[A morphological and electron radioautographic study of the wound in the diabetic foot syndrome].

Two groups of patients with a grave form of diabetes mellitus type I and II with diabetic foot syndrome have been examined. Group 1 (21 cases) consisted of patients whose foot was amputated. The cause of the necrotic process was ischemia produced by alteration of the arterial vessels aggravated by infection.

[10 years' experience of using cultured human skin cells for the treatment of thermal burns].

The authors have developed a unique method of treating extensive burns by transplantation of the cultivated cells on the affected area. The main elements of the transplant are not keratinocytes but fibroblasts, and this is a principal difference with other methods. The transplanted fibroblasts actively synthesize DNA, collagen, fibronectin, glycosaminoglycanes which comprise the extracellular matrix formed by cells.

[Clinico-laboratory effectiveness of modern ointments with a polyethylene glycol base in the treatment of purulent wounds].

The 25-year experience with the underbandage treatment of soft tissue purulent wounds of various location and genesis with modern ointments with polyethylene glycol as the basis was analyzed. Levocin, levomecole, dioxycole, 5-percent dioxydinic, 1-percent iodopyronic, 0.5-percent quinifuryl and furagel ointments proved to preserve their high activity against aerobic grampositive and gramnegative flora.

[Use of ceftriaxone in the prevention of postoperative purulent complications after surgery on the stomach and small intestine].

Ceftriaxone was administered intravenously in a single dose of 1.0 g 15 minutes prior to surgical intervention for peptic ulcer and gastric or duodenum tumor in 31 patients at the age of 33 to 74 years. In all the patients primary adhesion of the surgical wound was recorded.

[Use of pefloxacin in the treatment of patients with purulent wounds of soft tissues].

Pefloxacin was used in the treatment of 25 patients with wound infection in a dose of 400 mg orally twice a day for 10-12 days. As the monotherapy it was applied to 15 patients. 7 patients with clinical signs of non-clostridial anaerobic infection were treated with pefloxacin in combination with intravenous metronidazole.

[Laboratory and clinical study of nitazole].

Nitazole, a drug from the nitrotiazole group, was shown to be active in vitro against bacteroides, peptococci, peptostreptococci, clostridia, staphylococci, colibacilli and streptococci. By its activity and antibacterial spectrum nitazole had some advantages over metronidazole, a drug from the nitroimidazole group. Experimental study of nitazole aerosole formulation in 4 models of purulent wounds of rabbits infected by Bacteroides fragilis, B.

[Efficacy of lomefloxacin and ofloxacin in complex therapy of infections in patients with burns].

The experience with lomefloxacin and ofloxacin respectively in the complex therapy of 26 and 40 patients with burns is described. The drugs were shown to be highly active in the treatment of burn wound infections and infectious complications of burn disease. The clinical efficacy of lomefloxacin and ofloxacin amounted to 88 and 77.

[Clinical and laboratory study of cefodizime (Modivid) in prophylaxis and treatment of surgical patients].

The results of the clinical and laboratory study of the efficacy of the prophylactic and therapeutic use of cefodizime (modivid) in patients with chronic calculous cholecystitis and burns are presented. Expediency of the preoperative prophylactic use of the drug and its significance in the treatment of infectious complications of the burn disease were verified. The immunological investigation gave evidence of an increase of the phagocytosis functional activity when cefodizime (modivid) was used prophylactically in cholecystectomy.

[General pathology--an independent medical discipline].

Recognition of general pathology as an independent discipline is urgent at this stage of medical science development. Its contents are basic rules of the origin, development and outcomes of human diseases. It is desirable to organize in the medical schools chairs (courses) of general pathology as an supradiscipline subject the knowledge of which is necessary to the wide circle of students, interns, physicians of all specialties.

[Multicenter open randomized trial of meropenem in comparison to ceftazidime and amikacin used in combination in severe hospital infections].

