Comparison of the pharmacokinetics of a new 15-mg modified-release tablet formulation of metoclopramide versus a 10-mg immediate-release tablet: a single- and multiple-dose, randomized, open-label, parallel-group study in healthy Mexican male volunteers.

Background: Metoclopramide is a prokinetic and antiemetic agent.

Objective: The goal of this study was to assess the pharmacokinetics of a new, modified-release metoclopramide tablet and compare it with an immediate-release tablet to obtain marketing approval from the Mexican regulatory agency.

Methods: This was a single-center, randomized, open-label, parallel-group, single- and multiple-dose, pharmacokinetic study.