260 results match your criteria: "A.L.H.; Royal Alexandra Hospital P.E.[Affiliation]"
Purified Inactivated Zika Vaccine Candidates Afford Protection against Lethal Challenge in Mice.
Sci Rep
November 2018
Takeda Vaccines Inc, Cambridge, MA, USA.
Article Synopsis
- The development of a purified inactivated Zika virus (PIZV) vaccine candidate was a response to the Zika outbreak declared by the WHO in 2016, using a strain isolated during the 2015 outbreak.
- Mice tested with the vaccine showed strong immune responses and complete protection against a lethal Zika virus challenge after two doses.
- The results indicated that the antibodies produced could neutralize various Zika virus strains, supporting further clinical development of the PIZV vaccine.
Characterization of Red Wine Proanthocyanidins Using a Putative Proanthocyanidin Database, Amide Hydrophilic Interaction Liquid Chromatography (HILIC), and Time-of-Flight Mass Spectrometry.
Molecules
October 2018
Department of Viticulture & Enology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
Proanthocyanidins are complex polymers of flavan-3-ol monomers and play a key sensory and health role in foods and beverages. We describe here a novel method for characterizing wine proanthocyanidins using a theoretical database comprised of the chemical formula and exact mass of 996 compounds. The database was constructed using the four primary grape and wine proanthocyanidin monomers: (epi)catechin, (epi)catechin-3--gallate, (epi)gallocatechin, and (epi)gallocatechin-3--gallate, each combined in all possible combinations up to a polymerization of 10.
View Article and Find Full Text PDFTalazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation.
N Engl J Med
August 2018
From the University of Texas M.D. Anderson Cancer Center, Houston (J.K.L.), and the Texas Oncology-Baylor Charles A. Sammons Cancer Center, US Oncology Network, Dallas (J.L.B.) - both in Texas; University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center (H.S.R.), and Pfizer (R.G.W.Q., D.M., I.C.T., A.L.H.), San Francisco, University of California, Los Angeles, Los Angeles (S.A.H.), and Kaiser Permanente, Northern California, Vallejo (L.F.) - all in California; the Department of Obstetrics and Gynecology, Klinikum Rechts der Isar, Technische Universität München (J.E.), and Interdisziplinäres Onkologisches Zentrum München (W.E.) - both in Munich, Germany; Institut Paoli-Calmettes, Marseille (A.G.), and Institut Claudius Regaud, Institut Universitaire du Cancer Toulouse, Toulouse (H.R.) - both in France; Seoul National University Hospital (K.-H.L.) and Samsung Medical Center (Y.-H.I.) - both in Seoul, South Korea; Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel (R.Y.); Banner M.D. Anderson Cancer Center, Gilbert, AZ (L.A.M.); and Instituto de Investigación Sanitaria Gregorio Marañón, Centro de Investigación Biomédica en Red Oncología, Grupo Español de Investigación en Cáncer de Mama, Universidad Complutense, Madrid (M.M.).
Background: The poly(adenosine diphosphate-ribose) inhibitor talazoparib has shown antitumor activity in patients with advanced breast cancer and germline mutations in BRCA1 and BRCA2 ( BRCA1/2).
Methods: We conducted a randomized, open-label, phase 3 trial in which patients with advanced breast cancer and a germline BRCA1/2 mutation were assigned, in a 2:1 ratio, to receive talazoparib (1 mg once daily) or standard single-agent therapy of the physician's choice (capecitabine, eribulin, gemcitabine, or vinorelbine in continuous 21-day cycles). The primary end point was progression-free survival, which was assessed by blinded independent central review.
Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients.
Sci Rep
January 2018
Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Mass spectrometric glycomics was used as an innovative approach to identify biomarkers in serum and dialysate samples from peritoneal dialysis (PD) patients. PD is a life-saving treatment worldwide applied in more than 100,000 patients suffering from chronic kidney disease. PD treatment uses the peritoneum as a natural membrane to exchange waste products from blood to a glucose-based solution.
View Article and Find Full Text PDFCase 38-2017. A 20-Year-Old Woman with Seizures and Progressive Dystonia.
