256 results match your criteria: "AP-HP-Universite Paris[Affiliation]"
Efficacy of valaciclovir in preventing herpes zoster in patients receiving anifrolumab.
RMD Open
January 2025
Assistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Centre de Référence des maladies auto-immunes et auto-inflammatoires systémiques rares de l'adulte d'Ile-de-France, Centre et Martinique, Service de Médecine Interne 2, Institut E3M, Paris, France, paris, France.
Safety of Fertility Treatments in Women With Systemic Lupus Erythematosus: Data From a Prospective Population-Based Study.
BJOG
December 2024
Service de Médecine Interne, Centre de référence Des Maladies Auto-Immunes et Auto-Inflammatoires systémiques Rares d'Ile-de-France, de l'Est et de l'Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP)-Université Paris Cité, Paris, France.
Objective: To assess safety of fertility treatments in women with systemic lupus erythematosus (SLE).
Design: Data from the multicentre French observational GR2 (Groupe de Recherche sur la Grossesse et les Maladies Rares) study (2014-ongoing).
Setting: Seventy-six centres in France.
Role of molecular alterations in transplantation decisions for patients with primary myelofibrosis.
Blood Adv
November 2024
Hopital Saint Louis, Paris, France.
The aim of our study was to analyze the potential survival benefit associated with HSCT according to clinico-biological scores which incorporate molecular data (MIPSS70 and MIPSS70+V2) to facilitate decision-making in this context. One transplant (n=241) and one non-transplant cohorts (n=239) were used to test the hypothesis that PMF patients with higher risk molecular score benefit from HSCT. A weighted propensity score was applied to balance confounding factors with the transplanted cohort as reference.
View Article and Find Full Text PDFSubstantial reduction in the clinical and economic burden of disease following variant-adapted mRNA COVID-19 vaccines in immunocompromised patients in France.
Hum Vaccin Immunother
December 2024
Health Economics and Outcomes Research, Moderna France, Paris, France.
Article Synopsis
- An evaluation compared the economic and clinical impact of mRNA-1273 versus BNT162b2 COVID-19 vaccines for immunocompromised individuals aged 30 and older in France during Fall 2023 and Spring 2024.
- * The study estimated outcomes like infections, hospitalizations, deaths, long COVID cases, costs, and quality-adjusted life years (QALYs) using a decision-analytic model, finding that mRNA-1273 vaccines offer greater protection.
- * In a scenario with full vaccine coverage, mRNA-1273 could prevent nearly 4,000 infections and 326 long COVID cases, resulting in €10.1 million in societal cost-savings and 645 additional QALYs.
Reply of the authors: from breast cancer to fertility outcomes: increasing understanding of urgent fertility preservation.
Fertil Steril
October 2024
Department of Reproductive Medicine and Fertility Preservation, AP-HP - Université Paris-Saclay- Antoine Beclère Hospital, Clamart, France; Physiologie et physiopathologie endocrinienne, Université Paris Saclay, Inserm, Le Kremlin-Bicêtre, France.
The AXL inhibitor bemcentinib overcomes microenvironment-mediated resistance to pioglitazone in acute myeloid leukemia.
FEBS J
January 2025
Laboratoire Cellules Souches et Applications Thérapeutiques, UMR INSERM 1184, Commissariat à l'Energie Atomique et Aux Energies Alternatives, Fontenay-Aux-Roses, France.
Prognosis of acute myeloid leukemia (AML) remains poor especially in older patients who are ineligible for standard chemotherapy or have refractory disease. Here, we study the potential of Peroxisome Proliferator-Activated Receptor (PPAR)-γ agonist pioglitazone to improve the treatment of AML. We show that pioglitazone exerts an anti-proliferative and anti-clonogenic effect on AML cell lines KG-1a, MOLM-14 and OCI-AML3 and on primary cultures from AML patients.
View Article and Find Full Text PDFEstimating glomerular filtration in young people.
Clin Kidney J
September 2024
Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
Background: Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Function Consortium (EKFC) equations are the most validated. The EKFC and r-LMR equations have been suggested to have better performances in young adults, but this is debated.
View Article and Find Full Text PDFPremature ovarian insufficiency.
Nat Rev Dis Primers
September 2024
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Article Synopsis
- - Premature ovarian insufficiency (POI) is a condition where women's ovaries stop functioning normally before age 40, leading to infertility and hormonal issues, marked by absent menstrual cycles and high follicle-stimulating hormone levels.
- - POI can be triggered by various factors, including medical treatments, genetic conditions, infections, and autoimmune diseases, affecting around 1 in 100 women, with a higher incidence before age 30.
- - Recent advances in genetic research have improved our understanding of POI, allowing for better diagnosis and potential treatment options, including oocyte preservation for those with a family history of the condition.
Designing simulation-based curriculum content for emergency medicine residents in France: a Delphi method.
