246 results match your criteria: "ANDROFERT - Andrology & Human Reproduction Clinic[Affiliation]"
Socioeconomic Shadows in Sperm Epigenetics: Insights and Opportunities.
Fertil Steril
January 2025
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil; Division of Urology, Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address:
The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice.
Reprod Biol Endocrinol
January 2025
Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
The production of spermatozoa, a process known as spermatogenesis, is primarily controlled by follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-driven testosterone. LH acts on the Leydig cells, stimulating steroid production, predominantly testosterone, and activating critical inter-related spermatogenesis regulatory pathways. Despite evidence that exogenous gonadotropins containing LH activity can effectively restore spermatogenesis in males with hypogonadotropic hypogonadism, the use of these drugs to treat other forms of male infertility is the subject of an ongoing debate.
View Article and Find Full Text PDFAntimüllerian hormone and antral follicle count thresholds for hyperresponse risk assessment in in vitro fertilization: a Hyperresponse Risk Assessment consensus study.
Fertil Steril
November 2024
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Article Synopsis
- - The study aimed to identify serum anti-Müllerian hormone (AMH) and antral follicle count (AFC) thresholds that signal a higher risk of hyper-response to ovarian stimulation in women undergoing their first IVF cycle, following the HERA definition.
- - A total of 4220 women were analyzed, revealing thresholds of AMH≥4.38ng/mL and AFC≥16 for the overall cohort, with varying thresholds based on age groups.
- - The findings highlighted that factors like AMH, AFC, and age significantly predict the likelihood of hyper-response during ovarian stimulation, with older women requiring more hormonal treatment.
Exogenous progesterone rescue in patients with low mid-luteal serum progesterone levels undergoing true natural vitrified-warmed blastocyst transfer.
J Assist Reprod Genet
November 2024
Anatolia IVF and Women Health Centre, Ankara, Turkey.
Article Synopsis
- This study investigates whether daily subcutaneous administration of 25 mg progesterone improves the chances of live birth in women with low serum progesterone levels (7-10 ng/mL) before a frozen embryo transfer (FET).
- A cohort of 192 women was divided into three groups based on their progesterone levels and whether they received the rescue treatment, with the main focus on comparing live birth rates (LBR) among these groups.
- The results showed that the live birth rates were similar across the groups, indicating that adding the progesterone rescue treatment does not significantly improve outcomes for patients with low serum progesterone levels.
Effect of follicle-stimulating hormone dose on the risk of being classified as suboptimal responders according to the POSEIDON criteria.
J Assist Reprod Genet
December 2024
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil.
Article Synopsis
- This study explores how the daily dose of follicle-stimulating hormone (FSH) impacts the chances of suboptimal ovarian response during IVF, specifically using POSEIDON's criteria.
- It examines a group of 4005 women with normal hormone levels undergoing their first IVF/ICSI cycle, assessing whether varying FSH doses (≤300 IU vs >300 IU) influence the retrieval of 4-9 oocytes.
- Results show that increasing the FSH dose did not decrease the risk of suboptimal response, while factors like female age, and hormone levels were found to be significant predictors instead.
Patients with low prognosis in ART: a Delphi consensus to identify potential clinical implications and measure the impact of POSEIDON criteria.
Reprod Biol Endocrinol
October 2024
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, São Paulo, Brazil.
Article Synopsis
- A panel of international experts evaluated and discussed the POSEIDON criteria, aiming to improve management strategies for women with low prognosis in assisted reproductive technology (ART).
- Through a Delphi consensus process involving multiple rounds of voting, 53 experts reviewed 17 statements and reached consensus on their relevance for patient care and outcomes in ART.
- Key recommendations include using specific treatments and tools to enhance success rates, while emphasizing the need for more large-scale studies to validate existing findings.
Expert opinion on refined and extended key performance indicators for individualized ovarian stimulation for assisted reproductive technology.
Fertil Steril
October 2024
Department of Public Health, University of Naples Federico II, Naples, Italy.
Article Synopsis
- The objective of the study is to evaluate how well ovarian stimulation (OS) promotes follicular development and retrieves quality oocytes by examining antral follicle count (AFC) and its relationship to oocyte outcomes.
- The study emphasizes the need to enhance the key performance indicators (KPIs) used to assess OS effectiveness, introducing new metrics like "early FORT" and "modified FORT" for better evaluation of follicular growth and oocyte retrieval rates.
- The researchers advocate for incorporating these refined KPIs into clinical practices to improve the assessment of OS and its impact on ovarian follicular development, ultimately aiming for individualized treatments in assisted reproductive technology.
Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials.
Fertil Steril
September 2024
Department of Public Health, University of Naples Federico II, Naples, Italy.