Clinical efficacy and tolerance of meropenem were estimated by comparison with those of ceftazidime and amikacin used in combination in the therapy of hospital infections of the lower respiratory tract, skin and soft tissues, intraabdominal and gynecologic infections, urinary tract infection and sepsis. 48 patients were given meropenem in a dose of 1 g every 8 hours for 3-14 days (the average of 9 days). 47 patients were subjected to the routine combined therapy: ceftazidime in a dose of 1 g every 8 hours and amikacin in a dose of 0.

Crab collagenase in wound debridement.

A comparative study was performed of the caseinolytic, necrolytic and fibrinolytic activities of a crab collagenase product prepared from the hepatopancreas of the king crab (Paralithodes camtschatica) and four enzyme preparations (trypsin/chymotrypsin and protease complexes isolated from Aspergillus terricola, Carica papaya and pseudomonodaceae). This paper reports an in vitro investigation, an in vivo study with rats and a clinical evaluation. It was found that crab collagenase has the highest proteolytic activity measured with respect to fibrin clot and necrotic eschar in vitro although its caseinolytic activity is the lowest.

Surgical treatment of postburn boutonniere deformity.

A new method of surgical treatment of postburn boutonniere deformity was used in 124 fingers of 66 patients. This method includes reconstruction of the lateral band's position of an extensor apparatus and anatomic continuity of a central band. Before tendon plasty, passive movements in a proximal interphalangeal joint are restored and contracture of others joints is released.

[Effectiveness of pefloxacin in the surgical clinic].

Pefloxacin (Rhone-Poulenc, France) was used prophylactically and therapeutically in 8 and 21 surgical inpatients respectively. The majority of the Enterobacteriaceae isolates were susceptible to pefloxacin (91 to 100 per cent). The isolates of Acinetobacter spp.

[Microflora of purulent necrotic leisions of the foot in patients with diabetes mellitus].

Microflora of purulent necrotic lesions of the foot in 14 patients with diabetes mellitus was investigated by aerobic and anaerobic procedures. It was shown that the process was due to the same species of pathogenic microorganisms irrespective of the lesion severity. However, the number of the pathogens in the associations and the dissemination level per a patient were higher when the lesions were extended.

Postburn facial resurfacing with a split ascending neck flap.

Ninety-eight patients with postburn facial scar deformities were treated by using a split ascending neck flap. Anatomic studies and discovery of axial blood supply to the anterior of the neck are utilized, allowing for wide mobilization, thin flaps, and transfer of neck skin to the face and chest skin to the neck. By leaving the platysma muscle in situ and using vacuum drainage with a large tube in the subflap space, preservation of the chin and neck contours is obtained.

Enteral hyperalimentation of burned patients: the possibility of correcting metabolic disorders by the early administration of prolonged high calorie evenly distributed tube feeds.

Metabolic processes and the ways they may be treated were investigated in severely burned patients receiving prolonged high calorie evenly distributed tube feedings. It was shown that in critically ill patients the absorption of nutrients in the upper regions of the intestine was slightly impaired but the ability to absorb was preserved, which made it possible to provide prolonged evenly distributed tube feeding. For these purposes we used the nutrient mixture 'Combustal'.

[Clinical and laboratory effect of leukinferon in purulent infections].

Clinical trials of human leukocytic alpha-interferon for injections, leukinferon were performed in 51 patients with different forms of surgical purulent infections. It was shown that leukinferon lowered the terms of normalization of body's temperature, leukocytosis, respiratory neutrophilic outbreak and levels of active T-lymphocytes. The same was observed when leukinferon was used prophylactically in cardiosurgical patients.

One-stage operation for bilateral bullous lung disease.

Sixteen patients with bilateral bullous lung disease have been operated on. One-stage surgical interventions--bullectomy and parietal pleurectomy--have been performed on both sides through a transsternal approach. There was a complication in one case: relaxation of the right hemidiaphragm as a result of phrenic nerve injury.