327 results match your criteria: "A. Gemelli University Polyclinic Foundation[Affiliation]"

Fibrotic lung diseases (FLDs) represent a subgroup of interstitial lung diseases (ILDs), which can progress over time and carry a poor prognosis. Imaging has increased diagnostic discrimination in the evaluation of FLDs. International guidelines have stated the role of radiologists in the diagnosis and management of FLDs, in the context of the interdisciplinary discussion.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the impact of adequate empirical combination therapy (AECT) on 30-day mortality rates in septic shock patients infected with Pseudomonas aeruginosa.
  • Of 98 patients analyzed, those receiving AECT had a significantly lower mortality rate (25%) compared to those on adequate empirical monotherapy (AEMT) (56.8%), indicating AECT may enhance survival.
  • The findings suggest transitioning to a single effective antibiotic after confirming susceptibility is safe, highlighting the need for further research to validate these results.
View Article and Find Full Text PDF

Background: Sciatica usually results from lumbar nerve compression due to factors like disc herniations or lumbar canal stenosis. Despite its common causes, sciatic pain in a 52-year-old man following a coronavirus disease 2019 infection highlighted the importance of considering less common factors. Initially, minor disc protrusions were suspected as the cause of the symptoms, leading to the offer of surgery at another facility.

View Article and Find Full Text PDF

Over the past decade, dupilumab, a monoclonal human antibody that inhibits interleukin (IL)-4 and IL-13 signalling, has revolutionized the therapeutic management of moderate-to-severe atopic dermatitis (AD), facilitating long-term control of its signs and symptoms. The aim of this study was to identify histological predictors of the efficacy of dupilumab after 16 weeks of treatment in a cohort of 40 adults with moderate-to-severe AD who had undergone a skin biopsy for diagnostic purposes before treatment initiation. We found that Eczema Area and Severity Index (EASI) 75 and EASI 90 responses at week 16 were significantly associated with perivascular localization [odds ratio (OR) 17.

View Article and Find Full Text PDF

Background: Robotic-assisted surgery (particularly with the da Vinci Surgical System) has revolutionized urological interventions. The advent of the Versius Surgical System introduces a compelling alternative. This study compares outcomes of extraperitoneal robot-assisted radical prostatectomy (eRARP) using da Vinci and Versius, presenting the largest case series to date.

View Article and Find Full Text PDF

Background: A bloodstream infection (BSI) prognostic score applicable at the time of blood culture collection is missing.

Methods: In total, 4,327 patients with BSIs were included, divided into a derivation (80%) and a validation dataset (20%). Forty-two variables among host-related, demographic, epidemiological, clinical, and laboratory extracted from the electronic health records were analyzed.

View Article and Find Full Text PDF

Objective: The study aimed to assess the prevalence of dental malocclusion, orthodontic parameters, and parafunctional habits in children with developmental dyslexia (DD).

Methods: Forty pediatric patients (67.5% boys and 32.

View Article and Find Full Text PDF

In acute respiratory distress syndrome, the role of positive end-expiratory pressure (PEEP) to prevent ventilator-induced lung injury is controversial. Randomized trials comparing higher versus lower PEEP strategies failed to demonstrate a clinical benefit. This may depend on the inter-individually variable potential for lung recruitment (i.

View Article and Find Full Text PDF

Background: Differences between men and women in prognosis after sudden pre-hospital out-of-hospital cardiac arrest (OHCA) have been described in many studies, but the interplay between gender and pollution have not been characterized in detail. We aimed at appraising the interplay between gender and pollution on the prognosis of OHCA.

Methods: Details on patients with OHCA in whom return of spontaneous circulation was obtained and transferred to a large teaching hospital were obtained from the medical charts of the ambulance service and the Polish National Health Fund.

View Article and Find Full Text PDF

Multicenter external validation of prediction models for clinical outcomes after spinal fusion for lumbar degenerative disease.

Eur Spine J

September 2024

Machine Intelligence in Clinical Neuroscience and Microsurgical Neuroanatomy (MICN) Laboratory, Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background: Clinical prediction models (CPM), such as the SCOAP-CERTAIN tool, can be utilized to enhance decision-making for lumbar spinal fusion surgery by providing quantitative estimates of outcomes, aiding surgeons in assessing potential benefits and risks for each individual patient. External validation is crucial in CPM to assess generalizability beyond the initial dataset. This ensures performance in diverse populations, reliability and real-world applicability of the results.

View Article and Find Full Text PDF

Background: Urolithiasis prevalence varies globally between 1-20%, influenced by regional factors. Robotic pyelolithotomy (RPL) presents an interesting alternative to PCNL, considered the gold standard for symptomatic stones smaller than 20 mm, as it carries a risk of significant complications. However, studies on RPL are limited, especially in anatomically complex cases, where RPL proves to be particularly useful.

