10,573 results match your criteria: "AIx-Marseille University[Affiliation]"

Introduction: Treatment options for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) with disease progression on/after osimertinib and platinum-based chemotherapy are limited.

Methods: CHRYSALIS-2 Cohort A evaluated amivantamab+lazertinib in patients with EGFR exon 19 deletion- or L858R-mutated NSCLC with disease progression on/after osimertinib and platinum-based chemotherapy. Primary endpoint was investigator-assessed objective response rate (ORR).

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Antipsychotic use during pregnancy and outcomes in pregnant individuals and newborns.

J Affect Disord

January 2025

Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea; Department of Regulatory Science, Kyung Hee University, Seoul, South Korea; Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. Electronic address:

Background: Despite the increasing use of antipsychotics during pregnancy, comprehensive evaluations of their individual safety profiles using global data remain limited. This study aimed to assess the safety of various antipsychotics during pregnancy by comparing them to quetiapine, which has a relatively large body of safety data.

Method: Utilizing the World Health Organization pharmacovigilance database (1967-2023; n = 131,255,418 reports), we identified 11,406 reports of antipsychotic exposure during pregnancy.

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Complications of Nonsurgical Rhinoplasty with Hyaluronic Acid Injections: A Narrative Review.

Aesthetic Plast Surg

January 2025

Primus Medical Center (GVM), Gruppo Otorinolaringoiatrico della Romagna, Via Punta di Ferro 2/c, 47122, Forlì, FC, Italy.

Background: The increasing popularity of cosmetic procedures has led to a rise in both surgical and nonsurgical interventions. Rhinoplasty, particularly nonsurgical rhinoplasty using injectable fillers such as hyaluronic acid (HA), has become highly sought after due to its minimally invasive nature. Despite its benefits, complications can occur, ranging from minor to severe.

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Public health problems are complex; investigating them requires a framework that both accounts for multiple interactions among individuals and their intermediate and broader environment and also integrates equity concerns. Incorporating internal and external influences at the individual level, the health capability profile (HCP)'s 15 different health capabilities address this need.Using a systematic three-step deductive content analysis process, we examine hypothetical case studies representing leading causes of death in the USA (eg, heart disease, cancer and diabetes) as well as pressing public health issues such as COVID-19, alcohol use disorder, stigma and discrimination, intimate partner violence and firearm violence.

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Venous thromboembolism, characterized by deep vein thrombosis and pulmonary embolism, is the third cardiovascular disease in the world. Deep vein thrombosis occurs when a blood clot forms in areas of impaired blood flow, and it is significantly affected by environmental factors. Local hypoxia, caused by venous stasis, plays a critical role in deep vein thrombosis under normal conditions, and this effect is intensified when the Po decreases, such as during air travel or high-altitude exposure.

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Reliability of an electronic uterine diagram to standardize intrauterine adhesion scoring.

J Minim Invasive Gynecol

December 2024

CHU Rouen Department of Gynecology and Obstetrics, CHU Rouen, Rouen, France.

Study Objective: To study the inter-rater reliability of an electronic complementary uterine diagram (eAFS) in comparison to the conventional American Fertility Society intrauterine adhesions (IUA) scoring system (cAFS). As a secondary aim we wanted to assess the intra-rater reliability of these tools.

Design: This was an observational cross over study with a nested test re-test design.

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Delivering bad news in clinical hematology: a personal perspective.

Clin Hematol Int

December 2024

Department of Hematology, Institut Paoli-Calmettes, Cancer Sports Management Lab, Aix- Marseille University, Marseille, France.

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Background: The co-occurrence of anterior cruciate ligament (ACL) rupture with medial collateral ligament (MCL) rupture is a compound injury that can be associated with meniscal tears.

Purpose: To report the characteristics of meniscal tears in knees with isolated ACL versus combined ACL and MCL injuries, analyzing their frequency, distribution by site, and lesion type.