Article Synopsis
- The clinical management of women with diminished ovarian reserve (DOR) poses challenges, particularly due to inconsistent definitions of DOR across studies.
- This research aims to evaluate various adjuvant treatments for women with DOR based on the POSEIDON criteria, analyzing data from numerous studies published until June 2024.
- The analysis includes 38 randomized controlled trials, identifying testosterone supplementation as a treatment associated with higher live birth rates in women with DOR compared to those who did not receive supplementation.
Letter to the Editor: Evaluating magnetic-activated cell sorting and testicular sperm aspiration in high sperm DNA fragmentation-significant methodological flaws in a recent RCT.
J Assist Reprod Genet
October 2024
Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
Editorial: Reproductive microbiome and its interplay with the environment.
Front Endocrinol (Lausanne)
August 2024
Department of Public Health, University of Naples Federico II, Naples, Italy.
Non-Obstructive Azoospermia and Intracytoplasmic Sperm Injection: Unveiling the Chances of Success and Possible Consequences for Offspring.
J Clin Med
August 2024
ANDROFERT, Andrology & Human Reproduction Clinic, Campinas 13075-460, SP, Brazil.
Article Synopsis
- * The review highlights success factors for ICSI in NOA patients and suggests that while there may be increased chromosomal issues in retrieved sperm, overall risks to offspring like miscarriage or developmental delays are comparable to those from less severe infertility conditions.
- * It's crucial for NOA patients to receive tailored reproductive care and counseling before starting treatment to reduce health risks, improve success rates, and ensure the well-being of their future children.
To the editor: understanding presperm retrieval hormonal treatment effectiveness in nonobstructive azoospermia through real-world evidence.
Fertil Steril
January 2025
Division of Urology, Department of Surgery, State University of Campinas (UNICAMP), Campinas, Brazil.
A multi-faceted exploration of unmet needs in the continuing improvement and development of fertility care amidst a pandemic.
Int Braz J Urol
August 2024
AXDEV Group Inc., Brossard, QC, Canada.
Article Synopsis
- The study looked at fertility care challenges during the COVID-19 pandemic in eight countries, finding issues for both patients and doctors.
- It involved interviews and surveys to understand the problems people faced and what doctors needed to improve their skills.
- The results showed that there are still big gaps in understanding male infertility and the need for better access to fertility services, especially during tough times like a pandemic.
Letter to the editor: minimum number of mature oocytes in in vitro fertilization needed to obtain at least one euploid blastocyst - reinventing the wheel?
Fertil Steril
October 2024
The Fertility Clinic, Skive Regional Hospital, Skive, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Clinical factors impacting microdissection testicular sperm extraction success in hypogonadal men with nonobstructive azoospermia.
Fertil Steril
October 2024
Division of Urology, Department of Surgery, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Post-graduation Program in Surgical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil.
Article Synopsis
- The study aimed to identify factors that affect the success of microdissection testicular sperm extraction (micro-TESE) in men with low testosterone and nonobstructive azoospermia (NOA).
- Conducted at a reproductive health center, it involved 616 men aged 23-55 who had not undergone sperm retrieval before and were evaluated from 2014 to 2021.
- Results showed a 56.6% success rate, with factors like pre-surgery hormonal stimulation and follicle-stimulating hormone levels significantly influencing outcomes.
Clinical factors associated with unexpected poor or suboptimal response in Poseidon criteria patients.
Reprod Biomed Online
July 2024
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil.
Article Synopsis
- - The study investigates clinical factors linked to unexpected poor or suboptimal responses in IVF ovarian stimulation, identifying specific thresholds for AMH and AFC that could predict these outcomes according to POSEIDON's criteria.
- - Conducted from 2015 to 2017, this tri-centre retrospective cohort study analyzed data from 7,625 first-time IVF and ICSI cycles, revealing that 9.3% were poor responders and 90.7% were suboptimal responders.
- - The findings suggest that higher than expected AMH and AFC threshold values can predict poor or suboptimal responses, emphasizing the importance of these markers for customizing IVF treatment plans.
Prevalence and clinical implications of biochemical hypogonadism in patients with nonobstructive azoospermia undergoing infertility evaluation.
F S Rep
March 2024
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, São Paulo, Brazil.
Article Synopsis
- - The study aimed to assess how common biochemical hypogonadism is among infertile men with nonobstructive azoospermia (NOA) and its effects on clinical outcomes.
- - Out of 767 patients studied from 2014 to 2021, 80.8% were found to have biochemical hypogonadism, with various group distributions based on hormone levels: 42.4% hypergonadotropic hypogonadal, 38.5% normogonadotropic hypogonadal, and smaller percentages in the eugonadal groups.
