Nanoring interactions with bio-relevant molecule: A quantum chemical approach to C and BN systems.

This study investigates the interaction of a synthetic bio-relevant molecule with C and BN nanorings, exploring their potential applications in sensing and drug delivery. Employing Density Functional Theory (DFT) at the ωB97XD level with the 6-31G(d,p) basis set, we computed the adsorption and electronic properties of the resulting nanocomplexes. A total of ten distinct configurations were identified for the interactions, with adsorption energies ranging from -6.

Sensing of SARS-CoV-2-infected cells by plasmacytoid dendritic cells is modulated via an interplay between CD54/ICAM-1 and CD11a/LFA-1 α integrin.

Unlabelled: SARS-CoV-2 infection induces interferon (IFN) response by plasmacytoid dendritic cells (pDCs), but the underlying mechanisms are poorly defined. Here, we show that the bulk of the IFN-I release comes from pDC sensing of infected cells and not cell-free virions. Physical contact (or conjugates) between pDCs and infected cells is mediated through CD54-CD11a engagement, and such conjugate formation is required for efficient IFN-I production.

A standards-based application for improving platelet transfusion workflow.

Objective: Thrombocytopenia is a common complication of hematopoietic stem-cell transplantation (HSCT), though many patients will become immune refractory to platelet transfusions over time. We built and evaluated an electronic health record (EHR)-integrated, standards-based application that enables blood-bank clinicians to match platelet inventory with patients using data previously not available at the point-of-care, like human leukocyte antigen (HLA) data for donors and recipients.

Materials And Methods: The web-based application launches as an EHR-embedded application or as a standalone application.

Minimal invasive biopsies are highly sensitive for amyloid detection in hereditary transthyretin amyloidosis with polyneuropathy.

Objective: To assess the effectiveness of labial minor salivary gland biopsy (LSGB) alone or in combination with punch skin biopsy (SB) for the detection of amyloid deposits in hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN).

Methods: In this single-center retrospective study, Congo red staining of minimal invasive LSGB (4 mm) and SB (3 mm) was assessed in ATTRv-PN patients consecutively evaluated between 2012 and 2023.

Results: Histopathological data of 171 ATTRv-PN, including 49 early-onset p.

Towards Modern Care and Education for Persons with visual Impairments in Poland: Elżbieta Róża Czacka (1876-1961) and Her Contribution to the Development of Typhlology-Religious Inspirations.

The aim of this study is to show the relationship between spirituality and the development of modern typhlology focused on supporting people with visual impairments. The text presents the silhouette of Mother Rose Czacka, the sources of her Catholic spirituality and the development of typhlological thought related to her, as well as Dzieło Lasek, which is an emanation of these relationships. The aim of this study is to show the relationship between spirituality and the development of modern typhlology focused on supporting people with visual impairments.

Biarsenical-based fluorescent labeling of metallothioneins as a method for ultrasensitive quantification of poly-Cys targets.

Background: Mammalian metallothioneins (MTs) play a crucial role in maintaining Zn(II) and Cu(I) homeostasis, as well as regulating the cellular redox potential. They are involved in cancer resistance to cisplatin-related drugs and the sequestration of toxic metal ions. To investigate their participation in specific physiological and pathological processes, it is imperative to develop an analytical method for measuring changes in protein concentration both in vitro and in vivo.

Comparison of carbon dioxide control during pressure controlled versus pressure-regulated volume controlled ventilation in children (CoCO2): protocol for a pilot digital randomised controlled trial in a quaternary paediatric intensive care unit.

Introduction: Digital trials are a promising strategy to increase the evidence base for common interventions and may convey considerable efficiency benefits in trial conduct. Although paediatric intensive care units (PICUs) are rich in routine electronic data, highly pragmatic digital trials in this field remain scarce. There are unmet evidence needs for optimal mechanical ventilation modes in paediatric intensive care.

Bifunctional adsorbents based on hyper-cross-linked polymers containing carbonyl and amine species for the efficient removal of diclofenac from water in a broad pH range.

Development of new adsorbents for the efficient removal of organic pollutants from water is one of the most emerging environmental issues. Current studies in this field focus on improving the adsorption capacity of various materials and/or broadening the pH range in which the adsorbents can efficiently remove target pollutants. In this study, we designed bifunctional hyper-cross-linked polymers (HCPs) containing both carbonyl and amine species to investigate the effect of amine functional groups on the efficiency of adsorptive removal of non-steroidal anti-inflammatory drugs (NSAIDs) from water.

