7,525 results match your criteria: "APHP Sorbonne University; Sorbonne University (A.K.)[Affiliation]"

Introduction: The study aimed to identify and describe disease activity trajectories over 10 years in patients with recent-onset axial spondyloarthritis (axSpA) and determine their impact on long-term outcomes.

Methods: This prospective, multicentre study (Devenir des Spondylarthropathies Indifférenciées Récentes cohort, ClinicalTrials.gov NCT) followed patients with early axSpA for 10 years.

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Extracorporeal membrane oxygenation in trauma patient in France: a retrospective nationwide registry.

Anaesth Crit Care Pain Med

December 2024

Sorbonne University, GRC 29, Assistance Publique-Hôpitaux de Paris, DMU DREAM, Department of Anesthesiology and critical care, Pitié-Salpêtrière Hospital, Paris, France. Electronic address:

Background: Indications for Veno-venous (VV) or veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) after trauma rely on poor evidence. The main aims were to describe the population of trauma patients requiring either VV or VA ECMO and report their clinical management and outcomes.

Methods: An observational multicentre retrospective study was conducted in 17 Level 1 trauma centres in France between January 2010 and December 2021.

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Differences between hepatocellular carcinoma caused by alcohol and other aetiologies.

J Hepatol

December 2024

AP-HP, Hôpital Avicenne, Liver Unit, F-93000 Bobigny, France; University Sorbonne Paris Nord, UFR SMBH, F-93000 Bobigny, France; INSERM UMR-1168, Functional Genomics of Solid Tumours, F-75006 Paris, France.

Alcohol-related liver disease is the third cause of hepatocellular carcinoma worldwide and the leading cause in Europe. Additionally, the recent definition of Metabolic dysfunction-Associated Steatotic Liver Disease with increased alcoholic intake will enrich this population with a more nuanced phenotype, reflecting recent epidemiological trends. In these patients, hepatocellular carcinoma diagnosis is often delayed and less frequently detected through screening programs.

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Robot-Assisted Myomectomy versus Open Surgery : Cost-Effectiveness analysis: Cost-Effectiveness of Robotic Myomectomy.

J Gynecol Obstet Hum Reprod

December 2024

Assistance Publique-Hospitals of Paris, Department of Gynecological and Breast Surgery and Oncology, Pitié Salpêtrière Hospital, Paris, France; University Institute of Cancer (IUC), AP-HP, Sorbonne University, Paris, France; Saint-Antoine Research Center (CRSA), INSERM UMR_S_938, Biology and Therapeutics of Cancer, Sorbonne University, Paris, France. Electronic address:

Introduction: Fibroids are the most common benign uterine tumors. There are different possibilities for surgical approaches, and evaluating the cost of these operations is fundamental in modern surgery. The aim of our study is to evaluate the cost-effectiveness of robotic-assisted myomectomy (RAM) compared to open myomectomy (OM) in France.

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Neuromuscular disorders (NMD) with neonatal or early infantile onset are usually severe and differ in symptoms, complications, and treatment options. The establishment of a diagnosis relies on the combination of clinical examination, morphological analyses of muscle biopsies, and genetic investigations. Here, we re-evaluated and classified a unique collection of 535 muscle biopsies from NMD infants aged 0-6 months examined over a period of 52 years.

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SPECIFIC POSTURAL ALIGNMENT ALTERATIONS DUE TO LONG-FACE DEFORMITY IN PATIENTS WITH MAXILLO-MANDIBULAR DEFORMITIES.

J Stomatol Oral Maxillofac Surg

December 2024

Sorbonne Université, APHP. Sorbonne Université, Hopital Pitié-Salpêtrière, Service de chirurgie maxillo-faciale, Paris, FRANCE; Arts et Métiers Sciences et Technologies, Institut de Biomécanique Humaine Georges Charpak, Paris, FRANCE.

Background: A specific pathological postural adaptation is suspected in patients exhibiting maxillo-mandibular deformity (MMD); however, none study reported a correlation between facial dimensions and posture. In this study, we hypothesized that pathological postural adaptations are related to long-face deformity and subsequent oral breathing in patients with MMD METHODS: Thirty patients with MMD and 20 healthy subjects. Breathing mode, postural alignment and cephalometry were analyzed through a biplanar X-ray (EOS imaging®) of the skeleton in an upright position, followed by three-dimensional reconstruction.

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Allogeneic umbilical cord-derived mesenchymal stromal cells as treatment for systemic lupus erythematosus: a single-centre, open-label, dose-escalation, phase 1 study.