- - Factors like reduced testicular volume, lower estradiol levels, and older paternal age were identified as increasing the risk of hypogonadism
Effect of environmental factors on seminal microbiome and impact on sperm quality.
Front Endocrinol (Lausanne)
March 2024
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil.
Article Synopsis
- This review analyzes research from 1980-2023 on the male reproductive tract microbiome and its potential link to male infertility, identifying gaps that require additional exploration.
- The review included 37 studies with over 9,000 participants, revealing that while bacteria are present in all semen samples, there was significant variability in microbial species and community structures, and no studies investigated fungi or viruses.
- Findings showed shared microbial characteristics between sexually active couples and highlighted that the seminal microbiome can influence reproductive outcomes, although bacteria in IVF culture did not affect pregnancy success.
APHRODITE criteria: addressing male patients with hypogonadism and/or infertility owing to altered idiopathic testicular function.
Reprod Biomed Online
April 2024
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero - Universitaria of Modena, Modena, Italy.; Unit of Andrology and Sexual Medicine of the Unit of Endocrinology, Department of Medical Specialties, Azienda Ospedaliero - Universitaria of Modena, Modena, Italy.
Article Synopsis
- Scientists created a new system called 'APHRODITE' to classify different types of male infertility to help improve treatments and advice for doctors and patients.
- The APHRODITE system was developed by a team of experts, looking at patient information and lab tests like semen analysis to sort men into different groups based on their infertility issues.
- This system identifies five groups of male infertility to make it easier for doctors and researchers to communicate and ultimately help men have babies more effectively.
Significance of serum AMH and antral follicle count discrepancy for the prediction of ovarian stimulation response in Poseidon criteria patients.
J Assist Reprod Genet
March 2024
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil.
Article Synopsis
- - The study aimed to investigate the risks associated with differing ovarian reserve markers (AMH and AFC) in women undergoing IVF, particularly when one indicates normal reserve and the other suggests poor reserve according to Poseidon's criteria.
- - In a cohort of 8,797 women, 13.3% had discordant AMH and AFC values; 72.9% of these women still retrieved 4 or more oocytes, indicating that discordant markers don't always predict poor ovarian response.
- - The findings suggest that an AFC of 6 is a good predictor of successful oocyte retrieval even when AMH is low, while low AFC paired with higher AMH indicates a lower likelihood of poor response to stimulation.
High prevalence of low prognosis by the POSEIDON criteria in women undergoing planned oocyte cryopreservation.
Eur J Obstet Gynecol Reprod Biol
April 2024
In Vitro Fertilization Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, and Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address:
Article Synopsis
- Planned oocyte cryopreservation (OC) is gaining popularity, but some women struggle to obtain enough oocytes due to poor ovarian response, which can be classified using the POSEIDON system.
- In a study of 160 patients, 39.4% were identified as POSEIDON patients, showing significant differences compared to non-POSEIDON patients in terms of hormone levels and oocyte retrieval.
- The findings indicate that POSEIDON patients have a higher need for fertility medications and retrieve fewer oocytes, highlighting the importance of this classification for patient counseling and management in OC procedures.
Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for male infertility.
Lancet
March 2024
Fertility Clinic at Skive Regional Hospital, Faculty of Health, Aarhus University, Aarhus, Denmark.
Sperm DNA Fragmentation: causes, evaluation and management in male infertility.
JBRA Assist Reprod
June 2024
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, SP, Brazil.
Article Synopsis
- Male infertility accounts for about 40% of infertility cases, with High Sperm DNA Fragmentation (SDF) being a significant contributor, affecting natural conception and assisted reproductive technology (ART) outcomes.
- SDF is mainly caused by factors such as apoptosis, protamination failure, and excessive reactive oxygen species, highlighting the limitations of traditional infertility tests for men with normal sperm counts.
- Various testing and treatment strategies have been developed over the last 25 years to diagnose and reduce DNA fragmentation, aiming to improve sperm quality and enhance success rates in assisted reproduction.
Being a non-native English speaker in science and medicine.
Nat Rev Urol
March 2024
Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China.
Unraveling the Impact of Sperm DNA Fragmentation on Reproductive Outcomes.
Semin Reprod Med
November 2023
The Fertility Clinic, Skive Regional Hospital, Skive, Denmark.
In recent years, there has been a growing interest in identifying subcellular causes of male infertility, and sperm DNA fragmentation (SDF) research has been at the forefront of this focus. DNA damage can occur during spermatogenesis due to faulty chromatin compaction or excessive abortive apoptosis. It can also happen as sperm transit through the genital tract, often induced by oxidative stress.
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