Lactation Support Services in Level III Neonatal Intensive Care Units in Canada.

Introduction: Lactation support services can improve exclusive breastfeeding rates among infants in the neonatal intensive care unit (NICU). There are limited data on how many NICUs offer these services.

Objective: To assess prevalence and type of lactation services provided in level III Canadian NICUs.

Integrating Community-Based Doulas into the Maternity Health Care System in an Urban Hospital.

Background: Maternal morbidity and mortality in the United States are higher than peer countries. These adverse events disproportionally affect Black women.

Local Problem: Rates of maternal morbidity and mortality among Black childbearing women in West Louisville, Kentucky are higher than rates in Kentucky and the United States.

Public Health.

Background: Observational studies have reported cognitive domain alterations in individuals with Type 2 diabetes mellitus (T2D), affecting cognitive domains of information-processing speed, memory, attention, and executive function. Epidemiological observational studies have shown an association between higher blood pressure [HBP], low processing speed, short-term memory and learning, and delayed recall. Within the US Hispanic/Latino population, specifically Mexican Americans, cognition remains insufficiently studied.

Biomarkers.

Background: Less adequate cardiorespiratory fitness (CRF) is associated with several aspects of Alzheimer's disease (AD) pathology, including neuroinflammation, neurodegeneration and synaptic dysfunction, all of which are known contributors to the clinical outcome - progressive cognitive decline [1]. AD-associated biomolecular changes also seem to be attenuated in carriers of the functionally advantageous variant of the KLOTHO gene (KL-VS) [2]. While KL-VS and CRF both appear to mitigate aspects of AD pathology, they have been exclusively studied in isolation.

Could New Palm-Free Structured Lipids Mitigate Postprandial Hyperlipidemia and Inflammation Induced by High-Fat Meals in Swiss Mice?

A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants. We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.

Evaluating Minimal Residual Disease Negativity as a Surrogate Endpoint for Treatment Efficacy in Multiple Myeloma: A Meta-Analysis of Randomized Controlled Trials.

This meta-analysis examined the association between minimal residual disease (MRD) negativity and survival outcomes in 15 304 patients with multiple myeloma (MM) enrolled in randomized controlled trials published until June 2, 2024. Overall, there was a significant, negative and strong association between MRD negativity odds ratios and survival hazard ratios (β_PFS = -0.20, p < 0.

Role of a Whole Plant Foods Diet in Breast Cancer Prevention and Survival.

Breast cancer (BC) is one of the leading causes of death and morbidity among women worldwide. Epidemiologic evidence shows that the risk of BC and other chronic diseases decreases as the proportion of whole plant foods increases, while the proportion of animal foods (fish, meat, poultry, eggs, seafood, and dairy products) and non-whole plant foods (e.g.

Anti-Obesogenic and Antioxidant Potential of Lychee Seed Flour in Zebrafish Fed a High-Fat Diet.

Objective: Obesity has become one of the major public health issues and is associated with various comorbidities, including type 2 diabetes mellitus, dyslipidemia, and hypertension. Lychee seeds are considered promising ingredients for developing functional foods owing to their nutraceutical properties and phytochemical composition. This study aimed to induce obesity in zebrafish () through a hyperlipidic diet supplemented with different concentrations of lychee seed flour and to evaluate its effects on adipose tissue, biochemical parameters, oxidative stress, and caudal fin regeneration.

Permanent Nanobubbles in Water: Liquefied Hollow Carbon Spheres Break the Limiting Diffusion Current of Oxygen Reduction Reaction.

Porous liquids have traditionally been designed with sterically hindered solvents. Alternatively, recent efforts rely on dispersing microporous frameworks in simpler solvents like water. Here we report a unique strategy to construct macroporous water by selectively incorporating hydrophilicity on the surfaces of hydrophobic hollow carbon spheres (HCS).