N Engl J Med
December 2017
From the Departments of Neurology (F.S.E., K.J.S., A.L.H.) and Radiology (O.R.), Massachusetts General Hospital, the Departments of Neurology (F.S.E., K.J.S., A.L.H.), Ophthalmology (D.M.C.), and Radiology (O.R.), Harvard Medical School, and the Department of Ophthalmology, Massachusetts Eye and Ear Infirmary (D.M.C.) - all in Boston.
Comparison of UV-C and Pulsed UV Light Treatments for Reduction of Salmonella, Listeria monocytogenes, and Enterohemorrhagic Escherichia coli on Eggs.
J Food Prot
January 2018
Norwegian Institute of Food, Fisheries and Aquaculture Research (NOFIMA), P.O. Box 210, N-1431 Aas, Norway (ORCID: http://orcid.org/0000-0001-6338-357X [A.L.H.]).
Ten percent of all strong-evidence foodborne outbreaks in the European Union are caused by Salmonella related to eggs and egg products. UV light may be used to decontaminate egg surfaces and reduce the risk of human salmonellosis infections. The efficiency of continuous UV-C (254 nm) and pulsed UV light for reducing the viability of Salmonella Enteritidis, Listeria monocytogenes, and enterohemorrhagic Escherichia coli on eggs was thoroughly compared.
View Article and Find Full Text PDFDouble-Row Arthroscopic Rotator Cuff Repair Is More Cost-Effective Than Single-Row Repair.
J Bone Joint Surg Am
October 2017
1Division of Orthopedics (A.L.H. and P.L.) and Clinical Epidemiology Program (K.T. and S.v.K.), Ottawa Hospital Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada 2School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada 3Institute of Clinical and Evaluative Sciences, Ottawa, Ontario, Canada 4Section of Orthopaedic Surgery and the Pan Am Clinic, University of Manitoba, Winnipeg, Manitoba, Canada.
Background: The optimal technique for arthroscopic rotator cuff repair is controversial, and both single and double-row techniques are commonly used. In the current era of increasing costs, health-care delivery models are focusing on the value of care. In this study, we compared the cost-effectiveness of single-row and double-row reconstructions in patients undergoing arthroscopic rotator cuff repair.
View Article and Find Full Text PDFEffect of CPAP, Weight Loss, or CPAP Plus Weight Loss on Central Hemodynamics and Arterial Stiffness.
Hypertension
December 2017
From the Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX (S.J.); Divisions of Sleep Medicine (I.G., G.M., S.T.K, A.I.P.), Nephrology (R.T) and Cardiovascular Medicine (J.A.C., Z.A.), Department of Medicine and Center for Weight and Eating Disorders, Department of Psychiatry (T.A.W), University of Pennsylvania Perelman School of Medicine, Philadelphia; Hospital of University of Pennsylvania, Philadelphia (R.T., S.T.K., T.A.W., A.I.P., J.A.C.); Corporal Michael Crescenz VA Medical Center, Philadelphia, PA (I.G.); Division of Diabetes, National Institutes of Health, Bethesda, MD (K.T.); Departments of Biostatistics Consulting Unit (J.C.) and Family and Community Health, (A.L.H.), School of Nursing, University of Pennsylvania, Philadelphia; Department of Cardiology, Lehigh Valley Health Network, Allentown, PA (H.S.); and Johns Hopkins University Technology and Innovation Center, Johns Hopkins University, Baltimore, MD (P.B.).
Unlabelled: Obesity and obstructive sleep apnea tend to coexist. Little is known about the effects of obstructive sleep apnea, obesity, or their treatment on central aortic pressures and large artery stiffness. We randomized 139 adults with obesity (body mass index >30 kg/m) and moderate-to-severe obstructive sleep apnea to (1) continuous positive airway pressure (CPAP) therapy (n=45), (2) weight loss (WL) therapy (n=48), or (3) combined CPAP and WL (n=46) for 24 weeks.
View Article and Find Full Text PDFMast Cell: An Unexpected Villain in Venous Thromboembolism?
Circ Res
September 2017
From the Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Australia (A.L.H., K.P.); Department of Medicine (A.L.H., K.P.) and Department of Immunology (K.P.), Monash University, Melbourne, Australia; and Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Australia (J.J.B.).
Effects of exercise on fitness and health of adults with spinal cord injury: A systematic review.
