788 results match your criteria: "AC Camargo Cancer Center[Affiliation]"

Autonomously functioning thyroid nodules (AFTNs) represent ∼5% of all thyroid nodules and often necessitate definitive treatments such as surgery or radioiodine (I), both of which have inherent risks. Radiofrequency ablation (RFA) has emerged as an effective and safe therapeutic option for managing AFTNs. This study aims to assess the effectiveness and safety of RFA for solitary AFTNs in various countries across Latin America.

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Purpose: To provide evidence-based guidance for clinicians who treat patients with stage I-III anal cancer.

Methods: A systematic review of the literature conducted by the Minnesota Evidence-based Practice Center provided the evidence base for this guideline. An ASCO Expert Panel reviewed this evidence and came to consensus on a set of evidence-based recommendations.

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Although systemic therapy for multiple myeloma (MM) has evolved considerably over the past two decades, state-of-the-art treatment is not uniformly available in Latin America. In some countries, disparities between the public and private sectors in clinical presentation, access to novel agents and transplantation are striking, with the public sector lagging. We conducted a multicenter, observational study (NCT03955900) of patients with MM in five Latin American countries (Argentina, Brazil, Colombia, Mexico, and Panama).

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The global multiple myeloma incidence and mortality burden in 2022 and predictions for 2045.

J Natl Cancer Inst

December 2024

Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.

Background: Multiple myeloma (MM) is an important haematological malignancy in older adults, with a relatively poor prognosis. We aimed to present the current global patterns of incidence and mortality from MM, and predict new cases and deaths by 2045.

Methods: Estimated numbers of MM cases and deaths and age-standardized (World) incidence and mortality rates per 100,000 people were obtained from the GLOBOCAN 2022 database covering 185 countries.

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Introduction: Despite the declining public health emergency status, COVID-19 still poses significant risks, especially for immunocompromised individuals. We aimed to evaluate the effectiveness of tixagevimab-cilgavimab (T-C) prophylaxis in preventing severe COVID-19 in patients with hematologic malignancies (HM) treated with anti-CD20 therapy during the early Omicron variant phase of the pandemic.

Methods: The European Society of Clinical Microbiology and Infectious Diseases Study Group for Respiratory Viruses (ESGREV) conducted a multicenter retrospective cohort study involving 15 centers from 5 countries.

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Acute decompensated pulmonary hypertension outcomes in pulmonary arterial hypertension patients: systematic review and meta-analysis of proportions.

Heart Lung

November 2024

Intensive Care Unit, AC Camargo Cancer Center, São Paulo, Brazil; Pulmonary Department, Heart Institute (InCor), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Article Synopsis
  • Acute decompensated pulmonary arterial hypertension (ADPH) leads to right heart failure, posing a high risk of mortality, making the assessment of mortality rates and life-sustaining therapies essential for patient management.
  • A systematic review of 25 studies showed ICU mortality at 29% and hospital mortality at 38%, with higher mortality (45%) among patients needing extracorporeal membrane oxygenation (ECMO). Additional treatments like inotropes and vasopressors also indicated increased mortality rates.
  • The study highlights the variability in ADPH mortality related to different clinical settings and therapies, emphasizing the importance of these findings for clinical practice and discussions with patients and their families.
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Objective: To present the rates of intra- and postoperative complications and conversions in a large cohort of unselected vNOTES hysterectomies, performed by surgeons with different levels of expertise.

Design: International register-based cohort study.

Setting: Hysterectomies in the iNOTESs registry, 2015 to January 2024, performed by 201 surgeons from multiple countries.

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Background: 177-LuDOTATE is an effective but expensive treatment for neuroendocrine tumors (NETs). Reducing treatment-related costs, such as the number of images, could improve access to 177-LuDOTATE. We evaluated early radiological tumor progression and prognostic factors in patients with NETs treated with 177-LuDOTATE.

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Introduction: Squamous cell carcinoma of the head and neck (SCCHN) is a multifactorial disease involving genetic and environmental factors representing one of the most frequent cancer-related deaths worldwide. Tobacco and alcohol use account for most SCCHN, while a growing subset of oropharyngeal cancers is causally associated with human papillomavirus (HPV) infection. Despite improvements in overall survival, patients with HPV-negative locally advanced (LA) SCCHN continue to have a poor prognosis.