Effect of Mediterranean Diets on Cardiovascular Risk Factors and Disease in Overweight and Obese Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

We systematically evaluated effects of Mediterranean diets (MED) on cardiovascular (CV) disease and risk factors in overweight or obese adults. Five engines and two registries were searched until October 2023 for randomized controlled trials (RCTs) evaluating any type of MED compared to other diets or advice in adults. Outcomes of interest were clinical outcomes and CV risk factors (anthropometric, lipids, blood pressure, glucose metabolism, liver function).

Risk of Raynaud's Phenomenon Among Workers in the Occupational Disease Surveillance System.

Introduction: Raynaud's phenomenon (RP) is linked to occupational exposures such as vibration, cold temperature, and chemicals. However, large cohort studies examining RP by occupation and sex are scarce. To address this gap, this study aimed to assess risk of RP by both occupation and sex in a large cohort of workers in Ontario, Canada.

Engineering carbon assimilation in plants.

Carbon assimilation is a crucial part of the photosynthetic process, wherein inorganic carbon, typically in the form of CO, is converted into organic compounds by living organisms, including plants, algae, and a subset of bacteria. Although several carbon fixation pathways have been elucidated, the Calvin-Benson-Bassham (CBB) cycle remains fundamental to carbon metabolism, playing a pivotal role in the biosynthesis of starch and sucrose in plants, algae, and cyanobacteria. However, Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), the key carboxylase enzyme of the CBB cycle, exhibits low kinetic efficiency, low substrate specificity, and high temperature sensitivity, all of which have the potential to limit flux through this pathway.

How Do Common Marmosets Maintain the Balance Between Response Execution and Action Inhibition?

Socio-dynamic situations require a balance between response execution and action inhibition. Nonadaptive imbalance between response inhibition and execution exists in neurodevelopmental and neuropsychological disorders. To investigate the underlying neural mechanisms of cognitive control and the related deficits, comparative studies in human and nonhuman primates are crucial.

Developing Topics.

Background: Evidence suggests that a history of reduced estrogen exposure associates with greater Alzheimer's disease (AD) risk. However, the association of sex hormone levels with AD biomarkers has not been studied. We examined plasma levels of sex hormones in males and females with autosomal dominant AD due to the E280A Presenilin-1 mutation and age-matched non-carriers, and their relationship to AD brain pathology.

Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats.

Background: Traumatic spinal cord injury (SCI) is an incurable condition that is the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain unknown.

Methods: STVNa was given intraperitoneally after SCI to see if it had any neuroprotective benefits.

Developing Topics.

Background: Extensive research on the cerebral cortex and the hippocampus has improved our understanding of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Historically, however, the cerebellum's role in these stages of cognitive decline has been traditionally neglected due to its associations with motor function. Recent research has demonstrated cerebellar structural and connectivity differences in MCI and AD.

Alzheimer's Imaging Consortium.

Background: Older females, particularly susceptible to Alzheimer's disease (AD), may be affected by hormonal fluctuation during life. We aim to investigate the relationship between changes in brain volume and sex steroid hormones over time. We hypothesize that levels of sex hormones (17ß-estradiol, progesterone, and testosterone) relate to changes in brain volume, especially in the hippocampus (HPC) and cerebellum (CB).

Cardiopulmonary Exercise Test Interpretation Across the Lifespan in Congenital Heart Disease: A Scientific Statement From the American Heart Association.

Survivorship from congenital heart disease has improved rapidly secondary to advances in surgical and medical management. Because these patients are living longer, treatment and disease surveillance targets have shifted toward enhancing quality of life and functional status. Cardiopulmonary exercise testing is a valuable tool for assessing functional capacity, evaluating cardiac and pulmonary pathology, and providing guidance on prognosis and interventional recommendations.

Alzheimer's Imaging Consortium.

Background: Our studies show that the small non-coding RNA, mir20a-3p, is neuroprotective for stroke in the acute phase and also attenuates long term cognitive decline in middle-aged female rats. Cognitive decline due to vascular diseases, such as stroke, is associated with secondary neurodegeneration in cortex and limbic structures. In this study, we assessed the volume of white matter, ventricles and regional diffusion-weighted MR imaging measures to delineate pathological tissue characteristics from the postmortem brain of stroke rats.