From Outbreaks to Artificial Intelligence: A Comprehensive Review of Monkeypox Virus Epidemiology, Diagnosis, Treatment, Vaccination, and Deep Learning Applications.

After the global impact of the COVID-19 pandemic, concerns over virus transmission have risen. A state of health emergency was declared in 2022 due to Clade 2 of the monkeypox (MPOX) virus. In August 2024, another emergency was declared by the World Health Organization (WHO) because of the widespread Clade 1b, which caused a more severe and lethal disease.

Engendered nanoparticles for treatment of brain tumors.

Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain tumors. Its median survival time is typically less than a year after diagnosis. One of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous system.

Serum and Salivary Levels of Phosphate in Gastric and Colorectal Cancer Patients.

Objective: Gastrointestinal cancer is one of the most common causes of death worldwide. As there are no clinical symptoms at the beginning of the disease, the diagnosis can be delayed and the stage increased. Timely diagnosis is therefore crucial.

The effect of mobile health application training based on micro-learning method on the level of resilience and happiness among intensive care nurses: a randomized controlled trial.

Background: Increasing the level of resilience and happiness of intensive care nurses can lead to an improvement in their psychological health. This study aimed to extract the possible effectiveness of mHealth application utilizing the micro-learning method on a mobile phone platform on the intensive care nurses' resilience and happiness.

Materials And Methods: This single-blind randomized controlled trial was conducted in 2022-24.

The Impact of Functional Promoter Variants in Interleukin-18 on Susceptibility to Rheumatoid Arthritis in Iranian Population.

Background: Interleukin-18 (IL-18) is recognized for its pro-inflammatory properties and plays a central role in the progression of rheumatoid arthritis (RA). The specific single-nucleotide polymorphisms (SNPs), rs1946518 (-607C>A) and rs187238 (-137G), that are found in the IL-18 promoter region can potentially impact the expression of the IL-18 gene. This study aimed to investigate the correlation between these two polymorphisms and RA in the Iranian population.

Extensive Left Ventricular Thrombosis after Recovery from COVID-19: A Case Report.

Coagulation disorder is common among COVID-19 patients, particularly those afflicted with the severe form of the disease. Manifestations of thrombotic complications such as pulmonary embolism, deep vein thrombosis (DVT), ischemic stroke, cardiac infarction and arterial embolism is high in COVID-19 patients which have been assessed in various studies (5).It seems that COVID-19-related coagulopathy is a combination of low-grade DIC and pulmonary thrombotic microangiopathy which can have a significant effect on organ dysfunction in patients with severe COVID-19 (6).

The effect of fabrication procedures and thermomechanical loading on the structural properties of screw-retained metal-ceramic implant restorations: An in vitro study.

Purpose: Metal-ceramic screw-retained implant restorations persist as a fundamental choice in specific clinical scenarios. Little is known about the effects of fabrication steps and aging on their structural properties. This study aimed to investigate how laboratory fabrication procedures and thermomechanical loading affect the structural properties of screw-retained metal-ceramic implant restorations.

In vitro comparison of Enterococcus Faecalis survival in dentinal tubules following root canal therapy with AH plus, endoseal MTA, and cold ceramic sealers.

Background: Enterococcus faecalis (E. faecalis) is the most common microorganism responsible for post-endodontic infections, which can penetrate deep into dentinal tubules. This study aimed to compare the survival of E.

Immunoinformatics approach: Developing a multi-epitope vaccine with novel carriers targeting monkeypox virus.

Since May 2022, the global spread of monkeypox virus (MPXV) has presented a significant threat to public health. Despite this, there are limited preventive measures available. In this study, different computational tools were employed to design a multi-epitope vaccine targeting MPXV.

Comparison of Clinical Results Using Hamstring Versus Quadriceps Tendon Graft Versus Bone Patella Tendon in Anterior Cruciate Ligament Reconstruction Surgery: A Randomized Clinical Trial.

Background: Anterior cruciate ligament (ACL) reconstruction is pivotal for restoring knee stability and function in individuals with ACL injuries. While bone-patellar tendon-bone (PT), hamstring tendon (HT), and quadriceps tendon (QT) autografts are commonly employed, their comparative effectiveness remains a subject of ongoing research. This study aims to comprehensively compare the functional outcomes, knee stability, revision rates, and incidence of anterior knee pain associated with these autografts.

Reliability and Validity of the Persian Version of the Disaster Resilience Measuring Tool for Health care Rescuers in Iran.

Objectives: This study evaluated the validity and reliability of the Persian version of the Disaster Resilience Measuring Tool (DRMT-C19).