Neurology
August 2017
From the School for Sports, Exercise and Health Sciences (J.W.v.d.S., V.L.G.-T.), Peter Harrison Centre for Disability Sport, National Centre for Sport and Exercise Medicine, Loughborough University, UK; School of Health and Exercise Sciences (K.A.M.G.), University of British Columbia, Kelowna; ICORD (K.A.M.G., C.R.W.) and School of Kinesiology (C.R.W.), University of British Columbia, Vancouver; Department of Kinesiology (D.S.D.), Brock University, St. Catharines; Department of Kinesiology (A.L.H.), McMaster University, Hamilton; and Parkwood Institute (D.L.W.), Lawson Health Research Institute, London, Canada.
Objective: To synthesize and appraise research testing the effects of exercise interventions on fitness, cardiometabolic health, and bone health among adults with spinal cord injury (SCI).
Methods: Electronic databases were searched (1980-2016). Included studies employed exercise interventions for a period ≥2 weeks, involved adults with acute or chronic SCI, and measured fitness (cardiorespiratory fitness, power output, or muscle strength), cardiometabolic health (body composition or cardiovascular risk factors), or bone health outcomes.
Predicting Progression of Intracranial Arteriopathies in Childhood Stroke With Vessel Wall Imaging.
Stroke
August 2017
From the Department of Radiology (N.V.S., D.M.M.) and Departments of Pediatrics and Pediatric Neurology (T.J.B.), Children's Hospital Colorado, Aurora; and Hemophilia and Thrombosis Center (L.L.P., A.L.H., T.J.B.), Department of Anesthesiology (P.S.H., R.J.T.), and Department Neurology (S.P.), University of Colorado Denver, Aurora.
Background And Purpose: Childhood arterial ischemic stroke is frequently associated with an intracranial arteriopathy that often progresses in the first 3 to 6 months post stroke. We hypothesized that children with enhancing arteriopathies on vessel wall imaging (VWI) would have a higher risk of arteriopathy progression than those without enhancement.
Methods: Our institutional radiographic database was searched for cases of childhood stroke with VWI.
Effects of distributional information on categorization of prosodic contours.
Psychon Bull Rev
June 2018
Department of Brain and Cognitive Sciences, University of Rochester, 304 Meliora Hall, Rochester, NY, 14627, USA.
Although prosody clearly affects the interpretation of utterances, the mapping between prosodic representations and acoustic features is highly variable. Listeners may in part cope with this variability by adapting to distributions of acoustic features in the input. We examined whether listeners adapt to distributional changes using the construction It looks like an X.
View Article and Find Full Text PDFFire Simulation and Cardiovascular Health in Firefighters.
Circulation
April 2017
From British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (A.L.H., A.S.V.S., J.P.L., A.J.L., M.B., S.V., C.L.S., D.S., D.E.N., N.L.M.); ELEGI/Colt Laboratories, Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queens Medical Research Institute, United Kingdom (J.B.R.); Scottish Fire and Rescue Service, Edinburgh, United Kingdom (J.M.); Institute of Occupational Medicine, Edinburgh, United Kingdom (R.G.); and Edinburgh Heart Centre, Royal Infirmary of Edinburgh, United Kingdom (A.D.F.).
Background: Rates of myocardial infarction in firefighters are increased during fire suppression duties, and are likely to reflect a combination of factors including extreme physical exertion and heat exposure. We assessed the effects of simulated fire suppression on measures of cardiovascular health in healthy firefighters.
Methods: In an open-label randomized crossover study, 19 healthy firefighters (age, 41±7 years; 16 males) performed a standardized training exercise in a fire simulation facility or light duties for 20 minutes.
Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus.
Am J Gastroenterol
May 2017
GI Motility Program, Division of Gastroenterology, Department of Medicine, Cedars-Sinai, Los Angeles, California, USA.
Objectives: Breath tests (BTs) are important for the diagnosis of carbohydrate maldigestion syndromes and small intestinal bacterial overgrowth (SIBO). However, standardization is lacking regarding indications for testing, test methodology and interpretation of results. A consensus meeting of experts was convened to develop guidelines for clinicians and research.
View Article and Find Full Text PDFPhase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus.