Study Design: Cross-sectional study; Level of evidence, 3.

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The precise and fleeting moment of rich recollection triggered by an environmental cue is difficult to reproduce in the lab. However, epilepsy patients can experience sudden reminiscences after intracranial electrical brain stimulation (EBS). In these cases, the transient brain state related to the activation of the engram and its conscious perception can be recorded using intracerebral EEG (iEEG).

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Treating Presbyphonia in 2024: A Scoping Review.

J Voice

December 2024

Department of Oto-Rhino-Laryngology and Head and Neck Surgery, AP-HM, Marseille, La Conception University Hospital, Aix-Marseille University, 147 Boulevard Baille, CEDEX 5, 13385 Marseille, France.

Presbyphonia is a multi-dimensional pathology. Therefore, its treatment should address its different affecting factors, including a global health management to fight geriatric frailty, improve overall physical strength, and limit medication side-effects. The specific therapies should address glottal gap closure and vocal folds' pliability.

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Symmetry breaking organizes the brain's resting state manifold.

Sci Rep

December 2024

INSERM, INS, Institut de Neurosciences des Systèmes, Aix Marseille University, 13005, Marseille, France.

Spontaneously fluctuating brain activity patterns that emerge at rest have been linked to the brain's health and cognition. Despite detailed descriptions of the spatio-temporal brain patterns, our understanding of their generative mechanism is still incomplete. Using a combination of computational modeling and dynamical systems analysis we provide a mechanistic description of the formation of a resting state manifold via the network connectivity.

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Would you publish unrealistic models?

Biol Cybern

December 2024

Inst Neurosci Syst, INSERM, INS, Aix Marseille University, Marseille, France.

The theoretical neurosciences research community produces many models, of different natures, to capture activities or functions of the brain. Some of these models are presented as «realistic » models, often because variables and parameters have biophysical units, but not always. In this opinion article, I explain why this term can be misleading and I propose some elements that can be useful to characterize a model.

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Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity.

Nat Commun

December 2024

KU Leuven Department of Microbiology, Immunology and Transplantation, Virology, Antiviral Drug & Vaccine Research Group, Rega Institute for Medical Research, Leuven, Belgium.

The 2015-2016 Zika virus (ZIKV) outbreak in the Americas revealed the ability of ZIKV from the Asian lineage to cause birth defects, generically called congenital Zika syndrome (CZS). Notwithstanding the long circulation history of Asian ZIKV, no ZIKV-associated CZS cases were reported prior to the outbreaks in French Polynesia (2013) and Brazil (2015). Whether the sudden emergence of CZS resulted from an evolutionary event of Asian ZIKV has remained unclear.

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Purpose: Asymmetric anterior closing-wedge high tibial osteotomy (ACWHTO) allows correction of both excessive posterior tibial slope (PTS) and varus deformity. However, the complexity of this surgery requires a high degree of accuracy, which is less likely to be achieved with standard instrumentations. This study aimed to determine the accuracy of 3D patient-specific cutting guides (PSCGs) to provide the accurate planned correction in the frontal and sagittal planes.

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Objective: This study investigates whether early gestational age (GA) at delivery is associated with an increased risk for severe maternal morbidity (SMM) in women with preterm delivery.

Methods: This retrospective national cohort study based on the Programme de Médicalisation des Systèmes d'Information database included mothers who gave birth between 22 and 37 weeks in metropolitan France in 2019 (in utero deaths and medical terminations of pregnancies were excluded). SMM was defined as a composite criterion consisting of the occurrence of at least one of the following events: death, severe preeclampsia, obstetric surgical complications, severe maternal diseases, and admission to the intensive care unit.

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Anion Exchange Membranes (AEMs) are promising materials for electrochemical devices, such as fuel cells and electrolyzers. However, the main drawback of AEMs is their low durability in alkaline operating conditions. A possible solution is the use of composite ionomers containing inorganic fillers stable in a basic environment.