BMC Med Educ
August 2024
Université Paris Cité, AP-HP, Hôpital Cochin, Service d'Accueil des Urgences, Paris, France.
Background: The value of simulation in emergency medicine is indisputable because it allows training and acquisition of many technical and non-technical skills (TS and NTS). In France, there are no curriculum regarding the use of simulation as a teaching tool during emergency medicine residency. The aim of this study was to design the content of a national simulation-based curriculum for emergency medicine residency programs.
View Article and Find Full Text PDFComment on: Hydroxychloroquine levels in pregnancy and materno-fetal outcomes in Systemic Lupus Erythematosus patients: Reply.
Rheumatology (Oxford)
August 2024
Service de Médecine Interne, Centre de référence des maladies auto-immunes et auto-inflammatoires systémiques rares d'Ile-de-France, de l'Est et de l'Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP) - Université Paris Cité. Paris, France.
Whole-body distribution of tenofovir, emtricitabine and dolutegravir in non-human primates.
J Antimicrob Chemother
September 2024
Immunologie des Maladies Virales, Auto-immunes, Hématologiques et Bactériennes, Université Paris-Saclay, Inserm, CEA, 92265 Fontenay-aux-Roses, France.
Background: One major barrier to HIV cure is the persistence of virus, possibly linked to an insufficient antiretroviral drug (ARV) distribution into tissues.
Objectives: To draw the whole-body distribution of three antiretroviral drugs-tenofovir disoproxil fumarate, emtricitabine and dolutegravir-in non-human primates (NHPs).
Methods: Eight uninfected NHPs received a single injection of a solution containing the three ARVs.
Regulatory T cell homing and activation is a signature of neonatal sepsis.
Front Immunol
July 2024
Paris-City University, Mére et Enfants en Milieu Tropical: pathogénes, systéme de santé et transition épidémiologique (MERIT), Institute of Research for Development (IRD), Paris, France.
Article Synopsis
- Regulatory T cells (Treg) are crucial for managing immune responses in newborns, especially regarding tolerance to maternal antigens and fighting infections at birth.
- This study, focusing on newborns in West Africa, found that neonates with early-onset sepsis (EOS) had reduced Treg frequency and expression of the Foxp3 marker compared to healthy newborns with prenatal risk factors, indicating a compromised immune profile.
- The findings suggest that specific Treg markers like CTLA-4, PD-1, and CD39 could serve as potential early diagnostic indicators for EOS, as their expression correlates with the severity and outcome of the condition.
Complex Hybrids Detected in a Cohort of 31 Patients With Spinal Muscular Atrophy.
Neurol Genet
August 2024
From the Medicine Genetics Group (M.C.-R., L.B.-P., M.C.-S., J.L.-C., E.F.T.), Vall d'Hebron Research Institute (VHIR); Department of Clinical and Molecular Genetics (M.C.-R., L.B.-P., M.C.-S., J.L.-C., E.F.T.), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain; Neuromuscular Unit (L.G., M.G.-G.D.B., R.G.-U., P.S.-V., S.D., S.Q.-R.), Pediatric Neurology and ICU Department, Raymond Poincaré Hospital (UVSQ), AP-HP Université Paris-Saclay, Garches; and Laboratoire END-ICAP - UMR 1179 (INSERM/UVSQ) (S.Q.-R.), Equipe 1 Biothérapies des maladies neuromusculaires, Montigny-Le-Bretonneux, France.
Article Synopsis
- - Spinal muscular atrophy (SMA) is caused by mutations in the SMN1 gene, and its severity is often related to the number of copies of a related gene, SMN2, but discrepancies between the two exist.
- - In a study with 31 SMA patients, researchers found hybrid genes in about 45% of them, identifying 25 hybrid alleles with varying structures, some not detected by standard methods.
- - Despite expectations that hybrid genes might indicate milder symptoms, the study did not find a consistent link, highlighting the complexity of hybrid structures and the need for further individualized research.
Management of intrahepatic and perihilar cholangiocarcinomas: Guidelines of the French Association for the Study of the Liver (AFEF).
Liver Int
October 2024
Oncology Digestive Unit, INSERM U1312, University Hospital of Bordeaux, Bordeaux, France.
Article Synopsis
- * The French Association for the Study of the Liver created guidelines to summarize the best practices for managing iCCA and pCCA, based on comprehensive expert analysis and voting.
- * These guidelines cover the epidemiology of cholangiocarcinoma and outline management strategies from diagnosis to treatment, emphasizing advancements in personalized medicine and targeted therapies.
Epidemiology of childhood interstitial lung disease in France: the RespiRare cohort.
Thorax
August 2024
Paediatric Pulmonology Department and Reference Center for Rare Lung Diseases, RespiRare, Sorbonne University, AP-HP, Armand Trousseau Hospital, Paris, France
Article Synopsis
- A study examined the prevalence and incidence of interstitial lung disease in children (chILD) in France, finding it affects 44 children per million in 2022 and has an incidence of 4.4 per million.
