84 results match your criteria: "AMC Heart Center[Affiliation]"
Graph neural networks for automatic extraction and labeling of the coronary artery tree in CT angiography.
J Med Imaging (Bellingham)
May 2024
Amsterdam University Medical Center location University of Amsterdam, Department of Biomedical Engineering and Physics, Amsterdam, The Netherlands.
Purpose: Automatic comprehensive reporting of coronary artery disease (CAD) requires anatomical localization of the coronary artery pathologies. To address this, we propose a fully automatic method for extraction and anatomical labeling of the coronary artery tree using deep learning.
Approach: We include coronary CT angiography (CCTA) scans of 104 patients from two hospitals.
In-hospital mortality of patients with acute coronary syndrome (ACS) after implementation of national health insurance (NHI) in Indonesia.
BMC Health Serv Res
March 2024
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Article Synopsis
- The National Health Insurance (NHI) was introduced in Indonesia in 2014, leading to a significant increase in the number of patients with acute coronary syndrome (ACS) receiving hospital care, as seen in a study comparing pre- and post-NHI implementation data.
- The study found that NHI users skyrocketed from 20.1% to 95.6%, and ACS admissions increased over threefold, with more patients receiving invasive treatments for heart conditions.
- Notably, there was a 50.8% reduction in in-hospital mortality rates among ACS patients after NHI implementation, suggesting that universal health coverage may greatly enhance cardiovascular care and patient outcomes in Indonesia.
Deep learning-based detection of functionally significant stenosis in coronary CT angiography.
Front Cardiovasc Med
November 2022
Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Patients with intermediate anatomical degree of coronary artery stenosis require determination of its functional significance. Currently, the reference standard for determining the functional significance of a stenosis is invasive measurement of the fractional flow reserve (FFR), which is associated with high cost and patient burden. To address these drawbacks, FFR can be predicted non-invasively from a coronary CT angiography (CCTA) scan.
View Article and Find Full Text PDFStent-Save a Life international survey on the practice of primary percutaneous coronary intervention during the COVID-19 pandemic.
Rev Port Cardiol
March 2022
SSL Co-chairman, Academisch Medisch Centrum Universiteit van Amsterdam - AMC Heart Center, Amsterdam, Netherlands.
Article Synopsis
- The study aimed to evaluate how the COVID-19 pandemic affected patient admissions for acute coronary syndromes (ACS) and primary percutaneous coronary intervention (PPCI) in countries involved in the Stent-Save a Life (SSL) initiative.
- Data was collected from 17 out of 32 participating countries during March and April 2020 and compared to the same period in 2019, revealing a 27.5% reduction in ACS admissions, a 20% decrease in STEMI cases, and a 26.7% drop in PPCI procedures.
- The findings indicate that the pandemic significantly impacted hospital admissions for heart-related conditions due to both patient-related hesitations and healthcare system challenges.
ALPK3: a full spectrum cardiomyopathy gene?
Eur Heart J
August 2021
Department of Experimental Cardiology, Amsterdam UMC, AMC Heart Center, Amsterdam, The Netherlands.
Common genetic variants and modifiable risk factors underpin hypertrophic cardiomyopathy susceptibility and expressivity.
Nat Genet
February 2021
Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.
Hypertrophic cardiomyopathy (HCM) is a common, serious, genetic heart disorder. Rare pathogenic variants in sarcomere genes cause HCM, but with unexplained phenotypic heterogeneity. Moreover, most patients do not carry such variants.
View Article and Find Full Text PDFIlluminating the path from genetics to clinical outcome in Brugada syndrome.
Eur Heart J
March 2021
Department of Experimental Cardiology, Amsterdam UMC, AMC Heart Center, Amsterdam, The Netherlands.
Inter-observer differences in interpretation of coronary pressure-wire pullback data by non-expert interventional cardiologists.
Cardiovasc Interv Ther
July 2021
Hammersmith Hospital, Imperial College London, London, UK.
Article Synopsis
- - The study analyzed how non-expert interventional cardiologists interpret pressure-wire (PW)-pullback data for coronary artery disease, focusing on the consistency of their classifications of disease patterns as either focal or diffuse.
- - A total of 10 non-expert doctors were evaluated against expert consensus, showing their agreement ranged from 69.1% to 85.0%, with no significant difference based on years of experience but notable differences tied to the volume of the medical center they worked in.
- - Non-experts from high-volume centers had a higher accuracy rate (82.7%) compared to those from low-volume centers (75.1%), indicating that interpretation of PW-pullback data among non-experts is quite subjective
The Impact of a Chronic Total Coronary Occlusion on Outcomes of Patients With an Implantable Cardioverter Defibrillator: Insights From the EXPLORE Trial.