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Background: Colorectal surgeries are complex procedures associated with high rates of complications and hospital readmission.

Objective: This study aimed to develop an electronic post-discharge follow-up plan to remotely monitor patients' symptoms in the postoperative period of colorectal surgeries and evaluate the outcomes of emergency department visits and the rate of severe complications within 15 days after hospital discharge.

Design: We developed a digital tool capable of remotely assessing symptoms that could indicate complications related to colorectal surgical procedures and directing early management.

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Objective: To evaluate the impact of counseling and preoperative education on reducing anxiety in patients undergoing surgery for gynecologic cancer.

Methods: In this randomized clinical trial, patients with gynecological tumors undergoing surgical treatment between 15 and 60 days preoperatively, were included. The group was randomized to receive preoperative routine orientation plus preoperative counseling and education by nursing (experimental group [EG]) or receive preoperative routine orientation only (control group [CG]).

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Article Synopsis
  • The study analyzes the characteristics of oral reactions to injectable soft tissue fillers, focusing on 151 patients, predominantly females averaging 54.9 years old.
  • Most reactions occurred about 20.4 months after injection, often presenting as painless nodules in the lips, with silicone and polymethylmetacrylate being the most common fillers used.
  • Key findings showed differences in reaction patterns based on the type of filler and highlighted the importance for clinicians to recognize these potential reactions when assessing asymptomatic nodules in older female patients.
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Objective: The purpose of this study was to assess performance in the Brazilian Lung Cancer Registry Database by using the parsimonious EuroLung risk models for morbidity and mortality.

Methods: The EuroLung1 and EuroLung2 models were tested and evaluated through calibration (calibration plot, Brier score, and the Hosmer-Lemeshow test) and discrimination (ROC AUCs), in a national multicenter registry of 1,031 patients undergoing anatomic lung resection.

Results: The evaluation of performance in Brazilian health care facilities utilizing risk-adjustment models, specifically EuroLung1 and EuroLung2, revealed substantial miscalibration, as evidenced by calibration plots and Hosmer-Lemeshow tests in both models.

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Drug-induced lung disease: a narrative review.

J Bras Pneumol

October 2024

. Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo - HCFMUSP - São Paulo (SP) Brasil.

Article Synopsis
  • Drug-induced lung disease (DILD) happens when certain medicines harm the lungs, affecting between 3% and 5% of people with lung diseases.
  • Symptoms can appear quickly after starting treatment and may range from not feeling sick at all to having serious breathing problems.
  • To treat DILD, doctors usually stop the harmful medication and may give steroids, but the chances of recovery can be very different for each person and some cases can be very serious.
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Article Synopsis
  • Critically ill patients are more vulnerable to health care-associated infections from medical devices, prompting the study of daily chlorhexidine digluconate baths as a potential prevention strategy.
  • *The CLEAN-IT trial is a multicenter, randomized study comparing the effectiveness of chlorhexidine baths versus traditional soap and water in preventing infections in intensive care units.
  • *The trial's primary goal is to measure the reduction in device-associated infections, while also evaluating secondary outcomes like antibiotic use, duration of hospital stays, and overall mortality rates.
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Clinical Characteristics Associated with the PLP-PLS Index, a New Potential Metric to Phenotype Phantom Limb Pain.

Biomedicines

September 2024

Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.

Background: Phantom limb pain (PLP) is highly prevalent after amputation. However, the influence of non-painful sensations (PLS) remains unclear. This study examines the PLP-PLS index as a novel tool to differentiate PLP from PLS and explores the association of clinical factors with the index.

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The risk of hypoparathyroidism and hypocalcemia is a critical concern in thyroid surgery. Preserving parathyroid gland vascularization during surgery is essential for effective prevention. Preoperative and postoperative management, including calcium and Vitamin D supplementation, is paramount.

