QbD-guided phospholipid-tagged nanonized boswellic acid naturosomal delivery for effective rheumatoid arthritis treatment.

Studies have reported the potential role of Boswellic acids (BAs), bioactive pentacyclic triterpenes from (BS), in treating rheumatoid arthritis (RA). However, poor water solubility and limited oral absorption are restricting factors for its better therapeutic efficacy. Based on these assumptions, the current study aimed to develop naturosomal delivery of BAs to boost their extremely low bioavailability, colloidal stability, and water solubility.

Cost-effective synthesis of zinc oxide/crab shell-derived chitosan nanocomposite: Insights into its biomedical applications.

For biomedical applications, material scientists all over the world are working to develop cost-effective technologies and thereby synthesize new nanocomposite materials that are biocompatible, bioactive, scalable and naturally abundant. This study focuses on synthesizing and evaluating nanocomposites of zinc oxide (ZnO) and chitosan (CS) derived from crab shells, in three different weight proportions (1:0.5, 1:1, and 1:2).

Fruit Extract Mediated Formation of Luminescent Titanium Dioxide Nanometer-Sized Particles: An Innovative Strategy in Domain of Photodecomposition and Germicidal Properties.

Discoveries in nanotechnologies are placing a great deal of attention on greener strategies that use harmless substances and moderated reactions to promote healthy development. This work used a straightforward, innovative, and cost-effective sustainable approach to produce bio-augmented TiO nanometer-sized particles (NMSP) by applying a water-based extract of the star fruit as a stabilization and reduction agent. A variety of techniques, comprising UV-Vis, XRD, FT-IR, FE-SEM with EDAX, and TEM, have been employed to investigate the formed TiO NMSP.

Fabrication of Luminescent Titanium Dioxide Nanoparticles in a Biocompatible Approach: Its Potential for Photodecomposition and Germicidal Effects.

The fabrication of the green strategy of metallic oxide creation provides considerable profits via a minimum of effort, making it an acceptable substitute to the most laborious and challenging conventional processes. The suggested approach involved the creation of titanium dioxide (TiO) nanoparticles through Orthosiphon stamineus extracts of leaves. The synthesized nanoparticles (NPs) were then characterized using XRD, FT-IR, FE-SEM with EDX, and UV-visible spectroscopy.

Sustainable Fabrication of Luminescent Zinc Oxide Nanoparticles From Cucumis melo Fruit Peel Extract as Prospective Photocatalytic and Antigermicidal Agent.

The focus of current advances in nanotechnology has shifted significantly towards environmentally conscious methods that use harmless ingredients and moderated reaction circumstances to promote equitable development. Zinc oxide nanoparticles (NPs) currently grabbed attention of multiple medical fields owing to their unique ability to safeguard against cellular damage and alleviate serious human diseases via processes related to metabolism. This work focused on the generation of ZnO NPs using the peel of Cucumis melo fruit.

Coconut husk waste products valorization for fabrication of luminescent titanium dioxide NPs as powerful tool for photodecomposition and food born infection: A sustainable strategy.

Fabricating metal oxide nanoparticles has garnered much attention lately because creating safe chemicals, sustainable materials, economic processes, and renewable resources is becoming increasingly important. This research shows how TiO nanoparticles (NPs) could be generated in an ecologically responsible way using waste coconut husk with the help of tender coconut. This extract functions as both a reducing agent and a sealing agent.

Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris.

Background: The emergence and evolution of SARS-CoV-2 resulted a severe threat to public health globally. Due to the lack of an effective vaccine with durable immunity, the disease transited into the endemic phase, necessitating potent antiviral therapy including a scientific basis for current traditional herbal medicine.

Objective: This study aimed to conduct a pharmacoinformatic analysis of selected chemical ingredients and in-vitro evaluation of Cordyceps militaris extract against SARS-CoV-2.

Nucleic acid-based electrochemical biosensors.

