Nanodiagnostics in global eradication of hepatitis C virus.

Hepatitis C, caused by the hepatitis C virus (HCV), is a prevalent liver disease with severe outcomes, including cirrhosis and hepatocellular carcinoma. Traditional diagnostic methods primarily detect antiviral antibodies (anti-HCV) or viral RNA, but these approaches have limitations. Anti-HCV antibodies may take 2-4 weeks to develop in acute cases and can be absent in some individuals, leading to undiagnosed early-stage infections.

Impact of COVID-19 on the Participation of Iranian Adolescents in Daily Life: Development and Validation of the IAPAT-C Tool.

: The present study is aimed at evaluating the effects of the COVID-19 pandemic on Iranian adolescents' participation in various domains of life. The electronic version of the Iranian Adolescent Participation Assessment Tool-COVID-19 (IAPAT-C) was developed and validated for this purpose. : This study was conducted in two phases.

Global landscape of vancomycin-resistant enterococci in hematopoietic stem-cell transplantation patients: a systematic review and meta-analysis.

Background: One of the main risks of infection after hematopoietic stem cell transplantation (HSCT) is infection by gram-positive bacteria, including vancomycin-resistant enterococci (VRE). Based on the format of a global review and meta-analysis study, this study aims to investigate the incidence of VRE bloodstream infection (BSI) after HSCT in colonized individuals.

Methods: The keywords of the systematic search included vancomycin-resistant enterococci and HSCT.

Long Non-Coding RNA and as a Promising Diagnostic and Prognostic Biomarker in Glioblastoma Multiforme.

Background: Glioblastoma multiforme (GBM) is one of the most invasive types of brain cancer. LncRNAs can be considered a new prognostic and diagnostic biomarker in GBM. This study comprehensively explored the interaction of lncRNAs with mRNAs in the TCGA database and proposed a novel promising biomarker with favorable diagnostic and prognostic values.

Evaluation of anti-viral photodynamic therapy effects of different concentrations of 5-ALA using light irradiation on HSV-1.

Background: Herpes simplex virus (HSV) infections are prevalent worldwide, posing challenges due to asymptomatic carriage and recurrent outbreaks. Conventional treatments, including antiviral medications, are limited by drug resistance. Photodynamic therapy (PDT) offers a promising alternative, leveraging photosensitizers to induce viral inactivation via reactive oxygen species (ROS) generation upon light activation.

Factors affecting the spiritual rehabilitation of people affected by natural disasters: a systematic review.

Background: Every year, natural disasters in many countries lead to the destruction of infrastructure, loss of assets, and harm to the physical, mental, social, and spiritual health of people. The attention of policymakers and the media is mostly focused on the reconstruction of damaged buildings and the physical rehabilitation and recovery of the injured, while the spiritual rehabilitation of the people affected is often neglected. This study aims to identify the factors influencing the spiritual rehabilitation of people affected by natural disasters.

The multiple roles of interferon regulatory factor family in health and disease.

Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors. These interactions allow IRFs to modulate a broad spectrum of physiological processes, encompassing host defense, immune response, and cell development.

Effects of zinc supplementation on sleep quality in humans: A systematic review of randomized controlled trials.

Background And Aims: Alternative therapies, such as zinc supplementation, have been explored as potential interventions for sleep disorders. However, the efficacy of zinc supplementation in improving sleep quality remains uncertain. This systematic review aims to examine the impacts of zinc supplementation on sleep quality in humans.

The Effect of Vitamin D Deficiency on Immune-Related Hub Genes: A Network Analysis Associated With Type 1 Diabetes.

Background Type 1 diabetes (T1D) is an autoimmune disorder that results in the destruction of pancreatic beta cells, causing a shortage of insulin secretion. The development of T1D is influenced by both genetic predisposition and environmental factors, such as vitamin D. This vitamin is known for its ability to regulate the immune system and has been associated with a decreased risk of T1D.

Evaluating the potential effects of apigenin on memory, anxiety, and social interaction amelioration after social isolation stress.

Vigorous research confirmed the anti-inflammatory, antioxidant, and antidementia effects of apigenin (Api). The present study evaluated the beneficial impacts of Api administration on behaviour, brain-derived neurotrophic factor (BDNF), Interleukin 6 (IL-6), oxidative stress, and inflammation induced by social isolation (SI) stress in rats. For this purpose, rats underwent a 28-day SI period followed by a 4-week oral Api treatment (50 mg/kg/day, PO).

Remdesivir in solid organ transplant recipients with COVID-19: a systematic review and meta-analysis.

Background: The use of remdesivir in solid organ transplant recipients (SOTRs) with coronavirus disease 2019 (COVID-19) has been studied. The present systematic review and analysis aimed to assess its effectiveness in this population.

Methods: A comprehensive search of PubMed, Cochrane Library, Web of Science, Embase, medRxiv, and Google Scholar was conducted to identify relevant articles published up to April 2024.

Ethical Considerations and Equipoise in Cancer Surgery.

