791 results match your criteria: "AP-HP.centre[Affiliation]"

Evolution of minimally invasive liver surgery in France over the last decade.

Surg Endosc

August 2024

AP-HP Centre, Groupe Hospitalier Cochin Port-Royal, DMU Cancérologie et Spécialités Médico-Chirurgicales, Service de Chirurgie Hépatobiliaire, Digestive et Endocrinienne, Paris, France.

Background: Despite evidence of benefits on postoperative outcomes, minimally invasive liver surgery (MILS) had a very low diffusion up to 2014, and recent evolution is unknown. Our aim was to analyze the recent diffusion and adoption of MILS and compare the trends in indications, extent of resection, and institutional practice with open liver surgery (OLS).

Methods: We analyzed the French nationwide, exhaustive cohort of all patients undergoing a liver resection in France between January 1, 2013 and December 31, 2022.

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Cognitive impairment in children and adults with cerebrotendinous xanthomatosis: A French cohort study.

J Inherit Metab Dis

September 2024

Neurology Department, Reference Center for Neurological Metabolic and Lysosomal Diseases, Pitié-Salpêtrière University Hospital, AP-HP Sorbonne University, Paris, France.

Cerebrotendinous xanthomatosis is a rare and treatable metabolic disorder related to the accumulation of cholestanol. This disorder is primarily associated with motor and cognitive impairments, although the latter has not been extensively characterized. The objectives of this work were to define the cognitive profile found in cerebrotendinous xanthomatosis patients, investigate the progression of cognitive impairment over time, and search for radio-clinical correlations.

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Machine learning evaluation of immune infiltrate through digital tumour score allows prediction of survival outcome in a pooled analysis of three international stage III colon cancer cohorts.

EBioMedicine

July 2024

Centre de Recherche INSERM LNC-UMR1231, Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, Dijon, France; Genetic and Immunology Medical Institute, Dijon, France; University of Burgundy Franche-Comté, Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France. Electronic address:

Background: T-cell immune infiltrates are robust prognostic variables in localised colon cancer. Evaluation of prognosis using artificial intelligence is an emerging field. We evaluated whether machine learning analysis improved prediction of patient outcome in comparison with analysis of T cell infiltrate only or in association with clinical variables.

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Prevalence and target attainment of traditional cardiovascular risk factors in patients with systemic lupus erythematosus: a cross-sectional study including 3401 individuals from 24 countries.

Lancet Rheumatol

July 2024

Rheumatology Unit, First Department of Propaedeutic Internal Medicine, Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece. Electronic address:

Article Synopsis
  • Systemic lupus erythematosus (SLE) significantly increases the risk of cardiovascular disease, prompting a study to evaluate traditional cardiovascular risk factors in SLE patients worldwide between 2015 and 2020.
  • The study included 3,401 SLE patients from 24 countries, predominantly women, revealing high rates of hypertension (35.6%), obesity (23.7%), and hyperlipidaemia (19.8%), with poor control of these risk factors across the board.
  • Notably, patients with antiphospholipid syndrome had higher prevalence of cardiovascular risks but showed better control of blood pressure and lipid levels compared to those without, highlighting international discrepancies in risk factor management.
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Increased risk of gastric cancer in relation with pernicious anaemia in patients with primary antibody deficiency: A nationwide case control study.

Dig Liver Dis

October 2024

Department of Gastroenterology, AP-HP. Centre- Université Paris Cité, Hôpital Cochin, Paris, France; Université de Paris, INSERM UMR 1163 and Imagine Institute, Laboratory of Intestinal Immunity, Université Paris Cité, Paris, France. Electronic address:

Background/aim: We aimed to assess gastrointestinal cancers risks in a large cohort of individuals with primary antibody deficiency (PAD) and their association with risk of autoimmune and inflammatory gastrointestinal diseases.

Methods: Investigating a French national database of inpatient admissions between 2010 and 2018, we identified 12,748 patients with PAD and 38,244 control non-exposed individuals. We performed multiple exposed-non-exposed studies using conditional logistic regression.

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[The Green group of the French society of internal medicine].

Rev Med Interne

July 2024

Centre de recherche en épidémiologie et statistiques, Inserm UMR1153, Paris, France; Service de médecine interne, hôpital Cochin, AP-HP centre, université Paris Cité, Paris, France.

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Objective: To evaluate the relevance of the Rheumatoid Arthritis Impact of Disease (RAID) score as a disease activity marker of rheumatoid arthritis (RA) in a teleconsultation setting.

Methods: A prospective, observational, 24-month, single-center study involving patients with RA who underwent teleconsultations was performed. The RAID score was sent to all patients by email and completed the day before the scheduled session.