Improving the bioactivity of cellulose acetate hemodialysis membranes through nanosilver modification.

The effectiveness and safety of hemodialysis can be hindered by protein accumulation, mechanical instability of membranes and bacterial infection during the dialytic therapy. Herein, we show that cellulose acetate membranes modified with the low-fouling polymers (namely polyvinylpyrrolidone and polyethylene glycol), followed by the in situ reduction of different densities of silver oxide(I) nanoparticles, can effectively address these limitations. These improvements comprise the enhanced resistance to the protein fouling, improved antimicrobial capabilities against S.

Routine childhood rabies pre-exposure prophylaxis can be cost effective in low- and middle-income countries.

Background: Pre-exposure prophylactic rabies vaccination (PrEP) is advised for travellers to countries with high rabies incidence, but rarely available for local residents. Some studies suggest poor cost-effectiveness of PrEP in such settings, but have generally focused upon post-exposure prophylaxis (PEP) cost savings as the main benefit of PrEP, without considering lives saved by PrEP efficacy.

Methods: We compared incremental cost-effectiveness ratios (ICERs) of use of rabies PrEP, against an alternative of using only PEP, by adapting a decision-tree model previously used to inform Gavi's investment in rabies PEP.

Fatty acid carbon isotopes as tracers of trophic structure and contaminant biomagnification in Arctic marine food webs.

Mercury (Hg) and persistent organic pollutant (POP) accumulation among species and biomagnification through food webs is typically assessed using stable isotopes of nitrogen (δN) and carbon (δC) in bulk (whole) tissues. Yet, bulk isotopic approaches have limitations, notably from the potential overlap of isotope values from different dietary sources and from spatial variation in source (baseline) signals. Here, we explore the potential of fatty acid carbon isotopes (FA δC) to (1) evaluate the trophic structure of a marine food web, (2) distinguish feeding patterns among four marine mammal consumers, (3) trace contaminant biomagnification through a food web, and (4) explain interspecific variation in contaminants among high-trophic position predators.

The competitive esports physiological, affective, and video dataset.

Esports refers to competitive video gaming where individuals compete against each other in organized tournaments for prize money. Here, we present the Competitive Esports Physiological, Affective, and Video (CEPAV) dataset, in which 300 male Counter Strike: Global Offensive gamers participated in a study aimed at optimizing affect during esports tournament. The CEPAV dataset includes (1) physiological data, capturing the player's cardiovascular responses from before, during, and after over 3000 CS: GO matches; (2) self-reported affective data, detailing the affective states experienced before gameplay; and (3) video data, providing a visual record of 552 in-laboratory gaming sessions.

Evolving Roles: Adolescent perspectives on shared decision making with their parents and healthcare providers.

Introduction: Shared decision making (SDM) involving adolescents presents unique challenges. To adequately support and evaluate SDM that includes adolescents, parents, and healthcare providers, it is imperative to understand adolescent perspectives. This study aims to describe the perspectives of adolescents with chronic health conditions regarding sharing medical decisions with their parents and healthcare providers.

Elucidating the synergistic action between sulfonated lignin and lytic polysaccharide monooxygenases (LPMOs) in enhancing cellulose hydrolysis.

Modern enzyme cocktails often include lytic polysaccharide monooxygenase (LPMO) as an accessory enzyme that enhances cellulose accessibility during hydrolysis. Although lignin is known to generally impede cellulose hydrolysis, previous research has demonstrated lignin's potential to act as a co-factor in boosting LPMO activity and that the negative impact of lignin limiting enzyme accessibility can be mitigated by sulfonated. When sulphonated lignin was added to microcrystalline cellulose (Avicel) the activity of the lytic polysaccharide monooxygenase (LPMO) was boosted, as determined when using a quartz crystal microbalance and dissipation monitoring (QCM-D).

Digital Solutions for the Optimization of Pharmacologic Therapy for Heart Failure.

Data from large-scale, randomized, controlled trials demonstrate that contemporary treatments for heart failure (HF) can substantially improve morbidity and mortality. Despite this, observed outcomes for patients living with HF are poor, and they have not improved over time. The are many potential reasons for this important problem, but inadequate use of optimal medical therapy for patients with HF, an important component of guideline-directed medical therapy, in routine practice is a principal and modifiable contributor.

Revealing the Complexity of Host-Parasite Relationships Between Syringophilid Mites and Sunbirds in Their Global Range.

