51 results match your criteria: "984375 Nebraska Medical Center[Affiliation]"

Chronic alcohol consumption exacerbates ischemia-associated skeletal muscle mitochondrial dysfunction in a murine model of peripheral artery disease.

Biochim Biophys Acta Mol Basis Dis

February 2025

Department of Public Health, Usha Kundu MD College of Health, University of West Florida, Pensacola, FL, USA; Department of Biology, Baylor University, Waco, TX, USA. Electronic address:

Article Synopsis
  • Peripheral artery disease (PAD) leads to muscle damage linked to mitochondrial dysfunction, and the study aims to understand how alcohol and a high-fat diet affect this condition in a mouse model.
  • Mice were placed on high-fat-sucrose (HFS) or low-fat-sucrose (LFS) diets and given ethanol to analyze its impact on oxidative stress and mitochondrial health after inducing limb ischemia.
  • Findings revealed that high-fat and alcohol consumption worsened mitochondrial issues in muscles, with reduced levels of the enzyme ALDH2 correlating with increased oxidative stress, suggesting ALDH2 may be a therapeutic target for PAD patients with unhealthy diets.
View Article and Find Full Text PDF

Reflection function, reflectance, and area function measurements in ears of children and adults.

J Acoust Soc Am

October 2024

College of Public Health, Department of Biostatistics, University of Nebraska Medical Center, 984375 Nebraska Medical Center, Omaha, Nebraska 68198, USA.

The main experiment concerned time-domain measurements of the acoustical reflection function (RF) of the human ear in adults and children (aged 5 to 8 years) using a probe inserted into the ear canal. This RF was used to calculate the area function of the ear canal versus distance along its centerline. Acoustical reflectance was calculated in the frequency domain from the RF, as was the difference in sound pressure level near the tympanic membrane relative to the probe tip.

View Article and Find Full Text PDF

The effect of non-immersive virtual reality radiographic positioning simulation on first-year radiography students' image evaluation performance.

Radiography (Lond)

July 2024

Kinesiology and Sport Sciences Department, Kinesiology and Sport Sciences, University of Nebraska at Kearney, 1410 W 26th St. Kearney, Ne 68849, United States of America. Electronic address:

Introduction: Optimal radiographic image quality is critical because it affects the accuracy of the reporter's interpretation. Radiographers have an ethical obligation to obtain quality diagnostic images while protecting patients from unnecessary radiation, including minimizing rejected and repeated images. Repeated imaging due to positioning errors have increased in recent years.

View Article and Find Full Text PDF

Background: Over 50% of hospitalizations from hepatic encephalopathy (HE) are preventable, but patients often do not receive medical treatment.

Aims: To use a multimodal education intervention (MMEI) to increase HE treatment rates and to evaluate (1) trends in HE treatment, (2) predictors of receiving treatment, and (3) the impact of treatment on hospitalization outcomes.

Methods: Prospective single-center cohort study of patients hospitalized with HE from April 1, 2020-September 30, 2022.

View Article and Find Full Text PDF

Enhancing walking performance in patients with peripheral arterial disease: An intervention with ankle-foot orthosis.

Int J Cardiol

July 2024

Department of Biomechanics, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE 68182, USA; Department of Surgery and VA Research Service, VA Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA. Electronic address:

Lower extremity peripheral artery disease (PAD) is a cardiovascular condition manifesting from narrowed or blocked arteries supplying the legs. Gait is impaired in patients with PAD. Recent evidence suggests that walking with carbon fiber ankle foot orthoses (AFOs) can improve patient mobility and delay claudication time.

View Article and Find Full Text PDF

Comparing bullying to ACEs in the national survey of children's health: Examining 2016-2019 prevalence trends among children and adolescents.

Child Abuse Negl

May 2024

Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, 984395 Nebraska Medical Center, Omaha, NE 68198-4395, United States of America.

Objectives: To estimate adverse childhood experience (ACE) prevalence among children and adolescents aged 6-17 years in the United States, to examine factors influencing the prevalence of ACEs over the time period 2016-2019, and to examine the difference in bullying trends compared to ACEs in the NSCH.

Participants And Setting: The National Survey of Children's Health (NSCH) is a cross-sectional survey. Participants included respondents who completed the separate surveys for ages 6-11 and 12-17 from 2016 to 2019.

View Article and Find Full Text PDF

Objective: To analyze the rural-urban access to otolaryngology (OHNS) care within the state of Nebraska.

Design: Cross-sectional study.

Methods: Counties in Nebraska were categorized into rural versus urban status based upon the 2013 National Center for Health Statistics urban-rural classification scheme with I indicating most urban and VI indicating most rural.

View Article and Find Full Text PDF

Background: The Coronavirus disease 2019 (COVID-19) pandemic disrupted patient care and worsened the morbidity and mortality of some chronic diseases. The impact of the COVID-19 pandemic on hospitalizations and outcomes in patients with cirrhosis both before and during different time periods of the pandemic has not been evaluated.