Colorectal cancer, breast cancer, oxidative DNA damage, and viral infections are all significant and major health threats to human health, presenting substantial challenges in early diagnosis. In this regard, a wide range of nucleic acid-based electrochemical platforms have been widely employed as point-of-care diagnostics in health care and biosensing technologies. This review focuses on biosensor design strategies, underlying principles involved in the development of advanced electrochemical genosensing devices, approaches for immobilizing DNA on electrode surfaces, as well as their utility in early disease diagnosis, with a particular emphasis on cancer, leukaemia, oxidative DNA damage, and viral pathogen detection.

Production, optimization and characterization of partially purified anti-mycotic compound from marine soil derived streptomycetes originating at unexplored region of Bay of Bengal, India.

Sixty-eight morphologically distinct isolates of marine actinomycetes were derived from seashore, mangrove, and saltpan ecosystems located between the Palk Strait and Gulf of Mannar region, Bay of Bengal, Tamilnadu. Twenty-five (36.8%) isolates exhibited anti-mycotic activity against Candida albicans and Cryptococcus neoformans in preliminary screening, and 4 isolates with prominent activity were identified and designated at the genus level as Streptomyces sp.

Phytochemical composition, anti-microbial, anti-oxidant and anti-diabetic effects of Cav. leaves: and assessments.

The aim of this study was to screen the chemical components of leaves and assess their therapeutic attributes with regard to their antioxidant, antibacterial, and antidiabetic activities. The antidiabetic effects were explored to determine the α-amylase and α-glucosidase inhibitory potential of the leaf extract. To identify the active antidiabetic drugs from the extracts, the GC-MS-screened molecules were docked with diabetes-related proteins using the glide module in the Schrodinger Tool.

Process Optimization for the Bioinspired Synthesis of Gold Nanoparticles Using , Its Characterization, and Assessment of Enhanced Therapeutic Efficacy.

The promising therapeutic implications of nanoparticles have spurred their development for biomedical applications. An eco-friendly methodology synthesizes gold nanoparticles using , an edible mushroom (-Au-NPs), using a quality-by-design approach (central composite design). UV-visible spectroscopy analysis revealed an absorption peak at 540-550 nm, thus confirming the synthesis of gold nanoparticles.

Fabrication of chitosan nanocomposites loaded with biosynthetic metallic nanoparticles and their therapeutic investigation.

The present research demonstrates the formation of zinc oxide nanoparticles facilitated by Cissus quadrangularis (CQ-ZnONPs) and subsequent synthesis of chitosan-conjugated nanocomposites (CQ-CS/ZnONCs) along with their biological assessment. The biosynthesized nanoparticles and nanocomposites were physicochemically characterized and therapeutically assessed for their antioxidant, antibacterial, and antidiabetic potential. The formation of CQ-ZnONPs and CQ-CS/ZnONCs was preliminarily validated by the change in color and subsequently by UV-visible spectroscopic analysis.

Enhanced photocatalytic efficiencies in a bifunctional ZnO/PVA nanocomposites derived from Capparis zeylanica L.

The modern food sector demands versatile nanocomposites of polymers for food to wrappers to inactivate germs linked to foods in order to ensure quality throughout the packaging process. Recently, it has become quite appealing to use zinc oxide nanocomposite with polyvinyl alcohol (PVA) assistance for food storage containers. Variable combinations of zinc acetate and Capparis zeylanica leaf extract (3:1, 1:7, 1:3, and 1:1) were used to create nanostructured ZnO at the desired pH (10.

Eco synthesized chitosan/zinc oxide nanocomposites as the next generation of nano-delivery for antibacterial, antioxidant, antidiabetic potential, and chronic wound repair.

The present research work aimed at synthesizing chitosan-coated Zinc oxide nanocomposites (NS-CS/ZnONCs) by a bio-inspired method using an aqueous extract of Nigella sativa (NS) seeds and employing a quality-by-design approach (Box-Behnken design). The biosynthesized NS-CS/ZnONCs were physicochemically characterized and subjected to their in-vitro and in-vivo therapeutic potential. The zeta potential value of -11.

Ethnological validation of Ashwagandha (Withania somnifera L. Dunal) ghrita as 'Vajikarana Rasayana': In-silico, in-vitro and in-vivoapproach.

