Long term latency of highly mutated cells in normal mouse skin is reversed by exposure to tumor promoters and chronic tissue damage.

Historical studies performed nearly a century ago using mouse skin models identified two key steps in cancer evolution: initiation, a likely mutational event, and promotion, driven by inflammation and cell proliferation. Initiation was proposed to be permanent, with promotion as the critical rate-limiting step for cancer development. Here, we carried out whole genome sequencing to demonstrate that initiated cells with thousands of mutagen-induced mutations can persist for long periods and are not removed by cell competition or by immune intervention, thus mimicking the persistence of cells with cancer driver mutations in normal human tissues.

Low-input breeding potential in stone pine, a multipurpose forest tree with low genome diversity.

Stone pine (Pinus pinea L.) is an emblematic tree species within the Mediterranean basin, with high ecological and economic relevance due to the production of edible nuts. Breeding programmes to improve pine nut production started decades ago in Southern Europe but have been hindered by the near absence of polymorphisms in the species genome and the lack of suitable genomic tools.

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology.

Environmental ototoxicants: an update.

Approximately 5 years ago, we proposed the establishment of a new category of ototoxicants: environmental ototoxicants, in addition to the recognized categories of occupational and drug-related ototoxicants. Since the publication of our review, the scientific literature has confirmed the potential for hearing impairment (HI) caused by the general population's exposure to various chemicals. However, the extent of this exposure's contribution to the global incidence of hearing loss (HL) has yet to be estimated.

IgG4-related disease: lessons from the first 20 years.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease that is believed but not confirmed to have an autoimmune origin. Since its discovery nearly two decades ago, our understanding of its pathophysiology and clinical manifestations has grown substantially. Early diagnosis and treatment of this elusive disease can prevent substantial organ damage from end-stage fibrosis.

Routine anaesthesia ward-based patient visits in surgery: 1-year outcomes of the TRACE randomized clinical trial.

Background: The TRACE (Routine posTsuRgical Anaesthesia visit to improve patient outComE) RCT did not show any perioperative benefit from ward-based visits by anaesthetists after surgery. The aim of this study was to evaluate the impact of this intervention on longer-term outcomes.

Methods: Patients were followed up in the TRACE RCT to 1 year in nine hospitals in the Netherlands.

A more scientific blood lead reference value urgently needs to be updated in China: From a national and international insight.

Although blood lead levels (BLLs) in children have significantly decreased compared to two decades ago, incidents of lead poisoning and elevated BLLs among children continue to occur frequently. This trend suggests that China's current hygienic regulations are not sufficiently effective in managing children's lead exposure. This study analyzed the revision processes of blood lead reference values (BLRVs) in children from various countries, the current BLLs and their changing trends in China, potential sources of lead pollution and exposure, the requirements for managing and protecting children's health, as well as the national measures and strategies for lead emission management and control.

Six Decades of Scientific Output: A Bibliometric Analysis of Research Contributions from the National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez".

Introduction: The Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez (INNNMVS), established nearly six decades ago, was initially designed as a specialized hospital for neurological care. However, over time, it has evolved into a multifaceted health institute, encompassing three fundamental pillars: clinical care, scientific research, and academic education in neurology.

Aims And Objectives: The purpose of this study is to strengthen and expand knowledge in the field of neurology.

Intergroup-statement: statement of the german ovarian cancer commission, the North-Eastern German Society of gynecological Oncology (NOGGO), AGO Austria and AGO Swiss regarding the use of homologous repair deficiency (HRD) assays in advanced ovarian cancer.

Introduction: Homologous recombination deficiency (HRD) is a key biomarker in the management of high-grade serous ovarian cancer (HGSOC), guiding treatment decisions, particularly regarding the use of poly(ADP-ribose) polymerase inhibitors (PARPi). As multiple HRD assays are available, each with distinct methodologies and cutoff values, the interpretation and clinical application of HRD testing remain complex. This intergroup statement, endorsed by the German Ovarian Cancer Commission, NOGGO, AGO Austria, and AGO Swiss, aims to provide guidance on the indications, appropriate use, and limitations of HRD testing in ovarian cancer.

Evidence from Tinshemet Cave in Israel suggests behavioural uniformity across Homo groups in the Levantine mid-Middle Palaeolithic circa 130,000-80,000 years ago.

The south Levantine mid-Middle Palaeolithic (mid-MP; ~130-80 thousand years ago (ka)) is remarkable for its exceptional evidence of human morphological variability, with contemporaneous fossils of Homo sapiens and Neanderthal-like hominins. Yet, it remains unclear whether these hominins adhered to discrete behavioural sets or whether regional-scale intergroup interactions could have homogenized mid-MP behaviour. Here we report on our discoveries at Tinshemet Cave, Israel.

Improving the fast-charging capability of NbWO-based Li-ion batteries.

The discovery of Nb-W-O materials years ago marks the milestone of charging a lithium-ion battery in minutes. Nevertheless, for many applications, charging lithium-ion battery within one minute is urgently demanded, the bottleneck of which largely lies in the lack of fundamental understanding of Li storage mechanisms in these materials. Herein, by visualizing Li intercalated into representative NbWO, we find that the fast-charging nature of such material originates from an interesting rate-dependent lattice relaxation process associated with the Jahn-Teller effect.

Reply to Žárský and Eliáš.

The more we learn about the algal relatives of embryophytes (land plants), the more complex and fascinating the evolution of key streptophyte traits becomes. With the sequencing of the Klebsormidium nitens genome, a range of molecular traits shared with land plants were found - despite ca. 800 million years of divergence.

