99 results match your criteria: "AMC-University of Amsterdam[Affiliation]"

Cardiovascular diseases, both inherited and familial, indicate a risk of early and preventable cardiovascular events for relatives of affected individuals. A digital risk-prediction tool that enables general population individuals to evaluate their cardiovascular risk based on family health history could be a responsible approach to facilitate early detection and improve public health, but development and use of such a tool is not without legal and ethical requirements. At the start of tool development, experts addressed potential legal and ethical implications.

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Patient-related prognostic factors for function and pain after shoulder arthroplasty: a systematic review.

Syst Rev

November 2024

Department of Epidemiology and Data Science, University Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

Background: While shared decision making is a cornerstone of orthopedic care, orthopedic surgeons face challenges in tailoring their advice and expectation management to individual shoulder arthroplasty patients due to the lack of systematically summarized evidence-based knowledge. This systematic review aims to provide an overview of current knowledge on independent predictive effects of patient-related factors on functional and pain-related outcomes after shoulder arthroplasty.

Methods: We included longitudinal cohort studies including patients receiving total or reverse shoulder arthroplasty or hemiarthroplasty for primary osteoarthritis or cuff tear arthropathy.

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Antibodies have a key role in the immune system, making their characterization essential to biomedical, biopharmaceutical, and clinical research questions. Antibody effector functions are mainly controlled by quantity, subclass, and Fc glycosylation. We describe an integrated method to measure these three critical dimensions simultaneously.

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Cell culture-derived extracellular vesicles: Considerations for reporting cell culturing parameters.

J Extracell Biol

October 2023

Laboratory of Experimental Clinical Chemistry, Department of Clinical Chemistry, Amsterdam University Medical Centers Location AMC, University of Amsterdam Amsterdam The Netherlands.

Cell culture-conditioned medium (CCM) is a valuable source of extracellular vesicles (EVs) for basic scientific, therapeutic and diagnostic applications. Cell culturing parameters affect the biochemical composition, release and possibly the function of CCM-derived EVs (CCM-EV). The CCM-EV task force of the Rigor and Standardization Subcommittee of the International Society for Extracellular Vesicles aims to identify relevant cell culturing parameters, describe their effects based on current knowledge, recommend reporting parameters and identify outstanding questions.

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Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion.

Acta Neuropathol

March 2024

Department of Endocrinology and Metabolism, Amsterdam University Medical Centers, Location AMC. University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder of genetic etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of cases. Two distinct genetic subtypes of PWS deletions are characterized, where type I (PWS T1) carries four extra haploinsufficient genes compared to type II (PWS T2). PWS T1 individuals display more pronounced physiological and cognitive abnormalities than PWS T2, yet the exact neuropathological mechanisms behind these differences remain unclear.

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Dysregulated immune responses contribute to the excessive and uncontrolled inflammation observed in severe COVID-19. However, how immunity to SARS-CoV-2 is induced and regulated remains unclear. Here, we uncover the role of the complement system in the induction of innate and adaptive immunity to SARS-CoV-2.

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Multiple mask and boundary scoring R-CNN with cGAN data augmentation for bladder tumor segmentation in WLC videos.

Artif Intell Med

January 2024

CMEMS-UMinho, University of Minho, 4800-058 Guimaraes, Portugal; LABBELS - Associate Laboratory, Guimaraes, Portugal. Electronic address:

Automatic diagnosis systems capable of handling multiple pathologies are essential in clinical practice. This study focuses on enhancing precise lesion localization, classification and delineation in transurethral resection of bladder tumor (TURBT) to reduce cancer recurrence. Despite deep learning models success, medical applications face challenges like small and limited datasets and poor image characterization, including the absence lack of color/texture modeling.

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Article Synopsis
  • - The article discusses the effectiveness of conventional radiography (CR) for assessing sacroiliac joints in adults and juveniles suspected of having axial spondyloarthritis (axSpA), comparing it to MRI and CT.
  • - The subcommittees highlight MRI's superior ability to detect early sacroiliitis, emphasizing its importance for accurate diagnosis, particularly in children where it poses no radiation risk.
  • - While CR is suitable for identifying structural changes in late-stage axSpA or established cases, additional imaging methods may be necessary for adult differential diagnoses related to the pelvis.
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Response to Biologic Drugs in Patients With Rheumatoid Arthritis and Antidrug Antibodies.

JAMA Netw Open

July 2023

Rheumatology Department, Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale (INSERM) U1184, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (APHP), Fédération Hospitalo Universitaire Cancer and Autoimmunity Relationships, Paris, France.

Article Synopsis
  • The study looked at how antidrug antibodies affect the effectiveness of certain medications for treating rheumatoid arthritis (RA).
  • It involved 254 patients from 27 centers across four European countries, who were starting new biologic treatments.
  • Researchers measured the levels of these antibodies and patients' responses to the treatment at different times to better understand their connection.
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Unlabelled: The key to stopping Alzheimer's disease (AD) lies in the pre-dementia stages, with the goal to stop AD before dementia has started. We present the rationale and design of the ABOARD (A Personalized Medicine Approach for Alzheimer's Disease) project, which aims to invest in personalized medicine for AD. ABOARD is a Dutch public-private partnership of 32 partners, connecting stakeholders from a scientific, clinical, and societal perspective.