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Arthro-distension with early and intensive mobilization for shoulder adhesive capsulitis: A randomized controlled trial.

Ann Phys Rehabil Med

September 2024

Université Paris Cité, AP-HP, Lariboisière-Fernand Widal Hospital, Department of Physical Medicine and Rehabilitation, Paris, France; Université Paris Cité, AP-HP, Lariboisière-Fernand Widal Hospital, Department of Rheumatology, Paris, France.

Background: There are several therapeutic options for the management of shoulder adhesive capsulitis (AC). The superiority of arthro-distension over intra-articular steroid injection (ISI) for AC remains controversial.

Objectives: To evaluate the efficacy of a single arthro-distension procedure combined with early and intensive mobilization (ADM) and physiotherapy, versus ISI and physiotherapy, in people with AC lasting ≥3 months.

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[Palliative care training for physicians].

Rev Prat

April 2024

Professeur de médecine palliative, Hôpital Cochin AP-HP Centre, université Paris-Cité, Paris, France.

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Large-vessel involvement in ANCA-associated vasculitis: A multicenter case-control study.

Semin Arthritis Rheum

August 2024

Médecine Interne, Centre Hospitalier Universitaire Gabriel-Montpied, 63000 Clermont-Ferrand, France; Université Clermont Auvergne Inserm U1071, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), USC-INRA 2018, Clermont-Ferrand, France. Electronic address:

Objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) primarily affects small vessels. Large-vessel involvement (LVI) is rare. We aimed to describe the characteristics of LVI, to identify associated risk factors, and to describe its therapeutic management.

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Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control.

Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control.

Methods: In this cross-sectional study, we assessed real-world data using the MASK-air app.

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Article Synopsis
  • Six genes associated with high molecular weight penicillin-binding proteins (Pbp) are found in the β-lactam-resistant strain K411.
  • One specific gene linked to penicillin-binding protein 2c (Pbp2c) is present in resistant strains but absent in sensitive ones, demonstrating a clear relationship with resistance levels.
  • The Pbp2c protein significantly enhances β-lactam resistance and is regulated by a specific system activated by β-lactams, requiring up to 48 hours for detection in certain strains, with Pbp2c-expressing strains showing resistance to all tested β-lactam antibiotics.
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Introduction: Prognostication of outcome in severe stroke patients necessitating invasive mechanical ventilation poses significant challenges. The objective of this study was to assess the prognostic significance and prevalence of early electroencephalogram (EEG) abnormalities in adult stroke patients receiving mechanical ventilation.

Methods: This study is a pre-planned ancillary investigation within the prospective multicenter SPICE cohort study (2017-2019), conducted in 33 intensive care units (ICUs) in the Paris area, France.

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Objectives: Vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset autoinflammatory disease associated with somatic ubiquitin-like modifier-activating enzyme 1 (UBA1) mutations. We aimed to evaluate the efficacy and safety of targeted therapies.

Methods: Multicentre retrospective study including patients with genetically proven VEXAS syndrome who had received at least one targeted therapy.

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Background: Smoking is responsible for 80 % of cases of Chronic Obstructive Pulmonary Disease (COPD), while the prognosis is improved by smoking cessation (SC). We examined clinical factors associated with SC among smokers with COPD comparing women and men.

Methods: The study comprised a cohort of 1470 smokers who visited a SC service and completed at least 28-day of follow-up visits.

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Prognosis and assessment of the predictive value of severity scores in paediatric abdominal trauma: A French national cohort study.

Eur J Anaesthesiol

September 2024

From the Department of Paediatric Anaesthesia and Intensive Care, Necker-Enfants Malades University Hospital, AP-HP Centre - University of Paris, France (SH, JM, EV, GO).

Background: Paediatric closed abdominal trauma is common, however, its severity and influence on survival are difficult to determine. No prognostic score integrating abdominal involvement exists to date in paediatrics.

Objectives: To evaluate the severity and short-term and medium-term prognosis of closed abdominal trauma in children, and the performance of severity scores in predicting mortality.

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EPAS1-related pheochromocytoma/paraganglioma.

Endocr Relat Cancer

August 2024

Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

In 2012, somatic EPAS1 pathogenic variants were found to cause a triad of pheochromocytoma/paragangliomas (PPGLs), polycythemia, and somatostatinoma. Since then, a limited number of studies on this subject have been reported, and data on the long-term outcome of metastatic disease are not available on this rare syndrome. We comprehensively reviewed EPAS1-related PPGL and describe an unusual patient who has been living with an EPAS1-related metastatic PPGL for 47 years.