Two cases report on the relationship between white matter hyperintensity volume and cognitive dysfunction in cerebral small vessel disease based on magnetic resonance imaging.

Rationale: With the development of magnetic resonance imaging (MRI) technology, most of the research tends to find that there is a significant positive correlation between white matter hyperintensities (WMHs) and cognitive dysfunction in cerebral small vessel vascular disease. In this paper, we report 2 cases of cerebral small vessel disease with significant differences in cognitive function and analyze them by multidimensional assessment using imaging technology so as to provide a methodological reference for identifying and diagnosing the causes of differences in cognitive function in cerebral small vessel disease patients.

Patient Concerns: Patient 1 was a 64-year-old middle-aged man who presented 10 years ago with slow reaction time, memory loss, and loss of self-care ability, and MRI suggested multiple ischemic infarct foci with cerebral white matter changes.

Harnessing hyperaccumulator plants to recover technology-critical metals: where are we at?

Since its inception over three decades ago, phytomining has finally reached the stage of commercial-scale implementation, at least for nickel. Much potential remains to be realised for other elements, notably cobalt, selenium, and thallium, but this requires scientific impetus leveraging recent advances in insights garnered from molecular mechanisms of hyperaccumulation, domestication and agronomic development. These advances will also enable us to (genetically) improve hyperaccumulators for use in phytomining by targeted breeding, as well as synthetic biology approaches.

Management of Herpes Simplex Virus Reactivation Following Open Septorhinoplasty: A Case Report.

Herpes simplex virus (HSV) reactivation post-surgery is an important complication to watch out for in surgeries like septorhinoplasty. This case report discusses the difficulties in diagnosis and successful treatment approaches for HSV reactivation after an open septorhinoplasty, underscoring the need for increased clinical awareness. This is a case report of a 33-year-old female with no medical history and no allergies who underwent an open septorhinoplasty to correct nasal obstruction and external nasal deformity without any intraoperative complications.

Formulation of catechol-containing adhesives for enhanced underwater bonding and workability.

Catechol-containing polymers inspired by marine mussels have gained significant interest in recent years, leading to applications in several fields. Among these polymer systems, poly(vinylcatechol-styrene) (PVCS) has become a popular option due to its exceptional underwater adhesion strength, with readily available monomers and diverse synthetic routes being available. However, the translation of any novel adhesive chemistry from academic research to real-world applications can be challenging.

Long Term Follow Up of Children Who Received Rapid Genomic Sequencing.

Purpose: To explore long-term trajectories of children who received rapid genome sequencing (RGS) in intensive care settings.

Methods: We examined the electronic health records (EHR) of 67 critically ill pediatric patients who received RGS six to eight years ago with a collective initial diagnostic yield of 46%.

Results: The median length of follow up was 6.

Anti-nuclear Matrix Protein 2 Antibody-Positive Dermatomyositis Relapse With Preceding Panniculitis.

Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by cutaneous lesions such as heliotrope rash, Gottron's papules, and Gottron's sign. Panniculitis is rarely reported as a skin manifestation of DM. Herein, we present a case of anti-nuclear matrix protein 2 antibody (NXP-2)-positive DM relapse with panniculitis in the absence of muscle symptoms.

Distinctive imaging features of liver metastasis from gastric adenocarcinoma with enteroblastic differentiation: A case report.

Background: Gastric adenocarcinoma with enteroblastic differentiation (GAED) is one of the common subtypes of alpha-foetoprotein (AFP)-producing gastric cancer. GAED frequently results in venous invasion and liver metastasis, the latter being particularly linked to a poor prognosis. So far, the evidence for liver metastases from AFP-producing gastric cancer is only focused on those from gastric hepatoid adenocarcinoma, owing to their imaging similarities with hepatocellular carcinoma.

Spontaneous left pneumothorax revealing an atypical carcinoid tumor: a case report.

The association between spontaneous pneumothorax and a bronchial tumor is rare, and even more so with an atypical carcinoid tumor. This rare and unexpected case highlights the importance of raising clinician awareness about investigating the underlying cause of pneumothorax through endoscopic exploration. A 52-year-old female was exposed to passive smoking by her husband for 20 years.

Radiation-Induced Renal Artery Stenosis.

We present a case of a 33 year old male presenting with uncontrolled hypertension, requiring four drugs and renal dysfunction. Investigations revealed calcific atherosclerosis of abdominal aorta and bilateral renal artery stenosis. He had received radiotherapy for abdominal Non-Hodgkin's lymphoma 14 years ago.

In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection.

Open fracture-related infection challenges persist in healthcare. From the time open fractures were defined ∼50 years ago, infection rates have gone essentially unchanged. Contributing factors include compromised vasculature, biofilm, and stalled innovations in treatment and prophylaxis.

Retraction notice to 'Grape Powder Supplementation Prevents Oxidative Stress-Induced Anxiety-Like Behavior, Memory Impairment, and High Blood Pressure in Rats' [J Nutr 143 (2013) 835-842].

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

Bioproducts from renewable methanol: the paraformaldehyde approach.

Green methanol as feedstock in biotech operations at large scales is receiving in-depth attention for the production of Single Cell Protein (SCP) and circular chemicals. Several decades ago, cheap fossil-derived methanol was seen as an attractive feedstock. Now, renewable rather than fossil-derived methanol is in focus since its utilization does not depend on fossil resources and importantly it does not compete with food sources.