl)phenol (), namely, -tetra-kis-(μ-2-meth-oxy-6-{[2-(pyridin-2-yl)hydrazin-1-yl-idene]meth-yl}pheno-lato)tetra-nickel(II) tetra-kis-(perchlorate) aceto-nitrile monosolvate dihydrate, [Ni(CHNO)](ClO)·CHN·2HO, and characterized using micro-analytical and spectroscopic techniques. The crystal-structure determination reveals the formation of a distorted NiO cubane-like core architecture encapsulated by four hydrazone Schiff base () mol-ecules. A open-cube tetra-nuclear architecture is created in which nickel(II) ions of the NiNO unit are connected by μ-O anions of the phenolate moiety of .

Role of TfR2-Y250X and TfR1- rs3817672 Single Nucleotide Polymorphism on Pathophysiology of Iron Deficiency Anemia.

Background: Transferrin receptor (TfR) is a carrier protein for transferrin. It is regulated in response to intracellular iron concentration and plays a role for the import of iron into the cell. The transferring receptor 2 (TFR2) gene showed homology to transferrin receptor 1 (TFR1) gene and encodes a transmembrane protein with a large extracellular domain, which is able to bind transferrin.

Effect of an 8-Week Individualized Training Program on Blood Biomarkers, Adipokines and Endothelial Function in Obese Young Adolescents with and without Metabolic Syndrome.

Obesity is a chronic condition whose incidence is growing due to lack of exercise and frequent nutrition disorders. Childhood obesity has reached epidemic proportions worldwide. One of the best treatment methods is physical training.

Redox Status of Professional Soccer Players is Influenced by Training Load Throughout a Season.

The purpose of this study was to follow-up the variation of pro-/antioxidant status throughout a whole season in elite professional soccer players from the French league (n=19, 18.3±0.6 years) and to examine a possible link between these variations and training load.

Genetic divergence in natural populations of bronze featherback, Notopterus notopterus (Osteoglossiformes: Notopteridae) from five Indian rivers, analyzed through mtDNA ATPase6/8 regions.

The present study characterized 842 bp fragment of mitochondrial ATP synthase 6 and 8 (ATPase6/8) genes in Notopterus notopterus. In all, 97 samples of N. notopterus were collected from five distant rivers; viz Satluj, Gomti, Yamuna, Brahmaputra and Mahanadi representing 4 river basins in India.

Phenotypic heterogeneity of asian Indian inversion deletions gγ(aγδβ)0 breakpoint a and breakpoint B.

Asian Indian inversion deletion Gγ (Aγδβ)0-thalassemia is a rare entities characterized by high HbF. Due to interaction with various genetic factors, patients with Gγ (Aγδβ)0-thalassemia showed clinical variability. Here we are presenting the phenotypic expression of Gγ(Aγδβ)0 thalassemia under influence of various co-inherited factors.

Effectiveness of anti scorpion venom for red scorpion envenomation.

Objective: To study the efficacy of anti-scorpion venom plus prazocin.

Methods: Comparison of clinical features, outcome and duration of stay between children receiving anti-scorpion venom plus prazocin or prazocin alone for management of red scorpion envenomation.

Results: Requirement for dopamine and requirement and duration of dobutamine therapy were significantly less in patients received anti-venom plus prazocin than those had prazocin only.

Co-morbidities in hospitalized children with severe acute malnutrition.

Objective: To study the co morbidities in hospitalized children with severe acute malnourishment.

Methods: 104 severe acute malnourished children were included.

Results: 54% had diarrhea and 27.

Recovery (passive vs. active) during interval training and plasma catecholamine responses.

The effect of recovery mode (Active [AR] vs. Passive [PR]) on plasma catecholamine (Adrenaline [A] and Noradrenaline [NA]) responses to maximal exercise (Exemax) was studied during interval training (IT). 24 male subjects (21.

Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta.

Background: The aim of this study was to examine the effects of intense physical training on vascular function in streptozotocin-diabetic rats. We focused on the endothelium-dependent relaxation (EDR) induced by acetylcholine (ACh) and stable ADP adenosine-5'- O - (2-thiodiphosphate) (ADPβS).

Methods: Control or diabetic male Wistar rats (n=44) were randomly assigned to sedentary or trained groups.

Anti-diabetic compounds and their patent information: an update.

The increasing epidemic of diabetes mellitus around the globe is increasing the risk of various other chronic diseases i.e. coronary artery diseases, myocardial infarction, hypertension, dyslipidemia and number of other complicated disorders.