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Minimally modified human blood coagulation factor X to bypass direct factor Xa inhibitors.

J Thromb Haemost

August 2024

Department of Internal Medicine, Division of Thrombosis and Hemostasis, Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Background: Direct oral factor (F)Xa inhibitors are widely used as alternatives to conventional vitamin K antagonists in managing venous thromboembolism and nonvalvular atrial fibrillation. Unfortunately, bleeding-related adverse events remain a major concern in clinical practice. In case of bleeding or emergency surgery, rapid-onset reversal agents may be required to counteract the anticoagulant activity.

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Clinical assessment and management of lumbar spinal stenosis: clinical dilemmas and considerations for surgical referral.

Lancet Rheumatol

October 2024

Concord Repatriation General Hospital, Neurosurgical Department, Sydney, NSW, Australia; School of Clinical Medicine, University of New South Wales Medicine and Health, University of New South Wales, Sydney, NSW, Australia.

Lumbar spinal stenosis is the leading indication for spine surgery in older adults. Surgery is recommended in clinical guidelines if non-surgical treatments have been provided with insufficient benefit. The difficulty for clinicians is that the current number of randomised controlled trials is low, which creates uncertainty about which treatments to provide.

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Introduction: The prevalence of Barrett's esophagus (BE) in France is unknown. However, the management of dysplastic BE in expert centers is recommended and reduces the risk of developing invasive adenocarcinoma. Our aim was to determine the burden of BE patients in the Paris Region.

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Article Synopsis
  • Ageing affects immune responses, increasing the risk of infections like COVID-19 in older adults, particularly through factors related to cytotoxic T cells and chronic inflammation.* -
  • In a study of 104 patients over 70, severe COVID-19 correlated with higher levels of specific cytokines (like GM-CSF and IL-1β) and changes in CD8 T cell populations, including more terminally differentiated cells and fewer stem cell-like memory cells.* -
  • The findings suggest that certain cytokines are key indicators of COVID-19 severity in older patients and emphasizes the need for tailored care approaches based on these immune changes in this age group.*
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Pancreatic neuroendocrine tumors in French VHL mutation carriers: a multicentric retrospective study.

J Clin Endocrinol Metab

May 2024

University Paris-Cité, Department of Pancreatology and Digestive Oncology, Beaujon Hospital (AP-HP), Clichy, France.

Background: Von Hippel-Lindau disease (VHL) is a rare autosomal dominant hereditary cancer-predisposition syndrome caused by germline pathogenic variants (PV) in VHL gene. It is associated with a high penetrance of benign and malignant vascular tumors in multiples organs, including pancreatic neuroendocrine tumors (PanNETs), whose long-term natural history is ill-known.

Methods: Patients with both documented germline PV in VHL gene and PanNETs included in the French PREDIR database between 1995 and 2022 were included.

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Highly sensitive detection of Epstein-Barr virus-infected cells by EBER flow FISH.

Int J Hematol

August 2024

Deparment of Child Health and Development, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8519, Japan.

Article Synopsis
  • Identifying cells infected by Epstein-Barr virus (EBV) is crucial for understanding the disease's development, creating treatment plans, and predicting patient outcomes.
  • The study utilized the PrimeFlow™ RNA Assay Kit to detect EBV-encoded small RNAs (EBERs) in various patient groups, including those with chronic active EBV disease and other EBV-related disorders.
  • Findings revealed that patients with chronic active EBV disease showed widespread infection in T and NK cells, while other disorders demonstrated a mix of infected cell types, indicating that EBV may affect multiple cell types beyond just B cells.
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Relapsing polychondritis: clinical updates and new differential diagnoses.

Nat Rev Rheumatol

June 2024

Department of Rheumatology, National Reference Center for Rare Autoimmune Diseases (RESO), INSERM UMR-S 1109, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Relapsing polychondritis is a rare inflammatory disease characterized by recurrent inflammation of cartilaginous structures, mainly of the ears, nose and respiratory tract, with a broad spectrum of accompanying systemic features. Despite its rarity, prompt recognition and accurate diagnosis of relapsing polychondritis is crucial for appropriate management and optimal outcomes. Our understanding of relapsing polychondritis has changed markedly in the past couple of years with the identification of three distinct patient clusters that have different clinical manifestations and prognostic outcomes.

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Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring.

Eur J Endocrinol

May 2024

Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker-Enfants Malades University Hospital, Centre de Référence des Maladies endocriniennes Rares de la Croissance et du Développement (filière FIRENDO), AP-HP Centre, Paris, France.

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