Postbiotics and Dental Caries: A Systematic Review.

Objective: This systematic review aimed to evaluate the current evidence regarding the impact of postbiotics on dental caries, focusing on the effectiveness of postbiotic interventions in caries prevention, mechanisms of action, optimal dosages, and administration protocols.

Methods: A literature search was conducted across PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library. Eligible studies included randomized controlled trials, quasi-experimental, observational, and in vitro studies.

Healthcare research and education: actively constructed research knowledge-a model for online systematic reviews and meta-analyses courses.

Employing a mixed-methods approach, this study: (a) scoped the literature for desirable characteristics of online learning environments; (b) analyzed and compared the available online systematic review and meta-analysis (SR/MA) courses; and (c) proposed an outline for a model online systematic review SR/MA course that is aligned with PRISMA principles, and (d) charted learning outcomes, module contents, interactive elements, feedback and module assessment, and course evaluation of the proposed course. The findings highlight the many distinctive aspects and design of the proposed model course, including its comprehensiveness, alignment with PRISMA principles, self-pace and self-direction, with high interactivity levels, augmented by the expert trainer guidance ('human' factor), and individualized feedback, and its conclusion with the incorporation of the learners in virtual research teams undertaking real SR/MA. The proposed model course integrates principles of problem-based learning, where in addition to the provided resources (interactive assignments and video tutorials), trainees will be actively conducting their own real SR/MA as part of the course, while receiving expert feedback to enhance learning outcomes.

Correlation of the anatomical variations of pancreatic blood vessels and occurrence of diseases of pancreas.

Objective: Aim: The research aims to confirm or reject the hypothesis on the possible relationship between the influence of changes in pancreatic vascular variations on the mechanisms of occurrence of pancreatic diseases based on the collected scientific literature..

Patients And Methods: Materials and Methods: The bibliosemantic, bibliographic, statistical research methods were used in the research.

Artificial Intelligence in Histopathology.

Artificial intelligence will be revolutionizing the healthcare in near future and is already being integrated in several areas. The utilization of artificial intelligence algorithms to extract quantitative information from full-slide histopathology images has been demonstrated in digital pathology. Artificial intelligence (AI) is anticipated to reduce the workload of pathologists, enhance the impartiality and uniformity of pathology reports, and impact treatment choices through the identification of concealed information within easily accessible data.

The Crucial Role of Smoking Cessation in Preventing Oral Cancer.

Oral cancer remains a significant public health concern globally, with smoking being a primary risk factor. Smoking cessation has been identified as a crucial intervention in reducing the incidence of oral cancer. This abstract reviews the impact of smoking cessation on oral cancer prevention, emphasizing the benefits of quitting smoking in decreasing the risk of developing oral malignancies.

Diagnosis and Management of Inferior Alveolar Nerve Injury Caused by Calcium Hydroxide Extrusion during Root Canal Treatment: Case Report.

This report highlights a rare occurrence of inferior alveolar nerve (IAN) injury resulting from calcium hydroxide extrusion during endodontic treatment. The patient experienced severe pain and paresthesia in the lower right lip following root canal treatment due to the inadvertent overflow of calcium hydroxide into the IAN canal. No surgical intervention was performed, and the patient received non-steroidal anti-inflammatory analgesics and vitamin B complex injections to manage the symptoms.

In Silico Molecular Docking of Phytochemicals: Targeting Key Biomarkers in Oral Cancer.

Background: Oral cancer is the sixth most common cancer occurring anywhere in the globe. Cancers of the mouth are caused by tobacco and alcohol overuse, and also between pre-malignancy and full-fledged malignancy. In order to avoid the onset of illness, proper cleanliness of the mouth is important.

Exploring the Role of β-Sitosterol, Genistein, and Emodin in Periodontal Regeneration.

The incidence rate of periodontal diseases is high, which affects the quality of life of patients, and is one of the main causes of adult dentition defects. Periodontal diseases cause the periodontal intraosseous defect. If not treated in time, it can lead to alveolar bone resorption and defect, periodontal attachment loss, teeth loosening, and complete tooth loss.

