Metabolic dysfunction-associated steatotic liver disease and type 2 diabetes: A dual threat to cardiac dysfunction progression.

Metabolic dysfunction-associated steatotic liver disease (MASLD), particularly in patients with type 2 diabetes mellitus (T2DM), is increasingly recognized as a multi-system disease that affects both hepatic and cardiovascular health. This study explores the association between MASLD-related liver fibrosis and cardiac dysfunction, focusing on how liver fibrosis contributes to cardiac remodeling and dysfunction. Cernea 's research highlights the strong correlation between liver fibrosis and changes in left ventricular mass, left atrial dimensions, and systolic and diastolic function in diabetic patients.

Demographic trends in mortality with older population due to atrial fibrillation and flutter from 1999-2020.

Atrial fibrillation (AF)/atrial flutter (AFL) is the most common sustained cardiac arrhythmia. The known risk factors for developing AF/AFL include age, structural heart disease, hypertension, diabetes mellitus, or hyperthyroidism. This study aims to attribute the trends in AF/AFL-related mortalities over the past two decades 1999-2020 concerning race and sex and disparity among them.

Hypothyroidism Due to Thyroid Amyloidosis Simultaneously With AL Renal Amyloidosis to Give Better Idea of Association of the Two Conditions.

Primary amyloidosis (AL type) is a systemic disease that can lead to structural and functional damage to organs and tissues such as the kidney, heart and liver with non-specific symptoms. Most of the affected patients develop thyroid infiltration and thus diffuse enlargement of the thyroid gland, while cases leading to hypothyroidism are exceedingly rare. Some researchers have analyzed thyroid function in newly diagnosed patients with AL amyloidosis, and found that the incidence of overt hypothyroidism is only 7%.

Coming home: how visually navigating ants (Myrmecia spp.) pinpoint their nest.

Visually navigating Myrmecia foragers approach their nest from distances up to 25 m along well-directed paths, even from locations they have never been before ( Narendra et al., 2013). However, close to the nest, they often spend some time pinpointing the nest entrance, sometimes missing it by centimetres.

Sorting Out the SOCS Genes and Their Role in Macrophage Activation.

The suppressors of cytokine signaling (SOCS) genes were first described in a group of articles published in 1997. Since that time, much has been learned about the functional activities mediated by the corresponding proteins encoded by the SOCS genes. The SOCS gene family contains eight members: through and a highly related gene known as (cytokine-inducible SH2-containing protein).

Comparison of 3 methods of quantification of phenobarbital in canine plasma: high-performance liquid chromatography, a point-of-care immunoassay, and the FDA-approved immunoassay analyzer.

Phenobarbital is a common antiseizure medication that has a relatively narrow therapeutic window. Therapeutic drug monitoring (TDM) is a helpful tool to guide dose adjustments for phenobarbital and avoid its toxicity. We investigated the agreement among 3 methods of quantifying phenobarbital in canine plasma: high-performance liquid chromatography (HPLC), point-of-care (POC) testing, and the FDA-approved immunoassay analyzer.

High Entropy Fine-Tuning Achieves Fast Li Kinetics in High-Performance Co-Free High-Ni Layered Cathodes.

Co-free high-Ni layered cathode materials LiNiMeO (Me = Mn, Mg, Al, etc.) are a key part of the next-generation high-energy lithium-ion batteries (LIBs) due to their high specific capacity and low cost. However, the hindered Li kinetics and the high reactivity of Ni result in poor rate performance and unsatisfied cycling stability.

The Mediating Role of Teachers' Self-Efficacy in the Relationship Between Their Attitudes Toward School Bullying and Their Handling of Bullying Situations: A Study From Jordan.

Previous literature indicates that even when teachers hold antibullying attitudes, they may fail to intervene, suggesting that self-efficacy is essential for successful intervention. This study explored the mediating role of self-efficacy in the relationship between attitudes toward bullying and intervention efforts among teachers. A cross-sectional, mediational design was used with a convenience sample of 567 Jordanian teachers teaching students aged 12 to 17.

Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes.

Background: Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness is often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), a macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance.

Objective: This study aimed to evaluate the potentiation of DOX and its effectiveness against the MCF-7 breast cancer cell line by encapsulating both DOX and CAM in PEGylated liposomes.

Orbital textiloma: Two case reports and a literature review.

Purpose: This report presents two cases of orbital textiloma resulting from retained surgical gauze.