Aims: Describe characteristics of hospitalized patients with cirrhosis and evaluate inpatient mortality and 30-day readmission before and after the start of the COVID-19 pandemic.

View Article and Find Full Text PDF

Purpose: Robotic-assisted (RA) bariatric surgery has been increasingly used without consistent benefit over a laparoscopic approach (LA). We compared intra- and post-operative complications and 30- and 90-day all-cause readmissions between RA and LA using the Nationwide Readmissions Database (NRD).

Materials And Methods: We identified hospitalizations with adult patients who underwent RA or LA bariatric surgery from 2010 to 2019.

View Article and Find Full Text PDF

The purpose of this work is to improve the efficiency in estimating the average causal effect (ACE) on the survival scale where right-censoring exists and high-dimensional covariate information is available. We propose new estimators using regularized survival regression and survival Random Forest (RF) to adjust for the high-dimensional covariate to improve efficiency. We study the behavior of the adjusted estimators under mild assumptions and show theoretical guarantees that the proposed estimators are more efficient than the unadjusted ones asymptotically when using RF for the adjustment.

View Article and Find Full Text PDF

Background: Early studies during the COVID-19 pandemic identify the dissonance between feeling anxious about contracting the illness and the innate desire to serve the sick, as a main stressor for students.

Purpose: The purpose of this study is to better understand psychological stress and self-reported wellness of Physician Assistant (PA), Physical Therapy (PT), dental, and medical students during the early portions of the COVID-19 pandemic.

Methods: We utilized the 10-item Perceived Stress Scale (PSS) together with additional questions to assess self-perceived stress, anxiety, and wellness of healthcare students.

View Article and Find Full Text PDF

Background: Parental Medicaid eligibility has been shown to be linked to positive academic and school outcomes for children. However, the impact of adult Medicaid expansion on children's school absenteeism is largely unexplored in the literature. The aim of this study was to examine whether Medicaid expansion for adults under the Affordable Care Act (ACA), affected school absenteeism of children.

View Article and Find Full Text PDF
Article Synopsis
  • Point-of-care ultrasound (POCUS) devices are increasingly used in healthcare, but their cleaning practices needed evaluation to ensure safety, especially during the COVID-19 pandemic.
  • A study was conducted over a year, comparing cleaning rates of ultrasound machines before and after a quality improvement initiative focused on increasing physician knowledge and access to cleaning supplies.
  • Results showed a significant increase in cleaning thoroughness post-intervention, alongside improved physician understanding of cleaning guidelines, despite no change in cleaning rates before and after the pandemic.
View Article and Find Full Text PDF

Endothelial cell-derived pro-fibrotic factors increase TGF-β1 expression by smooth muscle cells in response to cycles of hypoxia-hyperoxia.

Biochim Biophys Acta Mol Basis Dis

January 2022

Department of Biology, Baylor University, B.207 Baylor Science Building, One Bear Place #97388, Waco, TX 76798-7388, USA. Electronic address:

Background: The vascular pathology of peripheral artery disease (PAD) encompasses abnormal microvascular architecture and fibrosis in response to ischemia-reperfusion (I/R) cycles. We aimed to investigate the mechanisms by which pathological changes in the microvasculature direct fibrosis in the context of I/R.

Methods: Primary human aortic endothelial cells (ECs) were cultured under cycles of normoxia-hypoxia (NH) or normoxia-hypoxia-hyperoxia (NHH) to mimic I/R.

View Article and Find Full Text PDF

Higher Readmission Rates After Hip Fracture Among Patients With Vestibular Disorders.

Otol Neurotol

October 2021

Department of Otolaryngology - Head and Neck Surgery, University of Nebraska Medical Center, 981225 Nebraska Medical Center.

Objective: Falls in older adults are associated with high morbidity and mortality. Patients with vestibular disorders may have an increased risk. The purpose of this study was to examine the outcomes among patients with underlying vestibular disorders who have hip fractures and identify predictors of increased morbidity and mortality.

View Article and Find Full Text PDF

Background: Perinatal inflammation adversely affects health. Therefore, aims of this IRB-approved study are: (1) compare inflammatory compounds within and between maternal and umbilical cord blood samples at the time of delivery, (2) assess relationships between inflammatory compounds in maternal and cord blood with birth characteristics/outcomes, and (3) assess relationships between blood and placental fat-soluble nutrients with blood levels of individual inflammatory compounds.

Methods: Mother-infant dyads were enrolled (n = 152) for collection of birth data and biological samples of maternal blood, umbilical cord blood, and placental tissue.

View Article and Find Full Text PDF

POISSON COKRIGING AS A GENERALIZED LINEAR MIXED MODEL.