Ethnopharmacological Relevance: Processing cow ghee (clarified butterfat) with therapeutic herbs, i.e. ghrita, is recognized for augmenting the therapeutic efficacy of plant materials.

Exploring the therapeutic mechanisms of in diabetes mellitus through network pharmacology, molecular docking and molecular dynamics.

is reported as anti-diabetic medicinal plant and is also used as an ethnomedicine. However, its mode of action as an anti-diabetic agent has not been clearly elucidated. Hence, the present study investigated the probable mechanism of action of to manage diabetes mellitus network pharmacology and molecular docking and simulations studies.

Computational and network pharmacology studies of to tackle SARS-CoV-2.

Background: Since December 2019, SARS-CoV-2 had been a significant threat globally, which has accounted for about two million deaths. Several types of research are undergoing and have reported the significant role of repurposing existing drugs and natural lead in the treatment of COVID-19. The plant (Synonym-) (Euphorbiaceae) is a rich source of vitamin C, and its use as an antiviral agent has been well established.

Evaluation of phytochemicals, enzyme inhibitory, antibacterial and antioxidant effects of Gaertn.

The study was aimed to investigate the phytochemical composition, antioxidant, antibacterial and enzyme inhibitory effects of leaf (PDL). Hydroalcoholic extract (HAE) was recorded with high concentration of total phenolics (59.68 ± 0.

Therapeutic potential of phytoconstituents of edible fruits in combating emerging viral infections.

Plant-derived bioactive molecules display potential antiviral activity against various viral targets including mode of viral entry and its replication in host cells. Considering the challenges and search for antiviral agents, this review provides substantiated data on chemical constituents of edible fruits with promising antiviral activity. The bioactive constituents like naringenin, mangiferin, α-mangostin, geraniin, punicalagin, and lectins of edible fruits exhibit antiviral effect by inhibiting viral replication against IFV, DENV, polio, CHIKV, Zika, HIV, HSV, HBV, HCV, and SARS-CoV.

Molecular characterization of endangered endemic plant using chloroplast and plastid gene.

An endangered and rare species from the plant family Asphodelaceae which is presently recorded as endangered in Saudi Arabia collected from Al-Baha region of Saudi Arabia its GPS Latitude and Longitude coordinates 19.8345, 41.5481.

Identification of potential drug targets in human pathogen Bacillus cereus and insight for finding inhibitor through subtractive proteome and molecular docking studies.

Bacillus cereus is a gram-positive, anaerobic, spore-forming bacterium related to food poisoning in humans. Vomit and diarrhea are the symptoms of foodborne B. cereus infection caused by emetic toxins and three enterotoxins, respectively.

Molecular perspective and anticancer activity of medicinal plants.

To evaluate phytochemical constituents from the methanolic extracts of medicinal plants and . The cytotoxic activity of and leaf extracts against Human colon cancer cell line (HCT-116) was also assessed. The two medicinal plant extracts having significant cytotoxic activity, meanwhile the methanolic extract of shows higher cytotoxic activity than extract.

Taxonomic identification and bioactive compounds characterization of Psilocybe cubensis DPT1 to probe its antibacterial and mosquito larvicidal competency.

Mushrooms have an important role in sustainability since they have long been used as valuable food source and traditional medicine around the world. Regrettably, they are among the most rigorously affected populations, along with several plants and animals, due to the destructive activities of mankind. Thus the authentication and conservation of mushroom species are constantly needed to exploit the remarkable potential in them.

Effect of traditionally used herb L. and its active compound pedalitin on urease expression - For the management of kidney stone.

L. is a medicinal herb that has been used for the treatment of diseases related to kidney in the traditional system of medicine. The current study aims to study the effect of ethyl acetate extract of (EAEP) and its fractionated compound pedalitin against urease production and gene expression in .

Evaluation of anti-urolithiatic potential of ethyl acetate extract of L. on struvite crystal (kidney stone).

(L.) is a traditional herb, commonly used for the treatment of kidney stone related problems. Struvite stone can swiftly grow and become 'staghorn calculi' in kidney and its associated areas, which is the most aching urological disorder.