1 results match your criteria: "AL Fenway Institute[Affiliation]"
Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial.
Medicine (Baltimore)
July 2016
University of Pittsburgh Magee-Womens Research Institute, Pittsburgh, PA Alpha StatConsult LLC, Damascus Johns Hopkins University, Baltimore, MD University of Alabama at Birmingham, Birmingham, AL Fenway Institute, Boston, MA FHI 360, Durham, NC International Partnership for Microbicides, Silver Spring, MD, USA.
Background: The ex vivo challenge assay is a bio-indicator of drug efficacy and was utilized in this randomized, placebo controlled trial as one of the exploratory endpoints. Fresh and cryopreserved tissues were evaluated for human immunodeficiency virus (HIV) infection and pharmacokinetic (PK)/pharmacodynamic (PD) relationships.
Methods: HIV-negative women used vaginal rings containing 25 mg dapivirine (DPV)/100 mg maraviroc (MVC) (n = 12), DPV only (n = 12), MVC only (n = 12), or placebo (n = 12) for 28 days.