Lancet Rheumatol

December 2024

SITI, CHU Rennes, Etablissement Français du Sang Bretagne, Rennes, France; INSERM UMR 1236, Université Rennes, INSERM, Etablissement Français du Sang Bretagne, Rennes, France. Electronic address:

Background: Patients with systemic lupus erythematosus (SLE) with inadequate responses to standard therapies have unmet therapeutic needs. The immunomodulatory, proangiogenic, and antifibrotic properties of mesenchymal stromal cells support their use in treating patients with SLE. We aimed to assess the safety of a single intravenous infusion of allogeneic umbilical cord-derived mesenchymal stromal cells in patients with severe SLE.

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Hereditary spastic paraplegias: When to expect bladder dysfunction a genetic and urodynamic study.

Eur J Neurol

January 2025

Sorbonne Université, Paris Brain Institute (ICM Institut du Cerveau), INSERM, CNRS, Assistance Publique-Hôpitaux de Paris (APHP), University Hospital Pitié-Salpêtrière, Paris, France.

Background: The aim of this study was to characterize hereditary spastic paraplegias (HSP) patients' urodynamic profiles and development of bladder symptoms.

Methods: This is a multicentric retrospective study which included patients presenting with bladder disorders. We reviewed medical and urodynamic records in individuals with HSP and recorded age at onset of gait and bladder disorders, disability stage at the time of urodynamic assessment.

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Anastomotic leak occurrence is a severe complication after colorectal surgery. Considering the difficulty of treating these leaks and their impact on patient care, there is a strong need for an efficient prevention strategy. We evaluated a combination of extracellular vesicles (EVs) from rat adipose-derived stromal cells with a thermoresponsive gel, Pluronic® F127 (PF-127) to prevent anastomotic leaks.

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Purpose: This study aimed to assess the relationship between kinetics of bladder sensations perception, detrusor overactivity (DO), and severity of overactive bladder (OAB) symptoms in patients with multiple sclerosis (PwMS).

Methods: All PwMS who underwent urodynamic assessment including three cystometries (20 ml/min, 100 ml/min, and 100 ml/min with 4°C fluid) between June 2020 and October 2022 were included in this retrospective study. Data collected were bladder diaries, symptoms assessed with Urinary Symptoms Profile (USP), bladder sensations with first desire to void (FDV) and strong desire to void (SDV) during the 20ml/min cystometry, and presence of DO.

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Contribution and evolution of respiratory muscles function in weaning outcome of ventilator-dependent patients.

Crit Care

December 2024

Service de Médecine Intensive - Réanimation-SRPR, APHP, Hôpital Pitié-Salpêtrière, Sorbonne Université, 75013, Paris, France.

Background: The present study was designed to investigate the evolution and the impact of respiratory muscles function and limb muscles strength on weaning success in prolonged weaning of tracheotomized patients. The primary objective was to determine whether the change in respiratory muscles function and limb muscles strength over the time is or is not associated with weaning success.

Methods: Tracheotomized patients who were ventilator dependent upon admission at a weaning center were eligible.

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Background: Data about the safety and the efficacy of flow diversion for distal anterior cerebral artery (DACA) aneurysms are limited. We present the largest multicenter analysis evaluating the outcomes of flow diversion in unruptured DACA aneurysm treatment.

Methods: Databases from 39 centers were retrospectively reviewed for unruptured DACA aneurysms treated with flow-diverting stents.

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Purpose: Neurological symptoms often prominent in post-acute sequelae of COVID-19 (PASC) necessitate deeper understanding. Our objective was to investigate brain metabolism in PASC and examine correlations with neurological symptoms during both the acute and chronic stages.

Methods: Eighty-seven adults experiencing PASC with neurocognitive symptoms were recruited in the PERSICOR prospective study and examined using brain [18F]FDG PET/CT.

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Recognition memory decline is associated with the progression to prodromal Alzheimer's disease in asymptomatic at-risk individuals.

J Neurol

December 2024

Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, U 1127, CNRS, UMR 7225, AP-HP, CENIR, Centre MEG-EEG, Hôpital de La Pitié-Salpêtrière, 47 Boulevard de L'Hôpital, 75013, Paris, France.

Episodic memory (EM) alterations are a hallmark of Alzheimer's disease (AD). We assessed EM longitudinally in cognitively normal elders at-risk for AD (with subjective memory complaints), as a function of amyloid-β (Aβ) burden, neurodegeneration (N), and progression to prodromal AD. We stratified 264 INSIGHT-preAD study subjects in controls (Aβ-/N-), stable/N- or N + (Aβ +), and progressors/N- or N + (Aβ +) groups (progressors were included only until AD-diagnosis).