The changing landscape of cancer surgery requires ongoing consideration of ethical issues to ensure patient-centered care and fair access to treatments. With technological advancements and the global expansion of surgical interventions, healthcare professionals must navigate complex ethical dilemmas related to patient autonomy, informed consent, and the impact of new technologies on the physician-patient relationship. Additionally, ethical principles and decision-making in oncology, especially in the context of genetic predisposition to breast cancer, highlight the importance of integrating patient knowledge, preferences, and alignment between goals and treatments.

Detailed pathological role of non-coding RNAs (ncRNAs) in regulating drug resistance of glioblastoma, and update.

Glioma is a kind of brain tumor that develops in the central nervous system and is classified based on its histology and molecular genetic features. The lifespan of patients does not exceed 22 months. One of the motives for the low effectiveness of glioma treatment is its radioresistance and chemoresistance.

Blue light emitting graphene quantum dots/ Rhodamine B doped gold nanostars for ratiometric detection of methotrexate.

In this work, an innovative ratiometric sensing platform was developed for the determination of methotrexate (MTX), an antifolate drug, a chemotherapy agent, and an immune system suppressant based on blue emission graphene quantum dots/Rhodamine B doped gold nanostars (B-GQDs/Au NSt-RB). The developed sensor was a dual-emission fluorescent probe with two major emission peaks at 440 nm (B-GQDs) and 580 nm (Au NSt-RB) by exciting at 330 nm. Based on the inhibiting effect of MTX on the system's fluorescence density, the stable ratiometric fluorescent probe was used for the rapid determination of MTX in aquatic solutions and spiked human serum samples.

Knowledge and acceptance of artificial intelligence and its applications among the physicians working in military medical centers affiliated with Aja University: A cross-sectional study.

Background: The use of artificial intelligence (AI) in medical sciences promises many benefits. Applying the benefits of this science in developing countries is still in the development stage. This important point depends considerably on the knowledge and acceptance levels of physicians.

Effects of β-sitosterol on anxiety in migraine-induced rats: The role of oxidative/nitrosative stress and mitochondrial function.

Aims: Anxiety often coexists with migraine, and both conditions share a commonality in oxidative/nitrosative stress and mitochondrial dysfunction contributing to their pathogenesis. β-Sitosterol, a plant sterol, has shown promise in mitigating oxidative/nitrosative stress, enhancing mitochondrial function, and exerting neuroprotective effects. In this study, we investigated the impact of β-sitosterol on migraine-associated anxiety and whether this effect was associated with alleviation of oxidative/nitrosative stress and improvement in mitochondrial function.

Design Criteria of Shelter Hospitals in Response to Biological Accidents: A Systematic Review.

Background: The appropriate response to mass causality biological events requires well-established preparedness and providing a surge capacity. In such a situation, a practical solution is to convert large public venues into shelter hospitals. Due to the lack of a guideline for the transformation of a large public center into a hospital, the present study collected the design criteria for the transformation of public buildings into shelter hospitals in response to biological events such as epidemics or mass causality biological accidents.

What is the impact of Endodontic Irrigant Solutions on the Viability of Stem Cells from Apical Papilla in an in-vitro setting: A Systematic Review.

Background: The success of regenerative endodontic procedures (REPs) is significantly influenced by the choice of endodontic irrigant solution. However, the impact of these solutions on the viability of stem cells from the apical papilla (SCAP), a critical component of the REP, remains a subject of ongoing debate.

Objective: This study aimed to investigate the effects of various endodontic irrigant solutions on the viability of stem cells from the apical papilla in an in vitro setting.

miR-6089 may prevent the inflammatory events leading to cardiovascular disorders in RA patients.

Background: Cardiovascular disease (CVD) is the most important comorbid condition in rheumatoid arthritis (RA) patients. Dysregulated expression of non-coding RNA families has a critical role in RA-associated inflammatory events, including cardiovascular manifestations. The long non-coding RNA (lncRNA)- HIX003209 has a role in RA associated inflammation.

Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial.

Purpose: To investigate the effect of topical Polyvinylpyrrolidone-iodine (PVP-I) 0.6% on the clinical course of adenoviral keratoconjunctivitis compared with PVP-I 1% and artificial tears.

Methods: We prospectively enrolled all patients over 18 years of age with a polymerase chain reaction (PCR)-confirmed diagnosis of adenoviral keratoconjunctivitis who presented to the hospital between November 2022 and June 2023.

Assessment of Corneal Biomechanical Properties using Scheimpflug Camera-Based Imaging in Night Shift Medical Staff.

Purpose: To evaluate the effect of night shifts on the biomechanical properties of the cornea using Scheimpflug camera-based imaging (Corvis and Pentacam).

Methods: Thirty-four participants from the medical staff who had at least six night shifts per month as a case group and fifty-two participants as a control group participated in the study. The biomechanical characteristics of the cornea using the Corvis device and the topographical characteristics of the cornea using the Pentacam device were investigated in the participants.