Unique effect of aspirin on local 15-oxo-eicosatetraenoic acid synthesis in asthma patients with aspirin hypersensitivity.

Background: Nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (NSAIDs-ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum is collected to perform cell counts and to identify local biomarkers in induced sputum supernatant (ISS). This study aimed to assess the levels of a newly identified eicosanoid, 15-oxo-eicosatetraenoic acid (15-oxo-ETE), in ISS at baseline and during aspirin-induced bronchospasm in patients with NSAIDs-ERD.

Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex.

The baroreflex is one of the most important control mechanisms in the human cardiovascular system. This work utilises a closed-loop in silico model of baroreflex regulation, coupled to pulsatile mechanical models with (i) one heart chamber and 36-parameters and (ii) four chambers and 51 parameters. We perform the first global sensitivity analysis of these closed-loop systems which considers both cardiovascular and baroreflex parameters, and compare the models with their respective unregulated equivalents.

Going from Pt to PGM-free Catalysts: Effects of Ink Compositions on PEM Water Electrolysis.

The commercialisation of PEM water electrolysis is still hindered by the necessity of using noble metals that are rare, expensive and therefore unsustainable. To replace the benchmark HER catalyst Pt with more abundant materials, promising non-noble catalysts need to be identified and optimal electrode preparation and electrolysis conditions need to be transferred between catalyst materials to reveal their full potential under industrially relevant conditions. This study investigates the optimal ink composition for spray-coating the cathode regarding the effects on electrode structure, performance and catalyst layer composition.

Perioperative lifestyle and nutritional interventions' details reporting in bariatric surgery trials according to the Template for Intervention Description and Replication (TIDieR) checklist: a cross-sectional study.

Background: Metabolic and bariatric surgery (MBS) is considered the most effective treatment for people with severe obesity, and certain interventions could enhance its long-term results. The complete reporting of interventions' details is necessary for their replication in clinical settings.

Objectives: To investigate the completeness of reporting of lifestyle and nutritional interventions applied in immediate perioperative period (30-days preoperatively and postoperatively) in patients undergoing MBS using the 12-item Template for Intervention Description and Replication (TIDieR) checklist, and to explore factors associated with compliant reporting.

Understanding responses to multi-electrode epiretinal stimulation using a biophysical model.

Objective: Neural interfaces are designed to evoke specific patterns of electrical activity in populations of neurons by stimulating with many electrodes. However, currents passed simultaneously through multiple electrodes often combine nonlinearly to drive neural responses, making evoked responses difficult to predict and control. This response nonlinearity could arise from the interaction of many excitable sites in each cell, any of which can produce a spike.

Analysis of the Influence of Different Diameters of De Laval Supersonic Nozzles on the Key Splashing Parameters of Remaining Slag.

The paper is devoted to the analysis of a supersonic nozzle system effect in gas-cooled lances on the technological parameters of slag splashing in an oxygen converter. Simulation calculations were carried out, taking into account the parameters of nozzles used in the technological lines of converter steel plants in Ukraine and Brazil. The problems were solved in several stages.

Silver Nanoparticles (AgNPs) Incorporation into Polymethyl Methacrylate (PMMA) for Dental Appliance Fabrication: A Systematic Review and Meta-Analysis of Mechanical Properties.

Polymethyl methacrylate (PMMA), widely used in orthodontics and dentures, exhibits suboptimal mechanical properties, including flexural strength (FS), impact strength (IS), and tensile strength (TS), which are critical for ensuring durability, resistance to fracture, and overall functionality of dental appliances. Silver nanoparticles (AgNPs) are a promising filler due to their antimicrobial properties. This pre-registered (osf.

Mechanical Synthesis and Calorimetric Studies of the Enthalpies of Formation of Chosen Mg-Pd Alloys.

Despite many years of research and continuous improvements in scientific equipment, some of the thermodynamic properties of binary systems are still unknown, or are only theoretically predicted or calculated. This situation often arises from the difficulties in preparing alloys for experimental measurements. The alloys from the Mg-Pd system, especially for the Pd-rich side, are difficult to produce, and the availability of thermodynamic data is very limited.

Hypoxia induces robust ATP release from erythrocytes in ApoE-LDLR double-deficient mice.

Red blood cells (RBCs) play a role in the regulation of vascular tone via release of adenosine triphosphate (ATP) into the vasculature in response to various stimuli. Interestingly, ApoE/LDLR double-deficient (ApoE/LDLR) mice, a murine model of atherosclerosis, display a higher exercise capacity compared to the age-matched controls. However, it is not known whether increased exercise capacity in ApoE/LDLR mice is linked to the altered ATP release from RBCs.

Post-implant transcatheter aortic prosthesis deformation: tricuspid versus bicuspid valve.

Objective: We sought to assess whether post-implant transcatheter aortic valve prosthesis multi detector computed characteristics differ between patients with native tricuspid and bicuspid aortic valve stenosis, as well as the effect on valve performance and clinical implications.

Methods: We analysed 100 consecutive post-implant multi detector computed tomography scans to assess self-expandable prosthesis non-uniform expansion at six pre-specified valvular levels, and other specific parameters, including valvular and perivalvular thrombosis at six months follow-up. Echocardiographic prosthesis performance and clinical outcome was also evaluated.

