6 results match your criteria: "A.G.Un.Co. Obstetrics and Gynaecology Center[Affiliation]"
Disclosing α-lactalbumin impact on the intestinal and vaginal microbiota of women suffering from polycystic ovary syndrome.
Microb Biotechnol
October 2024
Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
Article Synopsis
- Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women that negatively impacts their health and quality of life, and research suggests that changes in vaginal and intestinal bacteria may play a role in its development.
- A study highlights that women with PCOS experience a decrease in beneficial bacteria and an increase in harmful microbes, and examines the potential of a milk protein, α-lactalbumin (α-LA), to improve this bacterial imbalance.
- Results from both lab and initial human trials indicate that α-LA can promote the growth of healthy bacteria while suppressing harmful ones, suggesting its potential as a treatment to restore healthy microbial balance in women with PCOS.
Background: The management of mastodynia plays a central role in improving women quality of life. Despite its high occurrence, specific therapeutic guidelines for mastalgia are still lacking. Available therapies include unspecific anti-inflammatories, even though they may often expose to undesirable effects and low compliance.
View Article and Find Full Text PDFOral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
Biomed Pharmacother
September 2024
Istituto di Fisiologia Clinica - Consiglio Nazionale delle Ricerche (CNR), Pisa, Italy. Electronic address:
Article Synopsis
- - The study explored how inositol (INO) supplementation affects heart changes in mice caused by lithium (Li) exposure, using four different mouse groups over a 12-week period.
- - Findings showed that INO supplementation significantly reduced heart-related issues caused by Li, such as heart function impairment and arrhythmias, possibly by restoring potassium channel expression and inhibiting certain signaling pathways.
- - INO was effective both as a preventive measure when given with Li and as a therapeutic treatment when given after heart damage had occurred, highlighting its potential as a treatment for Li-induced heart problems.
Human papilloma virus (HPV) infection and the management of its persistence is still a great medical challenge. Recently, scientific evidence has supported the potential therapeutic effects of four combined natural molecules-epigallocatechin gallate (EGCG), folic acid, vitamin B12 and hyaluronic acid (HA)-in counteracting HPV DNA positivity and related cytological lesions. : Each patient of these five clinical cases had persistent HPV positivity in the anogenital site and assumed a dietary supplement based on a combination of 200 mg of EGCG, 50 mg of HA, 1 mg of vitamin B12 and 400 mcg of folic acid (Pervistop, Farmares s.
View Article and Find Full Text PDFLithium Treatment Induces Cardiac Dysfunction in Mice.
Int J Mol Sci
November 2023
Institute of Clinical Physiology, National Research Council (CNR), 56124 Pisa, Italy.
Lithium (Li) salts are commonly used as medications for bipolar disorders. In addition to its therapeutic value, Li is also being increasingly used as a battery component in modern electronic devices. Concerns about its toxicity and negative impact on the heart have recently been raised.
View Article and Find Full Text PDFHyperinsulinemia Alters Myoinositol to d-chiroinositol Ratio in the Follicular Fluid of Patients With PCOS.
Reprod Sci
July 2014
Département de Médecine et Physiologie/Biophysique, Université de Sherbrooke, Canada.
Myoinositol (MI) and d-chiroinositol (DCI) are 2 stereoisomers and insulin sensitizers. Their physiological ratio differs from tissue to tissue, and they are regulated by an insulin-dependent epimerase whose activity is drastically reduced in conditions of insulin resistance. Based on literature data and on the fact that MI phospholipids are follicle-stimulating hormone (FSH) second messengers, we speculated that patients with polycystic ovary syndrome (PCOS) having hyperinsulinemia, present an enhanced MI to DCI epimerization in the ovary, leading to MI deficiency that impairs FSH signaling, resulting in reduced oocyte quality.
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