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Background: Liquid biopsies combine minimally invasive sample collection with sensitive detection of residual disease. Pediatric malignancies harbor tumor-driving copy number alterations or fusion genes, rather than recurrent point mutations. These regions contain tumor-specific DNA breakpoint sequences.

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Introduction: We evaluated determinants associated with care partner outcomes along the Alzheimer's disease (AD) stages.

Methods: We included = 270 care partners of amyloid-positive patients in the pre-dementia and dementia stages of AD. Using linear regression analysis, we examined determinants of four care partner outcomes: informal care time, caregiver distress, depression, and quality of life (QoL).

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Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.

Nat Genet

November 2022

Center for Data Sciences, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups.

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Background: Currently, there is limited evidence about the long-term impact on physical, social and emotional functioning, i.e. health-related quality of life (HRQL) after mild or moderate COVID-19 not requiring hospitalization.

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Background: In patients with rheumatoid arthritis (RA) different joints were shown to share the same dominant T-cell clones, suggesting shared characteristics of the inflammatory process and indicating that strategies to selectively target the antigen receptor might be feasible. Since T- and B-lymphocytes closely interact in adaptive responses, we analysed to what extent different joints also share dominant B-cell clones.

Methods: In 11 RA patients, quantitative B-cell receptor (BCR) repertoire analysis was performed in simultaneously obtained samples from inflamed synovial tissue (ST) from distinct locations within one joint, from multiple joints, from synovial fluid (SF) and peripheral blood (PB).

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Background Idiopathic ventricular fibrillation (IVF) is diagnosed in patients with ventricular fibrillation of which the origin is not identified after extensive evaluations. Recent studies suggest an association between mitral annulus disjunction (MAD), mitral valve prolapse (MVP), and ventricular arrhythmias. The prevalence of MAD and MVP in patients with IVF in this regard is not well established.

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Background: Surgery for perihilar cholangiocarcinoma (PHCC) remains a challenging procedure with high morbidity and mortality. The Academic Medical Center (Amsterdam UMC) and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score (POMRS) and post-hepatectomy liver failure score (PHLFS) to predict patient outcomes. This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University.

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Background: Atopic dermatitis (AD or eczema) is a most common chronic skin disease. Designing personalised treatment strategies for AD based on patient stratification is of high clinical relevance, given a considerable variation in the clinical phenotype and responses to treatments among patients. It has been hypothesised that the measurement of biomarkers could help predict therapeutic responses for individual patients.

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Detection of bladder cancer with feature fusion, transfer learning and CapsNets.

Artif Intell Med

April 2022

CMEMS-UMinho Research Unit, University of Minho, Campus Azurém, 4800-058 Guimarães, Portugal; LABBELS -Associate Laboratory, Braga, Guimarães, Portugal. Electronic address:

This paper confronts two approaches to classify bladder lesions shown in white light cystoscopy images when using small datasets: the classical one, where handcrafted-based features feed pattern recognition systems and the modern deep learning-based (DL) approach. In between, there are alternative DL models that had not received wide attention from the scientific community, even though they can be more appropriate for small datasets such as the human brain motivated capsule neural networks (CapsNets). However, CapsNets have not yet matured hence presenting lower performances than the most classic DL models.

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Article Synopsis
  • The study aimed to create and validate a new subscale for the Child Behavior CheckList (CBCL) to help screen for Autism Spectrum Disorder (ASD) in children, considering differences in gender and age.
  • The researchers used both data-driven methods and expert clinician opinions, comparing these new findings to established CBCL profiles and DSM subscales.
  • While the overall effectiveness of the subscales was low in independent samples, the data-driven subscale showed the most promise for ASD screening, suggesting further validation is beneficial for clinical practice.
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Background: In a flipped classroom, students acquire knowledge before class and deepen and apply this knowledge during class. This way, lower-order learning goals are achieved before class and higher-order skills are reached during class. This study aims to provide an overview of the factors that contribute to the effectiveness of the flipped classroom and how these factors can be stimulated.

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Background: With advances in sequencing technologies, increasing numbers of people are being informed about a genetic disease identified in their family. In current practice, probands (the first person in a family in whom a genetic predisposition is identified) are asked to inform at-risk relatives about the diagnosis. However, previous research has shown that relatives are sometimes not informed due to barriers such as family conflicts.

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Pregnancy in women with Brugada syndrome: Is there an increased arrhythmia risk? A case-series report.

J Cardiovasc Electrophysiol

January 2022

Amsterdam University Medical Centers, Location AMC, Member of European Reference Network GUARD-Heart, University of Amsterdam, Amsterdam, The Netherlands.

Introduction: In some rare arrhythmia syndromes, arrhythmia risk in female patients increases during pregnancy, necessitating extra controls. We wanted to evaluate if the increased risk for arrhythmia during pregnancy applies in women with Brugada syndrome and their potentially affected fetuses.

Methods: A comprehensive literature search was performed on PubMed (MeSH search terms "Brugada syndrome," "pregnancy," "parturition," "labor," "delivery," "fetal death," and "stillbirth").

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Objectives: To update the EULAR points to consider (PtCs) on the use of immunomodulatory therapies in COVID-19.

Methods: According to the EULAR standardised operating procedures, a systematic literature review up to 14 July 2021 was conducted and followed by a consensus meeting of an international multidisciplinary task force. The new statements were consolidated by formal voting.

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