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Ototoxicity is among the adverse events related to cancer treatment that can have far-reaching consequences and negative impacts on quality-of-life for cancer patients and survivors of all ages. Ototoxicity management (OtoM) comprises the prevention, diagnosis, monitoring, and treatment, including rehabilitation and therapeutic intervention, of individuals who experience hearing loss, tinnitus, or balance/vestibular difficulties following exposures to ototoxic agents, including platinum chemotherapy (cisplatin, carboplatin) and cranial radiation. Despite the well-established physical, socioeconomic, and psychological consequences of hearing and balance dysfunction, there are no widely adopted standards for clinical management of cancer treatment-related ototoxicity.

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Duodenal-type follicular lymphoma (DFL) is a rare subtype classified by the 5th edition of the WHO and international consensus classifications of lymphoid neoplasms, typically presenting as localized disease with favorable outcomes. This multicenter retrospective study examines 53 Brazilian DFL patients with a median age of 58.2 years (33-85), with males comprising 50% ( = 27).

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Article Synopsis
  • Penile cancer is notably prevalent in underdeveloped countries, and markers like STAT3, CD44, CD24, and SOX2 are being explored for their potential in diagnosing and prognosing this disease.
  • A study conducted at the Hospital de Cancer de Pernambuco analyzed blood and tumor tissues of patients from 2015 to 2017, revealing significant differences in the levels of the markers between cancer patients and healthy controls.
  • The findings indicated that high levels of CD44, CD24, and low SOX2+ T cells are linked to advanced disease and poor prognosis, while high pSTAT3 and T cell counts were associated with better outcomes in penile cancer patients.
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Background: Ventilation management may differ between COVID-19 ARDS (COVID-ARDS) patients and patients with pre-COVID ARDS (CLASSIC-ARDS); it is uncertain whether associations of ventilation management with outcomes for CLASSIC-ARDS also exist in COVID-ARDS.

Methods: Individual patient data analysis of COVID-ARDS and CLASSIC-ARDS patients in six observational studies of ventilation, four in the COVID-19 pandemic and two pre-pandemic. Descriptive statistics were used to compare epidemiology and ventilation characteristics.

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Cordotomy for pain control and opioid reduction in cancer patients: A cancer center 11-year experience.

Eur J Surg Oncol

October 2024

Postgraduate Program in Health Sciences, Instituto de Assistência Mêdica ao Servidor Público Estadual (IAMSPE), São Paulo, Brazil; Pain Department, AC Camargo Cancer Center, São Paulo, Brazil; Neurosurgery Department, Hospital do Servidor Público Estadual, São Paulo, Brazil.

Background: Percutaneous lateral cervical cordotomy (PLCC) is a treatment option for predominantly nociceptive pain of oncological origin that is refractory to conservative methods, with unilateral distribution, particularly in the lower trunk or lower limbs of patients with a life expectancy of less than one year.

Objective: The aim of this study was to assess the analgesic efficacy and opioid utilization alteration in patients undergoing PLCC.

Methods: We retrospectively collected data from patients undergoing PLCC between 2011 and 2021 at the AC Camargo Cancer Center in São Paulo, Brazil.

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Early Toxicity and Efficacy of Four Different Conditioning Regimens for Autologous Hematopoietic Cell Transplantation in Patients With Lymphoma: Impact of Drug Shortages in a Resource-Constrained Country.

Transplant Cell Ther

October 2024

Laboratório de Investigação Médica (LIM) 31, Universidade de São Paulo, São Paulo, Brazil; Serviço de Hematologia, Hemoterapia e Terapia Celular, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Hospital Vila Nova Star-Rede D'Or, São Paulo, Brazil; Department of Hematology, Churchill Hospital Oxford, Oxford University Hospitals, Oxford, UK.

High-dose therapy followed by autologous hematopoietic cell transplant (AHCT) remains a viable consolidation strategy for a subset of patients with relapsed or refractory (R/R) lymphomas. BEAM (carmustine, etoposide, cytarabine, and melphalan) is widely recognized as the predominant conditioning regimen due to its satisfactory efficacy and tolerability. Nevertheless, shortages of carmustine and melphalan have compelled clinicians to explore alternative conditioning regimens.

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