This article emphasises the importance of parasitological research in understanding ecological dynamics and biodiversity conservation through a global analysis of quill mites (Syringophilidae) parasitising Sunbirds (Nectariniidae). Data from 764 Sunbird individuals across seventy-six species revealed twelve quill mite species, including three newly described species: Sikora and Unsoeld sp. n.

First Detection of in Namibian Bird Ectoparasites (Acariformes: Syringophilidae) with a Description of New Quill Mite Species.

is a common intracellular bacterial genus that infects numerous arthropods and filarial nematodes. In arthropods, it typically acts as a reproductive parasite, leading to various phenotypic effects such as cytoplasmic incompatibility, parthenogenesis, feminization, or male-killing. Quill mites (Acariformes: Syringophilidae) are a group of bird parasites that have recently attracted increasing interest due to the detection of unique phylogenetic lineages of endosymbiotic bacteria and potentially pathogenic taxa.

Longitudinal study of care needs and behavioural changes in people living with dementia using in-home assessment data.

Background: People living with dementia often experience changes in independence and daily living, affecting their well-being and quality of life. Behavioural changes correlate with cognitive decline, functional impairment, caregiver distress, and care availability.

Methods: We use data from a 3-year prospective observational study of 141 people with dementia at home, using the Bristol Activities of Daily Living Scale, Neuropsychiatric Inventory and cognitive assessments, alongside self-reported and healthcare-related data.

Measuring women's empowerment in aquaculture in northwestern Bangladesh using a project level women's empowerment in fisheries index (pro-WEFI).

Gender equality and women's empowerment have been increasingly emphasised in food production systems, including fisheries and aquaculture. Accurate assessment and understanding of the state, progress and changes in women's empowerment in the sub-sectors is required. We applied the project level Women's Empowerment in Fisheries and Aquaculture Index (pro-WEFI), which is based on the project-level women's empowerment in agriculture index (pro-WEAI) to standardize the measurement of women's agency and empowerment in fisheries and aquaculture.

Beyond Routine Maintenance: Current Trends in Working Memory Research.

Working memory (WM) is an evolving concept. Our understanding of the neural functions that support WM develops iteratively alongside the approaches used to study it, and both can be profoundly shaped by available tools and prevailing theoretical paradigms. Here, the organizers of the 2024 Working Memory Symposium-inspired by this year's meeting-highlight current trends and looming questions in WM research.

Excited state dynamics of azanaphthalenes reveal opportunities for the rational design of photoactive molecules.

Various photoactive molecules contain motifs built on aza-aromatic heterocycles, although a detailed understanding of the excited state photophysics and photochemistry in such systems is not fully developed. To help address this issue, the non-adiabatic dynamics operating in azanaphthalenes under hexane solvation was studied following 267 nm excitation using ultrafast transient absorption spectroscopy. Specifically, the species quinoline, isoquinoline, quinazoline, quinoxaline, 1,6-naphthyridine, and 1,8-naphthyridine were investigated, providing a systematic variation in the relative positioning of nitrogen heteroatom centres within a bicyclic aromatic structure.

Associations of personality traits with actigraphic sleep in middle-aged and older adults.

Although prior studies have examined associations of personality traits with sleep, most have investigated self-reported sleep, been cross-sectional, and focused on younger and middle-aged adults. We investigated associations of personality with actigraphic sleep parameters and changes in sleep in 398 cognitively normal adults aged 40-95 years (M ± SD = 70.1 ± 12.

Familiarity of an environment prevents song suppression in isolated zebra finches.

Despite the wide use of zebra finches as an animal model to study vocal learning and production, little is known about impacts on their welfare caused by routine experimental manipulations such as changing their social context. Here we conduct a post-hoc analysis of singing rate, an indicator of positive welfare, to gain insights into stress caused by social isolation, a common experimental manipulation. We find that isolation in an unfamiliar environment reduces singing rate for several days, indicating the presence of an acute stressor.

Effect of a Narrative-Based Online Course Aimed at Reducing Stigma Toward Transgender Children and Adolescents: Longitudinal Observational Study.

Background: Stigma toward transgender children and adolescents negatively impacts their health and educational outcomes. Contact with members of stigmatized groups can dismantle stereotypes and reduce stigma by facilitating exposure to the unique cognitive and emotional perspectives of individuals within the group. Recent evidence suggests that video-based contact interventions can be as effective as face-to-face encounters, but challenges lie in protecting the identities of transgender youth, since many of them live in stealth.