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Predicting attentional focus: Heartbeat-evoked responses and brain dynamics during interoceptive and exteroceptive processing.

PNAS Nexus

December 2024

Institut du Cerveau-Paris Brain Institute-ICM, Inserm, Sorbonne Université, CNRS, APHP,Hôpital de la Pitié Salpêtrière, 75013 Paris, France.

Attention shapes our consciousness content and perception by increasing the probability of becoming aware and/or better encoding a selection of the incoming inner or outer sensory world. Engaging interoceptive and exteroceptive attention should elicit distinctive neural responses to visceral and external stimuli and could be useful in detecting covert command-following in unresponsive patients. We designed a task to engage healthy participants' attention toward their heartbeats or auditory stimuli and investigated whether brain dynamics and the heartbeat-evoked potential (HEP) distinguished covert interoceptive-exteroceptive attention.

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Vaccine policies in France and Europe.

Curr Opin Immunol

December 2024

CERMES3 (INSERM, CNRS, EHESS, Université de Paris), Villejuif, France.

This review outlines the outcome of the COVID-19 vaccination campaign in France and assesses the respective roles of information and coercion in its overall success. These data are then put into perspective of the evolution of vaccination acceptance in France.

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Purpose: Missense de novo variants in CACNA1G, which encodes the Cav3.1 T-type calcium channel, have been associated with a severe, early-onset form of cerebellar disorder with neurodevelopmental deficits (SCA42ND). We explored a large series of pediatric cases carrying heterozygous variants in CACNA1G to further characterize genotype-phenotype correlations in SCA42ND.

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Induction triplet chemotherapy in patients with rectal adenocarcinoma and synchronous metastases, an AGEO-FFCD study.

Clin Res Hepatol Gastroenterol

December 2024

Sorbonne University, Hepato-gastroenterology and digestive oncology department, Pitié Salpêtrière hospital, APHP, Paris, 47-83 Boulevard de l'hôpital, Paris 75013, France. Electronic address:

Aim Of The Study: The management of synchronous metastatic rectal cancer (SMRC) is complex and multimodal, involving chemotherapy, surgery and/or radiotherapy. The aim of this study was firstly to confirm the efficacy of the induction FOLFIRINOX, and secondly to evaluate the different therapeutic strategies and outcomes of patients.

Patients And Methods: This French study combined data from a prospective FFCD trial and a multicenter cohort.

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Introduction: Lipodystrophy syndromes are rare diseases characterized by a generalized or partial lipoatrophic morphotype and metabolic complications. Data on health-related quality of life and impact of genetic lipodystrophy on social or psychological well-being are lacking.

Patients And Methods: Patients with genetic lipodystrophy were recruited throughout the French national reference network for rare diseases of insulin secretion and insulin sensitivity.

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Pediatric acute myeloid leukemia frequently harbor fusion oncogenes associated with poor prognosis, including KMT2A, NUP98 and GLIS2 rearrangements. While murine models have demonstrated their leukemogenic activities, the steps from a normal human cell to leukemic blasts remain unclear. Here, we precisely reproduced the inversion of chromosome 16 resulting in ETO2::GLIS2 fusion in human induced pluripotent stem cells (iPSC).

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Clinical, Dosimetric and Radiomic Features Predictive of Lung Toxicity After (Chemo)Radiotherapy.

Clin Lung Cancer

November 2024

Department of Radiation Oncology, Tenon University Hospital, APHP, Sorbonne University, Paris, France; Laboratoire d'Imagerie Biomédicale UMR 7371 - U1146, Sorbonne University, Paris, France.

Background: Treatment of locally advanced non small cell lung cancer (LA-NSCLC) is based on (chemo)radiotherapy, which may cause acute lung toxicity: radiation pneumonitis (RP). Its frequency seems to increase by the use of adjuvant durvalumab therapy.

Aims: To identify clinical, dosimetric, and radiomic factors associated with grade (G)≥2 RP and build a prediction model based on selected parameters.

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Tuberculosis in adult migrants in Europe: a TBnet consensus statement.

Eur Respir J

December 2024

Clinical Infectious Diseases, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Introduction: Global migration has increased in recent decades due to war, conflict, persecutions, and natural disasters, but also secondary to increased opportunities related to work or study. Migrants' risk of tuberculosis (TB) differs by reasons for migration, socioeconomic status, mode of travel and TB risk in transit, TB incidence and healthcare provision in country of origin. Despite advances in TB care for migrants and new treatment strategies, decisions for the management of migrants at risk of TB often rely on expert opinions, rather than clinical evidence.

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