Methods: The research was a methodological, psychometric study. Standard translation processes were performed.

Efficacy of photobiomodulation therapy on Bell's palsy symptoms: a systematic review.

Bell's palsy, characterized by sudden facial paralysis, affects a significant proportion of the population annually, yet its exact cause remains elusive. Recently, increasing attention has been directed towards photobiomodulation therapy (PBMT) and its prospective contribution to managing various neurological and musculoskeletal conditions, including Bell's palsy. A systematic literature search of different databases was performed using a specific search strategy to find eligible studies that evaluated the potential of PBMT in managing Bell's palsy, considering its non-invasive nature and tissue healing properties.

Bile's Hidden Weapon: Modulating the Microbiome and Tumor Microenvironment.

The human gut microbiome is a dynamic and intricate ecosystem, composed of trillions of microorganisms that play a pivotal role in maintaining overall health and well-being. However, the gut microbiome is constantly exposed to various environmental factors, including the bile produced by the liver, which can significantly impact its composition and function. Bile acids, secreted by the liver and stored in the gallbladder, modulate the gut microbiome, influencing its composition and function.

The effect of transcutaneous electrical nerve stimulation on lumbar range of motion and lumbar fascia characteristics in healthy individuals.

Objectives: To investigate the effect of Transcutaneous electrical nerve stimulation (TENS) on lumbar fascia thickness, lumbar flexion angle, and lumbar curvature in healthy people.

Design: Randomized, clinical trial.

Subjects: 100 healthy individuals.

Using signal detection test to assess the correlation between daily sleep duration, mental workload, and attention sensitivity in nurses.

Background: Increased attention among healthcare workers, particularly nurses, is crucial for preventing medical errors and patient harm. This study uses an objective approach that overcomes the limitations of the subjective self-report measures employed in prior research on nurses' attention.

Methods: This cross-sectional study was conducted from January to March 2023 among 108 nurses at Besat Hospital in Tehran, Iran.

Surgical versus non-surgical management of hyperfunctional thyroid metastasis: a case report.

Background: Hyperthyroidism, caused by metastatic differentiated thyroid cancer, is a rare condition that can be difficult to diagnose. Thyrotoxicosis and metastatic disease regarding functional metastasis increase morbidity and mortality in patients with functional metastasis and need to be treated. This study aims to present a case of hyper-functional metastasis of thyroid cancer to analyze its pathological features, diagnostic procedures, and treatment options and to gather and examine recent cases of hyper-functional metastasis of thyroid cancer.

A national platform for advancing self-care processes for the most common illnesses and conditions: designing, evaluating, and implementing.

Background: Effective self-care practices are crucial for maintaining health and well-being, as inadequate self-care can lead to increased health risks and decreased overall quality of life. To address these issues, one promising approach involves leveraging progressive web app (PWA) platforms to educate and empower individuals with necessary self-care services. This study aims to design, implement, and evaluate a national self-care PWA platform, aiming to enhance accessibility and effectiveness in promoting health and self-care practices.

CRISPR-Cas9 in basic and translational aspects of cancer therapy.

Introduction: The discovery of gene editing techniques has opened a new era within the field of biology and enabled scientists to manipulate nucleic acid molecules. CRISPR-Cas9 genome engineering has revolutionized this achievement by successful targeting the DNA molecule and editing its sequence. Since genomic changes are the basis of the birth and growth of many tumors, CRISPR-Cas9 method has been successfully applied to identify and manipulate the genes which are involved in initiating and driving some neoplastic processes.

Identification of meat adulteration in minced meat samples labeled as beef and mutton in Tehran stores using duplex PCR.

Food fraud and profiteering are becoming increasingly common in the meat industry. Therefore, it is essential to identify such practices to prevent consumer deception and maintain food safety. This study aimed to determine the contents of minced meat samples labeled as beef and mutton in retail stores across Tehran province, Iran, to identify instances of meat adulteration.

Non-Mutational Changes of Autophagy Marker LC3A in Patients with Acute Myeloid Leukemia; Effect of DNA Methylation and Expression Level of LncRNA-GAS5 and miRNA-155-5p, A Case Control Study.

Unlabelled: Clinical translation of autophagy modulators is tied to thoroughly acquainted with the precise state of this process and its regulators in a particular cancer. LC3Av1 is a marker of autophagosome membrane that has been contributed with pathobiology of myriad of human cancers. In the present study, we examined the effect of promoter methylation and miR-155 and LncRNA-GAS5 (GAS5) expression levels on transcription of LC3Av1 in AML patients.