From prolactin cell to prolactinoma.

The pathogenesis, diagnosis and treatment of common pituitary neoplasms is based on the understanding of the differentiated hormone expression by specific pituitary cell types and of the central hypothalamic, peripheral and local control of their hormonal secretion (endocrine, autocrine, paracrine regulation). Tumorigenesis is the result of a complex multistep process. It is likely that a molecular genetic alteration initially leads to cell transformation.

Successful use of an intraosseous infusion in an 800 grams preterm infant.

An intravascular access line for the administration of life support drugs and volume expanders may be particularly difficult, especially in very small premature babies. We report on the successful use of an intraosseous accessline in an 800 grams preterm infant for the administration of drugs and fluid. The use and technique of an intraosseous access is an important emergency alternative which may be lifesaving, even in very preterm babies, when other methods fail.

Homing mechanisms in the biology of multiple myeloma.

Throughout the last decades, new developments in cellular and molecular immunology have led to a better insight in the biological nature of MM. Ever since, MM has also been regarded as a tool for studying basic concepts of the terminal B cell differentiation. The first aim of our research work, was to clarify the intraclonal maturation of the tumor clone by examining the existence of myeloma precursor cells at the genetic level.

[A "good choice" of diagnostic imaging examinations: the knee].

A medically sound and cost-effective choice of diagnostic imaging investigations in knee pathology must be supported by a good evaluation of the respective strong and weak points of the available methods. These are: conventional radiology, C.T.

[The "right choice" in medical imaging studies: the radiologist's viewpoint--application to lumbosciatic pain].

These past few years, very efficient imaging technologies, which are not traumatic for the patient, but often quite expensive, have been developed. Within the context of budgetary restrictions, these progress require a carefully planned strategy on the choice of investigations. First of all basic rules are defined: "the most simple act", "the direct way", "the direct exploitation of results", "the therapeutic relevance", "the multidisciplinary integration".