Neurology
March 2017
From the Departments of Neurology (M.C.C., E.H.K., A.L.H., J.C.P., D.R.B., A.V., B.R., M.D., F.M.C., P.N.), Pediatrics (E.H.K., A.L.H.), and Anesthesiology-Critical Care Medicine (R.G.G.), Neurosurgery and Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurology (S.H.), Mayo Clinic, Rochester, MN; Neuroscience Institute (M.K., E.C.H., D.D., T.S.), Queen's Medical Center, Honolulu, HI; Department of Neurology (B.B.), Loyola University Health System, Maywood, IL; Institute for Clinical and Translational Research (B.H.-B.), Johns Hopkins University, Baltimore, MD; and Department of Neurology (P.W.K.), Johns Hopkins Bayview Medical Center, Baltimore, MD.
Objective: To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults.
Methods: We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was significant urine and serum ketone body production as a biomarker of feasibility.
Effects of Coping Skills Training on Quality of Life, Disease Biomarkers, and Clinical Outcomes in Patients With Heart Failure: A Randomized Clinical Trial.
Circ Heart Fail
January 2017
From the Duke University Medical Center, Durham, NC (A.S., J.A.B., B.M.H., L.L.W., P.J.S., C.M.O., J.G.R., K.S.J., J.S.); and University of North Carolina, Chapel Hill (G.G.K., K.F.A., C.S., P.P.C., A.L.H.).
Background: Heart failure (HF) is a chronic disease that compromises patients' quality of life (QoL). Interventions designed to reduce distress and improve disease self-management are needed. We evaluated the efficacy of a telephone-based coping skills training (CST) intervention.
View Article and Find Full Text PDFA live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation.
Nat Commun
December 2016
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization and there remains no pediatric vaccine. RSV live-attenuated vaccines (LAVs) have a history of safe testing in infants; however, achieving an effective balance of attenuation and immunogenicity has proven challenging. Here we seek to engineer an RSV LAV with enhanced immunogenicity.
View Article and Find Full Text PDFPrecise Noninvasive ECG Mapping Derived Localization of the Origin of an Epicardial Ventricular Tachycardia.
Circ Arrhythm Electrophysiol
December 2016
From the Cardiology Department (M.N., D.C.S.) and Division of Radiology (A.-L.H.), Geneva University Hospital, Switzerland; Federal Almazov North-West Medical Research Centre, Saint-Petersburg, Russia (M.C.); and EP Solutions SA, Yverdon-les-Bains, Switzerland (M.C.).
Disparities and guideline adherence in drugs of abuse screening in intracerebral hemorrhage.
Neurology
January 2017
From the Departments of Neurology (L.M.T., A.D.B., A.S., A.L.H., L.S.W., J.M.), Emergency Medicine (L.M.T.), Biostatistics (E.A.S.M., S.O.), Radiology (D.P.O.), and Neurosurgery (A.A.C.-G., T.J.L.), Indiana University School of Medicine; Regenstrief Institute (R.J.L.C., L.S.W., J.M.); and Richard L. Roudebush VA Medical Center (L.S.W.), Indianapolis, IN.
Objective: To characterize the pattern of urine drug screening in a cohort of intracerebral hemorrhage (ICH) patients at our academic centers.
Methods: We identified cases of primary ICH occurring from 2009 to 2011 in our academic centers. Demographic data, imaging characteristics, processes of care, and short-term outcomes were ascertained.
Combined Oral Contraceptives and Sexual Function in Women-a Double-Blind, Randomized, Placebo-Controlled Trial.
J Clin Endocrinol Metab
November 2016
Department of Learning, Informatics, Management and Ethics (N.Z.), Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Economics (A.D., M.J.), Stockholm School of Economics, 113 83 Stockholm, Sweden; Department of Economics (E.R.), University of Zurich, 8006 Zurich, Switzerland; Department of Women's and Children's Health (L.B., B.v.S., A.L.H), Karolinska Institutet, and Department of Obstetrics and Gynecology, Karolinska University Hospital, 171 76 Stockholm, Sweden; and Laval University (F.L.), Quebec City G1V 0A6, Canada.
Context: There is a lack of knowledge about how oral contraceptives may affect sexual function.
Objective: To determine whether there is a causal effect of oral contraceptives on sexuality. We hypothesized that a widely used pill impairs sexuality.
The Long-Term Outcome of Boys With Partial Androgen Insensitivity Syndrome and a Mutation in the Androgen Receptor Gene.