- The research included data from 790 patients across 42 centers, noting that the median age for diagnosis was 3 months, with a significant portion having familial forms.
- Management typically involved oxygen therapy and corticosteroids, with survival rates being 57.3% for children diagnosed before 2 years and 86% for those diagnosed between 2 and 18 years; the study highlights the need for improved international data collection and standardized practices.
Bacterial diversity and specific taxa are associated with decolonization of carbapenemase-producing enterobacterales after fecal microbiota transplantation.
J Infect
August 2024
Vedanta Biosciences Inc., Cambridge, MA 02139, USA.
Article Synopsis
- This study assessed the impact of fecal microbiota transplantation (FMT) on clearing carbapenemase-producing Enterobacterales (CPE) infections in patients.
- A total of 20 patients were monitored, showing a 20% success rate for complete CPE clearance two weeks post-FMT and 40% at three months, with no significant differences when compared to a control group.
- The analysis indicated that responder patients had a lower level of CPE before FMT and greater diversity in gut bacteria afterwards, suggesting that specific bacterial species may play a role in the success of the treatment.
Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus.
J Exp Med
August 2024
Laboratory of Neurogenetics and Neuroinflammation, Imagine Institute, INSERM UMR1163, Paris, France.
Article Synopsis
- UNC93B1 is a protein involved in signaling for Toll-like receptors, which are important for the immune response.
- Mutations in UNC93B1 (I317M, G325C, L330R, R466S, and R525P) have been linked to conditions like systemic lupus erythematosus (SLE) and chilblain lupus (CBL), exhibiting both autosomal dominant and recessive inheritance patterns.
- Different mutations impact the activity of TLR7 and TLR8 differently, suggesting that specific mutations in UNC93B1 lead to varying disease mechanisms for SLE and CBL.
Fertility outcomes several years after urgent fertility preservation for patients with breast cancer.
Fertil Steril
September 2024
Department of Reproductive Medicine and Fertility Preservation, Antoine Beclère Hospital, AP-HP-Université Paris-Saclay, Clamart, France; Physiologie et Physiopathologie Endocrinienne, Inserm, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Objective: To study the fertility outcomes of women who tried to conceive after breast cancer (BC) treatment and fertility preservation.
Design: Retrospective observational, bicentric cohort study.
Setting: University hospital.
A predictive score for the result of carbapenem-resistant Enterobacterales and vancomycin-resistant enterococci screening.
J Hosp Infect
June 2024
Service de Biologie Clinique, hôpital Foch, Suresnes, France.
Background: The duration of extensively drug-resistant bacteria (XDR) carriage depends on several factors for which the information can be difficult to recover.
Aim: To determine whether past screening and clinical results of patients can predict the results of subsequent screening.
Methods: In total, 256 patients were retrospectively included from 10 healthcare centres in France from January 2014 to January 2022.
Can haemodynamic effects be resumed to systolic arterial pressure?
Lancet
November 2023
Service de Réanimation Polyvalente, Antoine Béclère Hospital, AP-HP Université Paris-Saclay, Clamart 92140, France. Electronic address:
Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study.
Ann Intensive Care
November 2023
Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Intensive Care Medicine (CCM/CVK), Berlin, Germany.
Background: Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave.
Methods: This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020.
Deciphering Potential Molecular Signatures to Differentiate Acute Myeloid Leukemia (AML) with from Chronic Myeloid Leukemia (CML) in Blast Crisis.
Int J Mol Sci
October 2023
CHU de Poitiers, Service de Cancérologie Biologique, F86000 Poitiers, France.
Article Synopsis
- - Acute myeloid leukemia (AML) with a specific fusion gene is now recognized as a unique subtype, making it crucial to differentiate it from myeloid blast crisis chronic myeloid leukemia (BC-CML), particularly those without a chronic phase.
- - The study analyzed a diverse cohort of CML and AML patients, revealing that the fusion functioned as an essential genetic marker in characterizing AML, while also unearthing AML-specific mutations and distinct gene expression patterns.
- - Findings indicate that specific gene expressions, particularly of mRNAs like ID4, can help differentiate AML with the fusion from BC-CML, suggesting that further research is needed to validate these distinctions and deepen the understanding of this AML subtype.
Can HCC postresection survival be predicted with prognostic MRI features?
Eur Radiol
May 2024
Service de Radiologie, AP-HP-Université Paris Saclay Hôpital Paul Brousse, 12-14 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
A flow cytometry method for safe detection of bacterial viability.
Cytometry A
February 2024
Inflammation, Microbiome and Immunosurveillance, UMR-996, Université Paris-Saclay, Inserm, Orsay, France.
Flow cytometry is a relevant tool to meet the requirements of academic and industrial research projects aimed at estimating the features of a bacterial population (e.g., quantity, viability, activity).
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