Evaluation of Dental Panoramic Radiographs by Artificial Intelligence Compared to Human Reference: A Diagnostic Accuracy Study.

The role of artificial intelligence (AI) in dentistry is becoming increasingly significant, particularly in diagnosis and treatment planning. This study aimed to assess the sensitivity, specificity, accuracy, and precision of AI-driven software in analyzing dental panoramic radiographs (DPRs) in patients with permanent dentition. Out of 638 DPRs, 600 fulfilled the inclusion criteria.

Comparing structure-function relationships in brain networks using EEG and fNIRS.

Identifying relationships between structural and functional networks is crucial for understanding the large-scale organization of the human brain. The potential contribution of emerging techniques like functional near-infrared spectroscopy to investigate the structure-functional relationship has yet to be explored. In our study, using simultaneous Electroencephalography (EEG) and Functional near-infrared spectroscopy (fNIRS) recordings from 18 subjects, we characterize global and local structure-function coupling using source-reconstructed EEG and fNIRS signals in both resting state and motor imagery tasks, as this relationship during task periods remains underexplored.

Biocompatible nanocomposite hydroxyapatite-based granules with increased specific surface area and bioresorbability for bone regenerative medicine applications.

Hydroxyapatite (HA) granules are frequently used in orthopedics and maxillofacial surgeries to fill bone defects and stimulate the regeneration process. Optimal HA granules should have high biocompatibility, high microporosity and/or mesoporosity, and high specific surface area (SSA), which are essential for their bioabsorbability, high bioactivity (ability to form apatite layer on their surfaces) and good osseointegration with the host tissue. Commercially available HA granules that are sintered at high temperatures (≥ 900 °C) are biocompatible but show low porosity and SSA (2-5 m/g), reduced bioactivity, poor solubility and thereby, low bioabsorbability.

Pre-symptomatic scintigraphic and genetic cascade screening in cardiac transthyretin amyloidosis.

Purpose: While early diagnosis is crucial, as new treatments can significantly slow the progression of the disease, there is growing evidence on the application of novel imaging techniques for detecting transthyretin amyloidosis (ATTR) in pre-symptomatic stages. This study aimed to evaluate the utility of pre-symptomatic scintigraphic imaging cascade screening for early detection of ATTR.

Methods: During the period from 2020 to 2024, we conducted a prospective study that enrolled 100 consecutive adults.

Solvothermal Synthesis of Medium-Entropy Oxide Spheres for Thermocatalytic Conversion of CO to Methanol.

New chemical compositions and structures for medium- and high-entropy oxides (HEOs) currently represent a promising new avenue in materials research for a wide range of applications including catalysis, energy storage, and ceramics. To speed up further development, synthesis methods for multicationic oxides are needed for controlling features like morphology, porosity, and chemical compositions. In this work, mesoporous spinel oxide spheres with five cations are synthesized using solvothermal synthesis techniques.

Cytometry masked autoencoder: An accurate and interpretable automated immunophenotyper.

Single-cell cytometry data are crucial for understanding the role of the immune system in diseases and responses to treatment. However, traditional methods for annotating cytometry data face challenges in scalability, robustness, and accuracy. We propose a cytometry masked autoencoder (cyMAE), which automates immunophenotyping tasks including cell type annotation.

Precise control of neural activity using dynamically optimized electrical stimulation.

Neural implants have the potential to restore lost sensory function by electrically evoking the complex naturalistic activity patterns of neural populations. However, it can be difficult to predict and control evoked neural responses to simultaneous multi-electrode stimulation due to nonlinearity of the responses. We present a solution to this problem and demonstrate its utility in the context of a bidirectional retinal implant for restoring vision.

Controlled therapeutic cholesterol delivery to cells for the proliferation and differentiation of keratinocytes.

The challenge of enhancing wound healing and skin regeneration, particularly in conditions like burns and diabetic wounds, necessitates innovative solutions. Cholesterol, often associated with cardiovascular diseases, plays vital roles in cellular functions, maintaining skin integrity and preserving the skin barrier. Here, we explore cholesterol's significance, its influence on keratinocytes, and its potential application in skin regeneration.

The Influence of Thermal Treatment of Activated Carbon on Its Electrochemical, Corrosion, and Adsorption Characteristics.

Activated carbons can be applied in various areas of our daily life depending on their properties. This study was conducted to investigate the effect of thermal treatment of activated carbon on its properties, considering its future use. The characteristics of activated carbon heat-treated at temperatures of 1500, 1800, and 2100 °C based on its future use are presented.

Dissecting the importance and origin of circulating myokines in gastric cancer cachexia.

Background: Some experimental data suggest that myokines may play an important role in developing cancer-associated cachexia (CAC), but their relevance in humans remains poorly explored. In our study, we tested the hypothesis that circulating myokines are associated with the pathogenesis of CAC in a model population of gastric cancer.

Methods: A group of 171 treatment naïve patients with adenocarcinoma of the stomach were prospectively examined.