J Invasive Cardiol
March 2020
Amsterdam UMC, AMC Heart Center, Department of Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Article Synopsis
- - A study within the EXPLORE trial looked at patients who received implantable cardioverter-defibrillators (ICDs) over five years, specifically focusing on those with chronic total occlusion (CTO) in their coronary arteries.
- - Out of 22 ICD patients, only one in the CTO-PCI (the group that underwent intervention) received appropriate ICD therapy, while those with CTO showed a higher risk of adverse cardiac events (32% vs. 10%) and death (18% vs. 6%) compared to non-ICD patients.
- - The findings indicate that ICD patients with CTO are at a greater risk for serious health issues, leading to questions about the overall benefit of implantation in this group
Adherence to guideline recommendations for coronary angiography in a poor South-East Asian setting: Impact on short- and medium-term clinical outcomes.
Sci Rep
December 2019
Department of Cardio-thoracic Surgery, AMC Heart Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
In South-East Asian populations and particularly in Indonesia, access to coronary angiography (CAG) is limited. We aimed to assess the adherence for undergoing CAG for indicated patients, according to the guideline recommendations. We then examined whether this adherence would have an impact on patients' short- and medium-term mortality and morbidity.
View Article and Find Full Text PDFScientists on the Spot: The complex inheritance of cardiac disorders.
Cardiovasc Res
January 2020
Amsterdam UMC, AMC Heart Center, Department of Clinical & Experimental Cardiology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Sex Differences in Instantaneous Wave-Free Ratio or Fractional Flow Reserve-Guided Revascularization Strategy.
JACC Cardiovasc Interv
October 2019
Hammersmith Hospital, Imperial College London, London, United Kingdom.
Objectives: This study sought to evaluate sex differences in procedural characteristics and clinical outcomes of instantaneous wave-free ratio (iFR)- and fractional flow reserve (FFR)-guided revascularization strategies.
Background: An iFR-guided strategy has shown a lower revascularization rate than an FFR-guided strategy, without differences in clinical outcomes.
Methods: This is a post hoc analysis of the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate stenosis to guide Revascularization) study, in which 601 women and 1,891 men were randomized to iFR- or FFR-guided strategy.
Attenuated cardiac function degradation in ex vivo pig hearts.
Int J Artif Organs
March 2020
Department of Cardiothoracic Surgery, AMC Heart Center, Amsterdam University Medical Center-Location AMC, Amsterdam, The Netherlands.
Article Synopsis
- Isolated porcine hearts were used to study heart function without in vivo interference, focusing on how to delay the loss of cardiac performance and edema over time through optimal blood control methods.
- The research involved a control group and a hemodialysis group, where hemodialysis significantly reduced the degradation of cardiac pump function and output, showing better stability in blood parameters compared to the control group.
- The findings suggest that combining blood predilution with hemodialysis not only improved electrolyte and metabolic conditions but also enhanced oxygen transport, mitigating the negative effects of edema and preserving cardiac function longer.
Beyond the One Gene-One Disease Paradigm: Complex Genetics and Pleiotropy in Inheritable Cardiac Disorders.
Circulation
August 2019
Leon H. Charney Division of Cardiology (M.C., M.D.), NYU School of Medicine, New York.
Article Synopsis
- Inheritable cardiac disorders, like hypertrophic cardiomyopathy and long-QT syndrome, increase the risk of sudden death in young people due to their genetic factors.
- Recent studies indicate that most of these disorders have a complex genetic basis, involving multiple genetic variants rather than being caused by a single gene mutation.
- The review highlights two key phenomena: multiple genes contributing to a single genetic condition and one gene affecting various unrelated conditions, using cases like long-QT syndrome and specific genes such as SCN5A and PKP2 as examples.
Comparison of Major Adverse Cardiac Events Between Instantaneous Wave-Free Ratio and Fractional Flow Reserve-Guided Strategy in Patients With or Without Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial.
JAMA Cardiol
September 2019
Hammersmith Hospital, Imperial College London, London, England.
Importance: Invasive physiologic indices such as fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are used in clinical practice. Nevertheless, comparative prognostic outcomes of iFR-guided and FFR-guided treatment in patients with type 2 diabetes have not yet been fully investigated.
Objective: To compare 1-year clinical outcomes of iFR-guided or FFR-guided treatment in patients with and without diabetes in the Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularization (DEFINE-FLAIR) trial.
Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis.
Heart
November 2019
Heart Institute, University of Ottawa, Ottawa, Canada.
Objective: Contemporary data on patients with previously undiagnosed severe aortic stenosis (AS) are scarce. We aimed to address this gap by gathering data from consecutive patients diagnosed with severe AS on echocardiography.
Methods: This was a prospective, multicentre, multinational, registry in 23 tertiary care hospitals across 9 European countries.