View Article and Find Full Text PDF

The review explores the 2022 update to the World Health Organization (WHO) classification of pituitary adenomas, now referred to as pituitary neuroendocrine tumors (PitNETs), and his possible impact on the clinical management of PitNET patients. The review highlights the differences and the evolution from the 2017 to 2022 version, with the current classification considering the lineage of the tumor cells, cell type, hormones produced, and other auxiliary characteristics for a comprehensive histological classification. The revision in terminology reflects a broader perspective on neuroendocrine neoplasia.

View Article and Find Full Text PDF
Article Synopsis
  • - This study aimed to compare the number of pediatric admissions for acute bronchiolitis between the 2021-2022 and 2022-2023 seasons, and also to look at the recurrence of bronchiolitis in the same patients across these seasons.
  • - Conducted at a Pediatric Emergency Department in Rome, the research focused on children aged 0-2 years diagnosed with bronchiolitis, revealing notable differences in age and admission characteristics across the two seasons.
  • - Findings indicated that the median age of affected children decreased in the latest season, with an increase in severe cases and recurrence of bronchiolitis episodes, highlighting the evolving epidemiology of the condition post-COVID-19.
View Article and Find Full Text PDF

Introduction: Alterations of scapular kinematics are generically reported as scapular dyskinesis (SD), and are a nonspecific response to various shoulder pathologies. The most widely used classification is Kibler's (K), which is, however, characterized by poor sensitivity. To overcome this limit, using a 3D motion analysis system, we identified a specific pattern for each type of SD according to Kibler.

View Article and Find Full Text PDF

Malnutrition and sarcopenia in children with cancer.

Minerva Pediatr (Torino)

December 2024

Unit of Pediatric Oncology, IRCCS A. Gemelli University Polyclinic Foundation, Sacred Heart Catholic University, Rome, Italy -

View Article and Find Full Text PDF

Background: Nowadays children live in a digital world, exposed to relevant risks for their health and safety. The aim of this study is to investigate the use of multimedia devices in a sample of children and adolescents.

Methods: The study was performed between November 2018 and June 2019 in a third-level University Hospital, recruiting children and adolescents during general or specialistic follow-up visits.

View Article and Find Full Text PDF

Introduction: The role of rehabilitation during and after the COVID-19 pandemia was influenced by the progressive acquisition of knowledge on the pathology with the adaptation of the rehabilitative instruments to the heterogeneous impairments of the patients. The aim of this systematic review is to describe the effects of the rehabilitation tools applied in the last three years in the different phases of the COVID-19 disease.

Evidence Acquisition: A literature search of MEDLINE (PubMed), Scopus and Physiotherapy Evidence Database (PEDro) was conducted.

View Article and Find Full Text PDF

Background: Bowel preparation (BP) for colonoscopy induces significant changes in gut microbiota, causing dysbiosis that, in turn, elicits intestinal symptoms. Consequently, probiotics may counterbalance the disturbed microbiota after BP. So, probiotics may restore microbiota homeostasis.

View Article and Find Full Text PDF

Background: Catheter ablation (CA) of atrial fibrillation is routinely used to obtain rhythm control. Evidence suggest that catheter ablation should be done during uninterrupted oral anticoagulation.

Methods: Italian Registry in the setting of atrial fibrillation ablation with rivaroxaban (IRIS) is an Italian multicenter, non-interventional, prospective study which enrolled 250 consecutive atrial fibrillation patients eligible for catheter ablation on rivaroxaban.

View Article and Find Full Text PDF

Background: Alopecia areata (AA) is an organ-specific autoimmune disease that affects the hair follicles of the scalp and the rest of the body causing hair loss. Due to the unpredictable course of AA and the different degrees of severity of hair loss, only a few well-designed clinical studies with a low number of patients are available. Also, there is no specific cure, but topical and systemic anti-inflammatory and immune system suppressant drugs are used for treatment.

View Article and Find Full Text PDF

SIDeMaST (Società Italiana di Dermatologia Medica, Chirurgica, Estetica e delle Malattie Sessualmente Trasmesse) contributed to the development of the present guideline on the systemic treatment of chronic plaque psoriasis. With the permission of EuroGuiDerm, SIDeMaST adapted the guideline to the Italian healthcare context to supply a reliable and affordable tool to Italian physicians who take care of patients affected by atopic dermatitis. The evidence- and consensus-based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual.

View Article and Find Full Text PDF
Article Synopsis
  • - SIDeMaST developed guidelines for treating chronic plaque psoriasis and adapted them for the Italian healthcare system, aiming to provide a dependable resource for doctors treating atopic dermatitis patients in Italy.
  • - The guideline follows the EuroGuiDerm Manual and was created with the input of 29 experts from 12 European countries, involving four consensus conferences held between December 2020 and July 2021.
  • - It includes comprehensive information on systemic therapies, discussing conventional immunosuppressants, biologics, and Janus kinase inhibitors, while the second part will focus on factors like diet, immunotherapy, and considerations for special patient groups.
View Article and Find Full Text PDF

A new light on secukinumab in pediatric psoriasis.

Ital J Dermatol Venerol

August 2024

Unit of Dermatology, Department of Precision and Regenerative Medicine and Jonian Area, University of Bari Aldo Moro, Bari, Italy -

View Article and Find Full Text PDF