Case Description: Both patients presented with postoperative orbital inflammation unresponsive to medical treatment: one eight weeks after excision of an orbital cavernous hemangioma, and the other six months following surgical repair of an orbital floor fracture. CT scans of the orbit revealed well-defined lesions with a heterogeneous center.

Impact of frailty and comorbidity on initial response to lung cancer screening invitation and low-dose CT screening uptake: Findings from the Yorkshire Lung Screening Trial.

Background: Low-dose computed tomography screening reduces lung cancer-specific mortality in high-risk individuals. Lung cancer risk factors overlap with comorbid diseases, highlighting the significance of frailty and comorbidities for lung cancer screening (LCS). Here, we describe the prevalence of frailty and comorbidity in those invited for LCS and evaluate their associations with response to telephone risk assessment invitation and subsequent uptake of LCS.

Design of Litchi-Like Al/PTFE with Superior Reactivity and Application in Solid Propellants.

The combustion efficiency and reactivity of aluminum (Al) particles, as a crucial component in solid propellants, are constrained by the inert oxide layer aluminum oxide (AlO). Polytetrafluoroethylene (PTFE) can remove the oxide layer, however, carbon deposition generated during the reaction process still limits the reaction efficiency of Al/PTFE fuel. Here, a litchi-like Al/PTFE fuel with the nano-PTFE islands distributed on the Al particles surface is successfully designed, based on localized activation and synergistic reaction strategies, to solve the AlO layer and carbon deposition.

Generating Beta Zeolite Nanosheets of Intergrown Polymorph B and C Using Polycationic Structure-Directing Agent.

Zeolitic nanosheets possess great potential in catalysis due to their enhanced transport property and accessibility toward bulky molecules compared to conventional micron- meter scale crystals. However, the generation of Beta zeolite nanosheets, which are crucial for industrial catalysis, is still challenging for its intergrowth nature. In this work, aluminosilicate Beta nanosheets of ca.

The VA Million Veteran Program, Alzheimer's disease, and genetics: Important steps forward but many steps still to go on the march to control dementia and Alzheimer's disease.

The VA Million Veteran Program (MVP) is a nationwide initiative that seeks to examine how genes influence health and behaviors in military veterans. An article by Merritt et al. analyzing data from the MVP, developing and testing algorithms to query dementia and Alzheimer's disease (AD) diagnoses from the VA's electronic health record system and examining genetic factors, provides an extraordinarily important contribution to the dementia and AD fields.

Effect of one-week New Zealand blackcurrant extract on rowing performance and cognitive function in National team male rowers.

This research investigated the impact of New Zealand blackcurrant (NZBC) on 2000-meter rowing ergometer performance and cognitive abilities. Nine trained male rowers from Iran's national team participated in a double-blind, placebo-controlled crossover study, undergoing three sessions with NZBC (600 mg∙day-1), placebo (PL), and control (CL) treatments over seven days, followed by a 14-day washout period. Participants completed a 2000-meter ergometer test provided self-reported ratings of perceived exertion (RPE) and completed a cognitive function assessment five minutes following the rowing exercise.

Early achievement of hemostasis defined by transfusion velocity: A possible mechanism for whole blood survival benefit.

Introduction: Whole blood resuscitation is associated with survival benefits in observational cohort studies. The mechanisms responsible for outcome benefits have not been adequately determined. We sought to characterize the achievement of hemostasis across patients receiving early whole blood versus component resuscitation.

Organic-Free Synthesis of High-Silica Zeolite Y with Aluminophosphate as the Aluminum Carrier.

The wide application of zeolite Y in petrochemical industry is well known as one of the milestones in zeolite chemistry and heterogeneous catalysis. However, the traditional organic-free synthesis typically produces (hydro)thermally unstable zeolite Y with Si/Al atomic ratio (SAR) less than 2.5.

The efficacy of pulsed radiofrequency ablation of the dorsal root ganglion in the setting of failed spinal neuromodulation: A case report.

Radiofrequency ablation (RFA) is an interventional procedure that has been used to treat chronic back pain for over 50 years; this unique case report demonstrates the effectiveness of pulsed radiofrequency ablation (PRFA) on the dorsal root ganglion (DRG) in the treatment of chronic radicular pain (Russo et al., 2021, J Pain Res, 14, 3897). The RFA provides pain relief by using thermal energy to disrupt peripheral nerves carrying nociceptive signals back to the central nervous system (Abd-Elsayed et al.