Spat Stat

March 2020

Department of Statistics, University of Nebraska-Lincoln, 340 Hardin Hall North Wing, Lincoln, NE 68583-0963, USA.

It is often of interest to predict spatially correlated count outcomes that follow a Poisson distribution. For example, in the environmental sciences we may want to predict pollen counts using temperature or precipitation data as auxiliary variables. To predict a Poisson outcome variable in the presence of an auxiliary variable, Poisson cokriging as a Generalized Linear Mixed Model (GLMM) is proposed.

View Article and Find Full Text PDF

Background: Alcohol withdrawal and its consequences are a common concern for the large numbers of patients who present to emergency departments (EDs) with alcohol use disorders. While the majority of patients who go on to develop alcohol withdrawal experience only mild symptoms, a small proportion will experience seizures or delirium tremens. The aim of this study was to develop a tool to predict the need for hospital admission in patients at risk for alcohol withdrawal using only objective criteria that are typically available during the course of an ED visit.

View Article and Find Full Text PDF

Objectives: The primary objective of the current study is to describe the prevalence and profile of cognitive domains affected in older adults with hematological malignancies evaluated for hematopoietic cell transplantation (HCT) using the Montreal Cognitive Assessment (MoCA) and neuropsychological tests. The secondary objective is to determine if a specific MoCA cut-off score would correlate with the identification of cognitive impairment detected by neuropsychological tests. This would facilitate interpretation of cognitive screening and referral of patients who would likely need further neuropsychological testing.

View Article and Find Full Text PDF

Patient and system factors associated with unassisted and injurious falls in hospitals: an observational study.

BMC Geriatr

December 2019

Division of Physical Therapy Education, College of Allied Health Professions, University of Nebraska Medical Center, 984420 Nebraska Medical Center, Omaha, NE, 68198-4420, USA.

Background: Unassisted falls are more likely to result in injury than assisted falls. However, little is known about risk factors for falling unassisted. Furthermore, rural hospitals, which care for a high proportion of older adults, are underrepresented in research on hospital falls.

View Article and Find Full Text PDF

Background: A relationship exists between step width and energy expenditure, yet the contribution of dynamic stability to energy expenditure is not completely understood. Chronic obstructive pulmonary disease (COPD) patients' energy expenditure is increased due to airway obstruction. Further, they have a higher prevalence of falls and balance deficits compared to controls.

View Article and Find Full Text PDF

Background: Conducting post-fall huddles is considered an integral component of a fall-risk-reduction program. However, there is no evidence linking post-fall huddles to patient outcomes or perceptions of teamwork and safety culture. The purpose of this study is to determine associations between conducting post-fall huddles and repeat fall rates and between post-fall huddle participation and perceptions of teamwork and safety culture.

View Article and Find Full Text PDF

Association of electronic cigarette vaping and subsequent smoking relapse among former smokers.

Drug Alcohol Depend

June 2019

Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, United States; Department of Psychology, University of Southern California, Los Angeles, United States; USC Norris Comprehensive Cancer Center, Los Angeles, United States. Electronic address:

Background: Former combustible cigarette smokers who vape e-cigarettes after quitting smoking may experience health benefits if post-quit vaping prevents smoking relapse.

Methods: Former combustible cigarette smokers aged >18 that were recent (quit ≤ 12 months) or long-term (quit > 12 months) quitters at baseline were re-surveyed at 1-year follow-up in the Population Assessment of Tobacco and Health (PATH) U.S.

View Article and Find Full Text PDF

The impact of travel time on colorectal cancer stage at diagnosis in a privately insured population.

BMC Health Serv Res

March 2019

Department of Epidemiology, University of Nebraska Medical Center, College of Public Health, 984395 Nebraska Medical Center, Omaha, NE, 68198-4395, USA.

Background: Rural residents are less likely to receive screening for colorectal cancer (CRC) than urban residents. However, the mechanisms underlying this disparity, especially among people aged 50-64 years old with private health insurance, are not well understood. We examined the impact of travel time on stage at CRC diagnosis.

View Article and Find Full Text PDF

Stride-time variability is related to sensorimotor cortical activation during forward and backward walking.

Neurosci Lett

January 2019

Department of Biomechanics and Center for Research in Human Movement Variability, College of Education, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE, 68182-0860, USA; Department of Environmental, Agricultural, and Occupational Health, College of Public Health, University of Nebraska Medical Center, 984388 Nebraska Medical Center, Omaha, NE, 68198-4388, USA. Electronic address:

Previous research has used functional near-infrared spectroscopy (fNIRS) to show that motor areas of the cortex are activated more while walking backward compared to walking forward. It is also known that head movement creates motion artifacts in fNIRS data. The aim of this study was to investigate cortical activation during forward and backward walking, while also measuring head movement.

View Article and Find Full Text PDF