Outcomes of bioresorbable vascular scaffolds versus everolimus-eluting stents by coronary complexity: a sub-analysis of the AIDA trial.
EuroIntervention
December 2020
Amsterdam UMC and AMC Heart Center, University of Amsterdam, Amsterdam, the Netherlands.
Aims: We aimed to evaluate the impact of the complexity of coronary disease as assessed by the SYNTAX score (SXscore) on the clinical outcomes in the AIDA trial.
Methods And Results: In the AIDA trial, we compared Absorb versus XIENCE in routine clinical practice. Clinical outcomes were stratified by SXscore tertiles: SXlow (SXscore ≤8), SXmid (SXscore >8 and ≤15) and SXhigh (>15).
NVVC/NHJ Durrer prizes 2018.
Neth Heart J
May 2019
AMC Heart Center, Amsterdam UMC, location AMC , Amsterdam, The Netherlands.
Response by Wilde and Gollob to Letter Regarding Article, "Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome".
Circulation
April 2019
Department of Physiology and Department of Medicine, Toronto General Hospital, University of Toronto, ON, Canada (M.H.G.).
Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.
Circ Genom Precis Med
April 2019
Institute of Cardiovascular Science, Faculty of Population Health Science (R.S.P., A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A.).
Article Synopsis
- The study investigated the genetic variant rs1333049 at chromosome 9p21 to see its impact on subsequent coronary heart disease (CHD) events in over 100,000 Europeans with existing CHD.
- Results indicated no significant association between the variant and the risk of CHD death or myocardial infarction among those already diagnosed, contrasting with a strong link found in a separate group of CHD cases compared to healthy controls.
- There was a slight positive correlation found between the variant and subsequent revascularization procedures, suggesting some potential role in this specific outcome, but overall, the variant did not predict acute CHD events for those already affected.
Subsequent Event Risk in Individuals With Established Coronary Heart Disease.
Circ Genom Precis Med
April 2019
Institute of Health Informatics (N.F., A. Timmis, H.H., F.W.A.), Faculty of Population Health Science, University College London, United Kingdom.
Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.
Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.
Role of the Purkinje system in heritable arrhythmias.
Heart Rhythm
July 2019
Department of Pharmacology, Columbia University Medical Center, New York, New York. Electronic address:
Much has been written about arrhythmias in structurally normal hearts. In this review, we focus on rapid ventricular arrhythmias that occur in hearts having a pathogenic genetic variant that has been found in families in which arrhythmias occur. We discuss these mutations in terms of their effect on cardiac cell electrical function and initiation of arrhythmias.
View Article and Find Full Text PDFBackground: Physicians are not always comfortable deferring treatment of a stenosis in the left anterior descending (LAD) artery because of the perception that there is a high risk of major adverse cardiac events (MACE). The authors describe, using the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) trial, MACE rates when LAD lesions are deferred, guided by physiological assessment using fractional flow reserve (FFR) or the instantaneous wave-free ratio (iFR).
Objectives: The purpose of this study was to establish the safety of deferring treatment in the LAD using FFR or iFR within the DEFINE-FLAIR trial.
Relationship between FFR, CFR and coronary microvascular resistance - Practical implications for FFR-guided percutaneous coronary intervention.
PLoS One
September 2019
CREATIS, INSERM U1206, Université Lyon 1, INSA Lyon, Villeurbanne, France.
Article Synopsis
- The study aimed to explain the physiological factors influencing Fractional Flow Reserve (FFR), clarify the conflicting results often seen between FFR and Coronary Flow Reserve (CFR), and underscore the importance of using both metrics in clinical decisions related to heart disease.
- FFR was analyzed in relation to key pressures and resistance in the coronary arteries, with validation through extensive datasets of lesions before and after procedures.
- Results indicated that both hyperemic coronary microvascular resistance and pressure loss significantly affect FFR, and the strong correlation between CFR and FFR suggests that using both measures can enhance decision-making for patients undergoing procedures like Percutaneous Coronary Intervention (PCI).
The modular cardiac rhythm management system: the EMPOWER leadless pacemaker and the EMBLEM subcutaneous ICD.
Herzschrittmacherther Elektrophysiol
December 2018
Boston Scientific Corporation, St. Paul, MN, USA.
Article Synopsis
- Cardiac devices have been effectively managing heart rhythm issues for years, but complications, particularly from transvenous leads, still exist.
- New technologies like the subcutaneous implantable cardioverter-defibrillator (S-ICD) and leadless cardiac pacemakers (LCP) aim to reduce these complications.
- The innovative modular cardiac rhythm management (mCRM) system combines LCP and S-ICD, offering wireless communication for better coordination in therapy delivery.