Unlocking the Therapeutic Benefits of Artemisia Annua: A Comprehensive Overview of its Medicinal Properties.

Artemisia annua L., also referred to as sweet wormwood, sweet annie, sweet sagewort, and annual wormwood (Chinese: qngho), is a species of wormwood native to temperate Asia but naturalised worldwide. It is a member of the Asteraceae family.

Prevention of Oral Cancer: A Comprehensive Guide.

Oral cancer remains a significant global health challenge, with high mortality rates largely due to late-stage diagnosis. Prevention strategies are crucial for reducing the incidence and improving outcomes. Key preventive measures include public education on risk factors such as tobacco use, alcohol consumption, and human papillomavirus (HPV) infection.

Periodontal Diagnosis in a Young Patient with an Unusual Presentation of Dental Calculus.

This report details the periodontal diagnosis and phase I treatment of an 18-year-old male patient dissatisfied with his teeth. The patient, on 20 mg Isotretinoin for acne, exhibited heavy calculus and plaque, generalized gingival inflammation, carious lesions, remaining roots, an anterior open bite, bilateral cross-bite, and an ectopically erupted tooth (#25). Initial scaling enabled examination, revealing FMPS and FMBS of 100%, PD of 1-7 mm, gingival recession of 1-2 mm, a maximum CAL of 6 mm, and radiographic bone loss of around 48% of teeth, reaching up to 15% of the root length.

Smoking and its Role in Oral Cancer.

Oral cancer remains a significant public health concern globally, with smoking identified as a primary risk factor. This abstract reviews the role of smoking in the etiology of oral cancer, emphasizing its contribution to carcinogenesis through the induction of genetic mutations, oxidative stress, and inflammation. Tobacco smoke contains carcinogenic compounds such as polycyclic aromatic hydrocarbons, nitrosamines, and heavy metals, which are implicated in the transformation of oral mucosal cells.

A Review on the Expanding Role of Dentists in Facial Esthetics.

Dentists' role in facial esthetics is growing, with advancements in cosmetic procedures, such as Botox and dermal fillers. Understanding the range of practitioners and their professional backgrounds is crucial for addressing risks. Data collection and analysis was done to retrieve scholarly papers using databases, such as PubMed and advanced Google search, and analyze.

Computational Studies on Recent Congeners of Fluoroquinolones and Nitroimidazoles for Their Use in Periodontal Therapy.

Background: Periodontitis is a slow progressing infection and has profound systemic implications. The influence of various therapeutic drugs to inhibit inflammation and promote bone regeneration has been studied. Introduction of newer congeners of older drugs necessitates testing the efficacy of newer drugs for the said use.

Silver Nanoparticles (AgNPs): Comprehensive Insights into Bio/Synthesis, Key Influencing Factors, Multifaceted Applications, and Toxicity-A 2024 Update.

Silver nanoparticles (AgNPs) are widely recognized for their unique optical, electronic, and antibacterial properties, enabling their use in biosensing, photonics, electronics, drug delivery, and antimicrobial treatments. Green chemistry-based biological synthesis methods offer an eco-friendly alternative to traditional chemical techniques. Among metallic nanoparticles (NPs) and metal oxides, those derived from plant extracts exhibit notable medicinal properties.

Translation, Adaptation, and Validation of the Professional Collaborative Practice Tool for Community Pharmacists and Physicians in Arabic-Speaking Countries.

Background: The importance of collaboration between physicians and community pharmacists in healthcare is increasingly recognized. Enhanced cooperation positively impacts medication management and patient outcomes by merging medical and pharmaceutical expertise for improved health care. Previously, the Professional Collaborative Practice Tool, which is crucial for assessing such collaboration, was unavailable in Arabic.

Facile and cost-effective NiO/MgO-SiO composites for efficient oxygen evolution reaction and asymmetric supercapacitor systems.