J Clin Endocrinol Metab
November 2016
University of Glasgow (A.L.-H., J.B., J.J., M.R., R.S., M.B., S.F.A.), Glasgow G51 4TF, United Kingdom; University Hospital Pisa (S.B.), 56125 Pisa, Italy; Copenhagen University Hospital (A.J., M.L.J.), 2100 Copenhagen, Denmark; University of Luebeck (O.H.), 23562 Luebeck, Germany; Christian-Albrechts-University of Kiel and University Hospital of Schleswig-Holstein (P.M.H.), 24105 Kiel, Germany; University Hospital Ghent and Ghent University (M.C.), B-9000 Ghent, Belgium; State University of Campinas (UNICAMP) (G.G.-F., G.G.-J.), Campinas 13083-970, Brazil; Dana Dwek Children's Hospital (N.W.), Tel Aviv University, Tel Aviv 64239, Israel; Leids Universitair Medisch Centrum (S.H.), 2333 ZA Leiden, The Netherlands; Sophia Children's Hospital (S.H.), Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands; Marmara University (T.G.), 34722 Istanbul, Turkey; Istanbul University (F.D.), 34452 Istanbul, Turkey; Karolinska Institutet (A.N.), SE-171 77 Stockholm, Sweden; and University of Cambridge (I.A.H., C.A., R.T.-C.), Cambridge CB2 1TN, United Kingdom.
Background: In boys with suspected partial androgen insensitivity syndrome (PAIS), systematic evidence that supports the long-term prognostic value of identifying a mutation in the androgen receptor gene (AR) is lacking.
Objective: To assess the clinical characteristics and long-term outcomes in young men with suspected PAIS in relation to the results of AR analysis.
Methods: Through the International Disorders of Sex Development Registry, clinical information was gathered on young men suspected of having PAIS (n = 52) who presented before the age of 16 years and had genetic analysis of AR.
Imaging biomarker roadmap for cancer studies.
Nat Rev Clin Oncol
March 2017
CRUK and EPSRC Cancer Imaging Centre in Cambridge and Manchester, University of Manchester, Manchester, UK.
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development.
View Article and Find Full Text PDFA combined method for correlative 3D imaging of biological samples from macro to nano scale.
Sci Rep
October 2016
Biomedical Optics Department, Laser Zentrum Hannover e.V., Hannover, Germany.
Correlative analysis requires examination of a specimen from macro to nano scale as well as applicability of analytical methods ranging from morphological to molecular. Accomplishing this with one and the same sample is laborious at best, due to deformation and biodegradation during measurements or intermediary preparation steps. Furthermore, data alignment using differing imaging techniques turns out to be a complex task, which considerably complicates the interconnection of results.
View Article and Find Full Text PDFAtherosclerotic Plaque Rupture: Identifying the Straw That Breaks the Camel's Back.
Arterioscler Thromb Vasc Biol
August 2016
From the Atherothrombosis and Vascular Biology Laboratory (Y.-C.C., A.L.H., K.P.), and Vascular Biology and Atherosclerosis Laboratory (T.S.K., A.B.), Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia; and Departments of Medicine and Immunology, Monash University, Melbourne, Victoria, Australia (A.L.H., A.B., K.P.).
National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence.
Hypertension
August 2016
From the Division of Cardiovascular Sciences (Y.S.O, Z.S.G., C.M.-B., E.T.) and Division of Intramural Research (N.N.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; Department of Medicine, Johns Hopkins University, Baltimore, MD (L.J.A.); Department of Neurology and Department of Immunobiology, Yale University School of Medicine, New Haven, CT (A.L.H., D.A.H.); Department of Epidemiology, Tulane University, New Orleans, LA (J.H.); Department of Physiology and Pharmacology, University of Toledo, OH (B.J.); Department of Medicine and Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (S.A.K.); Department of Physiology, Medical College of Wisconsin, Milwaukee (D.M.); Department of Pathology and Immunology, Washington University in St. Louis, MO (G.R.); Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (M.R.); Department of Medicine, Georgetown University, Washington, DC (K.S.); Department of Medicine, Vanderbilt University, Nashville, TN (J.T., D.G.H.); and Department of Physiology, University of Texas Health Science Center at San Antonio (G.M.T.).