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Chemical Diversity of Mediterranean Seagrasses Volatilome.

Metabolites

December 2024

CNRS, Aix-Marseille University, Avignon University, IRD, UMR 7263 IMBE, 13397 Marseille, France.

Background/objectives: Biogenic volatile organic compounds (BVOCs), extensively studied in terrestrial plants with global emissions around 1 PgC yr, are also produced by marine organisms. However, benthic species, especially seagrasses, are understudied despite their global distribution (177,000-600,000 km). This study aims to examine BVOC emissions from key Mediterranean seagrass species (, , , and ) in marine and coastal lagoon environments.

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There is growing evidence that a wide range of human diseases and physiological traits are influenced by genetic variation of cis-regulatory elements. We and others have shown that a subset of promoter elements, termed Epromoters, also function as enhancer regulators of distal genes. This opens a paradigm in the study of regulatory variants, as single nucleotide polymorphisms (SNPs) within Epromoters might influence the expression of several (distal) genes at the same time, which could disentangle the identification of disease-associated genes.

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Periodontitis is the inflammation of the supporting structures around the dentition. Several microbial agents, mostly bacteria, have been identified as causative factors for periodontal disease. On the other hand, oral cavity is a rich reservoir for viruses since it contains a wide variety of cell types that can be targeted by viruses.

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Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma.

CPT Pharmacometrics Syst Pharmacol

December 2024

COMPutational Pharmacology and Clinical Oncology Department, Inria Sophia Antipolis - Méditerranée, Cancer Research Center of Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille University UM105, Marseille, France.

We employed a mechanistic learning approach, integrating on-treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post-progression survival (PPS)-the duration from the time of documented disease progression to death-and overall survival (OS) in Head and Neck Squamous Cell Carcinoma (HNSCC). We compared the predictive power of model-derived TK parameters versus RECIST and assessed the efficacy of nine TK-OS ML models against conventional survival models. Data from 526 advanced HNSCC patients treated with chemotherapy and cetuximab in the TPExtreme trial were analyzed using a double-exponential model.

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Self-reported penicillin allergy and beta-lactam allergy label: Is ICU so different?

Anaesth Crit Care Pain Med

December 2024

University Paris Cité, Paris, France; Anaesthesiology and Critical Care Medicine Department, DMU PARABOL, Bichat Hospital, AP-HP, Paris, France; Antibody in Therapy and Pathology, Pasteur Institute, UMR 1222 INSERM, Paris, France. Electronic address:

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Background: Previous economic evidence about interventions for schizophrenia is outdated, non-transparent and/or limited to a specific clinical context.

Aims: We developed a discrete event simulation (DES) model for estimating the cost-effectiveness of interventions in schizophrenia in the UK.

Method: The DES model was developed based on the structure of previous models, populated with demographic, clinical and cost data from the UK, and antipsychotics' effects from recent network meta-analyses.

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E3 ubiquitin ligases have been linked to developmental diseases including autism, Angelman syndrome (UBE3A), and Johanson-Blizzard syndrome (JBS) (UBR1). Here, we report variants in the E3 ligase UBR5 in 29 individuals presenting with a neurodevelopmental syndrome that includes developmental delay, autism, intellectual disability, epilepsy, movement disorders, and/or genital anomalies. Their phenotype is distinct from JBS due to the absence of exocrine pancreatic insufficiency and the presence of autism, epilepsy, and, in some probands, a movement disorder.

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Functional genomics of primary congenital glaucoma by pathway analysis and functional characterization of CYP1B1 mutations.

Vision Res

December 2024

Medical Biotechnology Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi 110007, India. Electronic address:

CYP1B1 is the most common gene implicated in primary congenital glaucoma (PCG) - the most common form of childhood glaucoma. How CYP1B1 mutations cause PCG is not known. Understanding the mechanism of PCG caused by CYP1B1 mutations is crucial for disease management, therapeutics development, and potential prevention.

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