Biomass waste from grapefruit peel extract was used for the preparation of MgO-SiO composites in order to develop effective electrocatalytic composites based on NiO/MgO-SiO. The MgO-SiO composites were subsequently deposited with NiO using a modified hydrothermal method. The synthesized materials were analyzed to investigate their morphology, crystal structure, chemical composition, functional group, and optical band gap.

Effects of Dietary Fiber Interventions on Glycemic Control and Weight Management in Diabetes: A Systematic Review of Randomized Controlled Trials.

This systematic review explores the impact of dietary fiber interventions on glycemic control and weight management in individuals with diabetes or at risk for diabetes. A comprehensive search was conducted across PubMed, Embase, and Cochrane Library following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, identifying randomized controlled trials published in the last five years. Ten studies met the inclusion criteria, evaluating various types of dietary fiber, including soluble, insoluble, viscous fiber, and resistant starch.

Leveraging swin transformer with ensemble of deep learning model for cervical cancer screening using colposcopy images.

Cervical cancer (CC) is the leading cancer, which mainly affects women worldwide. It generally occurs from abnormal cell evolution in the cervix and a vital functional structure in the uterus. The importance of timely recognition cannot be overstated, which has led to various screening methods such as colposcopy, Human Papillomavirus (HPV) testing, and Pap smears to identify potential threats and enable early intervention.

Targeting CXCR2 signaling in inflammatory lung diseases: neutrophil-driven inflammation and emerging therapies.

Inflammatory lung diseases (ILDs) such as asthma, acute respiratory distress syndrome, bronchiectasis, chronic obstructive pulmonary disease, COVID-19, cystic fibrosis, and lung cancer impose a substantial worldwide healthcare impact. The pathophysiology of these disorders is primarily influenced by the involvement of neutrophils, which are crucial triggers in the natural immune reaction. Neutrophils participate in pulmonary inflammation and tissue destruction.

Capturing pharmacists' perspectives on the value, risks, and applications of ChatGPT in pharmacy practice: A qualitative study.

Objectives: To investigate the pharmacists' perspectives on benefits and risks of using ChatGPT in pharmacy practice and explore how this disruptive and ground-breaking technology can be effectively integrated.

Methods And Materials: A qualitative approach that draws data from licensed pharmacists using semi-structured interviews.

Results: Most participants felt ChatGPT could enhance the compliance, use, management, safety, adherence to medication, medication counseling, minimize medication errors, and streamline medication dispensing.

Sustainable healthcare futures: how digital leadership stimulates nurses' green creativity: a quasi-experimental study.

Background: In the context of increasing environmental consciousness, integrating sustainable practices in healthcare is essential. Nurses' green creativity, defined as their ability to generate innovative, eco-friendly solutions, is pivotal in this transformation. Digital leadership, which leverages technology to guide sustainable practices, plays a critical role in fostering this creativity among nurses.

In silico screening and molecular dynamics analysis of natural DHPS enzyme inhibitors targeting Acinetobacter baumannii.

Over time, antimicrobial agents are losing their credibility in curbing infections due to the development of resistant pathogen strains. The resistant strains have proven to invade living beings and cause various diseases, leading to deaths at an alarming rate. Acinetobacter baumannii is one such pathogen, and to target it through enzyme inhibition, Dihydropteroate synthase enzyme's active site is virtually screened for antimicrobial agents against in-house libraries of natural molecules from medicinally important plants and Agaricus spp.

piRNAs in leukemogenesis: Mechanisms, biomarkers, and therapeutic implications.

The small, non-coding RNAs known as piwi-interacting RNAs (piRNAs) serve essential roles in gene regulation by silencing transposable elements and protecting oncogenes and tumour suppressors. The production of piRNA bioactive forms uses precursor mRNAs, which team with Piwi proteins to support genome maintenance. Accurate leukaemia regulation requires piRNAs because abnormalities in these regulatory elements contribute to disease development and drug resistance progression.