Interaction of - α 3.7, ß Thalassemia Mutation IVS 1-5 and HbD Punjab in a Family: A Case Report.

Hemoglobin D exist in four form; HbD trait, HbD-thalassemia, HbD sickle cell and HbD homozygous. HbD trait and HbD homozygous generally asymptomatic condition but when HbD co-inherit with thalassemia and sickle cell anemia, produces clinically significant conditions like chronic hemolytic anemia. Here we present a case of HbD Punjab with α 3.

Association of Low Serum Iron with Alpha Globin Gene Deletions and High Level of HbF with Xmn-1 Polymorphism in Sickle Cell Traits.

Usually sickle cell traits are asymptomatic but co-existence of various factrors may alter the clinical as well as biochemical levels. In India sickle cell traits are neglected condition. Here we are presenting the alpha deletion in association with low serum iron and increased HbF level with Xmn-1 carriers in sickle cell traits.

A new method to estimate energy expenditure from abdominal and rib cage distances.

The aim of this paper is to validate a new method of energy expenditure (EE) estimation stemming solely from the measurement of rib cage, abdominal and chest wall distances. We set out to prove that the variations of these distances, measured by two pairs of electromagnetic coils, lead to the estimation of the ventilation (VE) and the EE. Eleven subjects were recruited to take part in this study (27.

A comparison between ventilation and heart rate as indicator of oxygen uptake during different intensities of exercise.

The aim of this study is to compare the relation between ventilation (VE) and oxygen uptake (VO2) [VO2=ƒ(VE)] and between heart rate (HR) and VO2 [VO2=ƒ(HR)]. Each one of the subjects performed three types of activities of different intensities (walking without load, walking with load and intermittent work). VO2, VE, and HR were measured continuously by using indirect calorimetry and an electrocardiogram.

QSAR studies on benzopyran potassium channel activators.

QSAR studies on a series of benzopyrans as potassium channel activators have been carried out using a large set of distance-based topological indices. In addition, the molecular descriptors namely: negentropy and molecular redundancy indices have also been used. The relaxant potency in rat trachea, expressed as pEC(50) was used for biological characterization of the benzopyrans.

QSAR study on phosphoramidothioate (Ace) toxicities in housefly.

The present paper describes quantitative structure-activity relationships (QSARs) formulated for a series of phosphoramidothioate (Ace II) analogs. The k(e) values for Ace II-induced inhibition of fly-acetylcholinesterase as well as LD50 for housefly exposed to Ace II analogs were governed by distance-based topological as well as information theoretic indices. In addition, we have also modeled lipophilicity of the phosphoramidothioates used.

QSAR study on 5-lipoxygenase inhibitors using distance-based topological indices.

QSAR study on a large set of 5-lipoxygenase inhibitors has been carried out using distance-based topological indices. Regression analysis of the data has indicated that an excellent model is obtained when these topological indices are combined with some classical molecular descriptors. The obtained models are critically discussed and examined.

Quantitative structure-activity relationship study on sulfanilamide schiff's bases: carbonic anhydrase (CA) inhibitors.

The paper deals with quantitative structure-activity studies on a group of sulfanilamide Schiff's base inhibitors of carbonic anhydrase (CA) using distance-based topological indices. The regression analysis of the data has shown that the activities of the compounds used in inhibiting Carbonic AnhydraseII (CAII) activity can be modeled excellently in multi-parametric model in that some indicator parameters are also involved. The results are discussed critically.

QSAR study on binding affinity of PATs (rodenticides) to the [3H]-mepyramine-labelled H1 receptor in rat and guinea pig brain.

The binding of a series of PAT analogues (rodenticides) to the [3H]-mepyramine-labelled H1 receptor in rat and guinea pig brain was investigated topologically using negentropy (N), molecular redundancy (MRI), first-order molecular connectivity (1chi(v)), Wiener (W), and Szeged (Sz) indices. Multiple regression analyses showed that MRI provided excellent results upon introduction of indicator parameters. Predictive ability of the proposed models was discussed using cross-validation parameters.

QSAR studies on antimalarial 2,4-diamino-6-quinazoline sulfonamides.

The present paper discusses QSAR studies on antimalarial 2,4-diamino-6-quinazoline sulfonamide derivatives using electronic parameters, namely energy of highest occupied molecular orbitals (EH), energy of lowest unoccupied molecular orbitals (EL) and charge density (CD). The results have shown that better results are obtained by introducing dummy parameters (indicator parameter), Ip. Excellent results are obtained when all the four parameters (EH, EL, CD and Ip) are used in correlation analysis.